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Clinical Significance Of Serum And Urine Soluble Interleukin 2 Receptor, C-Reactive Protein, Cystatin C, and Serum and Urine Creatinine in Renal Transplant Patients 肾移植患者血清和尿可溶性白介素2受体、C反应蛋白、胱抑素C及血清和尿肌酐的临床意义
IF 1
Journal of Cutaneous Immunology and Allergy Pub Date : 2022-10-28 DOI: 10.37191/mapsci-2582-6549-3(2)-035
Kazim Khalid
{"title":"Clinical Significance Of Serum And Urine Soluble Interleukin 2 Receptor, C-Reactive Protein, Cystatin C, and Serum and Urine Creatinine in Renal Transplant Patients","authors":"Kazim Khalid","doi":"10.37191/mapsci-2582-6549-3(2)-035","DOIUrl":"https://doi.org/10.37191/mapsci-2582-6549-3(2)-035","url":null,"abstract":"Cytokines play a major role in the inflammatory and allo-specific components of allograft rejection, and in the migration of cells into graft tissue. IL-2 binding of sIL-2R plays a major role in T cell activation. It is suggested that high urinary sIL-2R (U/sIL-2R) in the first 3-5 post-transplant days identified the patient sub-group at risk of developing acute rejection (RX). However, it was difficult to distinguish between RX and infection (INFX) as both of these factors can potentially affect serum sIL-2R (S/sIL-2R) and U/sIL-2R concentrations independent of actual production rates. The aims of this study were to validate and extend previous findings of the use of sIL-2R in renal transplantation, to investigate other protein markers currently used such as serum C-reactive protein (CRP), serum cystatin C (cys. C), and serum and urine creatinine (S/creat. and UCRE) and attempt to differentiate RX from INFX. SIL-2R ELISA kit was validated and used to establish reference ranges in healthy donors, transplant (TX) recipients, and renal disease controls. These values were compared with serial estimations of S/sIL-2R and U/sIL-2R of patients post-TX. Levels of serum CRP, cys. C, S/creat. and UCRE were also investigated in the renal disease control and 21 TX subjects to determine if a panel of investigation would have enhanced clinical diagnosis. RX and INFX were determined retrospectively on an “intention to treat” basis. Results show that sIL-2R levels in normal serum and urine subjects are lower than in disease controls, that CRP and cys C are good indicators of RX as well as U/sIL-2R and S/sIL-2R, that UCRE is not a good marker of differentiation, and that stratifying levels of these markers according to treatment differentiated RX from INFX.","PeriodicalId":15543,"journal":{"name":"Journal of Cutaneous Immunology and Allergy","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89994535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Should the First Rejected Kidney Implant be Removed? 第一个被排斥的肾植入物是否应该被移除?
IF 1
Journal of Cutaneous Immunology and Allergy Pub Date : 2022-10-27 DOI: 10.37191/mapsci-2582-6549-3(2)-036
Kazim Khalid
{"title":"Should the First Rejected Kidney Implant be Removed?","authors":"Kazim Khalid","doi":"10.37191/mapsci-2582-6549-3(2)-036","DOIUrl":"https://doi.org/10.37191/mapsci-2582-6549-3(2)-036","url":null,"abstract":"Renal transplantation (TX) is widely used as a definitive therapy for chronic, end-stage organ failure. T cells are pivotal in rejection (RX), and RX is a process whereby donor tissue is recognized and destroyed by the host immune system. Within a rejecting graft it is likely that high concentrations of IL-2 are present. The binding of interleukin 2(IL-2) to its receptor (IL-2R) on human T cells constitutes the key regulatory event in the initiation and maintenance of the immune response.\u0000\u0000The receptor, IL-2R, is found in two forms: cellular and soluble. The surgical removal of a transplanted kidney following RX or failure can be hazardous. Two surgical techniques were applied: extracapsular and intracapsular removal. The technique of kidney transplant removal by either the intra- or extra-capsular route of the exact timing of the operation are important features for safe treatment of patients with end-stage graft failure.\u0000\u0000The results of the report are a prospective study on 21 renal TX recipients, and show that nephrectomy of previous TX kidney will reduce the levels of four markers in serum and urine.","PeriodicalId":15543,"journal":{"name":"Journal of Cutaneous Immunology and Allergy","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82807879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of disseminated extranodal Rosai–Dorfman disease diagnosed by skin manifestations 皮肤表现诊断为弥漫性结外Rosai–Dorfman病1例
IF 1
Journal of Cutaneous Immunology and Allergy Pub Date : 2022-10-24 DOI: 10.1002/cia2.12286
Shintaro Saito MD, Akihiko Uchiyama MD, PhD, Yayoi Shibusawa MD, PhD, Sei-ichiro Motegi MD, PhD
