Journal of Drugs in Dermatology最新文献_第10页

Myo-Inositol in Pregnancy: Implications for Acne Management. 妊娠期肌醇：对痤疮管理的影响。

IF 2.2 4区医学

Journal of Drugs in Dermatology Pub Date : 2026-07-01 DOI: 10.36849/JDD.9783

Daniela Baboun, Marita Yaghi, Jennifer Keelin, Daniella M Hernandez-Bueso, Valery Fernandez Fernandez, Jonette Keri

{"title":"Myo-Inositol in Pregnancy: Implications for Acne Management.","authors":"Daniela Baboun, Marita Yaghi, Jennifer Keelin, Daniella M Hernandez-Bueso, Valery Fernandez Fernandez, Jonette Keri","doi":"10.36849/JDD.9783","DOIUrl":"10.36849/JDD.9783","url":null,"abstract":"Background: Acne vulgaris is common during pregnancy and presents unique therapeutic challenges due to fetal safety considerations and restrictions on conventional acne medications. Adjunctive strategies that target hormonal and metabolic contributors to acne without teratogenic risk are therefore of particular relevance to dermatologic care.Objective: To review the evidence supporting myo-inositol as an adjunctive option for pregnancy-related acne and contextualize its dermatologic relevance within associated metabolic, endocrine, and psychosocial conditions.Methods: A literature review of randomized controlled trials, systematic reviews, meta-analyses, observational studies, and mechanistic investigations evaluating myo-inositol in acne, polycystic ovary syndrome (PCOS), gestational diabetes mellitus (GDM), preeclampsia, fertility, mental health, sleep, and topical applications was conducted.Results: Myo-inositol supplementation has been associated with reductions in acne severity, especially in patients with PCOS, along with improvements in insulin sensitivity and key metabolic parameters. In pregnancy, myo-inositol has been linked to reduced incidence of GDM, favorable endothelial and metabolic markers relevant to preeclampsia, and improved reproductive outcomes. Additional evidence suggests benefits for mood and sleep, factors that may indirectly influence acne. Available data support a favorable maternal and fetal safety profile, but evidence for topical myo-inositol in acne remains limited.Conclusion: Myo-inositol may represent a safe adjunctive option for acne management during pregnancy, particularly in patients with metabolic or hyperandrogenic features. Although acne-specific pregnancy data are limited, existing mechanistic and safety evidence supports its consideration in dermatologic practice when therapeutic options are restricted.","PeriodicalId":15566,"journal":{"name":"Journal of Drugs in Dermatology","volume":"25 7","pages":"611-614"},"PeriodicalIF":2.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148390926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychotherapeutic Interventions in Acne Vulgaris: A Call for Future Research. 寻常痤疮的心理治疗干预：对未来研究的呼吁。

IF 1.8 4区医学

Journal of Drugs in Dermatology Pub Date : 2026-06-01 DOI: 10.36849/JDD.9455

Rachel Thomas, Sydney Olszewski, Sheila Sharifi, Mohammad Jafferany

引用次数: 0

A Review of the Relationship Between Cutibacterium acnes, Biofilms, and Keratosis Pilaris. 痤疮表皮杆菌、生物膜与毛鳞角化病关系的研究进展。

IF 1.8 4区医学

Journal of Drugs in Dermatology Pub Date : 2026-06-01 DOI: 10.36849/JDD.9313

Emma Scott, Craig Burkhart

引用次数: 0

Perioperative Use of Angiotensin Inhibitors and Their Complications in Mohs Surgery: A Retrospective Cohort Study. Mohs手术围手术期血管紧张素抑制剂的使用及其并发症：一项回顾性队列研究。

IF 1.8 4区医学

Journal of Drugs in Dermatology Pub Date : 2026-06-01 DOI: 10.36849/JDD.9652

Hamza Malick, Seo Won Cho, Marcus Zaayman, Mojahed Mohammad K Shalabi, Stanislav N Tolkachjov, Chad Housewright

引用次数: 0

A Randomized Controlled Trial Analyzing the Likeability, Usability, and In-Use Efficacy of Mineral Sunscreens Across Diverse Skin Tones. 一项随机对照试验分析了不同肤色的矿物防晒霜的受欢迎程度、可用性和使用效果。

