Journal of Clinical Neurophysiology最新文献

Clinical and Electrophysiologic Features of Ulnar Neuropathy at the Wrist: Analysis of 150 Consecutive Cases. 腕部尺神经病变的临床和电生理特征：附150例病例分析。

IF 1.7 4区医学

Journal of Clinical Neurophysiology Pub Date : 2025-10-03 DOI: 10.1097/WNP.0000000000001211

Federica Ginanneschi, Marianna Curcio, Alessandro Aretini, Mauro Mondelli

{"title":"Clinical and Electrophysiologic Features of Ulnar Neuropathy at the Wrist: Analysis of 150 Consecutive Cases.","authors":"Federica Ginanneschi, Marianna Curcio, Alessandro Aretini, Mauro Mondelli","doi":"10.1097/WNP.0000000000001211","DOIUrl":"https://doi.org/10.1097/WNP.0000000000001211","url":null,"abstract":"Purpose: To report clinical and electrodiagnostic (EDX) findings in ulnar neuropathy at the wrist (UNW).Methods: This is a monocentric study. We collected demographic and clinical data, history, symptom type, neurologic examination findings, EDX results, as well as causes and risk factors of UNW.Results: We enrolled 150 consecutive cases. Based on EDX findings, the most common UNW pattern involved the ulnar nerve at the entrance of Guyon canal, prior to its bifurcation into sensory and motor branches (44% of cases). We identified atypical topographic lesions involving the superficial sensory branch and motor fibers innervating the hypothenar (4.7% of cases) or the interossei muscles (12.8% of cases). The most frequent causes were compressive (20.7%) and traumatic (22%), mainly affecting males, blue-collar workers, and individuals aged ≤60 years. Ganglion was prevalent in females (66.7%). Cases of UNW with unknown etiology were significantly associated with age >60 years, the presence of muscle atrophy, and a history of carpal tunnel syndrome (CTS).Conclusions: Clinical and EDX characteristics of UNW depend on injury site at wrist or hand palm. It is not possible to determine the cause with certainty based solely on the type, although some causes tend to affect specific sites of nerve injury. The coexistence of Guyon canal syndrome and CTS is confirmed to be a fairly frequent finding. The awareness of the ulnar nerve anatomical variations should not lead to the exclusion of UNW if EDX abnormalities do not fall into any of the five classical types according to Wu's classification.","PeriodicalId":15516,"journal":{"name":"Journal of Clinical Neurophysiology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Electric Source Imaging Approach Demonstrating Diagnostic Value of Nasopharyngeal Electrodes in Temporal Lobe Epilepsy. 鼻咽电极电成像对颞叶癫痫诊断价值的探讨。

IF 1.7 4区医学

Journal of Clinical Neurophysiology Pub Date : 2025-10-03 DOI: 10.1097/WNP.0000000000001213

Yun Ho Choi, Taeik Jang, Soo Hwan Yim, Kyoung Heo

{"title":"An Electric Source Imaging Approach Demonstrating Diagnostic Value of Nasopharyngeal Electrodes in Temporal Lobe Epilepsy.","authors":"Yun Ho Choi, Taeik Jang, Soo Hwan Yim, Kyoung Heo","doi":"10.1097/WNP.0000000000001213","DOIUrl":"https://doi.org/10.1097/WNP.0000000000001213","url":null,"abstract":"Purpose: To investigate the different regions covered by nasopharyngeal (NPEs) and anterior temporal (anterior temporal electrodes [ATEs]) electrodes in assessing temporal lobe epilepsy, to overcome the limitations of the 10 to 20 electroencephalography (EEG) in diagnosing the basal and mesial temporal regions.Methods: EEG data from 229 patients diagnosed with temporal lobe epilepsy were simultaneously analyzed with attached NPEs and ATEs. In case of discrepancies in EEG interpretation, a consensus interpretation was reached among three epilepsy experts. Spike detection was conducted using the Curry9 program for secondary analysis of electric source localization, with source location performed using standard brain MRI data.Results: In total, 2,721 interictal epileptiform discharges (IEDs) from 175 patients were analyzed. Of these, 734 IEDs from 48 patients were detected exclusively with NPEs, while 1,987 IEDs from 127 patients were detected simultaneously by both NPEs and the standard international 10 to 20 electrodes system supplemented with ATEs, respectively. The former IEDs exhibited clustering dipoles in the basal and mesial temporal regions, while the latter were localized solely to the frontotemporal and lateral temporal regions.Conclusions: Nasopharyngeals can identify IEDs in the mesial and basal temporal region that cannot be detected by ATEs. Nasopharyngeals offer additional diagnostic value in regions not confirmed by the existing 10 to 20 EEG electrode system, including those covered by ATE.","PeriodicalId":15516,"journal":{"name":"Journal of Clinical Neurophysiology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

