William V Stoecker, Jonathan Kopel, Navin Geria, Nasim Nosoudi
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Antioxidant, Keratolytic, and Hydrating Treatment for Seborrheic Keratoses.
Background: Seborrheic keratoses (SKs) are the most common skin lesions to prompt visits to a dermatologist. Patients may be concerned about unsightly appearance, irritation, or the possibility of skin cancer. They frequently ask if there is a topical treatment for these lesions.
Objective: We sought to determine an effective topical formula to improve the appearance of seborrheic keratosis and test the formula in a pilot observational study on a small number of patients.
Methods and materials: A topical mixture of antioxidants, hydrating, and keratolytic agents was applied to five SKs on four patients in a private dermatology clinic. Antioxidants included green walnut hull extract, green tea, ellagic acid from pomegranate, curcumin in turmeric, and rosemary. Urea, salicylic acid, zinc lactate, and glycerin promoted hydration and keratolysis. Lesions were covered with 3M Nexcare® dressings. Softened SK debris was removed with an emery board.
Results: The appearance of the SKs was improved in five cases.
Conclusions and relevance: A 5-to-17-day course of a topical mixture composed of antioxidant, keratolytic, and hydrating agents, followed by scooping of softened SK, improved the appearance of 5 SKs. The topical antioxidant mixture reported in this pilot study warrants further investigation. J Drugs Dermatol. 2025;24(2):183-187. doi:10.36849/JDD.7977.
期刊介绍：
The Journal of Drugs in Dermatology (JDD) is a peer-reviewed publication indexed with MEDLINE®/PubMed® that was founded by the renowned Dr. Perry Robins MD. Founded in 2002, it offers one of the fastest routes to disseminate dermatologic information and is considered the fastest growing publication in dermatology.
We present original articles, award-winning case reports, and timely features pertaining to new methods, techniques, drug therapy, and devices in dermatology that provide readers with peer reviewed content of the utmost quality.
Our high standards of content are maintained through a balanced, peer-review process. Articles are reviewed by an International Editorial Board of over 160 renowned experts.
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