IF 1.8 4区医学

Journal of Drugs in Dermatology Pub Date : 2026-06-01 DOI: 10.36849/JDD.9941

Milaan Shah, Joshua Burshtein, Danny Zakria, Thomas Shyr, Mark Benn, Gboyega Adenaike, Seng Khoon Teh, Joshua D Williams, Darrell Rigel

{"title":"A Randomized Controlled Trial Analyzing the Likeability, Usability, and In-Use Efficacy of Mineral Sunscreens Across Diverse Skin Tones.","authors":"Milaan Shah, Joshua Burshtein, Danny Zakria, Thomas Shyr, Mark Benn, Gboyega Adenaike, Seng Khoon Teh, Joshua D Williams, Darrell Rigel","doi":"10.36849/JDD.9941","DOIUrl":"10.36849/JDD.9941","url":null,"abstract":"Background: Mineral sunscreens are increasingly favorable among consumers. However, mineral sunscreens typically cause a white cast that can impact consumer selection and application.Objective: This study measured the whitening effect of mineral sunscreens across diverse skin tones and evaluated its relationship with consumer perception, application behavior, and the product's efficacy in terms of ultraviolet A protection factor (UVAPF) and sun protection factor (SPF).Methods: Five mineral sunscreens with differing whiteness and one chemical sunscreen were applied at 2 mg/cm2 on the forearm. Two of the 6 sunscreens were randomly assigned for uncontrolled application on the lower legs, and the participants' preferred product of the pair was then applied to the face at his/her discretion. Imaging and Hybrid Diffuse Reflectance Spectroscopy (HDRS) of the arm and face determined UVAPF and SPF.Results: Controlled application with all mineral sunscreens led to significant whitening, which was 3 times more pronounced on darker skin tones. Uncontrolled sunscreen application showed a significant reduction in the amount applied, whitening, and sunscreen efficacy. Participants had reduced preference for more whitening sunscreens and selected sunscreens in product pairings that resulted in less whitening.Conclusion: Patients may avoid sunscreens with negative whitening aesthetics or compensate with reduced application, compromising their ability to achieve appropriate sun protection, especially in darker skin tones. &nbsp.","PeriodicalId":15566,"journal":{"name":"Journal of Drugs in Dermatology","volume":"25 6","pages":"514-521"},"PeriodicalIF":1.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148156782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety and Effectiveness of Two Reconstitution Volumes of Poly-L-Lactic Acid for Correction of Décolletage Wrinkles. 两种聚l -乳酸复形剂矫正颈部颈部皱纹的安全性和有效性。

IF 1.8 4区医学

Journal of Drugs in Dermatology Pub Date : 2026-06-01 DOI: 10.36849/JDD.9928

John Joseph, Melanie D Palm, Daniel Bråsäter, Charlotta Wolgast, Felipe Weinberg, Inna Prygova

{"title":"Safety and Effectiveness of Two Reconstitution Volumes of Poly-L-Lactic Acid for Correction of Décolletage Wrinkles.","authors":"John Joseph, Melanie D Palm, Daniel Bråsäter, Charlotta Wolgast, Felipe Weinberg, Inna Prygova","doi":"10.36849/JDD.9928","DOIUrl":"10.36849/JDD.9928","url":null,"abstract":"Background: Aesthetic patients are increasingly aware of the contrast between rejuvenated facial skin and untreated aging skin of the décolletage, and frequently request cosmetic enhancement of this area. Poly-L-lactic acid (Sculptra®, Galderma; PLLA-SCA) is a regenerative biostimulator that stimulates collagen and elastin production to help regenerate the skin’s inner structure.Objective: This 9-month, open-label study investigated the effectiveness and safety of correcting décolletage wrinkles with PLLA-SCA using 2 reconstitution volumes.Method: Women with moderate/severe wrinkles on the Galderma Décolletage Scale (GDS) were randomized 1:1 to receive PLLA-SCA reconstituted with 8 mL or 17 mL sterile water for injection, plus 1 mL 2% lidocaine (up to 4 treatments, 1 month apart). Assessments included GDS, Global Aesthetic Improvement Scale (GAIS), subject satisfaction, skin quality, and adverse events (AEs).Results: Of 30 randomized subjects, the majority (8 mL: 93.8%; 17 mL: 78.6%) showed a ≥1-point improvement on investigator-assessed GDS at month 9 (primary endpoint), with ≥93% improved also at month 6. GAIS improvement was also great (>90% of subjects) across both groups at months 6 and 9. In both groups, >90% of subjects reported satisfaction with the appearance of their wrinkles by month 3, and this satisfaction was sustained throughout the study. The majority (>80%) of subjects were satisfied with the texture, smoothness, and radiance of their skin at months 6 and 9. One AE was judged as treatment-related; no AEs were serious or led to discontinuation.Conclusion: Treatment of the décolletage area with PLLA-SCA was effective and well tolerated with both reconstitution volumes, with high subject satisfaction.","PeriodicalId":15566,"journal":{"name":"Journal of Drugs in Dermatology","volume":"25 6","pages":"553-557"},"PeriodicalIF":1.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148156788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treating Acne Vulgaris and Scarring With Botulinum Toxin: A Systematic Review. 肉毒杆菌毒素治疗寻常性痤疮和疤痕：系统综述。

