Modeling Podocyte Ontogeny and Podocytopathies with the Zebrafish.

IF 2.2 Q3 DEVELOPMENTAL BIOLOGY

Journal of Developmental Biology Pub Date : 2023-02-20 DOI:10.3390/jdb11010009

Bridgette E Drummond, Wesley S Ercanbrack, Rebecca A Wingert

引用次数: 0

Abstract

Podocytes are exquisitely fashioned kidney cells that serve an essential role in the process of blood filtration. Congenital malformation or damage to podocytes has dire consequences and initiates a cascade of pathological changes leading to renal disease states known as podocytopathies. In addition, animal models have been integral to discovering the molecular pathways that direct the development of podocytes. In this review, we explore how researchers have used the zebrafish to illuminate new insights about the processes of podocyte ontogeny, model podocytopathies, and create opportunities to discover future therapies.

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用斑马鱼模拟荚膜细胞的本体发育和荚膜病变

荚膜细胞是一种造型精致的肾脏细胞，在血液过滤过程中发挥着重要作用。荚膜细胞的先天畸形或损伤会造成严重后果，并引发一系列病理变化，导致肾脏疾病，即荚膜细胞病。此外，动物模型对于发现指导荚膜细胞发育的分子途径也是不可或缺的。在这篇综述中，我们将探讨研究人员如何利用斑马鱼来阐明有关荚膜细胞本体发育过程的新见解、建立荚膜细胞病的模型以及创造发现未来疗法的机会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Developmental Biology Biochemistry, Genetics and Molecular Biology-Developmental Biology

CiteScore

4.10

自引率

18.50%

发文量

审稿时长

11 weeks

期刊介绍： The Journal of Developmental Biology (ISSN 2221-3759) is an international, peer-reviewed, quick-refereeing, open access journal, which publishes reviews, research papers and communications on the development of multicellular organisms at the molecule, cell, tissue, organ and whole organism levels. Our aim is to encourage researchers to effortlessly publish their new findings or concepts rapidly in an open access medium, overseen by their peers. There is no restriction on the length of the papers; the full experimental details must be provided so that the results can be reproduced. Electronic files regarding the full details of the experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material. Journal of Developmental Biology focuses on: -Development mechanisms and genetics -Cell differentiation -Embryonal development -Tissue/organism growth -Metamorphosis and regeneration of the organisms. It involves many biological fields, such as Molecular biology, Genetics, Physiology, Cell biology, Anatomy, Embryology, Cancer research, Neurobiology, Immunology, Ecology, Evolutionary biology.