Journal of Drugs in Dermatology最新文献

{"title":"GLP-1 Receptor Agonist Paradox in Hair Biology: A Biphasic dWAT-Follicle Signaling Hypothesis.","authors":"Michelle A Kahn, Marc R Avram","doi":"10.36849/JDD.9868","DOIUrl":"https://doi.org/10.36849/JDD.9868","url":null,"abstract":"","PeriodicalId":15566,"journal":{"name":"Journal of Drugs in Dermatology","volume":"25 9","pages":"874-876"},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":": Interleukin-31 in Atopic Dermatitis and Prurigo Nodularis: Pathophysiology, Neuroimmune Mechanisms, and Clinical Efficacy of Nemolizumab.","authors":"Naiem T Issa, Shawn Kwatra, Ali Shahbaz, Leon Kircik","doi":"10.36849/JDD.015471","DOIUrl":"https://doi.org/10.36849/JDD.015471","url":null,"abstract":"<p><p>Interleukin-31 (IL-31) is a central mediator in atopic dermatitis (AD) and prurigo nodularis (PN), functioning both as the principal pruritogenic cytokine, driving itch through direct neuronal activation via the IL-31RA/OSMR&beta; signaling axis, and as a key immunological amplifier that sustains Th2 polarization by promoting continued IL-4 and IL-13 production. Beyond these neuroimmune effects, IL-31 disrupts epidermal barrier integrity and acts directly on dermal fibroblasts to drive collagen synthesis and extracellular matrix remodeling, contributing to the lichenification of chronic AD and the hyperkeratotic nodule formation that defines PN. This narrative review integrates the mechanistic biology of IL-31 across both conditions with the clinical evidence base for nemolizumab, a humanized monoclonal antibody targeting IL-31RA, examining phase 3 trial data, long-term extension outcomes, translational biomarker evidence, and emerging real-world experience.</p>","PeriodicalId":15566,"journal":{"name":"Journal of Drugs in Dermatology","volume":"25 9","pages":"15471s2-15471s15"},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors Associated With Hyaluronic Acid Filler-Related Delayed Complications: A Literature Review and Expert Consensus.","authors":"Joel L Cohen, Julie Woodward, Sheila Barbarino, Steven Weiner, Young Cho, Kim Nichols, Charles Boyd, Jessica Hicks, Kandy Bouquet, Jaymie Gordon, David K Funt","doi":"10.36849/JDD.9766","DOIUrl":"10.36849/JDD.9766","url":null,"abstract":"<p><strong>Background: </strong>Delayed complications associated with hyaluronic acid (HA) fillers are a concern in aesthetic medicine. However, clinical strategies for mitigation remain inconsistent, and guidelines often make recommendations that may lack the support of robust evidence. To address this gap, a multidisciplinary expert safety council convened to develop evidence-based recommendations aimed at reducing the delayed complication risk of soft-tissue augmentation with fillers, noting which recommendations are uncertain due to lack of evidence.</p><p><strong>Methods: </strong>A structured advisory board meeting was held with 8 United States-based experts in aesthetic injectables. Discussions were informed by a comprehensive literature review, pre-meeting surveys, and real-time polling, with consensus statements refined following the meeting.</p><p><strong>Results: </strong>The council reached full consensus on 8 key recommendations across 4 risk factor categories: patient history, product characteristics, procedural technique, and postprocedure care. A consistent theme across all categories was the lack of robust clinical evidence supporting many current guidelines, underscoring the need for more evidence-based recommendations.</p><p><strong>Conclusion: </strong>This expert consensus highlights the need for evidence-informed approaches to HA filler safety. While definitive data remain limited, the panel offers a practical framework for minimizing delayed complications and identifying priorities for future research. &nbsp.</p>","PeriodicalId":15566,"journal":{"name":"Journal of Drugs in Dermatology","volume":"25 9","pages":"785-792"},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review of the Efficacy of Topical 5-Alpha Reductase Inhibitors for the Treatment of Androgenetic Alopecia.","authors":"Marissa M Yaldo, Anagha Srivatsa, Meghan R Mansour, Joseph W Fakhoury","doi":"10.36849/JDD.9620","DOIUrl":"https://doi.org/10.36849/JDD.9620","url":null,"abstract":"","PeriodicalId":15566,"journal":{"name":"Journal of Drugs in Dermatology","volume":"25 9","pages":"871-873"},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical Carboxytherapy as an Adjunct to Skin Recovery Post-CO2 Laser Fractional Resurfacing.","authors":"Barbara Hernandez-Rovira, Emma Villamaria, K-Raman Purushothaman, Rachel Ziebart, Bengisu Ozarslan, Ava Shamban, Saranya Wyles","doi":"10.36849/JDD.9635","DOIUrl":"10.36849/JDD.9635","url":null,"abstract":"<p><strong>Background: </strong>Topical carboxytherapy, a transcutaneous carbon dioxide (CO2) delivery system, may support skin repair and regeneration, yet its role as an adjunct to fractional laser treatment remains underexplored.