Journal of Comparative Neurology最新文献_第7页

Inter-Strain Differences in the Lumbar Spinal Cord Anatomy and Neuromorphology: Wistar Versus Dark Agouti Rats 腰椎脊髓解剖学和神经形态学的应变间差异：Wistar大鼠与深色阿古提大鼠。

IF 2.3 4区医学

Journal of Comparative Neurology Pub Date : 2024-10-08 DOI: 10.1002/cne.25673

Aleksandr Veshchitskii, Polina Shkorbatova, Evgeniya Efimova, Natalia Merkulyeva

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Cover Image, Volume 532, Issue 9 封面图片，第 532 卷第 9 期

IF 2.3 4区医学

Journal of Comparative Neurology Pub Date : 2024-09-27 DOI: 10.1002/cne.25676

Carol A. Barnes, Michele R. Permenter, Julie A. Vogt, Kewei Chen, Thomas G. Beach

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Human Alzheimer's Disease ATN/ABC Staging Applied to Aging Rhesus Macaque Brains: Association With Cognition and MRI-Based Regional Gray Matter Volume 将人类阿尔茨海默病 ATN/ABC 分期应用于老年猕猴大脑：与认知和基于核磁共振成像的区域灰质体积的关联。

IF 2.3 4区医学

Journal of Comparative Neurology Pub Date : 2024-09-24 DOI: 10.1002/cne.25670

Carol A. Barnes, Michele R. Permenter, Julie A. Vogt, Kewei Chen, Thomas G. Beach

{"title":"Human Alzheimer's Disease ATN/ABC Staging Applied to Aging Rhesus Macaque Brains: Association With Cognition and MRI-Based Regional Gray Matter Volume","authors":"Carol A. Barnes, Michele R. Permenter, Julie A. Vogt, Kewei Chen, Thomas G. Beach","doi":"10.1002/cne.25670","DOIUrl":"10.1002/cne.25670","url":null,"abstract":"<div>\u0000 \u0000 <p>The brain changes of Alzheimer's disease (AD) include Abeta (Aβ) amyloid plaques (“A”), abnormally phosphorylated tau tangles (“T”), and neurodegeneration (“N”). These have been used to construct in vivo and postmortem diagnostic and staging classifications for evaluating the spectrum of AD in the “ATN” and “ABC” (“B” for Braak tau stage, “C” for Consortium to Establish a Registry for Alzheimer's Disease [CERAD] neuritic plaque density) systems. Another common AD feature involves cerebral amyloid angiopathy (CAA). We report the first experiment to examine relationships among cognition, brain distribution of amyloid plaques, CAA, tau/tangles, and magnetic resonance imaging (MRI)-determined volume changes (as a measure of “N”) in the same group of behaviorally characterized nonhuman primates. Both ATN and ABC systems were applied to a group of 32 rhesus macaques aged between 7 and 33 years. When an immunohistochemical method for “T” and “B” was used, some monkeys were “triple positive” on ATN, with a maximum ABC status of A1B2C3. With silver or thioflavin S methods, however, all monkeys were classified as T-negative and B0, indicating the absence of mature neurofibrillary tangles (NFTs) and hence neuropathologically defined AD. Although monkeys at extremes of the ATN and ABC classifications, or with frequent CAA, had significantly lower scores on some cognitive tests, the lack of fully mature NFTs or dementia-consistent cognitive impairment indicates that fully developed AD may not occur in rhesus macaques. There were sex differences noted in the types of histopathology present, and only CAA was significantly related to gray matter volume.</p>\u0000 </div>","PeriodicalId":15552,"journal":{"name":"Journal of Comparative Neurology","volume":"532 9","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Invariance of Mitochondria and Synapses in the Primary Visual Cortex of Mammals Provides Insight Into Energetics and Function 哺乳动物初级视觉皮层线粒体和突触的不变性为了解能量学和功能提供了启示

