Journal of Clinical Neurophysiology最新文献_第2页

Response to: Usefulness of the H-Reflex for Intraoperative Monitoring of Thoracoabdominal Aneurysms. 对h反射在胸腹动脉瘤术中监测中的作用的回应。

IF 2.3 4区医学

Journal of Clinical Neurophysiology Pub Date : 2025-07-25 DOI: 10.1097/WNP.0000000000001200

Guillermo Martín-Palomeque, Jaime R López

引用次数: 0

Individualizing Programming of Responsive Neurostimulation and Deep Brain Stimulation Therapies in Epilepsy. 反应性神经刺激和深部脑刺激治疗癫痫的个体化规划。

IF 1.7 4区医学

Journal of Clinical Neurophysiology Pub Date : 2025-07-25 DOI: 10.1097/WNP.0000000000001195

Lara Wadi, Sandipan Pati, Shruti Agashe

{"title":"Individualizing Programming of Responsive Neurostimulation and Deep Brain Stimulation Therapies in Epilepsy.","authors":"Lara Wadi, Sandipan Pati, Shruti Agashe","doi":"10.1097/WNP.0000000000001195","DOIUrl":"10.1097/WNP.0000000000001195","url":null,"abstract":"Summary: Responsive neurostimulation and deep brain stimulation have emerged as effective intracranial neuromodulation therapies for drug-resistant epilepsy when surgical resection is not an option. However, programming these devices presents unique challenges in epilepsy. Without immediate feedback and a vast programming space, clinicians are often tasked with fine-tuning device settings without clear, mechanistic guidance and limited clinical time. Recent efforts toward individualized programming have shown promise, including the use of nonstandard parameter sets, target-specific stimulation strategies, and patient-tailored adaptations while avoiding unintended interference with critical functions such as emotional regulation. Emerging research in programming is shifting beyond the one-size-fits-all protocols, incorporating closed-loop biomarkers, integrating multimodal data and predictive modeling that hold promise for improving seizure control and reducing adverse effects. This review synthesizes current evidence on standard and individualized programming approaches for deep brain stimulation and responsive neurostimulation in epilepsy, highlighting practical strategies, clinical outcomes, and insights from recent studies. Although emerging tools such as biomarker-guided programming and predictive modeling are gaining interest, the focus of this review is on existing clinical literature shaping programming today.","PeriodicalId":15516,"journal":{"name":"Journal of Clinical Neurophysiology","volume":"42 6","pages":"513-520"},"PeriodicalIF":1.7,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leveraging Functional and Structural Connectomics to Guide Neuromodulation in Epilepsy. 利用功能和结构连接组学指导癫痫的神经调节。

IF 1.7 4区医学

Journal of Clinical Neurophysiology Pub Date : 2025-07-25 DOI: 10.1097/WNP.0000000000001196

Ketan Mehta, Arianna Damiani, Elvira Pirondini, Shruti Agashe, Cameron C McIntyre, Jorge A Gonzalez-Martinez

引用次数: 0

Refining the Interpretation of Bulbocavernosus Reflex Monitoring in Tethered Cord Surgery: Limitations, Potentials, and Contextual Value. 完善脊髓系扎手术中球海绵体反射监测的解释：局限性、潜力和背景价值。

IF 2.3 4区医学

Journal of Clinical Neurophysiology Pub Date : 2025-07-23 DOI: 10.1097/WNP.0000000000001197

Jongsuk Choi

引用次数: 0

Special Considerations for Personalization in Pediatric Intracranial Neuromodulation. 儿童颅内神经调节个体化治疗的特殊考虑。

IF 1.7 4区医学

Journal of Clinical Neurophysiology Pub Date : 2025-07-23 DOI: 10.1097/WNP.0000000000001193

Charuta Joshi

引用次数: 0

H-reflex Monitoring During Thoracoabdominal Aneurysm Surgery: Optimizing Clinical Application. 胸腹动脉瘤手术中h反射监测：优化临床应用。

IF 2.3 4区医学

Journal of Clinical Neurophysiology Pub Date : 2025-07-21 DOI: 10.1097/WNP.0000000000001199

Jongsuk Choi, Kieob Kim

引用次数: 0

Biomarkers for Epilepsy Deep Brain Stimulation. 癫痫深部脑刺激的生物标志物。

IF 1.7 4区医学

Journal of Clinical Neurophysiology Pub Date : 2025-07-17 DOI: 10.1097/WNP.0000000000001189

Gloria Ortiz-Guerrero, Nicholas M Gregg

引用次数: 0

Editorial: Personalizing Intracranial Neuromodulation in Epilepsy. 社论：癫痫的个体化颅内神经调节。

IF 1.7 4区医学

Journal of Clinical Neurophysiology Pub Date : 2025-07-16 DOI: 10.1097/WNP.0000000000001194

