Journal of Clinical Neurophysiology最新文献_第10页

Characterizing Seizure-Onset Patterns With the Responsive Neurostimulation System. 利用反应性神经刺激系统分析癫痫发作模式

IF 2.3 4区医学

Journal of Clinical Neurophysiology Pub Date : 2024-06-25 DOI: 10.1097/WNP.0000000000001090

Zulfi Haneef, Alexandra Celine Vallera, Sameera Vedantam, Maximillian S Feygin, Stephen Cleboski, Jay R Gavvala

{"title":"Characterizing Seizure-Onset Patterns With the Responsive Neurostimulation System.","authors":"Zulfi Haneef, Alexandra Celine Vallera, Sameera Vedantam, Maximillian S Feygin, Stephen Cleboski, Jay R Gavvala","doi":"10.1097/WNP.0000000000001090","DOIUrl":"10.1097/WNP.0000000000001090","url":null,"abstract":"Purpose: The responsive neurostimulation system (RNS) aims to improve seizures by delivering electrical stimulation in response to epileptiform patterns detected by electrocorticograms. Seizure-onset patterns (SOPs) correspond to outcomes in intracranial EEG (IC-EEG), although whether this is true for RNS is unknown. This study characterizes common RNS SOPs and correlates them with seizure outcomes.Methods: Among 40 patients with RNS implants, long-episode electrocorticogram characteristics of each patient's seizures were classified by visual analysis as one of the eight patterns previously described in IC-EEG. Correlation between each type of SOP and eventual seizure outcome was analyzed, with ≥50% improvement in a number of patient-reported seizure counts defined as a favorable outcome.Results: Across 263 LEs analyzed, the most common SOP observed was low-voltage fast activity. There was no difference between the distribution of RNS SOPs and that of IC-EEG SOPs described in the literature (Kolmogorov-Smirnov test, P = 0.98). Additionally, there was no correlation between any particular SOP and favorable outcomes (Fisher's omnibus test, P = 0.997).Conclusion: This initial description of RNS SOPs finds them to be similar to previously described IC-EEG SOPs, which suggests similar prognostic/therapeutic potential. However, we found that RNS efficacy is independent of patient SOP, suggesting that RNS is likely an equally effective treatment for all SOPs. Future research on stimulation parameters for particular RNS SOPs and correlation with IC-EEG SOPs in the same patients would be instrumental in guiding personalized neurostimulation.","PeriodicalId":15516,"journal":{"name":"Journal of Clinical Neurophysiology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141446283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interictal Electroencephalography and Functional Magnetic Resonance Imaging Reveals Involvement of Mesial Anterior Frontal Structures in Patients With Hyperkinetic Semiology Type I. 发作间期脑电图和功能磁共振成像揭示了过度动眼神经症I型患者的中前额叶结构受累。

IF 2.3 4区医学

Journal of Clinical Neurophysiology Pub Date : 2024-06-25 DOI: 10.1097/WNP.0000000000001104

Vasileios Kokkinos

{"title":"Interictal Electroencephalography and Functional Magnetic Resonance Imaging Reveals Involvement of Mesial Anterior Frontal Structures in Patients With Hyperkinetic Semiology Type I.","authors":"Vasileios Kokkinos","doi":"10.1097/WNP.0000000000001104","DOIUrl":"10.1097/WNP.0000000000001104","url":null,"abstract":"Purpose: This work investigates the presence of common anatomic regions associated with interictal activity in patients with hyperkinetic seizures type I by means of concurrent electroencephalography and functional magnetic resonance imaging.Methods: Six patients with hyperkinetic seizures type I were evaluated with video-EEG and electroencephalography and functional magnetic resonance imaging in the context of their presurgical evaluation. Statistical Parametric Mapping was used to perform a correlation study between the occurrence of interictal spikes on EEG and suprathreshold blood oxygen level-dependent changes in the whole-brain volume.Results: In all patients, Statistical Parametric Mapping revealed suprathreshold blood oxygen level-dependent clusters in the mesial anterior frontal areas, including the rostral mesial superior frontal gyrus and the anterior cingulate, associated with the patients' typical interictal activity.Conclusions: The electroencephalography and functional magnetic resonance imaging findings contribute to our understanding of hyperkinetic seizures type I semiology generation and can inform stereo-EEG targeting for surgical planning in refractory cases.","PeriodicalId":15516,"journal":{"name":"Journal of Clinical Neurophysiology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141446289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contraction-Induced H Reflexes of the Upper and Lower Limbs in Healthy Adults. 健康成年人上下肢收缩引起的 H 反射。

