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Life-Saver or Undertaker: The Relationship between Primary Cilia and Cell Death in Vertebrate Embryonic Development. 救命还是毁灭:脊椎动物胚胎发育中初级纤毛与细胞死亡的关系。
IF 2.7
Journal of Developmental Biology Pub Date : 2022-12-12 DOI: 10.3390/jdb10040052
Thorsten Pfirrmann, Christoph Gerhardt
{"title":"Life-Saver or Undertaker: The Relationship between Primary Cilia and Cell Death in Vertebrate Embryonic Development.","authors":"Thorsten Pfirrmann,&nbsp;Christoph Gerhardt","doi":"10.3390/jdb10040052","DOIUrl":"https://doi.org/10.3390/jdb10040052","url":null,"abstract":"<p><p>The development of multicellular organisms requires a tightly coordinated network of cellular processes and intercellular signalling. For more than 20 years, it has been known that primary cilia are deeply involved in the mediation of intercellular signalling and that ciliary dysfunction results in severe developmental defects. Cilia-mediated signalling regulates cellular processes such as proliferation, differentiation, migration, etc. Another cellular process ensuring proper embryonic development is cell death. While the effect of cilia-mediated signalling on many cellular processes has been extensively studied, the relationship between primary cilia and cell death remains largely unknown. This article provides a short review on the current knowledge about this relationship.</p>","PeriodicalId":15563,"journal":{"name":"Journal of Developmental Biology","volume":"10 4","pages":""},"PeriodicalIF":2.7,"publicationDate":"2022-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10428914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The Role of Primary Cilia-Associated Phosphoinositide Signaling in Development. 原生纤毛相关的磷酸肌肽信号在发育中的作用
IF 2.2
Journal of Developmental Biology Pub Date : 2022-12-02 DOI: 10.3390/jdb10040051
Chuan Chen, Jinghua Hu, Kun Ling
{"title":"The Role of Primary Cilia-Associated Phosphoinositide Signaling in Development.","authors":"Chuan Chen, Jinghua Hu, Kun Ling","doi":"10.3390/jdb10040051","DOIUrl":"10.3390/jdb10040051","url":null,"abstract":"<p><p>Primary cilia are microtube-based organelles that extend from the cell surface and function as biochemical and mechanical extracellular signal sensors. Primary cilia coordinate a series of signaling pathways during development. Cilia dysfunction leads to a pleiotropic group of developmental disorders, termed ciliopathy. Phosphoinositides (PIs), a group of signaling phospholipids, play a crucial role in development and tissue homeostasis by regulating membrane trafficking, cytoskeleton reorganization, and organelle identity. Accumulating evidence implicates the involvement of PI species in ciliary defects and ciliopathies. The abundance and localization of PIs in the cell are tightly regulated by the opposing actions of kinases and phosphatases, some of which are recently discovered in the context of primary cilia. Here, we review several cilium-associated PI kinases and phosphatases, including their localization along cilia, function in regulating the ciliary biology under normal conditions, as well as the connection of their disease-associated mutations with ciliopathies.</p>","PeriodicalId":15563,"journal":{"name":"Journal of Developmental Biology","volume":"10 4","pages":""},"PeriodicalIF":2.2,"publicationDate":"2022-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10782677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Activation of Sonic Hedgehog Signaling Promotes Differentiation of Cortical Layer 4 Neurons via Regulation of Their Cell Positioning. 激活Sonic Hedgehog信号通过调控细胞定位促进皮层第4层神经元的分化。
IF 2.7
Journal of Developmental Biology Pub Date : 2022-11-25 DOI: 10.3390/jdb10040050
Koji Oishi, Kazunori Nakajima, Jun Motoyama
{"title":"Activation of Sonic Hedgehog Signaling Promotes Differentiation of Cortical Layer 4 Neurons via Regulation of Their Cell Positioning.","authors":"Koji Oishi,&nbsp;Kazunori Nakajima,&nbsp;Jun Motoyama","doi":"10.3390/jdb10040050","DOIUrl":"https://doi.org/10.3390/jdb10040050","url":null,"abstract":"<p><p>Neuronal subtypes in the mammalian cerebral cortex are determined by both intrinsic and extrinsic mechanisms during development. However, the extrinsic cues that are involved in this process remain largely unknown. Here, we investigated the role of sonic hedgehog (Shh) in glutamatergic cortical subtype specification. We found that E14.5-born, but not E15.5-born, neurons with elevated Shh expression frequently differentiated into layer 4 subtypes as judged by the cell positioning and molecular identity. We further found that this effect was achieved indirectly through the regulation of cell positioning rather than the direct activation of layer 4 differentiation programs. Together, we provided evidence that Shh, an extrinsic factor, plays an important role in the specification of cortical superficial layer subtypes.</p>","PeriodicalId":15563,"journal":{"name":"Journal of Developmental Biology","volume":"10 4","pages":""},"PeriodicalIF":2.7,"publicationDate":"2022-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9787542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10483240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Organophosphate Insecticide Toxicity in Neural Development, Cognition, Behaviour and Degeneration: Insights from Zebrafish. 有机磷杀虫剂对神经发育、认知、行为和退化的毒性:来自斑马鱼的见解。
