Journal of Comparative Neurology最新文献_第10页

Distribution of Metabotropic Serotonin Receptors in GABAergic and Glutamatergic Neurons in the Auditory Midbrain 代谢性血清素受体在听觉中脑gaba能和谷氨酸能神经元中的分布。

IF 2.1 4区医学

Journal of Comparative Neurology Pub Date : 2026-02-22 DOI: 10.1002/cne.70139

Karen L. Galindo, Zoya A. Nazir, Marina A. Silveira

{"title":"Distribution of Metabotropic Serotonin Receptors in GABAergic and Glutamatergic Neurons in the Auditory Midbrain","authors":"Karen L. Galindo, Zoya A. Nazir, Marina A. Silveira","doi":"10.1002/cne.70139","DOIUrl":"10.1002/cne.70139","url":null,"abstract":"The neurotransmitter serotonin modulates a variety of behavioral and physiological responses in the brain. Serotonergic neurons from the dorsal raphe nuclei send a dense projection to the auditory system, including the inferior colliculus (IC), the midbrain hub of the central auditory system. In the IC, serotonin alters how neurons respond to complex sounds, and it has been implicated in the generation or perception of tinnitus. However, the distribution of serotonin receptors and the identity of neurons that express serotonin receptors in the IC remain unclear. Here, we hypothesized that IC GABAergic and glutamatergic neurons differentially express serotonin receptors. To test this hypothesis, we performed in situ hybridization in IC brain slices of male and female mice using probes for Vgat (GABAergic neuron marker) and Vglut2 (glutamatergic neuron marker), along with probes for six subtypes of metabotropic serotonin receptors: 5-HT1A and 5-HT1B (Htr1a and Htr1b, inhibitory, Gi/o G protein receptors), 5-HT2A, 5-HT2B, and 5-HT2C (Htr2a, Htr2b, and Htr2c excitatory, Gq11 G protein receptors), and 5-HT7 (excitatory, Gs G protein receptors). Our data show that glutamatergic IC neurons primarily express inhibitory serotonin receptors. In contrast, a larger proportion of GABAergic neurons express excitatory serotonin receptors. Our data suggest that serotonin likely exerts an inhibitory net effect on IC neuronal circuits. These findings contribute to our understanding of how serotonin signaling influences auditory processing. The differential expression of serotonin receptors may help shape the balance of excitation and inhibition in the auditory midbrain, affecting sound processing.","PeriodicalId":15552,"journal":{"name":"Journal of Comparative Neurology","volume":"534 2","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12925487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147271183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cortical Type: The Basis for a Modern Neurodevelopmental Synthesis (Ontogeny, Phylogeny, Synaptic Connectivity) of the Human Cerebral Cortex 皮层类型：人类大脑皮层现代神经发育综合（个体发育、系统发育、突触连接）的基础。

IF 2.1 4区医学

Journal of Comparative Neurology Pub Date : 2026-02-18 DOI: 10.1002/cne.70143

Josefa Zaldivar-Diez, Miguel Ángel García-Cabezas

{"title":"Cortical Type: The Basis for a Modern Neurodevelopmental Synthesis (Ontogeny, Phylogeny, Synaptic Connectivity) of the Human Cerebral Cortex","authors":"Josefa Zaldivar-Diez, Miguel Ángel García-Cabezas","doi":"10.1002/cne.70143","DOIUrl":"10.1002/cne.70143","url":null,"abstract":"The human cerebral cortex can be parceled into cortical areas according to particular physiological, clinico-pathological, and anatomical features. Alternatively, it can be parceled into cortical types based on laminar complexity. Cortical types are related to synaptic connectivity and are rooted in ontogeny and phylogeny. In this review, first, we summarize the history of human cortical type schemes and provide a Rosetta Stone to help identify the equivalences between them. Second, we review the developmental specification, phylogenesis, and embryogenesis of mammalian cortical types within the frame of the Prosomeric Model and the Hypothesis of the Dual Origin of the Neocortex and propose a causal model for human pallial patterning. Finally, we relate human cortical types to molecular features and synaptic connectivity according to the principles of the Structural Model. A Modern Neurodevelopmental Synthesis of the human cortex emerges, aiming to be a helpful framework for experimental design in basic and clinical neuroscience.","PeriodicalId":15552,"journal":{"name":"Journal of Comparative Neurology","volume":"534 2","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12915597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146220002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Regenerative Stage-Defined Neurogenic Properties in the Spinal Cord of Xenopus laevis: Correlation Between Neurogenic Potential and Functional Repair of the Spinal Cord 非洲爪蟾脊髓再生阶段神经发生特性：神经发生潜能与脊髓功能修复的关系。

