Journal of Clinical and Experimental Cardiology最新文献

{"title":"Pharmacological Cardioversion by Intravenous Amiodarone for Primary Treatment of a Neonatal Atrial Flutter","authors":"Yun Ju Lim","doi":"10.4172/2155-9880.1000597","DOIUrl":"https://doi.org/10.4172/2155-9880.1000597","url":null,"abstract":"Atrial flutter is an uncommon arrhythmia in newborn patients, but it can be fatal in intractable cases, which require emergent therapy with multiple antiarrhythmic therapies and an electrical cardioversion. Amiodarone is an antiarrhythmic drug commonly used to treat tachyarrhythmias of supraventricular tachycardia and atrial tachyarrhythmia in adults. The efficacy of amiodarone therapy for neonatal tachyarrhythmia including atrial flutter is currently unknown, but its estimated effectiveness is low with small experiences in neonates. We present a case of successful pharmacologic cardioversion, using intravenous amiodarone, of atrial flutter and did not require electrical cardioversion in a newborn. We suggest that intravenous amiodarone administration can be used to treat neonatal atrial flutter as effective pharmacological therapy in patient with hemodynamic stability.","PeriodicalId":15504,"journal":{"name":"Journal of Clinical and Experimental Cardiology","volume":"58 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85167863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health for all through wisdom - gain the optimal health while reversing the pandemic of noncommunicable diseases, particularly the cardiovascular illnesses","authors":"pSuresh Vatsyayannp","doi":"10.4172/2155-9880-C12-122","DOIUrl":"https://doi.org/10.4172/2155-9880-C12-122","url":null,"abstract":"","PeriodicalId":15504,"journal":{"name":"Journal of Clinical and Experimental Cardiology","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75395822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Dispute of Statins and Cholesterol: Can Statins Save Your Life by Abating the Risk of Heart Disease?","authors":"M. Uddin, Muniruddin Ahmed","doi":"10.4172/2155-9880.1000E153","DOIUrl":"https://doi.org/10.4172/2155-9880.1000E153","url":null,"abstract":"Md. Sahab Uddin1* and Muniruddin Ahmed2 1Department of Pharmacy, Southeast University, Dhaka, Bangladesh 2Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh *Corresponding author: Md. Sahab Uddin, Department of Pharmacy, Southeast University, Dhaka, Bangladesh, Tel: +88","PeriodicalId":15504,"journal":{"name":"Journal of Clinical and Experimental Cardiology","volume":"23 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83954428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis of Device-Related Infective Endocarditis with 99mTechnetium Mononuclear Leukocytes SPECT/CT","authors":"G. Oliveira, B. Gutfilen, F. Verocai, J. Mansur, A. Siciliano, M. Alcantara, L. Fonseca, M. C. P. Landesmann, S. Souza","doi":"10.4172/2155-9880.100060413","DOIUrl":"https://doi.org/10.4172/2155-9880.100060413","url":null,"abstract":"","PeriodicalId":15504,"journal":{"name":"Journal of Clinical and Experimental Cardiology","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78417911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endovascular Treatment of a Gunshot Injury of the Subclavian Artery","authors":"Jarosław Miszczuk, A. Barczak, Rafał Rylski, M. Miszczuk","doi":"10.4172/2155-9880.1000582","DOIUrl":"https://doi.org/10.4172/2155-9880.1000582","url":null,"abstract":"Objectives: We present a case of a patient with a right subclavian artery injury due to a gunshot, treated by endovascular approach in our clinic in Kielce, Poland. Case report: A 35-year-old male, presented with a penetrating injury of the right supraclavicular region due to a shotgun slug. The patient was hemodynamically unstable. Both chest radiograph and CTA (Computed Tomography Angiography) imaging presented an injury of the right subclavian artery, multisegmental rib fractures of ribs I-III and a hemo-pneumothorax. Endovascular repair of the subclavian artery was performed, followed by insertion of a Redon wound drain and right-sided pleural drain. The patient was then transported to the thoracic surgery unit, where further therapy, including a removal of the bullet from the thoracic wall, was performed. Upon a 4 months follow-up visit, the patient was in a good condition and a CTA scan performed at this time confirmed the patency of the right subclavian artery. Conclusions: Endovascular repair presents a viable alternative option for treating subclavian artery injuries, even in hemodynamically unstable patients.","PeriodicalId":15504,"journal":{"name":"Journal of Clinical and Experimental Cardiology","volume":"85 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84849567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between Mesenteric Fat Thickness and Characteristics of Coronary Artery Disease in Patients with Metabolic Syndrome","authors":"W. Wagdy, M. Mohamad, Wael Refat Abd El Hamed, Ahmed K. Motaweih, Mohamad Salem El Baz","doi":"10.4172/2155-9880.1000566","DOIUrl":"https://doi.org/10.4172/2155-9880.1000566","url":null,"abstract":"Background and aim: Metabolic syndrome (MetS) includes an assembly of conditions; the most important of which is obesity. The pandemic prevalence of obesity worldwide increased the awareness of MetS. Mesenteric fat thickness is linked to higher risk of coronary artery disease (CAD) complications