</p><p><strong>Objective: </strong>To investigate the effectiveness and safety of topical CO2 mask (CO2Lift&reg; Carboxy Gel, Lumisque Skincare) in supporting skin recovery and improving clinical outcomes following fractional CO2 laser resurfacing.</p><p><strong>Method: </strong>This 12-week randomized, placebo-controlled trial evaluated mild-to-moderate photoaging (n=6 females only). Participants received either topical carboxytherapy (n=4) or standard care (n=2). Assessments included VISIA-CR imaging, biophysical measurements, investigator ratings, and paired (baseline and 4-week) skin biopsies.</p><p><strong>Results: </strong>Topical carboxytherapy accelerated recovery and was well-tolerated, with no major adverse events. VISIA-CR imaging showed accelerated erythema resolution, transepidermal water loss normalized more rapidly, and pH remained stable. Skin histology at week 4 revealed epidermal thickening and rete ridge formation with topical carboxytherapy vs placebo. Investigator ratings demonstrated significantly improved healing, global assessment, and global aesthetic improvement scale scores, with trends toward improvement in photodamage, rhytides, and pigmentation.</p><p><strong>Conclusion: </strong>Adjunctive topical carboxytherapy after fractional CO2 resurfacing accelerated healing, improved barrier recovery, and overall aesthetic outcomes. Larger studies are needed to confirm these findings.</p>","PeriodicalId":15566,"journal":{"name":"Journal of Drugs in Dermatology","volume":"25 9","pages":"839-846"},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Botulinum Toxin in Facial Paralysis: A Neuroaesthetic Framework for Functional, Therapeutic, and Aesthetic Correction.","authors":"Roxane Scemla, Hayes B Gladstone","doi":"10.36849/JDD.9924","DOIUrl":"https://doi.org/10.36849/JDD.9924","url":null,"abstract":"<p><strong>Background: </strong>Facial paralysis (FP) produces functional deficits and facial asymmetry that may include neuromuscular discoordination with synkinesis, painful muscle contractions, disturbing facial spasms, and autonomic misdirection such as gustatory lacrimation. Although Botulinum toxin A (BTX-A) is widely used in dermatology for aesthetic indications, its therapeutic and functional role in facial paralysis is less commonly incorporated within a clinical unified framework.</p><p><strong>Objective: </strong>To propose a neuroaesthetic framework that integrates functional restoration, therapeutic relief, and correction of facial asymmetry using Botulinum toxin A (BTX-A) in the management of facial paralysis.</p><p><strong>Methods and materials: </strong>A structured narrative review of PubMed Index literature was conducted to evaluate aesthetic and therapeutic applications of BTX-A and facial paralysis. Evidence was synthesized across domains of facial asymmetry, functional impairment, and neuromuscular dysregulation and organized into a clinically applicable neuroaesthetic framework for dermatologists and advanced clinicians to support a comprehensive approach.</p><p><strong>Results: </strong>The reviewed literature supports BTX-A as an effective modality for reducing hyperkinesis and improving facial symmetry. Therapeutic benefit is also demonstrated for synkinesis, painful contractions, hemifacial spasms, and gustatory lacrimation. When applied using a comprehensive, integrated neuroaesthetic strategy, BTX-A enables concurrent management of functional deficits and therapeutic symptoms alongside aesthetic correction.</p><p><strong>Conclusions: </strong>This review introduces a neuroaesthetic framework that unifies aesthetic, functional, and therapeutic applications of BTX-A in facial paralysis and emphasizes its multi-systemic complexity. With appropriate knowledge and understanding of facial nerve dysfunction, dermatologists and clinicians experienced with neuromodulators are well positioned to deliver comprehensive function-guided treatments across the spectrum of facial paralysis-related sequelae.