IF 1.8 4区医学

Journal of Drugs in Dermatology Pub Date : 2026-06-01 DOI: 10.36849/JDD.9562

Jessica Igiede, Pranvera Sulejmani, Nicolas Vassiliev, Julie Bittar de la Cruz

{"title":"Treating Acne Vulgaris and Scarring With Botulinum Toxin: A Systematic Review.","authors":"Jessica Igiede, Pranvera Sulejmani, Nicolas Vassiliev, Julie Bittar de la Cruz","doi":"10.36849/JDD.9562","DOIUrl":"10.36849/JDD.9562","url":null,"abstract":"Background: Many treatments have been proposed for the treatment of acne vulgaris and acne scarring; however, few data exist regarding the efficacy of botulinum toxin A as a treatment option.Objective: To compile all available data on the efficacy and safety of botulinum toxin A as a treatment for acne vulgaris and acne scarring.Methods: A systematic review of PubMed/MEDLINE, Excerpta Medica Database (EMBASE), Scopus, CINAHL, and the Cochrane CENTRAL Register of Controlled Trials, and Google Scholar databases identified all cases of acne vulgaris and acne scarring treated with botulinum toxin.Results: Four hundred thirty-six patients (218 with acne vulgaris and 218 patients with acne scarring) from 14 manuscripts were included in this review. Results showed overall improvement for up to 3-6 months in the majority of patients based on sebometer readings, fine pore count, and patient satisfaction scores. Acne scarring improved in patients treated with botulinum toxin as a single therapy, as well as in combination with other therapies, with consistently high patient satisfaction scores.Conclusions: Patients experienced a significant reduction in sebum production, number of acne lesions, and improvement in the appearance of acne scars, indicating a role for botulinum toxin A in the treatment of acne and acne scarring.","PeriodicalId":15566,"journal":{"name":"Journal of Drugs in Dermatology","volume":"25 6","pages":"508-512"},"PeriodicalIF":1.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148156827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends in Fluorouracil and Calcipotriene Utilization for Actinic Keratosis. 氟尿嘧啶和钙化三烯在光化性角化病中的应用趋势。

IF 2.2 4区医学

Journal of Drugs in Dermatology Pub Date : 2026-06-01 DOI: 10.36849/JDD.9657

Angela X Wu, Yao Li, Kaiping Liao, Mujeeb Basit, Mackenzie R Wehner

引用次数: 0

Efficacy and Safety of Clascoterone Cream 1% and Clindamycin 1.2%/Benzoyl Peroxide 5% Gel Treatment in Patients With Acne. 1% Clascoterone乳膏和1.2%克林霉素/ 5%过氧化苯甲酰凝胶治疗痤疮患者的疗效和安全性。