IF 2.3 4区医学

Journal of Clinical Neurophysiology Pub Date : 2024-06-24 DOI: 10.1097/WNP.0000000000001070

Antony Winkel, Mark Cook, Leslie Roberts

{"title":"Contraction-Induced H Reflexes of the Upper and Lower Limbs in Healthy Adults.","authors":"Antony Winkel, Mark Cook, Leslie Roberts","doi":"10.1097/WNP.0000000000001070","DOIUrl":"https://doi.org/10.1097/WNP.0000000000001070","url":null,"abstract":"Purpose: Contraction-induced H reflexes are a late neurophysiologic response elicited with submaximal nerve stimulation during isometric muscle contraction. Mediated by spinal pathways, like other H reflexes, their use has remained somewhat limited despite a long history of development dating back to the original description by Hoffman. There is a paucity of data on normal reference ranges, which this article aims to add to.Methods: Contraction-induced H reflexes were elicited from the first dorsal interosseous, flexor carpi radialis, and tibialis anterior bilaterally in 100 healthy volunteers. Reference values, including side-to-side variation, were calculated. Pearson test and multiple regression were used to evaluate the relationship of H-reflex latency to height, age, and sex of participants.Results: The mean onset latencies of 28.00, 17.44, and 31.10 ms were seen for first dorsal interosseous, flexor carpi radialis, and tibialis anterior muscles, respectively. The calculated allowable side-to-side latency difference in individual participants was 3 to 4 ms. A correlation to participant height was seen.Conclusions: This work provides normal reference values of contraction-induced H reflexes to three muscles, including allowable side-to-side variation. The latter suggests that bilateral testing evaluating for asymmetry within an individual is likely to be optimally sensitive. The relationship to height is also confirmed.","PeriodicalId":15516,"journal":{"name":"Journal of Clinical Neurophysiology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141446284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Normative Data and Quantile Regression Analysis of the Sural-to-Radial Nerve Amplitude Ratio. 耳神经与桡神经振幅比的标准数据和量值回归分析

IF 2.3 4区医学

Journal of Clinical Neurophysiology Pub Date : 2024-06-21 DOI: 10.1097/WNP.0000000000001084

Kaveh Pourhamidi

{"title":"Normative Data and Quantile Regression Analysis of the Sural-to-Radial Nerve Amplitude Ratio.","authors":"Kaveh Pourhamidi","doi":"10.1097/WNP.0000000000001084","DOIUrl":"https://doi.org/10.1097/WNP.0000000000001084","url":null,"abstract":"Purpose: The aim of this study was to establish normative data for the sural-to-radial nerve amplitude ratio (SRAR) and develop a quantile regression model for individualized cutoff values.Methods: A cohort of 68 healthy individuals (36 female participants) aged 20 to 59 years was recruited. Sensory nerve conduction studies were conducted to measure sural and radial sensory nerve action potential amplitudes. Quantile regression analysis was used to determine the fifth percentile of SRAR after adjusting for age, sex, and other demographic variables.Results: This study found significant differences in body height and weight between the sexes, with radial sensory nerve action potential being higher in female participants. The sural-to-radial nerve amplitude ratio was negatively correlated with age (r = -0.3, p = 0.007) and showed significant sex differences. The final regression equation, SRAR = 0.519 - 0.006 × age + 0.046 × sex (1 = male, 0 = female), was developed for the fifth percentile cutoff, accounting for age and sex.Conclusions: This study establishes normative SRAR data and introduces a novel quantile regression approach to determine individualized cutoff values. Age and sex are critical factors for SRAR variation, necessitating tailored diagnostic criteria for neuropathy assessment. This model enhances diagnostic accuracy and potentially reduces misdiagnosis in clinical settings. Further research is recommended to validate the clinical applicability of SRAR across different types of neuropathies.","PeriodicalId":15516,"journal":{"name":"Journal of Clinical Neurophysiology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141432003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics and Usefulness of Neurophysiological Monitoring in Corrective Procedures for Abnormally Curved Spine in Young Patients. 神经电生理监测在年轻患者异常弯曲脊柱矫正手术中的特点和作用。