</p>","PeriodicalId":15566,"journal":{"name":"Journal of Drugs in Dermatology","volume":"25 9","pages":"800-805"},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Considerations for Laser and Energy-Based Devices in Transgender Patient Care.","authors":"Ariana Zarghami, Amreen Khakh, Mina Farah, Nikkia Zarabian, Dillon Nussbaum, Adam Friedman, Pooja Sodha","doi":"10.36849/JDD.0926","DOIUrl":"https://doi.org/10.36849/JDD.0926","url":null,"abstract":"","PeriodicalId":15566,"journal":{"name":"Journal of Drugs in Dermatology","volume":"25 9","pages":"881-882"},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracellular Matrix Remodeling as a Driver of Skin Tightening and Skin Quality: TriHex+ and Device-Assisted Delivery.","authors":"Alan D Widgerow","doi":"10.36849/JDD.10041","DOIUrl":"https://doi.org/10.36849/JDD.10041","url":null,"abstract":"","PeriodicalId":15566,"journal":{"name":"Journal of Drugs in Dermatology","volume":"25 9","pages":"e77-e80"},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment Adherence in Patients With Acne Vulgaris: A Narrative Review.","authors":"Steven R Feldman, Linda Stein Gold, Emil A Tanghetti, Karol Wroblewski, Vivek K Trivedi, Leon H Kircik","doi":"10.36849/JDD.10222","DOIUrl":"https://doi.org/10.36849/JDD.10222","url":null,"abstract":"<p><strong>Background: </strong>Acne vulgaris is a common dermatologic condition often requiring treatment using multiple mechanisms of action over a long time course to adequately clear symptoms. However, adherence to acne treatment is poor, preventing many patients from achieving their treatment goals.</p><p><strong>Methods: </strong>This narrative review provides an overview of reported adherence rates across different acne medications, major factors that influence adherence, and potential strategies to improve treatment compliance.</p><p><strong>Results: </strong>Reported adherence rates range widely depending on study design, treatment modality, and target population. Adherence to acne treatments is largely affected by patients' perceived lack of efficacy, complex treatment regimens, and tolerability to treatment. Adherence may improve with the development of rapid-acting medications, combination therapies to simplify treatment regimens, and therapeutics with minimal tolerability issues. Patient education to set expectations of the long treatment time course and strategies to alleviate common adverse events may improve treatment compliance.</p><p><strong>Conclusions: </strong>Poor adherence is a major barrier to treating acne, leading to negative impacts on patient outcomes. To improve adherence, physicians should address barriers through careful treatment selection and patient education. &nbsp.</p>","PeriodicalId":15566,"journal":{"name":"Journal of Drugs in Dermatology","volume":"25 9","pages":"821-826"},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Evidence of Skin Improvements With a Biologically Active Multimodal Topical Skin Treatment.","authors":"Zein E Obagi, Raffi J Balian, Susan V Ramsey, Frederick W Woodin, Grace H Nguyen","doi":"10.36849/JDD.10086","DOIUrl":"10.36849/JDD.10086","url":null,"abstract":"<p><strong>Background: </strong>Antiaging skin treatments are continuously in development to meet the needs of an aging population and counteract cosmetic effects of glucagon-like peptide-1 receptor agonists. Peptide Facial Refining Concentrate (ST26-PF-F1) serum contains multiple bioactive peptides within a penetrative delivery system. A clinical study of ST26-PF-F1 assessed its effects on skin health/appearance and tolerability/usability.</p><p><strong>Methods: </strong>This noncomparative 12-week study enrolled healthy females aged 45 years or older, Fitzpatrick phototypes I&ndash;VI, with evidence of skin aging. Participants applied ST26-PF-F1 twice daily. Efficacy (expert evaluation, instrumental measurements, confocal microscopy, and participant self-assessments) and tolerability/safety (dermatologist and participant reporting) were assessed at weeks 2, 4, 8, and 12.</p><p><strong>Results: </strong>Statistically significant improvements from baseline were observed for expert evaluator global assessments of fine lines, skin elasticity and plumpness, and facial contour and facial sagging (all time points); and wrinkles and skin firmness (weeks 4, 8, and 12). Significant improvements were also observed in skin hydration and elasticity (all time points); wrinkle volume, depth, and skin texture (weeks 4, 8, and 12); and lifting effect and V-shape (week 12). Confocal microscopy showed statistically significant improvements in interkeratinocyte brightness, papilla morphology, and dermal collagen fibers at weeks 4 and 12 and surface uniformity and keratinocyte morphology at week 12. Participants reported skin improvements across multiple measures and overall product satisfaction. ST26-PF-F1 was well tolerated with no treatment-related stinging, itching, or discomforting sensations.</p><p><strong>Conclusion: </strong>Clinical, instrumental, and microscopy assessments of ST26-PF-F1 demonstrated wrinkle-modulating and filler-like effects, visibly more balanced-looking facial geometry, favorable tolerability, and user satisfaction.</p>","PeriodicalId":15566,"journal":{"name":"Journal of Drugs in Dermatology","volume":"25 9","pages":"814-820"},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}