which may lead to death. Although many studies were done on patients with MetS worldwide, studies on Egyptian patients are limited. Thus, here we examined the relationship between mesenteric fat thickness and the severity and prevalence of CAD among Egyptian patients with MetS. Methods: Sixty-four patients with MetS were recruited in this prospective cohort study. We assessed the mesenteric fat, and carotid intima media thickness using ultrasonography. Moreover, we evaluated the coronary arteries using myocardial perfusion imaging, MSCT, and/or coronary angiography. Results: Twenty-three patients had a mesenteric fat thickness less than 10 mm, while 41 patients had a mesenteric fat thickness equal to 10 mm or more. Severity and prevalence of CAD were significantly higher in patients with a mesenteric fat thickness of 10 mm or more (P<0.001, and 0.007). Moreover, there was a significant positive correlation between carotid intima media thickness and a number of diseased vessels in patients with CAD. Conclusion: Our results suggest that mesenteric fat thickness and carotid intima media thickness are good indicators of the prevalence and severity of CAD in patients with MetS. More studies on a large number of the population are required to define MetS in Egyptian patients with MetS, especially in those with a higher risk of CAD.","PeriodicalId":15504,"journal":{"name":"Journal of Clinical and Experimental Cardiology","volume":"22 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82957842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of Combined Ischemic Pre- and Post-Conditioning to Protect the Human Myocardium","authors":"Kelly Casós, Paula Soler-Ferrer, María L Pérez, Juan M Gracia-Baena, M. A. Castro, C. Sureda, M. Galiñanes","doi":"10.4172/2155-9880.1000611","DOIUrl":"https://doi.org/10.4172/2155-9880.1000611","url":null,"abstract":"Objective: Ischemic pre-conditioning (IPreC) and post-conditioning (IPostC) protect the human myocardium against ischemia/reoxygenation (I/R) injury. However, the two interventions may induce variable degrees of protection, suggesting different mechanisms of action. This study assessed whether IPreC and IPostC confer greater protection when used in combination rather than individually. Methods: The right atrial appendages from 50 patients were subjected to 90 min of ischemia and 120 min of reoxygenation according to different protocols: IPostC (1 cycle of 120 and 180 sec of I/R) and IPreC (1 cycle of 5 min ischemia/5 min reoxygenation), alone and in combination. Lactate dehydrogenase (LDH) release was measured as an index of tissue injury and 3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) reduction as an index of cell viability. Results: The results showed that in one half of muscles the combined use of IPreC and IPostC reduced injury compared to either intervention alone whereas in the remaining half the combined approach had no greater effect. Nonetheless, the addition of IPreC to IPostC increased the number of protected samples by almost 20% compared to IPostC alone. Conclusion: The results demonstrate the lack of a uniform response to IPreC and IPostC and that the combined use of the two treatments improves protection although does not abolish the further myocardial injury that occurs in some instances in response to IPostC.","PeriodicalId":15504,"journal":{"name":"Journal of Clinical and Experimental Cardiology","volume":"11 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89723557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics, Treatment and In-hospital Outcomes of Unselected Patients with Non-ST-Elevation Myocardial Infarction in Daily Clinical Practice at An Interventional Centre over a Period of Ten Years: Results from the MIRLU-Registry","authors":"S. Liosis, S. Schneider, N. Werner, ra Tielke, A. Gitt, B. Mark, R. Winkler, C. Kilkowski, T. Kleemann, U. Zeymer, T. Bauer, R. Schiele, R. Zahn","doi":"10.4172/2155-9880.1000614","DOIUrl":"https://doi.org/10.4172/2155-9880.1000614","url":null,"abstract":"Background: Since the definition of Non-ST-Elevation Myocardial Infarction (NSTEMI) in 2000, its in-hospital management is rapidly developing. There is only a few available data, though, to describe the long-term changes in clinical characteristics, treatment patterns and outcomes in “real world” unselected patients and provide a feedback regarding guideline implementation. Methods and results: We conducted a retrospective data collection of all consecutive patients admitted to our clinic with an acute myocardial infarction (AMI) between 2000 and 2009 (Myocardial Infarction Registry Ludwigshafen- MIRLU). From the overall 6119 patients included, 2976 were diagnosed with NSTEMI (48.6%). The median age was 67.9 ± 11.9 years and 68.5% were men. 93.4% underwent coronary angiography, 60.6% of them received percutaneous coronary intervention (PCI) and 4.8% immediate emergency bypass surgery. The rate of guideline adherent medical therapy was high at admission and at discharge. The most common in-hospital complications were post-infarction angina (4.4%), congestive heart failure (4.0%), cardiogenic shock (2.8%) and blood loss requiring transfusion (2.8%). Average in-hospital mortality was 4.2%. Over the period of ten years we observed an increase of 4.4 years in mean age (p for trend <0.01) and no changes in gender proportion (p=0.25). The rates of coronary