Journal of Clinical and Experimental Cardiology最新文献_第6页

Septic Pulmonary Embolism: A Rare and Cataclysmic Complication of Infective Endocarditis 感染性心内膜炎的一种罕见且灾难性的并发症:脓毒性肺栓塞

Journal of Clinical and Experimental Cardiology Pub Date : 2018-01-01 DOI: 10.4172/2155-9880.1000596

E. Yap, L. Cuenza

{"title":"Septic Pulmonary Embolism: A Rare and Cataclysmic Complication of Infective Endocarditis","authors":"E. Yap, L. Cuenza","doi":"10.4172/2155-9880.1000596","DOIUrl":"https://doi.org/10.4172/2155-9880.1000596","url":null,"abstract":"Background: Septic pulmonary embolism (SPE) is an uncommonly reported complication of IE requiring a high index of suspicion. Case: We report a 21-year-old male, former methamphetamine user, complaining of intermittent fever, cough and dyspnea for 6 months. He had a Graham-Steell murmur, grade 3/6 pansystolic murmur at the left lower sternal border, bipedal edema and petechiae on the trunk and extremities. Ceftriaxone and Gentamicin were given empirically for possible infective endocarditis. 2D echocardiography revealed heavy echogenic densities attached to the pulmonic valve cusps (2.0 × 0.79 cm), fluttering echogenic densities at the tricuspid valve leaflet tips and spontaneous echo contrast. Anticoagulation with Enoxaparin was started. Streptococcus agalactiae grew on blood culture (3 sites). On the 10th hospital day, he had an episode of hemoptysis (~600 ml) requiring endotracheal intubation. CT angiogram of the pulmonary arteries revealed several filling defects adherent to the pulmonary valve (endocarditic lesion), pulmonary embolism/septic emboli involving the left lateral wall of the main pulmonary artery, anterior segmental arteries of both upper lobes, and bilateral lower lung pulmonary arteries. Multiple small nodules, some exhibiting cavitation and the feeding vessel sign, were seen in both mid to lower lungs. Antibiotics were continued. Repeat blood cultures after 2 weeks no longer showed any growth. He was successfully extubated. Valve surgery was advised but no consent was given. Medical management was maximized. He was discharged improved after 2 months. Conclusion: Patients with RSIE are at risk to develop SPE which is an uncommon and potentially fatal complication of IE which may go unrecognized without a high index of suspicion. Early recognition is therefore important.","PeriodicalId":15504,"journal":{"name":"Journal of Clinical and Experimental Cardiology","volume":"50 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85139759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Propofol Prevents Thrombosis in a Rat Common Carotid Artery Thrombosis Model 异丙酚对大鼠颈总动脉血栓形成模型的预防作用

Journal of Clinical and Experimental Cardiology Pub Date : 2018-01-01 DOI: 10.4172/2155-9880.1000576

Yongshan Nan, Haiying Jiang, X. Jin, Xiang Li, Chunzi Jin, X. Cheng

{"title":"Propofol Prevents Thrombosis in a Rat Common Carotid Artery Thrombosis Model","authors":"Yongshan Nan, Haiying Jiang, X. Jin, Xiang Li, Chunzi Jin, X. Cheng","doi":"10.4172/2155-9880.1000576","DOIUrl":"https://doi.org/10.4172/2155-9880.1000576","url":null,"abstract":"Aim: The aim of this study was investigated the beneficial effect of propofol on thrombosis in a rat carotid artery thrombosis model. Methods and results: Sprague-Dawley rats underwent iron chloride3 (FeCl3)-induced carotid artery thrombosis model surgery were treated with vehicle (M group), low- (PL group), middle- (PM group) or high-dose propofol (PH group). Rats were received sham operation served as control (C group). As compared with the M group, propofol treatment significantly inhibited thrombus weights and improved the degree of embolization. Propofol also markedly improved blood CD62P intensity. Moreover, as compared with C group rats, the levels of plasma TXA2, PGI2, t-PA, t-PA/PAI-1 ratio, and P-selectin were harmful altered in M group rats in response to FeCl3 induction; these effects were improved in the PL and/or PM and PH groups. Conclusions: These findings suggested that the beneficial anti-thrombotic effect of propofol is likely attributable, at least in part, to attenuation of the endothelia injury, platelet activation and fibrinolytic inactivation induced by FeCl3 in a rat carotid artery thrombosis model.","PeriodicalId":15504,"journal":{"name":"Journal of Clinical and Experimental Cardiology","volume":"421 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82729515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiovascular Disease Risk Assessment of Senior Staff Members of a Nigerian University 尼日利亚某大学高级工作人员心血管疾病风险评估