IF 2.4 4区医学

Journal of Clinical Neurophysiology Pub Date : 2024-06-10 DOI: 10.1097/WNP.0000000000001074

Avner Michaeli, Sara Miller, Joseph Danto, Harel Arzi, Josh E Schroeder, Dror Ovadia

{"title":"Characteristics and Usefulness of Neurophysiological Monitoring in Corrective Procedures for Abnormally Curved Spine in Young Patients.","authors":"Avner Michaeli, Sara Miller, Joseph Danto, Harel Arzi, Josh E Schroeder, Dror Ovadia","doi":"10.1097/WNP.0000000000001074","DOIUrl":"10.1097/WNP.0000000000001074","url":null,"abstract":"Purpose: To identify and characterize events of deterioration in intraoperative neuromonitoring data during correction procedures for thoracic and lumbar abnormal spinal curvature in young patients.Methods: Records of 1,127 cases were retrospectively reviewed to identify events with deterioration of the neuromonitoring data. General etiological and demographic variables were summarized, and neuromonitoring events were studied and characterized.Results: Adolescent idiopathic cases were associated with female dominance and older age. Nonadolescent idiopathic cases were associated with a higher rate of neuromonitoring events. The neuromonitoring events evolved during the different procedural stages, were primarily reflected in the motor-evoked potential data and affected a range of neural structures to varying degrees. Most of the events were resolved, partially or completely, following a corresponding intervention by the surgical team, before the end of the procedure. Significant immediate weakness of the lower extremities was demonstrated in patients with unresolved neuromonitoring events, most of them were nonadolescent idiopathic patients.Conclusions: Neurophysiological monitoring enables the intraoperative assessment of the integrity of neural pathways and allows the detection of surgery-related impending neural injuries. Neuromonitoring contributes to intraoperative decision making, either when data are uneventful and allow confident continuation or when data deteriorate and lead to corresponding intervention. Further awareness should be paid to the vulnerable characteristics of the patient, surgery course, and neuromonitoring data. Proper interpretation of the neuromonitoring data, together with corresponding intervention by the surgeon when necessary, has the potential to reduce postoperative neurological insults and improve clinical outcomes.","PeriodicalId":15516,"journal":{"name":"Journal of Clinical Neurophysiology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141300782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reflex Responses in Muscles of the Lower Extremities Elicited by Transcutaneous Stimulation of Cauda Equina: Part 1. Methodology and Normative Data. 经皮刺激马尾引起的下肢肌肉反射反应：第 1 部分。方法和标准数据。

IF 2.4 4区医学

Journal of Clinical Neurophysiology Pub Date : 2024-06-10 DOI: 10.1097/WNP.0000000000001088

