{"title":"Identification of an error in the implementation of the Eleveld model in a commercial TCI pump.","authors":"Nicolas Milliet","doi":"10.1007/s10877-025-01333-8","DOIUrl":"https://doi.org/10.1007/s10877-025-01333-8","url":null,"abstract":"","PeriodicalId":15513,"journal":{"name":"Journal of Clinical Monitoring and Computing","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Enrique Monares-Zepeda, Christopher Barrera-Hoffmann, Ulises Wilfrido Cerón-Díaz, Yesica Ivone Martínez-Baltazar
{"title":"Presentation of a novel method to estimate analog mean systemic filling pressure based on cardiac power.","authors":"Enrique Monares-Zepeda, Christopher Barrera-Hoffmann, Ulises Wilfrido Cerón-Díaz, Yesica Ivone Martínez-Baltazar","doi":"10.1007/s10877-025-01336-5","DOIUrl":"10.1007/s10877-025-01336-5","url":null,"abstract":"<p><p>Mean systemic filling pressure (MSFP) is a critical hemodynamic parameter for managing critically ill patients. Existing estimation methods either require invasive procedures or assume constant vascular resistances, limiting their applicability in clinical settings. We propose a novel method to estimate MSFP using cardiac power (CP), this method was developed in a cohort of 50 patients, validated in a different cohort of 50 patients, and tested in a historical cohort of 21 patients, showing a high correlation (r = 0.95 - 0.90) and agreement with Parkin analog Mean Systemic Filling Pressure (MSFPa) method. In brief MSFPe = (3.3*CP) + 2.2 + CVP. Our method provides an accurate, non-invasive bedside approach for estimating MSFP, facilitating hemodynamic assessment in critically ill patients and opening new research avenues on vascular resistance dynamics.</p>","PeriodicalId":15513,"journal":{"name":"Journal of Clinical Monitoring and Computing","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Assessment of intraoperative high frequency variability index as a predictor of postoperative pain after open liver or pancreatic surgery under combined general and epidural anesthesia: a prospective observational study.","authors":"Keisuke Yoshida, Takahiro Hakozaki, Takayuki Hasegawa, Tatsumi Yakushiji, Yukihiro Fukuhara, Shinju Obara, Satoki Inoue","doi":"10.1007/s10877-025-01332-9","DOIUrl":"https://doi.org/10.1007/s10877-025-01332-9","url":null,"abstract":"<p><p>The aim of the present study was to investigate the utility of the intraoperative high frequency variability index (HFVI) / Analgesia Nociception Index (ANI) for predicting postoperative pain in patients undergoing open liver or pancreatic surgery under combined general and epidural anesthesia, with a particular focus on HFVI/ANI measured immediately before extubation. We investigated whether maximum postoperative pain at rest and postoperative morphine consumption were associated with intraoperative HFVI/ANI values, including those measured immediately before extubation, the mean intraoperative values, the difference between values immediately before and 5 min after the first administration of local anesthetics via epidural catheter, and the difference between values immediately before and 5 min after the start of surgery. We analyzed the data obtained from 52 patients and found that HFVI/ANI measured immediately before extubation showed a limited but statistically significant association with postoperative pain at rest. However, receiver operating characteristic curve analysis failed to demonstrate clinically useful predictive performance of HFVI/ANI for postoperative pain defined as Numerical Rating Scale > 3 or > 7. In addition, no association was observed between intraoperative HFVI/ANI measured at any time point and postoperative morphine consumption. The present study demonstrated that intraoperative HFVI/ANI may reflect postoperative pain levels to a limited extent, particularly when measured immediately before extubation, but lacks sufficient accuracy to be used as a standalone predictor of postoperative pain.</p>","PeriodicalId":15513,"journal":{"name":"Journal of Clinical Monitoring and Computing","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sebastian Zinn, Nia Joseph, Travis Stanley CreveCoeur, Roman M Sniecinski, Paul S García