IF 2.1 4区医学

Journal of Comparative Neurology Pub Date : 2026-02-17 DOI: 10.1002/cne.70141

Ryohei Seki-Omura, Yousuke Nakano, Shinichi Hayashi, Hikaru Iwashita, Hitoshi Yokoyama, Taro Koike, Yuki Sato, Souichi Oe, Yukie Hirahara, Haruki Ochi, Hajime Ogino, Koji Tamura, Mari Dezawa, Masaaki Kitada

{"title":"The Regenerative Stage-Defined Neurogenic Properties in the Spinal Cord of Xenopus laevis: Correlation Between Neurogenic Potential and Functional Repair of the Spinal Cord","authors":"Ryohei Seki-Omura, Yousuke Nakano, Shinichi Hayashi, Hikaru Iwashita, Hitoshi Yokoyama, Taro Koike, Yuki Sato, Souichi Oe, Yukie Hirahara, Haruki Ochi, Hajime Ogino, Koji Tamura, Mari Dezawa, Masaaki Kitada","doi":"10.1002/cne.70141","DOIUrl":"10.1002/cne.70141","url":null,"abstract":"<div>\u0000 \u0000 Many treatments for spinal cord injury (SCI) have been developed; however, none of these treatments enable complete functional repair. In this study, we utilized a model amphibian, Xenopus laevis, which has regeneration capacity of the spinal cord in the tadpole stages but loses it during metamorphosis, to identify differences in spinal cord properties between the regenerative and non-regenerative stages. We compared the spatiotemporal expression patterns of transcription factors important for neural tube development as well as cell proliferation markers between tadpoles and metamorphosed young adults (froglets) in Xenopus as well as between Xenopus and mouse embryos. We found that Xenopus drastically changed properties in ependymal cells of the spinal cord during the transition from regenerative to non-regenerative stages, and that similar change occurred in the mouse neural tube between 12.5 and 14.5 dpc, during which neurogenesis is known to cease. We then investigated neurogenic activity during Xenopus metamorphosis by labeling newly generated neurons and found that it was correlated with regeneration capacity. We also found that neurogenesis actively occurred after SCI at the regenerative stages but was scarcely reactivated at the non-regenerative stages, suggesting that neurogenesis may play an important role in the process of spontaneous regeneration in Xenopus. We propose that supplying neurons as a treatment for SCI is a valid strategy based on principles of regeneration, which are naturally possessed by regenerative animals.\u0000 </div>","PeriodicalId":15552,"journal":{"name":"Journal of Comparative Neurology","volume":"534 2","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146213335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuromeric Organization of the Microbat Brain: Conserved and Distinct Regional Features 微型蝙蝠大脑的神经组织：保守和独特的区域特征。

IF 2.1 4区医学

Journal of Comparative Neurology Pub Date : 2026-02-17 DOI: 10.1002/cne.70140

F. Lucero-Arteaga, A. Abrego-Alvarez, M. Clauzure, S. Labegorra, V. Heck, A. I. Portu, M. A. Boeris, M. A. Mondino, B. Ribeiro Do-Couto, K. Y. Tseng, M. Á. García-Cabezas, J. L. Ferran

{"title":"Neuromeric Organization of the Microbat Brain: Conserved and Distinct Regional Features","authors":"F. Lucero-Arteaga, A. Abrego-Alvarez, M. Clauzure, S. Labegorra, V. Heck, A. I. Portu, M. A. Boeris, M. A. Mondino, B. Ribeiro Do-Couto, K. Y. Tseng, M. Á. García-Cabezas, J. L. Ferran","doi":"10.1002/cne.70140","DOIUrl":"10.1002/cne.70140","url":null,"abstract":"Myotis myotis and Tadarida brasiliensis are both microbat species belonging to the Vespertilionidae and Molossidae families, respectively. Our goal is to determine if the 85-million-year evolutionary divergence between microbats and the Muridae family (mice and rats) has led to significant regional variations in the brain. However, the 34-million-year split between M. myotis and T. brasiliensis serves as in-group control to contextualize the larger divergence with rodents. Using the prosomeric framework, main brain derivatives from each neuromeric partition were compared between these two microbats and with rodents. We found that although the fundamental neuromeric organization is conserved across microbats (M. myotis and T. brasiliensis) and rodents (rats, mice, and gerbils), there are significant regional differences within distinct derivatives such that microbats exhibit smaller corpus callosum, isocortex, optic chiasm, and cerebellum when compared to rodents. On the other hand, the overall pattern of tyrosine hydroxylase (TH)-positive processes and tracts in the basal plate of the diencephalon-midbrain-rostral hindbrain in both bats is similar to that found in rodents and primates. However, a key difference was found in the medial habenula (MHb). Although M. myotis showed selective TH expression in the MHb, this was absent in T. brasiliensis. Collectively, these findings suggest that the 85-million-year evolutionary divergence between bats and rodents has led to notable regional variations in brain anatomy, even though their basic modular plan remained the same.","PeriodicalId":15552,"journal":{"name":"Journal of Comparative Neurology","volume":"534 2","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12914228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146213376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cover Image, Volume 534, Issue 2 封面图片，第534卷，第2期