Julija Rimac, Davor Jančuljak, Biserka Kovač, Miloš Jovičić, Josipa Forjan

{"title":"Reflex Responses in Muscles of the Lower Extremities Elicited by Transcutaneous Stimulation of Cauda Equina: Part 1. Methodology and Normative Data.","authors":"Julija Rimac, Davor Jančuljak, Biserka Kovač, Miloš Jovičić, Josipa Forjan","doi":"10.1097/WNP.0000000000001088","DOIUrl":"https://doi.org/10.1097/WNP.0000000000001088","url":null,"abstract":"Introduction: Transcutaneous electrical stimulation is used to stimulate the dorsal roots of the cauda equina. Multiple elicited responses recorded in the lower extremity muscles are called posterior root muscle reflexes (PRMRs). Normal PRMR values in the muscles of healthy lower extremities have yet to be determined.Methods: Thirty subjects without known lumbosacral spinal root illness were included in this study. Subsequently, they were subjected to transcutaneous electrical stimulation of the cauda equina. Posterior root muscle reflex was recorded in the four muscle groups of both lower extremities. We elicited multiple PRMR and examined their characteristics in order to establish normal electrophysiological parameter values.Results: Posterior root muscle reflex was successfully elicited in the tibialis anterior (96.7%), gastrocnemius (100%), quadriceps femoris (93.3%), and hamstring (96.7%). No statistically significant differences were found in the intensity of stimulation, latencies, or area under the PRMR between the right and left leg muscles. The area under PRMR varied significantly among the participants. Higher body weight and abdominal girth showed a significant positive correlation with stimulation intensity for eliciting PRMR, and a significant negative correlation with the area under PRMR. Older age showed a significant negative correlation with the success of eliciting PRMR and the area under the PRMR.Conclusions: Posterior root muscle reflex is a noninvasive and successful method for eliciting selective reflex responses of cauda equina posterior roots. Obtained values could be used in future studies to evaluate the utility of this methodology in clinical practice. This methodology could improve testing of the proximal lumbosacral nervous system functional integrity.","PeriodicalId":15516,"journal":{"name":"Journal of Clinical Neurophysiology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141300784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The First 100 Seconds of Sleep of rEEGs Can Be a Reliable Scoring Method for D/EE-SWAS. 脑电图的前 100 秒睡眠时间可作为 D/EE-SWAS 的可靠评分方法。

IF 2.4 4区医学

Journal of Clinical Neurophysiology Pub Date : 2024-06-10 DOI: 10.1097/WNP.0000000000001089

Neil Kulkarni, Brett Klamer, Michael Drees, Jaime D Twanow

{"title":"The First 100 Seconds of Sleep of rEEGs Can Be a Reliable Scoring Method for D/EE-SWAS.","authors":"Neil Kulkarni, Brett Klamer, Michael Drees, Jaime D Twanow","doi":"10.1097/WNP.0000000000001089","DOIUrl":"10.1097/WNP.0000000000001089","url":null,"abstract":"Purpose: Developmental/epileptic encephalopathy with spike wave activation with sleep, formerly known as electrical status epilepticus in sleep, is an electrographic pattern in which the interictal epileptiform activity is augmented by transition to sleep. Recent studies demonstrate the utility of the first 100 seconds of sleep of long-term monitoring (LTM) as a scoring method for electrical status epilepticus in sleep. Our aim was to measure the reliability of the spike-wave index (SWI) of the first 100 seconds of sleep of routine EEG (rEEG) as a tool for diagnosis of developmental/epileptic encephalopathy with spike wave activation with sleep.Methods: Approximately three hundred forty LTMs were reviewed, and 25 studies from 25 unique patients had comparable rEEGs. Two neurophysiologists calculated the SWI of the first 100 seconds of spontaneous stage II non-random eye movement sleep, the first 5-minute bin of sleep, and three separate 5-minute bins throughout sleep in LTM. This was compared to the SWI of the first 100 seconds of sleep in rEEG. Agreement was analyzed using Lin's concordance correlation coefficient (CCC).Results: Using 50% as a diagnostic cut-off, we observed moderate agreement between the SWI of the first 100 seconds of sleep of rEEG and three bin LTM (CCC = 0.94, 95% CI: 0.88-0.97). Agreement was slightly higher for the comparison to first bin LTM SWI (CCC = 0.96, 95% CI: 0.92-0.98) and first 100 seconds LTM SWI (CCC = 0.96, 95% CI: 0.92-0.98).Conclusions: This study demonstrates the first 100 seconds of sleep of rEEG technique as a time efficient diagnostic tool for patients with concern for developmental/epileptic encephalopathy with spike wave activation with sleep.","PeriodicalId":15516,"journal":{"name":"Journal of Clinical Neurophysiology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141300785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Continuous Electroencephalogram Use and Hospital Outcomes in Critically Ill Children. 连续脑电图的使用与重症儿童的住院效果