IF 2.7
Journal of Developmental Biology Pub Date : 2022-11-21 DOI: 10.3390/jdb10040049
Jeremy Neylon, Jarrad N Fuller, Chris van der Poel, Jarrod E Church, Sebastian Dworkin
{"title":"Organophosphate Insecticide Toxicity in Neural Development, Cognition, Behaviour and Degeneration: Insights from Zebrafish.","authors":"Jeremy Neylon,&nbsp;Jarrad N Fuller,&nbsp;Chris van der Poel,&nbsp;Jarrod E Church,&nbsp;Sebastian Dworkin","doi":"10.3390/jdb10040049","DOIUrl":"https://doi.org/10.3390/jdb10040049","url":null,"abstract":"<p><p>Organophosphate (OP) insecticides are used to eliminate agricultural threats posed by insects, through inhibition of the neurotransmitter acetylcholinesterase (AChE). These potent neurotoxins are extremely efficacious in insect elimination, and as such, are the preferred agricultural insecticides worldwide. Despite their efficacy, however, estimates indicate that only 0.1% of organophosphates reach their desired target. Moreover, multiple studies have shown that OP exposure in both humans and animals can lead to aberrations in embryonic development, defects in childhood neurocognition, and substantial contribution to neurodegenerative diseases such as Alzheimer's and Motor Neurone Disease. Here, we review the current state of knowledge pertaining to organophosphate exposure on both embryonic development and/or subsequent neurological consequences on behaviour, paying particular attention to data gleaned using an excellent animal model, the zebrafish (<i>Danio rerio</i>).</p>","PeriodicalId":15563,"journal":{"name":"Journal of Developmental Biology","volume":"10 4","pages":""},"PeriodicalIF":2.7,"publicationDate":"2022-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10383229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Seeking Sense in the Hox Gene Cluster. 在 Hox 基因簇中寻找意义
IF 2.2
Journal of Developmental Biology Pub Date : 2022-11-15 DOI: 10.3390/jdb10040048
Stephen J Gaunt
{"title":"Seeking Sense in the Hox Gene Cluster.","authors":"Stephen J Gaunt","doi":"10.3390/jdb10040048","DOIUrl":"10.3390/jdb10040048","url":null,"abstract":"<p><p>The Hox gene cluster, responsible for patterning of the head-tail axis, is an ancestral feature of all bilaterally symmetrical animals (the Bilateria) that remains intact in a wide range of species. We can say that the Hox cluster evolved successfully only once since it is commonly the same in all groups, with <i>labial</i>-like genes at one end of the cluster expressed in the anterior embryo, and <i>Abd-B</i>-like genes at the other end of the cluster expressed posteriorly. This review attempts to make sense of the Hox gene cluster and to address the following questions. How did the Hox cluster form in the protostome-deuterostome last common ancestor, and why was this with a particular head-tail polarity? Why is gene clustering usually maintained? Why is there collinearity between the order of genes along the cluster and the positions of their expressions along the embryo? Why do the Hox gene expression domains overlap along the embryo? Why have vertebrates duplicated the Hox cluster? Why do Hox gene knockouts typically result in anterior homeotic transformations? How do animals adapt their Hox clusters to evolve new structural patterns along the head-tail axis?</p>","PeriodicalId":15563,"journal":{"name":"Journal of Developmental Biology","volume":"10 4","pages":""},"PeriodicalIF":2.2,"publicationDate":"2022-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10329329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coordination of Cilia Movements in Multi-Ciliated Cells. 多纤毛细胞中纤毛运动的协调。
IF 2.7
Journal of Developmental Biology Pub Date : 2022-11-11 DOI: 10.3390/jdb10040047
Masaki Arata, Fumiko Matsukawa Usami, Toshihiko Fujimori