24-Hour Video EEG in the Evaluation of the Seizure-Free Patient Before Antiseizure Medication Withdrawal. 24小时视频脑电图在无癫痫患者停药前的评价。

IF 1.7 4区医学

Journal of Clinical Neurophysiology Pub Date : 2025-10-01 DOI: 10.1097/WNP.0000000000001212

Areej Nauman, Ahamed Lazim Vattoth, Gayane Melikyan, Musab Ali, Yaser Othman, Boulenouar Mesraoua, Hasan Al Hail, Soha Roger Dargham, Farhana Khan, Abdulraheem Alrabi, Ziyad Mahfoud, Naim Haddad

{"title":"24-Hour Video EEG in the Evaluation of the Seizure-Free Patient Before Antiseizure Medication Withdrawal.","authors":"Areej Nauman, Ahamed Lazim Vattoth, Gayane Melikyan, Musab Ali, Yaser Othman, Boulenouar Mesraoua, Hasan Al Hail, Soha Roger Dargham, Farhana Khan, Abdulraheem Alrabi, Ziyad Mahfoud, Naim Haddad","doi":"10.1097/WNP.0000000000001212","DOIUrl":"https://doi.org/10.1097/WNP.0000000000001212","url":null,"abstract":"Purpose: In patients with epilepsy who achieve seizure freedom, physicians may consider discontinuing antiseizure medications, often using EEG beforehand to guide the decision. This study evaluates the gain in detection of epileptiform discharges (EDs) in 24-hour video EEG (VEEG) monitoring in seizure-free patients.Methods: The authors identified patients with epilepsy who were seizure free on antiseizure medications and had undergone 24-hour VEEG after an unrevealing routine EEG. The authors evaluated the yield and latency of observed EDs in the VEEG study. The authors compared the rate of ED detection during the first 60 minutes versus later in the recording.Results: Of the 27 patients, aged 19 to 51 years, 10 (37%) exhibited EDs on 24-hour VEEG. The latency to the first EDs ranged from 52 to 748 minutes, with a median of 164 minutes. Nine of these 10 patients (90%) had their EDs appear only after the first 60 minutes of recording. In other words, prolonging the EEG beyond 1 hour yielded an additional 33.3% of patients with EDs that a 1-hour recording would have missed. Younger age and presence of EDs on a past EEG were predictive of the presence of EDs on VEEG ( P = 0.040 and P = 0.039 respectively).Conclusions: The results suggest that 24-hour VEEG is more sensitive in detecting EDs than routine EEG in seizure-free patients and thus may be superior in individualized risk assessments for seizure recurrence on potential antiseizure medication discontinuation.","PeriodicalId":15516,"journal":{"name":"Journal of Clinical Neurophysiology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

S2, S3, and S4 Sacral Dermatomal Evoked Potentials: Technical Parameters and Normative Values. S2， S3和S4骶皮诱发电位：技术参数和标准值。

IF 1.7 4区医学

Journal of Clinical Neurophysiology Pub Date : 2025-09-17 DOI: 10.1097/WNP.0000000000001206