IF 2.1 4区医学

Journal of Comparative Neurology Pub Date : 2026-02-16 DOI: 10.1002/cne.70138

Anna Lysakowski, Aravind Chenrayan Govindaraju, Steven D. Price, Sophie Gaboyard-Niay, Irina Calin-Jageman, Robstein L. Chidavaenzi, Ruth Anne Eatock, Robert M. Raphael, Jay M. Goldberg

引用次数: 0

Age-Dependent Area-, Lamina- and Cell-Type-Specific Distribution of the Cannabinoid Type 1 Receptor in the Mouse Visual Cortex 小鼠视觉皮层中大麻素1型受体的年龄依赖性区域、层和细胞特异性分布。

IF 2.1 4区医学

Journal of Comparative Neurology Pub Date : 2026-02-09 DOI: 10.1002/cne.70136

Lucas J. A. Durieux, Maria João Pereira, Agnès Villers, Sara R. J. Gilissen, Lutgarde Arckens

{"title":"Age-Dependent Area-, Lamina- and Cell-Type-Specific Distribution of the Cannabinoid Type 1 Receptor in the Mouse Visual Cortex","authors":"Lucas J. A. Durieux, Maria João Pereira, Agnès Villers, Sara R. J. Gilissen, Lutgarde Arckens","doi":"10.1002/cne.70136","DOIUrl":"10.1002/cne.70136","url":null,"abstract":"<div>\u0000 \u0000 The efficient processing of visual information relies on a mature visual cortex, characterized by hierarchically organized areas and a broad diversity of inhibitory and excitatory neurons. A tightly regulated excitation-inhibition (E/I) balance is essential for the optimal processing of visual inputs. A known regulator of the cortical E/I balance is the endocannabinoid (ECB) system, which relies on the cannabinoid type-1 receptor (CB1R) to perform its functions. To better understand the embedding of the CB1R in the neuronal networks of the visual cortex in adolescence and adulthood, we characterized the distribution of the receptor protein and its mRNA (cnr1) across layers, areas, and interneuron subtypes. We describe a specific laminar distribution of CB1R in the mature visual cortex along the full extent of the rostrocaudal brain axis. Moreover, cnr1 is expressed in the three main nonoverlapping subtypes of interneurons and is predominantly enriched in the 5ht3ar subtypes. Comparison of adolescent and adult visual cortex revealed a higher number of cnr1+ reelin interneurons in layer 1 and a lower number of cnr1+ somatostatin interneurons in layer 4 of the primary visual cortex (V1) in adolescence compared with adulthood. Overall, our findings confirm a distinct distribution of the receptor in V1 compared with higher-order visual areas based on a lower CB1R expression in layer 4, a broad cnr1 expression across cortical interneurons in key locations of top-down modulation, and a still immature ECB system in adolescence, making it potentially vulnerable to exogenous cannabinoids during this life period.\u0000 </div>","PeriodicalId":15552,"journal":{"name":"Journal of Comparative Neurology","volume":"534 2","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146142664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RVLM C1 Neurons Innervate Sacral as well as Thoracolumbar Autonomic Preganglionic Neurons in the Rat RVLM C1神经元支配大鼠骶神经和胸腰椎自主神经节前神经元。