IF 1.8 4区医学

Journal of Drugs in Dermatology Pub Date : 2026-06-01 DOI: 10.36849/JDD.9745

Charles Kircik, Leon Kircik, Nicholas Squittieri, Kizito Kyeremateng

{"title":"Efficacy and Safety of Clascoterone Cream 1% and Clindamycin 1.2%/Benzoyl Peroxide 5% Gel Treatment in Patients With Acne.","authors":"Charles Kircik, Leon Kircik, Nicholas Squittieri, Kizito Kyeremateng","doi":"10.36849/JDD.9745","DOIUrl":"10.36849/JDD.9745","url":null,"abstract":"Background: Clascoterone cream 1% is a topical androgen receptor inhibitor approved to treat acne vulgaris in patients ≥12 years of age. The American Academy of Dermatology recommends combining topical therapies that target different mechanisms of acne pathogenesis as first-line treatment for acne. This 16-week, open-label pilot study evaluated the efficacy and safety of clascoterone cream 1% combined with clindamycin 1.2%/benzoyl peroxide 5% gel in patients with acne.Methods: Patients aged ≥12 years with moderate acne applied clascoterone cream 1% twice daily and clindamycin 1.2%/benzoyl peroxide 5% gel once daily for 12 weeks. Assessments included Investigator's Global Assessment (IGA) score; inflammatory, noninflammatory, and total lesion counts; Dermatology Life Quality Index (DLQI) score; tolerability (through local skin reactions); and safety (through adverse events) through week 16.Results: Nine patients were enrolled in the study (female, 56%; White, 56%; mean [standard deviation (SD)] age, 33 [17] years). At week 16, all patients had an IGA score of clear (0) or almost clear (1); from baseline to week 16, there were significant decreases in lesion counts (mean [SD] percent reduction; inflammatory: 96.4 [6.0], P=0.007; noninflammatory: 86.1 [15.3], P=0.009; total: 92.0 [8.2], P=0.008) and DLQI scores (mean [SD] reduction, 3.1 [2.1], P=0.014). The treatment was well tolerated with no adverse events reported through week 16.Conclusions: Based on data from 9 patients, combination treatment with clascoterone cream 1% and clindamycin 1.2%/benzoyl peroxide 5% gel is safe and effective to treat patients with acne. &nbsp.","PeriodicalId":15566,"journal":{"name":"Journal of Drugs in Dermatology","volume":"25 6","pages":"537-542"},"PeriodicalIF":1.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148156867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding Patient Perspectives on Rosacea: A Cross-Sectional Analysis of the r/Rosacea Forum on Reddit. 了解患者对酒渣鼻的看法：Reddit上r/酒渣鼻论坛的横断面分析。

IF 1.8 4区医学

Journal of Drugs in Dermatology Pub Date : 2026-06-01 DOI: 10.36849/JDD.9643

Sonia P Goyal, Adam Friedman

{"title":"Understanding Patient Perspectives on Rosacea: A Cross-Sectional Analysis of the r/Rosacea Forum on Reddit.","authors":"Sonia P Goyal, Adam Friedman","doi":"10.36849/JDD.9643","DOIUrl":"10.36849/JDD.9643","url":null,"abstract":"Background: As the largest online rosacea forum, r/Rosacea, a subreddit hosted on Reddit, provides a unique opportunity to better understand the concerns of rosacea patients.Methods: Using Python software and artificial intelligence models, a total of 1,000 posts from the r/Rosacea subreddit were analyzed for emotional tone, post category, and mentions of signs and symptoms, as well as medications.Results: The majority of posts were classified as seeking advice (n = 631), and posts categorized as patient stories received the highest median upvotes (P<0.001). Rosacea patients were found to be most concerned with external appearance, with redness (45.2%) and pustules (24.2%) being the most discussed signs in advice-seeking posts. Posts referencing burning exhibited strong negative emotional tones of anger and disgust. Ivermectin (12.7%) and azelaic acid (10.9%) were the most discussed medications in advice-seeking posts, and ivermectin received significantly lower median upvotes (P=0.0067).Conclusion: The insights of this cross-sectional analysis aid in achieving a deeper understanding of the rosacea patient perspective. Additional emotional analysis of the posts highlights the need for greater focus on the psychological burden of the disease. The frequency and popularity of rosacea medications reveal potential gaps in patient education and raises concerns regarding treatment adherence to medications, including ivermectin. It is imperative to increase rosacea patient access to quality-assured educational resources and to limit the potential spread of misinformation on r/Rosacea. &nbsp.","PeriodicalId":15566,"journal":{"name":"Journal of Drugs in Dermatology","volume":"25 6","pages":"530-536"},"PeriodicalIF":1.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148156853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0