angiography, PCI and stent implantation increased, while emergency bypass surgery rate declined (p<0.01). The complications’ rate remained unchanged (p=0.13). In-hospital mortality showed no significant variation (p=0.71). In a multivariate analysis cardiogenic shock, moderately and severely impaired left ventricular function and increasing age were independent mortality predictors. Conclusion: The observation of NSTEMI patients over 10 years showed an increase in mean age, rates of coronary angiography and PCI with stent implantation, while emergency bypass surgery declined. Administration rate of guideline adherent medical therapy was high. However, overall mortality remained unchanged. Cardiogenic shock, significantly reduced left ventricular function and increasing age were the strongest predictors of in-hospital mortality.","PeriodicalId":15504,"journal":{"name":"Journal of Clinical and Experimental Cardiology","volume":"142 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77383238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term Heart Function Change of Catheter Ablation in Persistent Atrial Fibrillation and Heart Failure: A Meta-analysis of Randomized Controlled Trials","authors":"Q. Xiong, Jiaolin Shangguan, G. He, Zhiyu Ling, S. Nazarian, Y. Yin","doi":"10.4172/2155-9880.1000618","DOIUrl":"https://doi.org/10.4172/2155-9880.1000618","url":null,"abstract":"Background: The effect of catheter ablation (CA) versus drug therapy on cardiac function improvement is not clear for patients with persistent atrial fibrillation and heart failure. To compare the short-term therapeutic effects between CA and conventional drug therapy, we conducted a meta-analysis of the current randomized controlled trials (RCTs). Objective and method: The analyses systematically collected PubMed, Embase, and the Cochrane Library for RCTs comparing catheter ablation with medical therapy in patients with persistent atrial fibrillation and heart failure. In order to reduce the impact of other factors on cardiac function, we limited the maximum follow-up time to two years. The primary outcome is changes in left ventricular ejection fraction (LEVF), second outcomes are changes in 6-minute walk test (6MWT), Minnesota Living with Heart Failure Score (MLHFQ), B-type natriuretic peptide (BNP). SMD was used for the results measured by different methods. Random-effects model or fixed-effects model was used to estimate relative risks (RRs) with 95% confidence intervals (CIs). Results: A total of six randomized controlled trials included 775 patients included in the final analysis, compared with drug therapy, catheter ablation has a better improvement in left ventricular ejection fraction (SMD, 0.57; 95% CI [0.40, 0.94], p<0.00001), 6-minute walk distance(MD 23.35, 95% CI [5.51, 41.19], p<0.00001), Minnesota Living with Heart Failure Score (MD -11.13, 95% CI [-2.52, -19.75], p=0.01), and B-type natriuretic peptide (110.93, 95% CI [82.84, 139.3], p<0.00001). Conclusion: Catheter ablation has a better improvement than medical treatment in heart function for patients with persistent atrial fibrillation and heart failure.","PeriodicalId":15504,"journal":{"name":"Journal of Clinical and Experimental Cardiology","volume":"29 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87667475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carotid Duplex Study in Correlation with High Sensitivity C-Reactive Protein and Lipid Profile in Children with Type-1 Diabetes Mellitus","authors":"Ashraf Mohamed Abdelfadil, M. Mourad, L. Ali","doi":"10.4172/2155-9880.1000602","DOIUrl":"https://doi.org/10.4172/2155-9880.1000602","url":null,"abstract":"Background: Chronic diabetic hyperglycemia is well known to be associated with long-term damage of various organs, including heart and blood vessels. Even if manifestation is seen in the adult diabetic patient, the process of vascular changes starts much earlier in childhood. Carotid Intima-Media Thickness (CIMT), a pre-atherosclerosis marker, and its relation to different risk factors in Diabetic children is not fully investigated. Aim of the work: To evaluate serum hs-CRP levels in type-I diabetic T1DM children and its relation with CIMT. Methods: This study included group I: 60 T1DM children and group II: 40 apparently healthy age, sex and BMI matched control. Both were subjected to; full history taking, thorough clinical examination (BP, anthropometry, lab studies, including oral glucose tolerance test, Lipid Profile (serum cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol, and triglyceride), high sensitive CRP (HS-CRP) and 24 h microalbuminuria). Carotid duplex study B-mode and color-coded duplex sonography of extra cranial carotid. Results: The CIMT of both RCCA and LCCA in diabetic children was significantly increased. CIMT positively correlated with age, duration of diabetes, BMI, DBP, LDL, TG, HbA1c, as well as daily insulin dose and negatively with HDL. On the other hand, there were insignificant correlations with other risk factors. Conclusion: Regular monitoring of the high-risk children may help to identify the development and progression of atherosclerotic changes and cardiovascular disease.","PeriodicalId":15504,"journal":{"name":"Journal of Clinical and Experimental Cardiology","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77799516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}