{"title":"Coordination of Cilia Movements in Multi-Ciliated Cells.","authors":"Masaki Arata,&nbsp;Fumiko Matsukawa Usami,&nbsp;Toshihiko Fujimori","doi":"10.3390/jdb10040047","DOIUrl":"https://doi.org/10.3390/jdb10040047","url":null,"abstract":"<p><p>Multiple motile cilia are formed at the apical surface of multi-ciliated cells in the epithelium of the oviduct or the fallopian tube, the trachea, and the ventricle of the brain. Those cilia beat unidirectionally along the tissue axis, and this provides a driving force for directed movements of ovulated oocytes, mucus, and cerebrospinal fluid in each of these organs. Furthermore, cilia movements show temporal coordination between neighboring cilia. To establish such coordination of cilia movements, cilia need to sense and respond to various cues, including the organ's orientation and movements of neighboring cilia. In this review, we discuss the mechanisms by which cilia movements of multi-ciliated cells are coordinated, focusing on planar cell polarity and the cytoskeleton, and highlight open questions for future research.</p>","PeriodicalId":15563,"journal":{"name":"Journal of Developmental Biology","volume":"10 4","pages":""},"PeriodicalIF":2.7,"publicationDate":"2022-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10383227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Appropriate Amounts and Activity of the Wilms' Tumor Suppressor Gene, wt1, Are Required for Normal Pronephros Development of Xenopus Embryos. 爪蟾胚胎正常原肾发育需要适当数量和活性的Wilms肿瘤抑制基因wt1。
IF 2.7
Journal of Developmental Biology Pub Date : 2022-10-29 DOI: 10.3390/jdb10040046
Taisei Shiraki, Takuma Hayashi, Jotaro Ozue, Minoru Watanabe
{"title":"Appropriate Amounts and Activity of the Wilms' Tumor Suppressor Gene, <i>wt1</i>, Are Required for Normal Pronephros Development of <i>Xenopus</i> Embryos.","authors":"Taisei Shiraki,&nbsp;Takuma Hayashi,&nbsp;Jotaro Ozue,&nbsp;Minoru Watanabe","doi":"10.3390/jdb10040046","DOIUrl":"https://doi.org/10.3390/jdb10040046","url":null,"abstract":"<p><p>The Wilms' tumor suppressor gene, <i>wt1</i>, encodes a zinc finger-containing transcription factor that binds to a GC-rich motif and regulates the transcription of target genes. <i>wt1</i> was first identified as a tumor suppressor gene in Wilms' tumor, a pediatric kidney tumor, and has been implicated in normal kidney development. The WT1 protein has transcriptional activation and repression domains and acts as a transcriptional activator or repressor, depending on the target gene and context. In <i>Xenopus</i>, an ortholog of <i>wt1</i> has been isolated and shown to be expressed in the developing embryonic pronephros. To investigate the role of <i>wt1</i> in pronephros development in <i>Xenopus</i> embryos, we mutated <i>wt1</i> by CRISPR/Cas9 and found that the expression of pronephros marker genes was reduced. In reporter assays in which known WT1 binding sequences were placed upstream of the <i>luciferase</i> gene, WT1 activated transcription of the <i>luciferase</i> gene. The injection of wild-type or artificially altered transcriptional activity of <i>wt1</i> mRNA disrupted the expression of pronephros marker genes in the embryos. These results suggest that the appropriate amounts and activity of WT1 protein are required for normal pronephros development in <i>Xenopus</i> embryos.</p>","PeriodicalId":15563,"journal":{"name":"Journal of Developmental Biology","volume":"10 4","pages":""},"PeriodicalIF":2.7,"publicationDate":"2022-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10383228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Involvement of a Basic Helix-Loop-Helix Gene BHLHE40 in Specification of Chicken Retinal Pigment Epithelium. 碱性螺旋-环-螺旋基因BHLHE40参与鸡视网膜色素上皮的形成。
IF 2.7
Journal of Developmental Biology Pub Date : 2022-10-29 DOI: 10.3390/jdb10040045
Toshiki Kinuhata, Keita Sato, Tetsuya Bando, Taro Mito, Satoru Miyaishi, Tsutomu Nohno, Hideyo Ohuchi
{"title":"Involvement of a Basic Helix-Loop-Helix Gene <i>BHLHE40</i> in Specification of Chicken Retinal Pigment Epithelium.","authors":"Toshiki Kinuhata,&nbsp;Keita Sato,&nbsp;Tetsuya Bando,&nbsp;Taro Mito,&nbsp;Satoru Miyaishi,&nbsp;Tsutomu Nohno,&nbsp;Hideyo Ohuchi","doi":"10.3390/jdb10040045","DOIUrl":"https://doi.org/10.3390/jdb10040045","url":null,"abstract":"<p><p>The first event of differentiation and morphogenesis in the optic vesicle (OV) is specification of the neural retina (NR) and retinal pigment epithelium (RPE), separating the inner and outer layers of the optic cup, respectively. Here, we focus on a basic helix-loop-helix gene, <i>BHLHE40</i>, which has been shown to be expressed by the developing RPE in mice and zebrafish. Firstly, we examined the expression pattern of <i>BHLHE40</i> in the developing chicken eye primordia by in situ hybridization. Secondly, <i>BHLHE40</i> overexpression was performed with in ovo electroporation and its effects on optic cup morphology and expression of NR and RPE marker genes were examined. Thirdly, we examined the expression pattern of <i>BHLHE40</i> in <i>LHX1</i>-overexpressed optic cup. <i>BHLHE40</i> expression emerged in a subset of cells of the OV at Hamburger and Hamilton stage 14 and became confined to the outer layer of the OV and the ciliary marginal zone of the retina by stage 17. <i>BHLHE40</i> overexpression in the prospective NR resulted in ectopic induction of <i>OTX2</i> and repression of <i>VSX2</i>. Conversely, <i>BHLHE40</i> was repressed in the second NR after <i>LHX1</i> overexpression. These results suggest that emergence of <i>BHLHE40</i> expression in the OV is involved in initial RPE specification and that BHLHE40 plays a role in separation of the early OV domains by maintaining <i>OTX2</i> expression and antagonizing an NR developmental program.