IF 2.3 4区医学

Journal of Comparative Neurology Pub Date : 2024-09-18 DOI: 10.1002/cne.25669

Molly T. Karl, Young Do Kim, Kavita Rajendran, Paul R. Manger, Chet C. Sherwood

{"title":"Invariance of Mitochondria and Synapses in the Primary Visual Cortex of Mammals Provides Insight Into Energetics and Function","authors":"Molly T. Karl, Young Do Kim, Kavita Rajendran, Paul R. Manger, Chet C. Sherwood","doi":"10.1002/cne.25669","DOIUrl":"https://doi.org/10.1002/cne.25669","url":null,"abstract":"<div>\u0000 \u0000 <p>The cerebral cortex accounts for substantial energy expenditure, primarily driven by the metabolic demands of synaptic signaling. Mitochondria, the organelles responsible for generating cellular energy, play a crucial role in this process. We investigated ultrastructural characteristics of the primary visual cortex in 18 phylogenetically diverse mammals, spanning a broad range of brain sizes from mouse to elephant. Our findings reveal remarkable uniformity in synapse density, postsynaptic density (PSD) length, and mitochondria density, indicating functional and metabolic constraints that maintain these fundamental features. Notably, we observed an average of 1.9 mitochondria per synapse across mammalian species. When considered together with the trend of decreasing neuron density with larger brain size, we find that brain enlargement in mammals is characterized by increasing proportions of synapses and mitochondria per cortical neuron. These results shed light on the adaptive mechanisms and metabolic dynamics that govern cortical ultrastructure across mammals.</p>\u0000 </div>","PeriodicalId":15552,"journal":{"name":"Journal of Comparative Neurology","volume":"532 9","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142244804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Covariation of Skull and Brain Morphology in Domestic Dogs 家犬头骨和大脑形态的变异

IF 2.3 4区医学

Journal of Comparative Neurology Pub Date : 2024-09-13 DOI: 10.1002/cne.25668

Sophie A. Barton, Marc Kent, Erin E. Hecht

{"title":"Covariation of Skull and Brain Morphology in Domestic Dogs","authors":"Sophie A. Barton, Marc Kent, Erin E. Hecht","doi":"10.1002/cne.25668","DOIUrl":"https://doi.org/10.1002/cne.25668","url":null,"abstract":"<div>\u0000 \u0000 <p>Despite their distinct embryonic origins, the skull and brain are highly integrated. Understanding the covariation between the skull and brain can shed light on anatomical, cognitive, and behavioral traits in extant and extinct species. Domestic dogs offer a unique opportunity to investigate skull–brain covariation due to their diverse skull morphologies and neural anatomy. To assess this question, we examined <i>T</i>2-weighted MRI studies of 62 dogs from 33 breeds, plus an additional 17 dogs of mixed or unknown breeds. Scans were opportunistically collected from a veterinary teaching hospital of dogs that were referred for neurological examination but did not have grossly observable structural brain abnormalities. As the neurocrania of dogs become broader and shorter, there is a significant decrease in the gray matter volume of the right olfactory bulb, frontal cortex, marginal gyrus, and cerebellum. On the other hand, as the neurocrania of dogs become narrower and longer, there is a significant decrease in the gray matter volume of the olfactory bulb, frontal cortex, temporal cortex, amygdala, hypothalamus, hippocampus, periaqueductal gray, cerebellum, and brainstem. Selective breeding for specific skull shapes may impact canine brain anatomy and function.</p>\u0000 </div>","PeriodicalId":15552,"journal":{"name":"Journal of Comparative Neurology","volume":"532 9","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142233195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Thorny and Tufted Retinal Ganglion Cells Express the Transcription Factor Forkhead Proteins Foxp1 and Foxp2 in Marmoset (Callithrix jacchus) 狨猴视网膜神经节细胞表达转录因子叉头蛋白 Foxp1 和 Foxp2。