{"title":"Evaluating the efficacy of intraoperative NIRS cutoff values in detecting spinal cord ischemia during surgery.","authors":"Sebastian Zinn, Nia Joseph, Travis Stanley CreveCoeur, Roman M Sniecinski, Paul S García","doi":"10.1007/s10877-025-01331-w","DOIUrl":"https://doi.org/10.1007/s10877-025-01331-w","url":null,"abstract":"<p><strong>Purpose: </strong>Paralysis is a serious complication of surgeries that interferes with the blood supply of the anterior spinal cord, with rates of spinal cord injury (SCI) from approximately 1% in general spine surgeries to 4-40% following thoracoabdominal aortic aneurysm (TAAA) repair. Near-infrared spectroscopy (NIRS) provides a non-invasive, real-time method for monitoring tissue oxygenation, largely unaffected by anesthetics. Given the heightened risk of neurologic injury during TAAA repair, this procedure is used to evaluate the effectiveness of standard regional spinal oxygen saturation (rSpO₂) cutoff values in predicting neurological outcomes.</p><p><strong>Methods: </strong>This retrospective study analyzed 25 patients undergoing open TAAA repair. NIRS data were recorded at the ischemic site and a reference location throughout surgery. Neurological outcomes were assessed postoperatively based on paralysis, hemiparesis, or extremity weakness. After excluding eight patients due to poor signal quality, 17 patients were included. NIRS values at six key time points were compared between outcome groups. Bayesian statistics assessed the relationship between significant NIRS \"drops\" (< 80% of baseline) and neurological outcomes.</p><p><strong>Results: </strong>Seven patients exhibited new neurological deficits (4 temporary). No credible association was found between intraoperative NIRS drops and postoperative neurological outcomes at any analyzed time point. A moderate effect was observed at the end of surgery (Hedges' g = - 1.21), suggesting a potential difference between groups, although the Bayesian credible interval included zero (posterior mean = - 0.82, 94% HDI [- 1.8, 0.18]).</p><p><strong>Conclusions: </strong>In this limited cohort, intraoperative NIRS cutoff values did not significantly correlate with postoperative neurological deficits following TAAA repair. Postoperative NIRS monitoring may be more informative for detecting spinal cord ischemia and preventing paralysis.</p>","PeriodicalId":15513,"journal":{"name":"Journal of Clinical Monitoring and Computing","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Change in pulse wave transit time measured using ear plethysmography is a useful substitute for finger plethysmography.","authors":"Ryota Nakano, Midoriko Higashi, Kazuhiro Shirozu, Shoko Ozasa, Makoto Sumie, Tetsuhiro Fujiyoshi, Ken Yamaura","doi":"10.1007/s10877-025-01327-6","DOIUrl":"https://doi.org/10.1007/s10877-025-01327-6","url":null,"abstract":"<p><strong>Purpose: </strong>Plethysmography using the finger is affected by various clinical conditions, including sympathetic tone. This study aimed to evaluate whether pulse wave transit time (PWTT) calculated using ear plethysmography could be used as a substitute for finger PWTT.</p><p><strong>Methods: </strong>In this prospective observational study, 50 patients underwent elective hepatectomy between December 2021 and April 2022. PWTT was simultaneously measured using finger and ear plethysmography. The primary outcome was the global agreement of all PWTT measurements. The secondary outcome was trending ability during hemodynamic changes.</p><p><strong>Results: </strong>In total, 311 paired readings from 50 patients were collected. PWTT-ear was shorter than PWTT (68.1 ± 15.1 ms). For the percent change in PWTT from baseline (%ΔPWTT), linear regression analyses showed a strong correlation between %ΔPWTT-ear and %ΔPWTT (r = 0.85, P < 0.001). In Bland-Altman analyses, the bias between %ΔPWTT-ear and %ΔPWTT was - 0.04% and limits of agreement from - 0.17 to 0.17%, with a percentage error (2 standard deviation/mean %ΔPWTT) of 4.2%. The conductance rate of the two methods was 95.9% based on a four-quadrant plot analysis. The angular conductance rate was 98.9% with a radial limit of ± 25.3 based on a polar plot analysis.</p><p><strong>Conclusion: </strong>PWTT-ear was shorter than PWTT, but the % change in PWTT-ear was similar to that in PWTT. PWTT measured using ear plethysmography can be used as a substitute for measuring changes in PWTT.</p><p><strong>Trial registration: </strong>This study was registered in the UMIN-CTR Clinical Database (ID: UMIN000045950), https://center6.umin.ac.jp/cgi-open-bin/icdr_e/ctr_view.cgi?recptno=R000052326 on December 08, 2021.</p>","PeriodicalId":15513,"journal":{"name":"Journal of Clinical Monitoring and Computing","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jinyang Yu, Tomas Dybos Tannvik, Anders Austlid Taskén, Erik Andreas Rye Berg, Katrine Hordnes Slagsvold, Idar Kirkeby-Garstad, Eirik Skogvoll, Gabriel Kiss, Bjørnar Grenne, Svend Aakhus