Prasad Malladi, Llwyd Orton, Sara Simeoni, Jalesh Panicker

{"title":"S2, S3, and S4 Sacral Dermatomal Evoked Potentials: Technical Parameters and Normative Values.","authors":"Prasad Malladi, Llwyd Orton, Sara Simeoni, Jalesh Panicker","doi":"10.1097/WNP.0000000000001206","DOIUrl":"https://doi.org/10.1097/WNP.0000000000001206","url":null,"abstract":"Purpose: The existing literature on the sacral dermatomal evoked potentials (dSEPs) is limited. This study aims to develop stimulating parameters and establish normative values for S2, S3, and S4 sacral dermatomes in healthy adult populations.Methods: Twenty healthy adult volunteers were enrolled in the study. The study was ethically approved, and written consent for participation was provided. All participants underwent tibial, pudendal, S2, S3, and S4 dSEPs. Stimulating and recorded parameters were established for all evoked potentials. P40 latency, amplitude, and interpeak parameters were calculated for each waveform. A comparison was made between tibial, pudendal somatosensory evoked potentials, and all sacral dSEPs. Normative values were generated for sacral dSEPs based on various height, age, and Body Mass Index (BMI) parameters.Results: The sacral dSEPs were well tolerated and recorded in all participants. S2 latency was mildly influenced by age and height, while S3 and S4 latencies were unaffected by age or height. BMI does not affect the S2 and S3 latencies but mildly affects the S4 latency. Sacral dSEP latencies were comparable with pudendal SEPS but not with the tibial somatosensory evoked potential.Conclusions: The S2, S3, and S4 sacral dSEPs can be used as diagnostic tools to evaluate sacral nerve lesions such as cauda equina syndrome and Tarlov cysts, complementary to pudendal and tibial somatosensory evoked potentials.","PeriodicalId":15516,"journal":{"name":"Journal of Clinical Neurophysiology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of Electrophysiologic Monitoring in Contralateral C7 Nerve Transfer Surgery. 电生理监测在对侧C7神经转移手术中的应用。

IF 1.7 4区医学

Journal of Clinical Neurophysiology Pub Date : 2025-09-03 DOI: 10.1097/WNP.0000000000001205

Chengyuan Ji, Hao Liu, Hongjun Zhu, Hongbin Ni, Jiangang Liu

{"title":"Application of Electrophysiologic Monitoring in Contralateral C7 Nerve Transfer Surgery.","authors":"Chengyuan Ji, Hao Liu, Hongjun Zhu, Hongbin Ni, Jiangang Liu","doi":"10.1097/WNP.0000000000001205","DOIUrl":"10.1097/WNP.0000000000001205","url":null,"abstract":"Purpose: This study aimed to evaluate the intraoperative localization and prognostic utility of electrophysiologic monitoring for upper limb and hand muscle groups during contralateral C7 nerve transfer surgery.Methods: In this retrospective, dual-center study, patients with spastic hemiparesis of a single upper limb who underwent contralateral C7 nerve transfer between July 2022 and November 2023 at the First Affiliated Hospital of Soochow University and Nanjing Drum Tower Hospital were included. Sensory, motor, and muscle tone changes were assessed using free electromyography, compound muscle action potentials, somatosensory evoked potentials, and transcranial electrical stimulation motor evoked potentials.Results: Ten patients (eight males and two females; mean age: 54 ± 10.7 years) were included. Free electromyography demonstrated 100% accuracy in detecting nerve traction. Stimulation of the C7 nerve elicited 100% positive compound muscle action potential responses in the triceps brachii, extensor carpi radialis brevis, and flexor carpi ulnaris muscles. All patients exhibited somatosensory evoked potential wave amplitude reductions greater than 50%, whereas latency changes were observed in 10% of cases.Conclusions: Real-time free electromyography and triggered stimulation enabled accurate localization of C5-C8 nerve roots. Somatosensory evoked potential and transcranial electrical stimulation motor evoked potential monitoring were predictive of postoperative sensory and motor function in the unaffected upper limb.","PeriodicalId":15516,"journal":{"name":"Journal of Clinical Neurophysiology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Auditory Reaction Time in People With Epilepsy and Healthy Controls. 癫痫患者和健康对照者的听觉反应时间

IF 1.7 4区医学

Journal of Clinical Neurophysiology Pub Date : 2025-09-03 DOI: 10.1097/WNP.0000000000001202

Nora Schwab, Roland Renzel, Murezi Capaul, Pascal Luc Faber, Tena Dubcek, Lukas Imbach, Debora Ledergerber