IF 2.4 4区医学

Journal of Clinical Neurophysiology Pub Date : 2024-05-01 Epub Date: 2023-03-09 DOI: 10.1097/WNP.0000000000000993

Ahyuda Oh, Courtney J Wusthoff, Hyunmi Kim

{"title":"Continuous Electroencephalogram Use and Hospital Outcomes in Critically Ill Children.","authors":"Ahyuda Oh, Courtney J Wusthoff, Hyunmi Kim","doi":"10.1097/WNP.0000000000000993","DOIUrl":"10.1097/WNP.0000000000000993","url":null,"abstract":"Purpose: To examine the association between CEEG use and discharge status, length of hospitalization, and health care cost in a critically ill pediatric population.Methods: Four thousand three hundred forty-eight critically ill children were identified from a US nationwide administrative health claims database; 212 (4.9%) of whom underwent CEEG during admissions (January 1, 2015-june 30, 2020). Discharge status, length of hospitalization, and health care cost were compared between patients with and without CEEG use. Multiple logistic regression analyzed the association between CEEG use and these outcomes, controlling for age and underlying neurologic diagnosis. Prespecified subgroups analysis was performed for children with seizures/status epilepticus, with altered mental status and with cardiac arrest.Results: Compared with critically ill children without CEEG, those who underwent CEEG were likely to have shorter hospital stays than the median (OR = 0.66; 95% CI = 0.49-0.88; P = 0.004), and also total hospitalization costs were less likely to exceed the median (OR = 0.59; 95% CI = 0.45-0.79; P < 0.001). There was no difference in odds of favorable discharge status between those with and without CEEG (OR = 0.69; 95% CI = 0.41-1.08; P = 0.125). In the subgroup of children with seizures/status epilepticus, those with CEEG were less likely to have unfavorable discharge status, compared with those without CEEG (OR = 0.51; 95% CI = 0.27-0.89; P = 0.026).Conclusions: Among critically ill children, CEEG was associated with shorter stay and lower costs of hospitalization but was not associated with change of favorable discharge status except the subgroup with seizures/status epilepticus.","PeriodicalId":15516,"journal":{"name":"Journal of Clinical Neurophysiology","volume":" ","pages":"291-296"},"PeriodicalIF":2.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9084701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Motor Evoked Potential-A Pilot Study Looking at Reliability and Clinical Correlations in Multiple Sclerosis. 运动诱发电位--多发性硬化症可靠性与临床相关性试验研究

IF 2.4 4区医学

Journal of Clinical Neurophysiology Pub Date : 2024-05-01 Epub Date: 2023-03-21 DOI: 10.1097/WNP.0000000000001003