IF 2.1 4区医学

Journal of Comparative Neurology Pub Date : 2026-01-31 DOI: 10.1002/cne.70134

I. J. Llewellyn-Smith, L. Travis, A. A. Connelly, J. K. Bassi, C. Menuet, A. M. Allen

{"title":"RVLM C1 Neurons Innervate Sacral as well as Thoracolumbar Autonomic Preganglionic Neurons in the Rat","authors":"I. J. Llewellyn-Smith, L. Travis, A. A. Connelly, J. K. Bassi, C. Menuet, A. M. Allen","doi":"10.1002/cne.70134","DOIUrl":"10.1002/cne.70134","url":null,"abstract":"We examined the distribution of axons throughout the spinal cord of the rat that were either immunoreactive for the adrenaline-synthesizing enzyme, phenylethanolamine N-methyltransferase (PNMT), or derived from medullary C1 neurons, one of the three groups of neurons in the brain that synthesize PNMT. We observed that PMNT-immunoreactive axons, as well as C1 axons labelled with GFP from viral transduction, innervate most, but not all, sympathetic preganglionic neurons in the thoracolumbar spinal cord. GFP-positive C1 axons provided innervation to sympathetic preganglionic neurons that expressed cocaine and amphetamine regulated transcript, an accepted marker of sympathetic vasomotor neurons. In addition, we observed axons from PNMT-containing and C1 neurons caudal to the distribution of sympathetic preganglionic neurons in the sacral spinal cord where they closely apposed parasympathetic preganglionic neurons retrogradely labelled from the major pelvic ganglion. We also found close appositions from PNMT-immunoreactive or GFP-labelled C1 axons on choline acetyltransferase-stained parasympathetic preganglionic neurons activated by the micturition reflex, thus providing clear evidence of a non-cardiovascular target for RVLM C1 neurons. Furthermore, we observed a few PNMT-positive and GFP-positive C1 axons making close appositions with somatic motor neurons in Onuf's nucleus in the sacral cord and in the ventral horn at more rostral levels. These data provide a comprehensive map of the distribution of adrenergic inputs to the spinal cord and identify parasympathetic preganglionic neurons, including those involved in the micturition reflex, as well as sympathetic preganglionic neurons as the major targets for these inputs.","PeriodicalId":15552,"journal":{"name":"Journal of Comparative Neurology","volume":"534 2","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12859742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146093313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glucagon-Like Peptide-1 Targets in the Human Nodose Ganglion 胰高血糖素样肽-1在人类结节神经节中的靶点。

IF 2.1 4区医学

Journal of Comparative Neurology Pub Date : 2026-01-31 DOI: 10.1002/cne.70135

Warda Merchant, Claire Mackaaij, Cindy G. J. Cleypool, Laurent Gautron

{"title":"Glucagon-Like Peptide-1 Targets in the Human Nodose Ganglion","authors":"Warda Merchant, Claire Mackaaij, Cindy G. J. Cleypool, Laurent Gautron","doi":"10.1002/cne.70135","DOIUrl":"10.1002/cne.70135","url":null,"abstract":"Given the rapidly expanding clinical use of glucagon-like peptide-1 receptor (GLP1R) agonists—well-known for their antidiabetic and antiobesity effects—it is increasingly important to understand the precise distribution of GLP1R expression in the human body, as this knowledge is crucial for elucidating both their therapeutic effects and side effects. In this study, we investigated Glp1r mRNA expression in the human nodose ganglion, a key sensory relay between the periphery and the brain. We analyzed postmortem paraffin-embedded nodose ganglia sections from 10 human donors, using RNAscope analysis. We found that optimal tissue required fixation times under 48 h and postmortem intervals of approximately 10 h or less. Ultimately, nine nodose ganglia from six donors met quality standards for analysis. Using multiplex RNAscope, we detected moderate to high levels of Glp1r expression in approximately 7% of all nodose neurons, with no clear differences between sides, sex, or age. The proportion of neurons with low Glp1r expression rose to nearly 28%. Notably, Glp1r expression was also observed in nonneuronal cells within the perineurium, epineurium, and fascicles of the human vagus nerve. As a point of comparison, we also examined Glp1r expression in mice, where 17.9%–29.1% of nodose neurons were positive, with slightly higher expression on the right side. In mice, Glp1r expression was strictly neuronal. Overall, our findings demonstrate that the human nodose ganglion is a potential target for GLP1R-based therapeutics and reveal species similarities and differences in Glp1r expression between humans and mice.","PeriodicalId":15552,"journal":{"name":"Journal of Comparative Neurology","volume":"534 2","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12860426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146093331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distribution of Voltage-Gated Sodium Channels and Scaffolding Proteins on Vestibular Calyx Ending Delineates the Axon Initial Segment 电压门控钠通道和支架蛋白在前庭花萼末端的分布描绘了轴突起始段。

IF 2.1 4区医学

Journal of Comparative Neurology Pub Date : 2026-01-28 DOI: 10.1002/cne.70127

Anna Lysakowski, Aravind Chenrayan Govindaraju, Steven D. Price, Sophie Gaboyard-Niay, Irina Calin-Jageman, Robstein L. Chidavaenzi, Ruth Anne Eatock, Robert M. Raphael, Jay M. Goldberg

