The Impact of Transcranial Direct Current Stimulation on Drug-Resistant Temporal Lobe Epilepsy.

IF 1.7 4区医学 Q3 CLINICAL NEUROLOGY

Journal of Clinical Neurophysiology Pub Date : 2025-07-25 DOI:10.1097/WNP.0000000000001201

Omar El-Nakah, Ann Ali AbdelKader, Nirmeen A Kishk, Radwa Mahmoud Azmy, Mohamed Khaled Al Menabbawy, Hagar Hassan Mourad, Eman El-Zamarany

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Abstract

Purpose: Cathodal transcranial direct current stimulation (c-tDCS), a noninvasive neuromodulation technique, is effective in reducing cortical excitability in patients with drug-resistant epilepsy.This study aimed to examine the impact of c-tDCS on seizure frequency, Liverpool Seizure Severity Scale, and electroencephalography in patients with drug-resistant temporal lobe epilepsy.

Methods: A randomized, double-blind, placebo-controlled clinical trial was conducted on 30 patients with temporal lobe drug-resistant epilepsy. The patients were randomized into two groups. Group A received a once-daily split session (20 minutes stimulation-20 minutes break-20 minutes stimulation) on five consecutive days of 1 mA c-tDCS over the side of most frequent interictal epileptiform discharges or the area of suspected ictal onset. Group B underwent the sham sessions.

Results: A statistically significant reduction in seizure frequency, Liverpool Seizure Severity Scale, and epileptiform discharges on the EEG record was detected in the c-tDCS group after one month of the five daily sessions.

Conclusions: In patients with temporal lobe drug-resistant epilepsy, c-tDCS improved seizure control by lowering seizure frequency, severity, and epileptiform discharges in the EEG for up to one month after the sessions.

Significance: This confirmatory study is consistent with several previous studies showing the efficacy of c-tDCS in reducing seizure frequency in patients with temporal lobe drug-resistant epilepsy.

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经颅直流电刺激对耐药颞叶癫痫的影响。

目的：阴极经颅直流电刺激（c-tDCS）是一种无创神经调节技术，可有效降低耐药癫痫患者的皮质兴奋性。本研究旨在探讨c-tDCS对耐药颞叶癫痫患者癫痫发作频率、利物浦癫痫严重程度评分和脑电图的影响。方法：对30例颞叶耐药癫痫患者进行随机、双盲、安慰剂对照临床试验。患者随机分为两组。A组连续5天接受1 mA c-tDCS，每日1次（20分钟刺激-20分钟休息-20分钟刺激），在最常见的癫痫样间歇放电一侧或疑似癫痫发作区域。B组进行模拟实验。结果：c-tDCS组在5次每日治疗一个月后，脑电图记录上的癫痫发作频率、利物浦发作严重程度量表和癫痫样放电均有统计学意义的降低。结论：在颞叶耐药癫痫患者中，c-tDCS通过降低癫痫发作频率、严重程度和脑电图中癫痫样放电来改善癫痫控制，持续时间长达一个月。意义：这一验证性研究与之前的几项研究一致，显示了c-tDCS在减少颞叶耐药癫痫患者发作频率方面的疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Neurophysiology 医学-临床神经学

CiteScore

4.60

自引率

4.20%

发文量

198

审稿时长

6-12 weeks

期刊介绍： The Journal of Clinical Neurophysiology features both topical reviews and original research in both central and peripheral neurophysiology, as related to patient evaluation and treatment. Official Journal of the American Clinical Neurophysiology Society.