什么导致ME/CFS:功能失调的免疫系统和病毒感染的作用

IF 1.1 Q4 ALLERGY
A. Bansal
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引用次数: 2

摘要

肌痛性脑脊髓炎/慢性疲劳综合征(ME/CFS)是一种难以理解的、高度致残的、复杂的长期疾病,具有广泛的病因和症状。患者通常会提到病毒发作,最终会扰乱几个身体系统。这与长期covid的相似之处很明显。然而,免疫失调与受损NK细胞功能障碍和倾向于新的自身免疫经常被报道。这些可能导致先前获得的病毒/逆转录病毒的再激活,并伴有内分泌调节和线粒体能量产生的受损。对几种对抗疗法和替代疗法反应不良的看似不相关和多样的症状的不可预测性导致疾病升级,并发多个其他系统的继发性功能障碍。因此,治疗已确定的ME/CFS是困难的,需要针对受该疾病影响的每个领域进行多专业投入。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
What Causes ME/CFS: The Role of the Dysfunctional Immune System and Viral Infections
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) remains an enigmatic highly disabling and complex long-term condition with a wide range of aetiologies and symptoms. A viral onset is commonly mentioned by patients and several bodily systems are ultimately disturbed. The parallel with long-covid is clear. However, immune dysregulation with impaired NK cell dysfunction and tendency to novel autoimmunity have been frequently reported. These may contribute to reactivation of previous acquired viruses/retrovirusesaccompanied by impaired endocrine regulation and mitochondrial energy generation. The unpredictable nature of seemingly unconnected and diverse symptoms that are poorly responsive to several allopathic and alternative therapies then contributes to an escalation of the illness with secondary dysfunction of multiple other systems. Treatment of established ME/CFS is therefore difficult and requires multi-specialty input addressing each of the areas affected by the illness.
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来源期刊
CiteScore
0.60
自引率
10.00%
发文量
69
审稿时长
12 weeks
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