Journal of Clinical and Experimental Cardiology Pub Date : 2018-01-01 DOI: 10.4172/2155-9880.1000588

R. Adedoyin, T. Awotidebe, Gladys Annuolowapo Dada, R. N. Ativie, M. Balogun, R. Adebayo, O. Akinola, A. A. Olawoye

{"title":"Cardiovascular Disease Risk Assessment of Senior Staff Members of a Nigerian University","authors":"R. Adedoyin, T. Awotidebe, Gladys Annuolowapo Dada, R. N. Ativie, M. Balogun, R. Adebayo, O. Akinola, A. A. Olawoye","doi":"10.4172/2155-9880.1000588","DOIUrl":"https://doi.org/10.4172/2155-9880.1000588","url":null,"abstract":"Purpose: Cardiovascular disease (CVD) risk assessment is not a routine screening practice in many establishments despite the reported increasing prevalence of CVD globally. This study assessed the level of CVD risk among senior staff members of a Nigerian university.Methods: This cross-sectional study involved 221 academic and non-academic staff members of the Obafemi Awolowo University, Ile–Ife, Nigeria. Purposive sampling technique was used to recruit the participants. CVD risk was assessed using the Framingham Heart study questionnaire. Risk factors recorded were age, sex, personality type, sedentary lifestyle, smoking, weight and blood pressure. Risk scores were classified as low (0-19), moderate (20-29) and high (40+). Data were analyzed using descriptive and inferential statistics. Alpha level was set at p 0.05). Participants in high risk category were almost twice more likely to develop CVD compared to those at low risk (OR=1.933, CI=0.457-8.184). Similarly, males and females in high risk category were almost twice at risk of developing CVD compared to those at moderate risk (OR=1.882, CI=0.434-8.167). Furthermore, they were twice more likely to develop CVD compared to those in low risk category (OR=2.056, CI=0.495-8.533).Conclusion: Cardiovascular disease risk of participants in this study appears to be low and CVD risk was not associated with occupation type. Strategic plan to prevent or delay CVD is recommended.","PeriodicalId":15504,"journal":{"name":"Journal of Clinical and Experimental Cardiology","volume":"146 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86097890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Analysis of Bleeding Complications in Acute Coronary Syndrome: Comparison of Effect of Tirofiban in Diabetic and Non-Diabetic Patients 急性冠脉综合征出血并发症分析:替罗非班对糖尿病和非糖尿病患者的疗效比较

Journal of Clinical and Experimental Cardiology Pub Date : 2018-01-01 DOI: 10.4172/2155-9880.1000598

Samir M Rafla, A. Zaki, M. Loutfi, E. El-sharkawy, Hala labib Frishah

{"title":"Analysis of Bleeding Complications in Acute Coronary Syndrome: Comparison of Effect of Tirofiban in Diabetic and Non-Diabetic Patients","authors":"Samir M Rafla, A. Zaki, M. Loutfi, E. El-sharkawy, Hala labib Frishah","doi":"10.4172/2155-9880.1000598","DOIUrl":"https://doi.org/10.4172/2155-9880.1000598","url":null,"abstract":"Background: Coronary artery disease (CAD) is the most prevalent manifestation of cardiovascular diseases and is associated with high mortality and morbidity. The clinical presentations of CAD include silent ischemia, stable angina pectoris, unstable angina, myocardial infarction (MI), heart failure, and sudden death. Objective: This study was designed to define the frequency of hemorrhagic complications and to identify clinical variables associated with increased risk of bleeding complications in diabetic versus non-diabetic patients presented with acute coronary syndrome whom received aspirin, clopidogrel and heparin only or in combination with GPIIb/IIIa receptors blockade (Tirofiban) and to detect any bleeding complications in all patients during the period of admission in the hospital. Patients and Methods: 150 patients with ACS were divided into two groups, 82 diabetic patients and 68 nondiabetic patients. 40 patients out of total sample received tirofiban. Assessment of in hospital TIMI bleeding, GRACE and CRUSADE risk scores was estimated for all of them. Results: We observed that, there is no statistically significant difference in TIMI bleeding in both heparin and tirofiban group in diabetic versus non-diabetic patients. Cardiac catheterization access site was the most frequent location of bleeding most likely secondary to the high rate of coronary angiography performed in the study. Tirofiban added to heparin did not increase the risk of bleeding at the vascular access site.Conclusion: There was no statistically significant increase in all TIMI bleeding, thrombocytopenia or blood transfusions with the combination of tirofiban with heparin in both diabetic and non-diabetic patients.","PeriodicalId":15504,"journal":{"name":"Journal of Clinical and Experimental Cardiology","volume":"189 1","pages":"2-6"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83468280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RANK-L is a Potential Therapeutic Target in Homogeneous Atherosclerotic Plaques RANK-L是均匀动脉粥样硬化斑块的潜在治疗靶点