{"title":"Distribution of Voltage-Gated Sodium Channels and Scaffolding Proteins on Vestibular Calyx Ending Delineates the Axon Initial Segment","authors":"Anna Lysakowski, Aravind Chenrayan Govindaraju, Steven D. Price, Sophie Gaboyard-Niay, Irina Calin-Jageman, Robstein L. Chidavaenzi, Ruth Anne Eatock, Robert M. Raphael, Jay M. Goldberg","doi":"10.1002/cne.70127","DOIUrl":"10.1002/cne.70127","url":null,"abstract":"The amniote inner ear contains an unusual type of hair cell and a unique postsynaptic calyx terminal with specialized ion channel expression and afferent transmission mechanisms. The calyceal afferent terminal enwraps the hair cell and leads to a heminode. It has morphological and functional microdomains with distinct complements of potassium channels and scaffolding proteins. Stimulation of hair cells gives rise to postsynaptic potentials in the membrane facing the hair cell that propagate along the outer face of the calyx and parent axon to the heminode, giving rise to spikes with timing and response properties that vary with location (epithelial zone) and afferent morphology (calyx-only vs. dimorphic with additional bouton terminals). Heminodes of calyx-only afferents lie within the epithelium, placing the calyces themselves closer to the heminode. We report that diverse voltage-gated sodium (NaV) channel proteins (including NaV1.1–1.3, 1.5. 1.6, 1.8, and 1.9), HCN (hyperpolarization-activated cyclic nucleotide-gated) channels, and associated scaffolding proteins (ankyrins, βIV-spectrin, and ezrin) are differentially deployed across calyx microdomains, and specific complements of proteins also vary with innervation zone in vestibular epithelia. Our results suggest the calyx outer surface plays a role analogous to an axon initial segment in central neurons, and that systematic variation in NaV pore-forming subunits underlies differences in firing properties of vestibular afferents in different epithelial zones.","PeriodicalId":15552,"journal":{"name":"Journal of Comparative Neurology","volume":"534 2","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12852067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146093326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Core and Matrix Thalamopallial Projections in Birds: A Study in the Pigeon (Columba livia) 鸟类的核心和基质丘脑突起：以鸽子为研究对象。

IF 2.1 4区医学

Journal of Comparative Neurology Pub Date : 2026-01-28 DOI: 10.1002/cne.70133

Máximo Fernández, Miccaella E. Vergara-Cereghino, Elisa Sentis, Gonzalo J. Marín, Jorge Mpodozis

{"title":"Core and Matrix Thalamopallial Projections in Birds: A Study in the Pigeon (Columba livia)","authors":"Máximo Fernández, Miccaella E. Vergara-Cereghino, Elisa Sentis, Gonzalo J. Marín, Jorge Mpodozis","doi":"10.1002/cne.70133","DOIUrl":"10.1002/cne.70133","url":null,"abstract":"<div>\u0000 \u0000 The ascending sensory projections from the dorsal thalamus to the pallium are one of the most distinctive features of the amniote brain. In mammals, these projections can be broadly classified into two main types: (1) those arising from “core” neurons, mostly located in the central region of sensory nuclei, which relay topographic inputs to the intermediate layers of primary sensory cortices, forming a reciprocal circuit with the reticular thalamic nucleus (RTN); and (2) those originating from “matrix” neurons, located in the periphery of sensory nuclei, which project to superficial layers of primary and higher order cortices. To date, both the reciprocal core-RTN circuitry and the matrix projections have only been described in mammals. In this study, we re-examined the organization of thalamic projections to the visual dorsal ventricular ridge (DVR) in pigeons using neural tracing techniques. In addition to the well-known projection from the thalamic nucleus rotundus (Rt) to the ventral layer of the visual DVR (entopallium), we described a reciprocal projection pattern between the Rt and the RTN. Moreover, we identified a second ascending thalamopallial projection, arising from neurons surrounding the Rt and terminating primarily in the intermediate layer of the visual DVR. These neurons form a continuous “matrix” of cells within the dorsal thalamus, which as a group also give rise to axons targeting several associative pallial areas. Furthermore, we found that this “matrix” region receives descending inputs from the motor arcopallium. Collectively, these findings indicate that the avian thalamopallial system is more complex than previously recognized and thus more comparable to its mammalian counterpart.\u0000 </div>","PeriodicalId":15552,"journal":{"name":"Journal of Comparative Neurology","volume":"534 2","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146063959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0