F H Jacques, B E Apedaile, I Danis, V Sikati-Foko, M Lecompte, J Fortin

{"title":"Motor Evoked Potential-A Pilot Study Looking at Reliability and Clinical Correlations in Multiple Sclerosis.","authors":"F H Jacques, B E Apedaile, I Danis, V Sikati-Foko, M Lecompte, J Fortin","doi":"10.1097/WNP.0000000000001003","DOIUrl":"10.1097/WNP.0000000000001003","url":null,"abstract":"Purpose: Multiple sclerosis (MS) is a clinically heterogeneous disease. Biomarkers that can assess pathological processes that are unseen with conventional imaging remain an unmet need in MS disease management. Motor evoked potentials (MEPs) could be such a biomarker. To determine and follow longitudinal MEP reliability and correlations with clinical measures in MS patients.Methods: This is a single-center study in alemtuzumab-treated MS patients to evaluate temporal reliability of MEPs, identify MEP minimum detectible differences, and explore correlations with existing clinical scales. Ten MS patients recently treated with alemtuzumab were evaluated every 6 months over 3 years. Clinical evaluations consisted of expanded disability status scale, timed 25-foot walk, 6-minute walk, and nine-hole peg test. MEPs were measured twice, 2 weeks apart, every 6 months.Results: Eight patients completed all 3 years of study. The intraclass correlation coefficient for MEP parameters ranged from 0.76 to 0.98. TA latency and amplitude with facilitation significantly and strongly correlated with all clinical measures, whereas the MEP duration modestly correlated. Biceps latency with facilitation significantly and moderately correlated with 9-hole peg test. Longitudinal correlations demonstrated good predictive values for either clinical deterioration or improvement.Conclusions: MEPs have excellent intrapatient and intrarater reliability, and TA MEPs significantly and strongly correlated with expanded disability status scale, 6-minute walk, and timed 25-foot walk, whereas biceps MEPs significantly and moderately correlated with nine-hole peg test. Further studies using larger cohorts of MS patients are indicated.Clinical trial registration: ClinicalTrials.gov, Identifier: NCT02623946.","PeriodicalId":15516,"journal":{"name":"Journal of Clinical Neurophysiology","volume":" ","pages":"357-364"},"PeriodicalIF":2.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11060055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9500469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing Surgical Planning for Epilepsy Patients With Multimodal Neuroimaging and Neurophysiology Integration: A Case Study. 利用多模态神经成像和神经生理学整合优化癫痫患者的手术规划：案例研究。

IF 2.3 4区医学

Journal of Clinical Neurophysiology Pub Date : 2024-05-01 Epub Date: 2024-02-20 DOI: 10.1097/WNP.0000000000001071

Ruxue Gong, Stephan Bickel, Gelana Tostaeva, Fred A Lado, Ashesh D Metha, Ruben I Kuzniecky, Leonardo F Bonilha, Ezequiel L Gleichgerrcht

{"title":"Optimizing Surgical Planning for Epilepsy Patients With Multimodal Neuroimaging and Neurophysiology Integration: A Case Study.","authors":"Ruxue Gong, Stephan Bickel, Gelana Tostaeva, Fred A Lado, Ashesh D Metha, Ruben I Kuzniecky, Leonardo F Bonilha, Ezequiel L Gleichgerrcht","doi":"10.1097/WNP.0000000000001071","DOIUrl":"10.1097/WNP.0000000000001071","url":null,"abstract":"Summary: Current preoperative evaluation of epilepsy can be challenging because of the lack of a comprehensive view of the network's dysfunctions. To demonstrate the utility of our multimodal neurophysiology and neuroimaging integration approach in the presurgical evaluation, we present a proof-of-concept for using this approach in a patient with nonlesional frontal lobe epilepsy who underwent two resective surgeries to achieve seizure control. We conducted a post-hoc investigation using four neuroimaging and neurophysiology modalities: diffusion tensor imaging, resting-state functional MRI, and stereoelectroencephalography at rest and during seizures. We computed region-of-interest-based connectivity for each modality and applied betweenness centrality to identify key network hubs across modalities. Our results revealed that despite seizure semiology and stereoelectroencephalography indicating dysfunction in the right orbitofrontal region, the maximum overlap on the hubs across modalities extended to right temporal areas. Notably, the right middle temporal lobe region served as an overlap hub across diffusion tensor imaging, resting-state functional MRI, and rest stereoelectroencephalography networks and was only included in the resected area in the second surgery, which led to long-term seizure control of this patient. Our findings demonstrated that transmodal hubs could help identify key areas related to epileptogenic network. Therefore, this case presents a promising perspective of using a multimodal approach to improve the presurgical evaluation of patients with epilepsy.","PeriodicalId":15516,"journal":{"name":"Journal of Clinical Neurophysiology","volume":" ","pages":"317-321"},"PeriodicalIF":2.3,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11073903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139905656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0