Journal of Clinical and Experimental Cardiology Pub Date : 2018-01-01 DOI: 10.4172/2155-9880.1000574

F. Galfo, C. Zito, G. Caridi, L. Longobardo, M. Massara, S. Carerj, M. Cusmà-piccione, D. Altavilla, F. Squadrito, A. Bitto

{"title":"RANK-L is a Potential Therapeutic Target in Homogeneous Atherosclerotic Plaques","authors":"F. Galfo, C. Zito, G. Caridi, L. Longobardo, M. Massara, S. Carerj, M. Cusmà-piccione, D. Altavilla, F. Squadrito, A. Bitto","doi":"10.4172/2155-9880.1000574","DOIUrl":"https://doi.org/10.4172/2155-9880.1000574","url":null,"abstract":"Objective and design: The late stages of carotid atherosclerosis are responsible for increased local stiffness, suggesting the need for a therapeutic target that affect either plaque composition and arterial stiffness. There is a lack of data on the role of the local arterial stiffness, assessed by radio-frequency based system and its relationship with the molecular profile of plaques. Subjects: In this study we enrolled 18 consecutive patients undergoing carotid endoarterectomy, with homogeneus or heterogeneous plaques, as established by Doppler-ultrasound and local pulse-wave velocity was assessed before surgery. Methods: In carotid plaque specimens, we evaluated inflammasome (NLRP3), Receptor Activator of Nuclear Factor κB (RANK) and its natural ligand (RANK-L), Osteoprotegerin (OPG), and other inflammatory and apoptotic molecules by Western Blotting and qPCR analysis. In addition, lipid peroxidation of arterial specimens was assessed by TBARS assay. Results: In heterogeneus plaques we observed increased OPG expression (p=0.04), positively correlated with lipid peroxidation values (r=0.511, p=0.03); increased levels of RANK (p=0.02), and other inflammatory and apoptotic molecules. RANK-L protein was augmented in homogeneus plaques (p=0.01) and correlated to s-index (r=0.514, p=0.03) and PWV (r=0.525, p=0.03) values. Conclusions: Our data provide evidence that increased local PWV and s-index might identify plaque evolution towards calcification.","PeriodicalId":15504,"journal":{"name":"Journal of Clinical and Experimental Cardiology","volume":"21 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81795731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictors of Ischaemia and Outcomes in Egyptian Patients with Diabetes Mellitus Referred for Perfusion Imaging 埃及糖尿病患者接受灌注成像的缺血和预后预测因素

Journal of Clinical and Experimental Cardiology Pub Date : 2018-01-01 DOI: 10.4172/2155-9880.1000591

Samir M Rafla, A. Abdel-Aaty, M. Sadaka, Aly Ahmed Abo Elhoda, A. Shams

引用次数: 0

Evaluation of Ceruloplasmin - A Potential Biomarker in Chronic Heart Failure 评价铜蓝蛋白-慢性心力衰竭的潜在生物标志物

Journal of Clinical and Experimental Cardiology Pub Date : 2018-01-01 DOI: 10.4172/2155-9880.1000601

T. Andreasová, D. Vondrakova, L. Sedláčková, J. Dvořák, L. Táborský, P. Neužil, F. Málek

引用次数: 4

Too Many Twos in One Patient: Two Central Venous Catheters, Two Routes, Two Hospitals, Two Lost Guidewires, Two Vascular Systems, One Patient 一个病人身上有太多的“二”:两个中心静脉导管，两条路径，两个医院，两个丢失的导丝，两个血管系统，一个病人

Journal of Clinical and Experimental Cardiology Pub Date : 2018-01-01 DOI: 10.4172/2155-9880.1000605

R. Chalwade

引用次数: 0

Real-World Data of Adaptive Servo-Ventilation Therapy for Patients with Heart Failure with Reduced Ejection Fraction: Three-Year Follow-Up Data Based on Comparison with Standard Medical Therapy 自适应伺服通气治疗心力衰竭伴射血分数降低患者的真实世界数据:基于与标准药物治疗比较的三年随访数据

Journal of Clinical and Experimental Cardiology Pub Date : 2018-01-01 DOI: 10.4172/2155-9880.1000586

