Effects on the Skin Microbiome by a Moisturizer Formulated for Eczema-Prone and Sensitive Skin.

IF 1.5 4区医学 Q3 DERMATOLOGY

Journal of Drugs in Dermatology Pub Date : 2025-03-01 DOI:10.36849/JDD.8707

Cleo Whiting, Sara Abdel Azim, Nicolas Joly-Tonetti, Nadège Lachmann, Adam Friedman

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引用次数: 0

Abstract

Background: Cutaneous dysbiosis contributes to the pathophysiology of atopic dermatitis and potentially that of sensitive skin; regulation of the bacterial communities through skincare products is an emerging management strategy. Previous studies have highlighted the utility of ingredients that function as prebiotics, are anti-inflammatory, and have barrier-repairing properties to help shift species richness and composition toward more eubiotic states.

Methods: In a single-site open-label study, a moisturizer containing colloidal oatmeal, Ophiopogon japonicus root extract (AD-Resyl®, SILAB, France), and a patented filaggrin protein byproduct was evaluated for its effect on the bacterial communities of eczema-prone and sensitive skin (n=12). Skin swab samples from participants' cheeks were collected before and after applying the moisturizer twice daily for 21 days. Measures of alpha diversity (richness, Shannon diversity index) and beta diversity were calculated using paired, comparative analyses of sampled bacterial loads.

Results: Bacterial species richness was significantly increased in 10 participants (P<0.05) without dysbiotic shifts in overall microbial composition.

Conclusion: These results support the use of a moisturizer containing anti-inflammatory and skin barrier-repairing ingredients for managing atopic dermatitis and add to our knowledge of the skin microbiome in sensitive skin. J Drugs Dermatol. 2025;24(3):275-280. doi:10.36849/JDD.8707.

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针对易患湿疹和敏感皮肤的润肤霜对皮肤微生物组的影响。

背景：皮肤生态失调有助于特应性皮炎的病理生理和潜在的敏感皮肤；通过护肤产品调节细菌群落是一种新兴的管理策略。先前的研究强调了益生元成分的效用，这些成分具有抗炎和修复屏障的特性，有助于将物种丰富度和组成转变为更益生的状态。方法：在一项单点开放标签研究中，对含有胶体燕麦、麦冬根提取物（AD-Resyl®， SILAB，法国）和一种获得专利的聚丝蛋白副产物的保湿霜（n=12）进行了评估，以评估其对易患湿疹和敏感皮肤细菌群落的影响。在21天内，每天两次涂抹润肤霜之前和之后，从参与者的脸颊上收集皮肤拭子样本。α多样性（丰富度、Shannon多样性指数）和β多样性通过对采样细菌负荷的配对比较分析来计算。结果：10名参与者的细菌种类丰富度显著增加（P<0.05），但总体微生物组成未发生生态失调。结论：这些结果支持使用含有抗炎和皮肤屏障修复成分的保湿剂来治疗特应性皮炎，并增加了我们对敏感皮肤中皮肤微生物群的了解。皮肤医学杂志，2025;24(3):275-280。doi: 10.36849 / JDD.8707。

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来源期刊

Journal of Drugs in Dermatology DERMATOLOGY-

CiteScore

2.20

自引率

13.30%

发文量

289

审稿时长

3-6 weeks

期刊介绍： The Journal of Drugs in Dermatology (JDD) is a peer-reviewed publication indexed with MEDLINE®/PubMed® that was founded by the renowned Dr. Perry Robins MD. Founded in 2002, it offers one of the fastest routes to disseminate dermatologic information and is considered the fastest growing publication in dermatology. We present original articles, award-winning case reports, and timely features pertaining to new methods, techniques, drug therapy, and devices in dermatology that provide readers with peer reviewed content of the utmost quality. Our high standards of content are maintained through a balanced, peer-review process. Articles are reviewed by an International Editorial Board of over 160 renowned experts.