{"title":"Monitoring systemic ventriculoarterial coupling after cardiac surgery using continuous transoesophageal echocardiography and deep learning.","authors":"Jinyang Yu, Tomas Dybos Tannvik, Anders Austlid Taskén, Erik Andreas Rye Berg, Katrine Hordnes Slagsvold, Idar Kirkeby-Garstad, Eirik Skogvoll, Gabriel Kiss, Bjørnar Grenne, Svend Aakhus","doi":"10.1007/s10877-025-01328-5","DOIUrl":"https://doi.org/10.1007/s10877-025-01328-5","url":null,"abstract":"<p><p>Deterioration of ventriculoarterial coupling is detrimental to cardiovascular and left ventricular function. To enable continuous monitoring of left ventricular function, we have developed autoMAPSE, a new tool that combines transoesophageal echocardiography with deep learning for automatic measurement of mitral annular plane systolic excursion. We hypothesised that autoMAPSE could be used to monitor systemic ventriculoarterial coupling and detect alterations in postoperative cardiac biomarkers. To test this hypothesis, we monitored 50 patients for 120 min immediately after cardiac surgery by measuring autoMAPSE and mean arterial pressure (MAP) every 5 min. Postoperative N-terminal pro B-type natriuretic peptide (ProBNP) and high-sensitivity troponin-T (TnT) were measured twice daily until the evening of postoperative day 1. Ventriculoarterial coupling was assessed non-invasively by calculating arterial elastance and end-systolic elastance (Ea/Ees-ratio). The relationship between autoMAPSE and ventriculoarterial coupling was assessed by 1) correlating Ea/Ees-ratio with one simultaneous autoMAPSE measurement, and 2) relating the measurements of autoMAPSE with corresponding MAP within each patient using a linear mixed model with random slopes. We found that autoMAPSE correlated negatively with Ea/Ees-ratio (rho = - 0.61, P < 0.05). Furthermore, the individual slopes relating autoMAPSE to MAP were highly significant (P < 0.001) and markedly heterogeneous (both positive and negative), suggesting that ventriculoarterial coupling differs substantially in different individual patients. Finally, continuous autoMAPSE measurements were negatively correlated with both peak postoperative ProBNP (rho = - 0.46, P < 0.001) and TnT (rho = - 0.29, P < 0.05). In conclusion, continuous monitoring using autoMAPSE in the first two postoperative hours reflected ventriculoarterial coupling as well as peak ProBNP and TnT during the subsequent 24 h.</p>","PeriodicalId":15513,"journal":{"name":"Journal of Clinical Monitoring and Computing","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Julian Runge, Carla D Grundmann, Carolina Mucha, Robin Denz, Karim Kouz, Manuel Ignacio Monge García, Elisabetta Cerutti, Luciano Frassanito, Michael Sander, Simon J Davies, Abele Donati, Javier Ripolles-Melchor, Daniel García-Lopez, Benjamin Vojnar, Etienne Gayat, Eric Nol, Tim van den Boom, Peter Bramlage, Bernd Saugel, Thomas W L Scheeren, Ulrich H Frey
{"title":"Association of intraoperative hypotension and acute kidney injury in noncardiac surgery patients: a post hoc secondary analysis of the EU HYPROTECT registry.","authors":"Julian Runge, Carla D Grundmann, Carolina Mucha, Robin Denz, Karim Kouz, Manuel Ignacio Monge García, Elisabetta Cerutti, Luciano Frassanito, Michael Sander, Simon J Davies, Abele Donati, Javier Ripolles-Melchor, Daniel García-Lopez, Benjamin Vojnar, Etienne Gayat, Eric Nol, Tim van den Boom, Peter Bramlage, Bernd Saugel, Thomas W L Scheeren, Ulrich H Frey","doi":"10.1007/s10877-025-01329-4","DOIUrl":"https://doi.org/10.1007/s10877-025-01329-4","url":null,"abstract":"<p><strong>Purpose: </strong>Previous cohort studies suggest that intraoperative hypotension is associated with acute kidney injury (AKI) in noncardiac surgical patients. We sought to ascertain that intraoperative hypotension is independently associated with AKI within the first 3 days after surgery in a contemporary cohort of noncardiac surgery patients in whom clinicians strove to avoid profound intraoperative hypotension.</p><p><strong>Methods: </strong>This was a post hoc secondary analysis of the multicentre EU HYPROTECT registry, which includes patients undergoing major noncardiac surgery who underwent predictive blood pressure monitoring. The primary outcome of this secondary analysis was AKI within the first 3 days after surgery. To quantify the duration and severity of intraoperative hypotension we calculated the area under a mean arterial pressure (MAP) of 65 mmHg. We used logistic regression analysis to identify factors independently associated with AKI.</p><p><strong>Results: </strong>We analysed 697 patients. 62 of these 697 patients (9%) developed AKI within the first 3 days after surgery. In multivariable binary logistic regression analysis adjusted for confounding variables, the area under a MAP of 65 mmHg was independently associated with AKI within the first 3 days after surgery (OR 1.03 [95% CI 1.01-1.05] per 10 mmHg*min; P < 0.001).