Keita Goto, N. Takama, Y. Sano, M. Kurabayashi

{"title":"Real-World Data of Adaptive Servo-Ventilation Therapy for Patients with Heart Failure with Reduced Ejection Fraction: Three-Year Follow-Up Data Based on Comparison with Standard Medical Therapy","authors":"Keita Goto, N. Takama, Y. Sano, M. Kurabayashi","doi":"10.4172/2155-9880.1000586","DOIUrl":"https://doi.org/10.4172/2155-9880.1000586","url":null,"abstract":"Background: Sleep-disordered breathing (SDB) is a cause of heart failure. Adaptive servo-ventilation (ASV) is one of the treatments for SDB. Recently, ASV has been applied to the treatment of patients with heart failure and SDB. The aim of this study was to estimate whether ASV therapy is effective and safe for patients with heart failure with reduced ejection fraction (HFrEF) compared with standard medical therapy in the real world, using three-year follow-up data. Methods: The patients with HFrEF (n=186) were treated with standard medical therapy plus ASV therapy (ASV group; n=57) or standard medical therapy alone (control group; n=129). We followed up the patients for 3 years. Results: The ASV group had significantly lower baseline left ventricular ejection fraction than the control group (27.9 ± 8.6% vs. 34.1 ± 8.8%; P<0.0001). Baseline brain natriuretic peptide (BNP) did not differ significantly between the groups. On follow-up, the changes in BNP level indicated that the ASV group showed significantly better improvement than the control group. There was no significant difference between the groups in the rate of fatal cardiovascular events (P=0.190, log-rank test). Conclusion: ASV therapy was effective for the treatment of HFrEF, and the rate of fatal cardiovascular events were not higher in the ASV group in the real world.","PeriodicalId":15504,"journal":{"name":"Journal of Clinical and Experimental Cardiology","volume":"9 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78627504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Double Emergency Associating Acute Aortic Dissection and Pulmonary Embolism of Fatal Evolution: About a Case 急性主动脉夹层合并肺栓塞双重急诊致死性进展1例

Journal of Clinical and Experimental Cardiology Pub Date : 2018-01-01 DOI: 10.4172/2155-9880.1000617

M. Bodian, A. Guindo, F. Aw, Carole Fadilath Yekiny, S. A. Sarr, D. Balde, I. Sylla, M. Ndiaye, M. Diouf, M. Ndiaye, Ngaide Aa, M. Dioum, Beye Sm, W. N. Mboup, Y. Diouf, C. Diop, A. Mbaye, A. Kane, M. Diao, A. Kane, S. Bâ

{"title":"Double Emergency Associating Acute Aortic Dissection and Pulmonary Embolism of Fatal Evolution: About a Case","authors":"M. Bodian, A. Guindo, F. Aw, Carole Fadilath Yekiny, S. A. Sarr, D. Balde, I. Sylla, M. Ndiaye, M. Diouf, M. Ndiaye, Ngaide Aa, M. Dioum, Beye Sm, W. N. Mboup, Y. Diouf, C. Diop, A. Mbaye, A. Kane, M. Diao, A. Kane, S. Bâ","doi":"10.4172/2155-9880.1000617","DOIUrl":"https://doi.org/10.4172/2155-9880.1000617","url":null,"abstract":"Pulmonary embolism and acute aortic dissection are two formidable cardio-vascular emergencies. Their association, although exceptional, is burdened with a heavy mortality in the absence of an early and adapted surgery. We report a case of Standford acute type A aortic dissection associated with fatal pulmonary embolism. This is a 66-years old man with a notion of a long trip received for prolonged chest pain since 3 days, of sudden onset, maximal intensity, tearing, transfixing, migratory, radiating towards the back and the loins, exacerbated by breathing. The examination noted 120 bpm tachycardia, 70% SaO2 desaturation, asymetric blood pressure and asymetric pulse, aortic insufficiency murmur and bilateral crackling rettles at lungs. The chest X-ray showed an enlargement of the upper mediastinum with double-contoured image. The electrocardiogram recorded a regular sinus tachycardia at 132 cycles/min, a lateral sub epicardial ischemia in lateral leads. CT scan revealed total thrombosis of the right branch of the pulmonary artery extending to part of the trunk and an intimal flap from the aortic arch to the abdominal aorta. The evolution was brutally lethal two days after hospitalization. The dissection of the aorta and the pulmonary embolism are medical emergencies whose association poses more difficulties as well on the diagnosis plan but especially therapeutic.","PeriodicalId":15504,"journal":{"name":"Journal of Clinical and Experimental Cardiology","volume":"25 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81576557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2