{"title":"Auditory Reaction Time in People With Epilepsy and Healthy Controls.","authors":"Nora Schwab, Roland Renzel, Murezi Capaul, Pascal Luc Faber, Tena Dubcek, Lukas Imbach, Debora Ledergerber","doi":"10.1097/WNP.0000000000001202","DOIUrl":"10.1097/WNP.0000000000001202","url":null,"abstract":"Objective: Simple reaction time (SRT) to acoustic stimuli is a typical parameter used in the assessment of driving ability in people with epilepsy (PWE). In clinical practice, auditory SRT is commonly compared during and outside of epileptiform discharges (ED). Yet, a subset of PWE also has slowed SRT outside their ED, possibly because of antiseizure medication (ASM) or disease-associated network alterations. SRT values should therefore be compared with reference values from matched controls which are currently lacking in practice. We here aimed to find a reference range of SRT in healthy controls using the same paradigm as commonly used in PWE.Methods: We measured auditory SRT in heathy control subjects without epilepsy and a cohort of patients with epilepsy. We matched the control cohort, according to age and sex, to a cohort of PWE who had previously been recorded at our center using the same task. This allowed to compare auditory SRT between a control cohort and a cohort of PWE.Results: The control group showed a significantly lower mean SRT latency and a smaller SRT variability as compared with PWE. Within the cohort of PWE, the SRT was significantly prolonged during periods with ED. Potential confounding factors, such as age, did not show any significant contribution to auditory SRT.Conclusions: Our findings demonstrate a small intrapersonal variance of SRT in the control group. Therefore, outlier SRT values in PWE during ED are likely a useful parameter for assessing driving ability.","PeriodicalId":15516,"journal":{"name":"Journal of Clinical Neurophysiology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transdural Stimulation for the Identification of a Dehiscent Geniculate Ganglion in Intradural Middle Cranial Fossa Surgery: A Proof-of-Principle Study. 硬膜内颅中窝手术中经硬膜刺激识别裂膝状神经节：一项原理证明研究。

IF 1.7 4区医学

Journal of Clinical Neurophysiology Pub Date : 2025-08-22 DOI: 10.1097/WNP.0000000000001204

Sebastian Niedermeyer, Andrea Szelenyi, Christian Schichor

{"title":"Transdural Stimulation for the Identification of a Dehiscent Geniculate Ganglion in Intradural Middle Cranial Fossa Surgery: A Proof-of-Principle Study.","authors":"Sebastian Niedermeyer, Andrea Szelenyi, Christian Schichor","doi":"10.1097/WNP.0000000000001204","DOIUrl":"https://doi.org/10.1097/WNP.0000000000001204","url":null,"abstract":"Purpose: Facial nerve injury is a potential complication in intradural middle cranial fossa surgery, particularly because of dehiscence of the geniculate ganglion, exposing the nerve to thermal injury. Identifying the geniculate ganglion during surgical approaches is crucial for preserving facial nerve function. This study aimed to evaluate the feasibility and efficacy of transdural stimulation in identifying the geniculate ganglion during intradural approaches to improve the preservation of facial nerve function.Methods: We conducted a retrospective analysis on patients who underwent surgery for middle cranial fossa lesions using intraoperative neuromonitoring including facial motor evoked potentials and transdural direct nerve stimulation of the geniculate ganglion, from January 2016 to January 2024.Results: We identified eight consecutive patients with various pathologies of the middle cranial fossa who underwent surgery with direct nerve stimulation of the geniculate ganglion. Specific responses from facial muscles were registered in four out of eight patients, with stimulation intensity varying between 0.5 and 2 mA. None of the patients who underwent surgery with direct nerve stimulation experienced facial palsy. Notably, even when CT scans suggested bony covering of the geniculate ganglion, the facial nerve could still be stimulated.Conclusions: This proof-of-principle study demonstrates that transdural stimulation is a promising technique for identifying the geniculate ganglion during intradural middle cranial fossa surgery. This approach has the potential to improve preservation of facial nerve function and reduce the risk of postoperative facial palsy.","PeriodicalId":15516,"journal":{"name":"Journal of Clinical Neurophysiology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Significance of Positive Spike Wave Discharges in the Pediatric Population: Insights Beyond Neonates. 儿科人群中正尖峰波放电的临床意义：超越新生儿的见解。

IF 1.7 4区医学

Journal of Clinical Neurophysiology Pub Date : 2025-08-14 DOI: 10.1097/WNP.0000000000001203