{"title":"A case of disseminated extranodal Rosai–Dorfman disease diagnosed by skin manifestations","authors":"Shintaro Saito MD,&nbsp;Akihiko Uchiyama MD, PhD,&nbsp;Yayoi Shibusawa MD, PhD,&nbsp;Sei-ichiro Motegi MD, PhD","doi":"10.1002/cia2.12286","DOIUrl":"10.1002/cia2.12286","url":null,"abstract":"<p>Rosai–Dorfman disease (RDD) is a rare non-Langerhans cell histiocytosis that was first described as sinus histiocytosis with massive lymphadenopathy by Rosai and Dorfman in 1969. While classical/nodal RDD is typical, extranodal involvement is seen in up to 43% of all cases, with 23% showing only extranodal lesions. Here, we present a case of disseminated extranodal RDD, where the initial symptoms were cutaneous manifestations.</p>","PeriodicalId":15543,"journal":{"name":"Journal of Cutaneous Immunology and Allergy","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cia2.12286","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46485252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cold-induced anaphylactic shock during playing in a thigh-deep river: A pediatric case 在大腿深的河里玩耍时冷致过敏性休克：一例儿科病例
IF 1
Journal of Cutaneous Immunology and Allergy Pub Date : 2022-10-24 DOI: 10.1002/cia2.12285
Ayumi Sakai MD, Naoko Inomata MD, PhD, Kohei Yamakawa MD, Yukie Yamaguchi MD, PhD
{"title":"Cold-induced anaphylactic shock during playing in a thigh-deep river: A pediatric case","authors":"Ayumi Sakai MD,&nbsp;Naoko Inomata MD, PhD,&nbsp;Kohei Yamakawa MD,&nbsp;Yukie Yamaguchi MD, PhD","doi":"10.1002/cia2.12285","DOIUrl":"10.1002/cia2.12285","url":null,"abstract":"<p>We report a pediatric patient with acquired cold urticaria who developed a systemic reaction triggered by localized cold exposure. By determining the critical threshold temperature using TempTest®, we were able to minimize restriction in activities.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":15543,"journal":{"name":"Journal of Cutaneous Immunology and Allergy","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cia2.12285","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44906283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adult-onset Still's disease following mRNA-1273 Moderna COVID-19 vaccination: A case report mRNA - 1273现代COVID - 19疫苗接种后成人发病Still's病:1例报告
IF 1
Journal of Cutaneous Immunology and Allergy Pub Date : 2022-10-19 DOI: 10.1002/cia2.12281
Masahiro Iwata MD, Tatsuya Ogawa MD, PhD, Keisuke Anju MD, Naoko Okiyama MD, PhD, Toshifumi Nomura MD, PhD
{"title":"Adult-onset Still's disease following mRNA-1273 Moderna COVID-19 vaccination: A case report","authors":"Masahiro Iwata MD,&nbsp;Tatsuya Ogawa MD, PhD,&nbsp;Keisuke Anju MD,&nbsp;Naoko Okiyama MD, PhD,&nbsp;Toshifumi Nomura MD, PhD","doi":"10.1002/cia2.12281","DOIUrl":"10.1002/cia2.12281","url":null,"abstract":"<p>A 57-year-old woman who was inoculated with the second dose of the mRNA-1273 Moderna COVID-19 vaccine and then developed adult-onset still’s disease as a result.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":15543,"journal":{"name":"Journal of Cutaneous Immunology and Allergy","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cia2.12281","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45591410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
A successful switch from guselkumab to tildrakizumab during the treatment of a patient with psoriasis vulgaris 在治疗寻常型牛皮癣患者期间，从guelkumab成功切换到tildrakizumab
IF 1
Journal of Cutaneous Immunology and Allergy Pub Date : 2022-10-19 DOI: 10.1002/cia2.12284
Kazuki Yatsuzuka MD, Masamoto Murakami MD, PhD
{"title":"A successful switch from guselkumab to tildrakizumab during the treatment of a patient with psoriasis vulgaris","authors":"Kazuki Yatsuzuka MD,&nbsp;Masamoto Murakami MD, PhD","doi":"10.1002/cia2.12284","DOIUrl":"10.1002/cia2.12284","url":null,"abstract":"<p>This was the first case report in which an in-class IL-23 p19 inhibitor was switched (from guselkumab to tildrakizumab) during psoriasis vulgaris treatment. Four months after the switch, genital lesions, which were the patient's most significant complaint, improved with no subsequent worsening. We believe that our case will aid physicians who work in this problematic clinical setting.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":15543,"journal":{"name":"Journal of Cutaneous Immunology and Allergy","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cia2.12284","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48477591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Dupilumab treatment reduces serum SCCA2 levels in patients with atopic dermatitis Dupilumab治疗降低特应性皮炎患者血清SCCA2水平
IF 1
Journal of Cutaneous Immunology and Allergy Pub Date : 2022-10-17 DOI: 10.1002/cia2.12282
Kanako Kita MD, Yasutomo Imai MD, PhD, Makoto Nagai MD, PhD, Masaru Natsuaki MD, PhD, Nobuo Kanazawa MD, PhD