Shruti Agashe, Gregory Worrell

引用次数: 0

Responsive Neurostimulation for Treatment of Drug-Resistant Epilepsy in a Child With Dravet Syndrome. 反应性神经刺激治疗儿童Dravet综合征耐药癫痫。

IF 2.3 4区医学

Journal of Clinical Neurophysiology Pub Date : 2025-07-14 DOI: 10.1097/WNP.0000000000001190

Reilly F Philliben, Shanna M Swartwood, Audie C Espinoza

{"title":"Responsive Neurostimulation for Treatment of Drug-Resistant Epilepsy in a Child With Dravet Syndrome.","authors":"Reilly F Philliben, Shanna M Swartwood, Audie C Espinoza","doi":"10.1097/WNP.0000000000001190","DOIUrl":"https://doi.org/10.1097/WNP.0000000000001190","url":null,"abstract":"Summary: Dravet syndrome is an intractable developmental and epileptic encephalopathy caused primarily by SCN1A haploinsufficiency, leading to impaired NaV1.1 sodium channel function and reduced inhibitory signaling. Despite treatment with antiseizure medications, many patients remain drug resistant, necessitating alternative approaches such as neuromodulation. Responsive neurostimulation (RNS), which detects and responds to abnormal brain activity in real time, has shown promise in generalized epilepsy by targeting the thalamus. Thalamic stimulation can disrupt abnormal oscillatory activity, potentially reducing seizure frequency and severity. This report presents a 7-year-old girl with Dravet syndrome in the setting of a pathogenic SCN1A variant and drug-resistant epilepsy, who experienced numerous generalized seizures daily. After extensive testing and multiple antiseizure medication trials, RNS was implanted with bilateral centromedian nucleus of the thalamus depth electrodes. At her most recent clinic visit, she exhibited a 50% to 75% reduction in seizure frequency, with resolution of myoclonic and myoclonic-atonic seizures. Her family reported significant reductions in rescue medication use, seizure duration, and seizure severity after RNS implantation. This case adds to the growing evidence supporting the use and safety of RNS in pediatric patients with drug-resistant generalized epilepsy and is the first reported instance of RNS treatment in a patient with Dravet syndrome. Although the initial results are promising, further research is needed to explore the long-term efficacy, safety, and neurodevelopmental impacts of RNS in this population. This case highlights the importance of continued research and clinical innovation in neuromodulation therapies for Dravet syndrome.","PeriodicalId":15516,"journal":{"name":"Journal of Clinical Neurophysiology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mapping the Effects of Intracranial Electrical Stimulation of the Human Orbitofrontal Cortex. 绘制颅内电刺激对人眶额皮质的影响。

IF 2.3 4区医学

Journal of Clinical Neurophysiology Pub Date : 2025-07-10 DOI: 10.1097/WNP.0000000000001184

Sofia Pantis, Dian Lyu, Weichen Huang, Abby Kwon, Claire Cheng, Anna Duong, Eileen Ma, Kieran C R Fox, Josef Parvizi

{"title":"Mapping the Effects of Intracranial Electrical Stimulation of the Human Orbitofrontal Cortex.","authors":"Sofia Pantis, Dian Lyu, Weichen Huang, Abby Kwon, Claire Cheng, Anna Duong, Eileen Ma, Kieran C R Fox, Josef Parvizi","doi":"10.1097/WNP.0000000000001184","DOIUrl":"https://doi.org/10.1097/WNP.0000000000001184","url":null,"abstract":"Introduction: Prior findings on direct intracranial electrical stimulation (iES) of the human orbitofrontal cortex (OFC), which includes the orbital and ventromedial prefrontal regions, have been mixed, with several reports lacking replication. We aimed to clarify the effects of iES in the OFC.Methods: We analyzed data from 608 stimulations across 277 OFC site pairs (352 sites total) in 49 patients collected over 17 years of our practice.Results: We found 24.4% of sites as responsive to iES, with subjects reporting visual and olfactory sensations. However, post hoc analysis revealed that these responses largely originated from the stimulation of nearby non-OFC optic and olfactory structures. After applying quality controls, stimulation of only 0.6% of OFC sites (2 sites, 2 patients) produced changes in subjective domain, while 99.4% had no reportable effects. Contrary to earlier studies, we found no evidence of valence lateralization or functional organization within the OFC.Conclusions: Our findings suggest that the electrical perturbation of OFC is largely silent and does not lead to reportable change in the subjective state of the individual.Significance: Orbitofrontal cortex is a higher transmodal cortical area. The variability and limited replicability of reported effects from prior publications and the inconsistencies in the extant literature about OFC stimulations can be attributed to methodological shortcomings.","PeriodicalId":15516,"journal":{"name":"Journal of Clinical Neurophysiology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0