</p><p><strong>Conclusion: </strong>Our secondary analysis of the EU HYPROTECT registry shows that, in a contemporary population of noncardiac surgery patients in whom clinicians strove to avoid profound intraoperative hypotension, intraoperative hypotension is independently associated with AKI within the first 3 days after surgery.</p>","PeriodicalId":15513,"journal":{"name":"Journal of Clinical Monitoring and Computing","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Intraoperative analgesia management by monitoring the analgesia nociception index in gynecological surgeries involving erector spinae plane block: a randomized controlled study.","authors":"Zeynep Koç, Çağdaş Baytar, Keziban Bollucuoğlu, Bengü Gülhan Köksal, Rahşan Dilek Okyay, Özcan Pişkin, Hilal Ayoğlu","doi":"10.1007/s10877-025-01330-x","DOIUrl":"https://doi.org/10.1007/s10877-025-01330-x","url":null,"abstract":"<p><p>To determine the effect of monitoring the Analgesia Nociception Index (ANI) on intraoperative opioid use, postoperative recovery, and analgesia in patients receiving preoperative bilateral erector spinae plane block (ESPB) for gynecological surgery under general anesthesia. Eighty patients classified in the American Society of Anesthesiologists physical status I-III scheduled for hysterectomy under general anesthesia were included in the study. After ultrasound-guided ESPB, patients were divided into 2 groups: control and ANI. In the control group, the intraoperative remifentanil infusion dose was adjusted using conventional methods; in the ANI group, the dose was adjusted according to ANI values of 50-70. Intraoperative remifentanil consumption, postoperative pain scores, additional analgesic requirements, and complications were recorded. Intraoperative remifentanil consumption was lower in the ANI group than in the control group (p < 0.001). Numerical rating scale (NRS) scores and requirements for additional analgesics in the postoperative recovery unit were both lower in the ANI group (p < 0.05). There were no significant differences between the groups in terms of nausea or vomiting in the recovery unit. ANI monitoring in patients undergoing gynecological surgery under general anesthesia with ESPB reduced opioid consumption during the intraoperative period. Intraoperative ANI monitoring enabled individualized opioid administration and guided determination of the required dose of analgesic agent.</p>","PeriodicalId":15513,"journal":{"name":"Journal of Clinical Monitoring and Computing","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elaine Cavalcante Dos Santos, Zoé Demailly, Jan Bakker, Fabio Silvio Taccone
{"title":"Evaluating local ischemic preconditioning effects on skin perfusion using capillary refill time in healthy volunteers.","authors":"Elaine Cavalcante Dos Santos, Zoé Demailly, Jan Bakker, Fabio Silvio Taccone","doi":"10.1007/s10877-025-01324-9","DOIUrl":"https://doi.org/10.1007/s10877-025-01324-9","url":null,"abstract":"<p><p>Capillary refill time (CRT) is a vaso-occlusive test that allows the non-invasive assessment of skin perfusion. A vascular occlusive test (VOT) induces transient ischemia similar to that used in preconditioning ischemia. We hypothesized that CRT could be influenced by local tissue compression mimicking ischemic preconditioning when repeated measurements are performed. In healthy volunteers (n = 30), CRTs were performed twice on the index and middle fingers of the dominant hand and the index finger of the non-dominant hand at 15-minute intervals on the first day. On the second day, two CRT measurements were taken at 30-minute intervals. No significant differences were observed in CRT measurements repeated at 15- and 30-minute intervals. Additionally, baseline CRT values did not significantly differ between the fingers of the dominant and non-dominant hands on either study day. Repeated CRT measurements are not influenced by local ischemic preconditioning in the finger over short intervals.</p>","PeriodicalId":15513,"journal":{"name":"Journal of Clinical Monitoring and Computing","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144618134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shavin S Thomas, Katharyn L Flickinger, Jonathan Elmer, Clifton W Callaway
{"title":"Correction: Evaluation of non-invasive sensors for monitoring core temperature.","authors":"Shavin S Thomas, Katharyn L Flickinger, Jonathan Elmer, Clifton W Callaway","doi":"10.1007/s10877-025-01325-8","DOIUrl":"10.1007/s10877-025-01325-8","url":null,"abstract":"","PeriodicalId":15513,"journal":{"name":"Journal of Clinical Monitoring and Computing","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144608542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}