</p>","PeriodicalId":15563,"journal":{"name":"Journal of Developmental Biology","volume":"10 4","pages":""},"PeriodicalIF":2.7,"publicationDate":"2022-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10672974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The Shape of the Jaw-Zebrafish Col11a1a Regulates Meckel's Cartilage Morphogenesis and Mineralization. 颌-斑马鱼Col11a1a的形状调节梅克尔软骨的形态发生和矿化。
IF 2.7
Journal of Developmental Biology Pub Date : 2022-09-22 DOI: 10.3390/jdb10040040
Jonathon C Reeck, Julia Thom Oxford
{"title":"The Shape of the Jaw-Zebrafish Col11a1a Regulates Meckel's Cartilage Morphogenesis and Mineralization.","authors":"Jonathon C Reeck,&nbsp;Julia Thom Oxford","doi":"10.3390/jdb10040040","DOIUrl":"https://doi.org/10.3390/jdb10040040","url":null,"abstract":"<p><p>The expression of the <i>col11a1a</i> gene is essential for normal skeletal development, affecting both cartilage and bone. Loss of function mutations have been shown to cause abnormalities in the growth plate of long bones, as well as in craniofacial development. However, the specific effects on Meckel's cartilage have not been well studied. To further understand the effect of <i>col11a1a</i> gene function, we analyzed the developing jaw in zebrafish using gene knockdown by the injection of an antisense morpholino oligonucleotide using transgenic Tg(sp7:EGFP) and Tg(Fli1a:EGFP) EGFP reporter fish, as well as wildtype AB zebrafish. Our results demonstrate that zebrafish <i>col11a1a</i> knockdown impairs the cellular organization of Meckel's cartilage in the developing jaw and alters the bone formation that occurs adjacent to the Meckel's cartilage. These results suggest roles for Col11a1a protein in cartilage intermediates of bone development, the subsequent mineralization of the bony collar of long bones, and that which occurs adjacent to Meckel's cartilage in the developing jaw.</p>","PeriodicalId":15563,"journal":{"name":"Journal of Developmental Biology","volume":"10 4","pages":""},"PeriodicalIF":2.7,"publicationDate":"2022-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9590009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10723300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Extracellular Vesicles and Membrane Protrusions in Developmental Signaling. 发育信号中的细胞外小泡和膜突起
IF 2.2
Journal of Developmental Biology Pub Date : 2022-09-21 DOI: 10.3390/jdb10040039
Callie M Gustafson, Laura S Gammill
{"title":"Extracellular Vesicles and Membrane Protrusions in Developmental Signaling.","authors":"Callie M Gustafson, Laura S Gammill","doi":"10.3390/jdb10040039","DOIUrl":"10.3390/jdb10040039","url":null,"abstract":"<p><p>During embryonic development, cells communicate with each other to determine cell fate, guide migration, and shape morphogenesis. While the relevant secreted factors and their downstream target genes have been characterized extensively, how these signals travel between embryonic cells is still emerging. Evidence is accumulating that extracellular vesicles (EVs), which are well defined in cell culture and cancer, offer a crucial means of communication in embryos. Moreover, the release and/or reception of EVs is often facilitated by fine cellular protrusions, which have a history of study in development. However, due in part to the complexities of identifying fragile nanometer-scale extracellular structures within the three-dimensional embryonic environment, the nomenclature of developmental EVs and protrusions can be ambiguous, confounding progress. In this review, we provide a robust guide to categorizing these structures in order to enable comparisons between developmental systems and stages. Then, we discuss existing evidence supporting a role for EVs and fine cellular protrusions throughout development.</p>","PeriodicalId":15563,"journal":{"name":"Journal of Developmental Biology","volume":"10 4","pages":""},"PeriodicalIF":2.2,"publicationDate":"2022-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10712191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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