IF 2.3 4区医学

Journal of Comparative Neurology Pub Date : 2024-09-05 DOI: 10.1002/cne.25663

Sammy C. S. Lee, Anlai J. Wei, Paul R. Martin, Ulrike Grünert

{"title":"Thorny and Tufted Retinal Ganglion Cells Express the Transcription Factor Forkhead Proteins Foxp1 and Foxp2 in Marmoset (Callithrix jacchus)","authors":"Sammy C. S. Lee, Anlai J. Wei, Paul R. Martin, Ulrike Grünert","doi":"10.1002/cne.25663","DOIUrl":"10.1002/cne.25663","url":null,"abstract":"<p>The transcription factor forkhead/winged-helix domain proteins Foxp1 and Foxp2 have previously been studied in mouse retina, where they are expressed in retinal ganglion cells named F-mini and F-midi. Here we show that both transcription factors are expressed by small subpopulations (on average less than 10%) of retinal ganglion cells in the retina of the marmoset monkey (<i>Callithrix jacchus</i>). The morphology of Foxp1- and Foxp2-expressing cells was revealed by intracellular DiI injections of immunofluorescent cells. Foxp1- and Foxp2-expressing cells comprised multiple types of wide-field ganglion cells, including broad thorny cells, narrow thorny cells, and tufted cells. The large majority of Foxp2-expressing cells were identified as tufted cells. Tufted cells stratify broadly in the middle of the inner plexiform layer. They resemble broad thorny cells but their proximal dendrites are bare of branches and the distal dendrites branch frequently forming dense dendritic tufts. Double labeling with calretinin, a previously established marker for broad thorny and narrow thorny cells, showed that only a small proportion of ganglion cells co-expressed calretinin and Foxp1 or Foxp2 supporting the idea that the two markers are differentially expressed in retinal ganglion cells of marmoset retina.</p>","PeriodicalId":15552,"journal":{"name":"Journal of Comparative Neurology","volume":"532 8","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cne.25663","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Connectivity of the Claustrum–Endopiriform Complex with the Presubiculum and Hippocampal Regions in the Common Marmoset (Callithrix jacchus) 普通狨猴的咽鼓管-咽鼓膜复合体与咽鼓管前区和海马区的连接性。

IF 2.3 4区医学

Journal of Comparative Neurology Pub Date : 2024-09-05 DOI: 10.1002/cne.25666

Yoshiko Honda, Keiko Moriya-Ito, Tetsuya Shimokawa, Yasushi Kobayashi

{"title":"Connectivity of the Claustrum–Endopiriform Complex with the Presubiculum and Hippocampal Regions in the Common Marmoset (Callithrix jacchus)","authors":"Yoshiko Honda, Keiko Moriya-Ito, Tetsuya Shimokawa, Yasushi Kobayashi","doi":"10.1002/cne.25666","DOIUrl":"10.1002/cne.25666","url":null,"abstract":"<p>We have investigated the hippocampal connectivity of the marmoset presubiculum (PreS) and reported that major connections of PreS in the rat were conserved in the marmoset. Moreover, our results indicated the presence of several additional projections that were almost absent in the rat brain, but abundant in the marmoset, such as direct projections from CA1 to PreS. However, little is known about the connectivity between the frontal brain regions and PreS or hippocampal formation. Therefore, we investigated the distribution of cells of the origins and terminals of the presubicular and hippocampal projections in the marmoset frontal brain regions using the retrograde and anterograde tracer cholera toxin B subunit. In cases of tracer injections into all layers of PreS, many neurons and terminals were labeled in the claustrum–endopiriform (Cl–En) complex almost entirely along the rostrocaudal axis. Even in cases where the injection site involved the superficial (not deep) layers of PreS, labeled neurons and terminals were distributed over a wide rostrocaudal range of the Cl–En complex, but their number and density were significantly lower than the whole-layer injection cases. In cases where the injection site was confined to the hippocampal formation, labeled cells and terminals were localized at a restricted portion of the Cl–En complex. Here, we demonstrate for what we believe to be the first time the strong, reciprocal connections of the Cl–En complex with PreS and projections from the Cl–En complex to the hippocampal regions (CA1 and the subiculum) in the marmoset. Our findings indicate that the Cl–En complex may exert a strong influence on the cortical and subcortical outputs from PreS and, in turn, the entire memory circuitry in the marmoset brain.</p>","PeriodicalId":15552,"journal":{"name":"Journal of Comparative Neurology","volume":"532 8","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cne.25666","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Scaled Complexity of Mammalian Astrocytes: Insights From Mouse and Macaque 哺乳动物星形胶质细胞的规模复杂性：来自小鼠和猕猴的启示

IF 2.3 4区医学

Journal of Comparative Neurology Pub Date : 2024-09-05 DOI: 10.1002/cne.25665

Kate S. Heffernan, Indeara Martinez, Dieter Jaeger, Baljit S. Khakh, Yoland Smith, Adriana Galvan