{"title":"Dupilumab treatment reduces serum SCCA2 levels in patients with atopic dermatitis","authors":"Kanako Kita MD,&nbsp;Yasutomo Imai MD, PhD,&nbsp;Makoto Nagai MD, PhD,&nbsp;Masaru Natsuaki MD, PhD,&nbsp;Nobuo Kanazawa MD, PhD","doi":"10.1002/cia2.12282","DOIUrl":"10.1002/cia2.12282","url":null,"abstract":"<p>Dupilumab treatment reduced serum SCCA2 levels in patients with atopic dermatitis. Interestingly, even though the skin eruptions had not yet fully disappeared, serum SCCA2 levels were reduced well to below normal by the administration of dupilumab.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":15543,"journal":{"name":"Journal of Cutaneous Immunology and Allergy","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cia2.12282","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44774205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relapsing erythema nodosum-like eruption in a patient with granulomatosis with polyangiitis 肉芽肿合并多血管炎患者复发性结节样红斑
IF 1
Journal of Cutaneous Immunology and Allergy Pub Date : 2022-10-13 DOI: 10.1002/cia2.12283
Satomi Imamoto MD, Chie Miyabe MD, PhD, Ryujin Miyata MD, Yasuko Fukuya MD, PhD, Naoko Ishiguro MD, PhD
{"title":"Relapsing erythema nodosum-like eruption in a patient with granulomatosis with polyangiitis","authors":"Satomi Imamoto MD,&nbsp;Chie Miyabe MD, PhD,&nbsp;Ryujin Miyata MD,&nbsp;Yasuko Fukuya MD, PhD,&nbsp;Naoko Ishiguro MD, PhD","doi":"10.1002/cia2.12283","DOIUrl":"10.1002/cia2.12283","url":null,"abstract":"<p>We report a rare case of granulomatosis with polyangiitis (GPA) who presented with relapsing erythema nodosum (EN)-like eruption as a solo vasculitis-associated cutaneous manifestation. We suggest that EN-like eruption alone can be a cutaneous symptom of GPA if subcutaneous medium-sized vessels are exclusively affected. \u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":15543,"journal":{"name":"Journal of Cutaneous Immunology and Allergy","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cia2.12283","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46036935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Criteria for Accepting or Rejecting Cord Blood Units 接受或拒绝脐带血单位的标准
IF 1
Journal of Cutaneous Immunology and Allergy Pub Date : 2022-10-10 DOI: 10.37191/mapsci-2582-6549-3(2)-037
Khalid Kazim
{"title":"Criteria for Accepting or Rejecting Cord Blood Units","authors":"Khalid Kazim","doi":"10.37191/mapsci-2582-6549-3(2)-037","DOIUrl":"https://doi.org/10.37191/mapsci-2582-6549-3(2)-037","url":null,"abstract":"Rare hematopoietic stem cell populations are responsible for the transplantation engraftment process. Umbilical cord blood (UCB) is usually processed to the total nucleated cell (TNC), but not to the mononuclear cell (MNC) fraction. TNC counts are used to determine UCB unit storage, release for transplantation and correlation with time to engraftment [1]. It has been mentioned in the literature that there are several factors that affect harvesting of cord blood stem cells [2]. It was set to analyze the relationship between fetal weight and other factors that led to rejection of CBUs brought to DCRC from public and private donations. In this retrospective study, 375 donations of CBUs from January 2018 to October 2018 at DCRC were recorded. From literature, factors that are usually involved in rejection of CBUs were recorded and analyzed to mark the leading cause of rejection criteria. In this study, it showed that results did not find infants’ birth weight or mother’s age to have any value in rejection. Other factors’ results will be discussed.","PeriodicalId":15543,"journal":{"name":"Journal of Cutaneous Immunology and Allergy","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85919744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional and Cellular Immunotherapy (FCIT) Concept 功能和细胞免疫治疗(FCIT)概念
IF 1
Journal of Cutaneous Immunology and Allergy Pub Date : 2022-10-10 DOI: 10.37191/mapsci-2582-6549-3(2)-034
Khalid Kazim
{"title":"Functional and Cellular Immunotherapy (FCIT) Concept","authors":"Khalid Kazim","doi":"10.37191/mapsci-2582-6549-3(2)-034","DOIUrl":"https://doi.org/10.37191/mapsci-2582-6549-3(2)-034","url":null,"abstract":"Inflammation is the process by which the immune system recognizes and removes environmental factors, and begins the healing process. Inflammation can be either acute or chronic. However, the cause of many chronic inflammatory conditions is poorly understood. Chronic inflammatory responses are an ongoing process as long as the environmental factor is present. Sometimes, the response makes the body attack itself.\u0000\u0000In this paper a closer look at finding out the causes of chronic inflammations, how to treat them on an individual basis, how to reverse the disease early on, and how to repair damages that the inflammation has caused.","PeriodicalId":15543,"journal":{"name":"Journal of Cutaneous Immunology and Allergy","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83486955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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