Shishir Duble, Anita N Datta

{"title":"Clinical Significance of Positive Spike Wave Discharges in the Pediatric Population: Insights Beyond Neonates.","authors":"Shishir Duble, Anita N Datta","doi":"10.1097/WNP.0000000000001203","DOIUrl":"https://doi.org/10.1097/WNP.0000000000001203","url":null,"abstract":"Introduction: Positive spike wave (PSW) discharges on EEG are well-documented in neonates, but data regarding their significance in other populations are limited. This study aimed to assess the clinical significance of PSW in children aged 1 month to 19 years at a single tertiary care center over approximately three decades.Methods: Clinical information of children with focal PSW (n = 326) was compared with control patients with focal negative interictal epileptiform discharges (n = 898).Results: From 77,500 pediatric EEGs in our laboratory from 1992 to 2020, PSW were identified in 445 (0.57%) children, of which 326 met inclusion criteria. Positive spike waves were located in the following brain regions: occipital (139), central (65), frontal (63), temporal (43), parietal (9), and centro-temporal (7). Positive spike wave patients had a younger median age of seizure onset than control patients (1.1 years [0.30, 4.00] versus 4 years [1.3, 7.5], P < 0.001).Logistic regression analysis confirmed that PSW were associated with high odds of seizures [odds ratios (OR) 3.78; CI: 2.14-2.14; P < 0.005], epilepsy [OR 2.05; CI: 1.39-1.39; P < 0.005], and drug-resistant epilepsy, [OR 3.51; CI: 2.67-2.67; P < 0.005]. Furthermore, PSW correlated with a greater odd of developmental delay [OR 3.69; CI: 2.77-2.77; P < 0.005], school difficulties [OR 2.85; CI: 2.07-2.07; P < 0.005], abnormal neurologic exam [OR 2.8; CI: 2.15-2.15; P < <0.005], and structural brain abnormalities [OR 1.74; CI: 1.32-1.32; P < 0.005], such as malformation of cortical development, compared with control patients.Conclusions: Positive spike waves on pediatric EEG are associated with congenital or acquired brain abnormalities and less favorable seizure and neurodevelopmental outcomes.","PeriodicalId":15516,"journal":{"name":"Journal of Clinical Neurophysiology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144855385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply to "Refining the Interpretation of Bulbocavernosus Reflex Monitoring in Tethered Cord Surgery: Limitations, Potentials, and Contextual Value". 回复“完善对脊髓栓系手术中球海绵体反射监测的解释：局限性、潜力和背景价值”。

IF 2.3 4区医学

Journal of Clinical Neurophysiology Pub Date : 2025-07-25 DOI: 10.1097/WNP.0000000000001198

Giovanna Squintani, Andrea Rasera, Francesco Sala

引用次数: 0

The Impact of Transcranial Direct Current Stimulation on Drug-Resistant Temporal Lobe Epilepsy. 经颅直流电刺激对耐药颞叶癫痫的影响。

IF 2.3 4区医学

Journal of Clinical Neurophysiology Pub Date : 2025-07-25 DOI: 10.1097/WNP.0000000000001201

Omar El-Nakah, Ann Ali AbdelKader, Nirmeen A Kishk, Radwa Mahmoud Azmy, Mohamed Khaled Al Menabbawy, Hagar Hassan Mourad, Eman El-Zamarany

{"title":"The Impact of Transcranial Direct Current Stimulation on Drug-Resistant Temporal Lobe Epilepsy.","authors":"Omar El-Nakah, Ann Ali AbdelKader, Nirmeen A Kishk, Radwa Mahmoud Azmy, Mohamed Khaled Al Menabbawy, Hagar Hassan Mourad, Eman El-Zamarany","doi":"10.1097/WNP.0000000000001201","DOIUrl":"https://doi.org/10.1097/WNP.0000000000001201","url":null,"abstract":"Purpose: Cathodal transcranial direct current stimulation (c-tDCS), a noninvasive neuromodulation technique, is effective in reducing cortical excitability in patients with drug-resistant epilepsy.This study aimed to examine the impact of c-tDCS on seizure frequency, Liverpool Seizure Severity Scale, and electroencephalography in patients with drug-resistant temporal lobe epilepsy.Methods: A randomized, double-blind, placebo-controlled clinical trial was conducted on 30 patients with temporal lobe drug-resistant epilepsy. The patients were randomized into two groups. Group A received a once-daily split session (20 minutes stimulation-20 minutes break-20 minutes stimulation) on five consecutive days of 1 mA c-tDCS over the side of most frequent interictal epileptiform discharges or the area of suspected ictal onset. Group B underwent the sham sessions.Results: A statistically significant reduction in seizure frequency, Liverpool Seizure Severity Scale, and epileptiform discharges on the EEG record was detected in the c-tDCS group after one month of the five daily sessions.Conclusions: In patients with temporal lobe drug-resistant epilepsy, c-tDCS improved seizure control by lowering seizure frequency, severity, and epileptiform discharges in the EEG for up to one month after the sessions.Significance: This confirmatory study is consistent with several previous studies showing the efficacy of c-tDCS in reducing seizure frequency in patients with temporal lobe drug-resistant epilepsy.","PeriodicalId":15516,"journal":{"name":"Journal of Clinical Neurophysiology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0