{"title":"Scaled Complexity of Mammalian Astrocytes: Insights From Mouse and Macaque","authors":"Kate S. Heffernan, Indeara Martinez, Dieter Jaeger, Baljit S. Khakh, Yoland Smith, Adriana Galvan","doi":"10.1002/cne.25665","DOIUrl":"10.1002/cne.25665","url":null,"abstract":"<div>\u0000 \u0000 <p>Astrocytes intricately weave within the neuropil, giving rise to characteristic bushy morphologies. Pioneering studies suggested that primate astrocytes are more complex due to increased branch numbers and territory size compared to rodent counterparts. However, there has been no comprehensive comparison of astrocyte morphology across species. We employed several techniques to investigate astrocyte morphology and directly compared them between mice and rhesus macaques in cortical and subcortical regions. We assessed astrocyte density, territory size, branching structure, fine morphological complexity, and interactions with neuronal synapses using a combination of techniques, including immunohistochemistry, adeno-associated virus–mediated transduction of astrocytes, diOlistics, confocal imaging, and electron microscopy. We found significant morphological similarities between primate and rodent astrocytes, suggesting that astrocyte structure has scaled with evolution. Our findings show that primate astrocytes are larger and more numerous than those in rodents but contest the view that primate astrocytes are morphologically far more complex.</p>\u0000 </div>","PeriodicalId":15552,"journal":{"name":"Journal of Comparative Neurology","volume":"532 8","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Sources of Rapid and Delayed New Lower Jaw Input in the Forepaw Barrel Subfield (FBS) in Rat Primary Somatosensory Cortex (SI) Following Forelimb Deafferentation 大鼠初级躯体感觉皮层（SI）前肢去感觉化后前爪桶状亚场（FBS）中快速和延迟的新下颚输入源

IF 2.3 4区医学

Journal of Comparative Neurology Pub Date : 2024-09-05 DOI: 10.1002/cne.25664

Violeta Pellicer-Morata, Lie Wang, Amy de Jongh Curry, Jack W. Tsao, Robert S. Waters

{"title":"Sources of Rapid and Delayed New Lower Jaw Input in the Forepaw Barrel Subfield (FBS) in Rat Primary Somatosensory Cortex (SI) Following Forelimb Deafferentation","authors":"Violeta Pellicer-Morata, Lie Wang, Amy de Jongh Curry, Jack W. Tsao, Robert S. Waters","doi":"10.1002/cne.25664","DOIUrl":"10.1002/cne.25664","url":null,"abstract":"<div>\u0000 \u0000 <p>Previously, we reported an immediate emergence of new lower jaw input to the anterior forepaw barrel subfield (FBS) in primary somatosensory cortex (SI) following forelimb deafferentation. However, a delay of 7 weeks or more post-amputation results in the presence of this new input to both anterior and posterior FBS. The immediate change suggests pre-existing latent lower jaw input in the FBS, whereas the delayed alteration implies the involvement of alternative sources. One possible source for immediate lower jaw responses is the neighboring lower jaw barrel subfield (LJBSF). We used anatomical tracers to investigate the possible projection of LJBSF to the FBS in normal and forelimb-amputated rats. Our findings are as follows: (1) anterograde tracer injection into LJBSF in normal and amputated rats labeled fibers and terminals exclusively in the anterior FBS; (2) retrograde tracer injection in the anterior FBS in normal and forelimb-amputated rats, heavily labeled cell bodies predominantly in the posterior LJBSF, with fewer in the anterior LJBSF; (3) retrograde tracer injection in the posterior FBS in normal and forelimb-amputated rats, sparsely labeled cell bodies in the posterior LJBSF; (4) retrograde tracer injection in anterior and posterior FBS in normal and forelimb-amputated rats, labeled cells exclusively in ventral posterior lateral (VPL) nucleus and posterior thalamus (PO); (5) retrograde tracer injection in LJBSF-labeled cell bodies exclusively in ventral posterior medial thalamic nucleus and PO. These findings suggest that LJBSF facilitates rapid lower jaw reorganization in the anterior FBS, whereas VPL and/or other subcortical sites provide a likely substrate for delayed reorganization observed in the posterior FBS.</p>\u0000 </div>","PeriodicalId":15552,"journal":{"name":"Journal of Comparative Neurology","volume":"532 8","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Cover Image, Volume 532, Issue 8 封面图片，第 532 卷第 8 期

IF 2.3 4区医学

Journal of Comparative Neurology Pub Date : 2024-09-05 DOI: 10.1002/cne.25667

Wenyao Wang, Chengdong Wang, Yan Nan, Yuan Zhou, Ronping Wei, Shanshan Ling, Honglin Wu, Linhua Deng, Jie Gao, Qihua He, Xin Huang, Chun Zhang, Desheng Li, Mingliang Pu

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