Journal of Clinical Neuroscience最新文献

{"title":"Distal versus proximal transradial access for diagnostic cerebral angiography: A single-center experience","authors":"Shan Jiang ,&nbsp;Shanlin Yu ,&nbsp;Baodong Gu ,&nbsp;Xin Li ,&nbsp;Hui Xiao ,&nbsp;Dandan Zhao ,&nbsp;Xianjun Ma","doi":"10.1016/j.jocn.2025.111283","DOIUrl":"10.1016/j.jocn.2025.111283","url":null,"abstract":"<div><h3>Background</h3><div>To compare the safety and effectiveness of cerebral angiography via distal transradial access puncture (dTRA) versus proximal radial artery puncture (pTRA).</div></div><div><h3>Methods</h3><div>A total of 494 patients undergoing cerebral angiography were randomly assigned to either the dTRA or pTRA groups in a 1:1 ratio. The study evaluated puncture success rates, puncture time, procedural fluoroscopy time, operation time, and the incidence of complications between the two groups.</div></div><div><h3>Results</h3><div>The success rate for dTRA was 92.7 % (229/247), compared to 99.19 % (245/247) for pTRA. In cases where dTRA failed, switching to pTRA achieved a 100 % success rate (18/18). The average puncture time for dTRA was 6.61 ± 4.12 min (p = 0.021), compared to 5.74 ± 4.12 min for pTRA. Fluoroscopy time was 8.03 ± 3.50 min for dTRA and 8.18 ± 3.30 min for pTRA (p = 0.639). The procedural operation time was 17.33 ± 5.38 min for dTRA and 16.84 ± 5.11 min for pTRA (p = 0.32). The incidence of radial artery occlusion, hand edema, and subcutaneous hematoma was significantly lower in the dTRA group compared to the pTRA group.</div></div><div><h3>Conclusions</h3><div>Cerebral angiography via the dTRA approach is safe and effective, with a lower incidence of radial artery occlusion. Failure of dTRA does not preclude subsequent successful pTRA, making dTRA a viable option for cerebral angiography.</div></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"137 ","pages":"Article 111283"},"PeriodicalIF":1.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143911871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative efficacy of drug-eluting stents vs. bare-metal stents in symptomatic vertebral artery stenosis: A prospective single-center study","authors":"Shanquan Jing ,&nbsp;Bo Jia ,&nbsp;Kang An ,&nbsp;Nanding Li ,&nbsp;Haiyan Guo ,&nbsp;Xiaole Li ,&nbsp;Jiwei Wang ,&nbsp;Wei Liu","doi":"10.1016/j.jocn.2025.111299","DOIUrl":"10.1016/j.jocn.2025.111299","url":null,"abstract":"<div><h3>Objective</h3><div>To explore the safety, efficacy of drug-eluting stents and bare-metal stents in the treatment of vertebral artery stenosis, and the influencing factors of in-stent restenosis.</div></div><div><h3>Methods</h3><div>From June 2022 to October 2023, 129 patients undergoing vertebral artery stent implantation in the Department of Neurosurgery of the First Hospital of Hebei Medical University were randomly divided into the drug-eluting stent group and the bare-metal stent group using a randomized controlled method and followed up. The clinical data of the patients were recorded and divided into the stenosis group and the non-stenosis group according to whether in-stent restenosis occurred after surgery. Through Logistic regression analysis, the risk factors affecting in-stent restenosis were analyzed.</div></div><div><h3>Results</h3><div>All stents were successfully implanted, and there were no puncture site hematoma, intracranial hemorrhage, or death events after surgery. The incidence of in-stent restenosis in the drug-eluting stent group was significantly lower than that in the bare-metal stent group (4.8% vs 31.1%). Multivariate regression analysis confirmed that the bare-metal stent group was an independent risk factor for in-stent restenosis. In addition, contralateral vertebral artery stenosis is also an important risk factor.</div></div><div><h3>Conclusion</h3><div>Stent implantation is a safe and effective method for treating patients with symptomatic vertebral artery stenosis who are poorly controlled by drugs, and drug-eluting stents can significantly reduce the incidence of in-stent restenosis.</div></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"136 ","pages":"Article 111299"},"PeriodicalIF":1.9,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143911596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential utility of arterial spin labeling in predicting brain amyloidosis","authors":"Kimia Kazemzadeh ,&nbsp;Nasim Naseri ,&nbsp;Mahsa Mombeini ,&nbsp;Amirhossein Khodadadi ,&nbsp;Mina Jafari ,&nbsp;Rezvaneh Rostami ,&nbsp;Parisa Enayat ,&nbsp;Maryam Sadeghi ,&nbsp;Soorin Berenjian ,&nbsp;Seyed Mohammad Amin Alavi","doi":"10.1016/j.jocn.2025.111248","DOIUrl":"10.1016/j.jocn.2025.111248","url":null,"abstract":"<div><h3>Background</h3><div> <!-->Declines in regional cerebral blood flow (rCBF) are common in Alzheimer’s disease. Previous studies have linked higher amyloid beta-protein (Aβ) loads, detected by Positron Emission Tomography (PET), with rCBF in normally aging individuals. This study aims to assess the potential of Arterial Spin Labeling (ASL) in predicting brain amyloidosis.</div></div><div><h3>Methods</h3><div> <!-->The study included 140 participants from the<!--> <!-->Alzheimer’s<!--> <!-->Disease Neuroimaging Initiative (ADNI), comprising 43 cognitively normal (CN) individuals, 70 patients with mild cognitive impairment (MCI), and 27 with<!--> <!-->Alzheimer’s<!--> <!-->disease (AD). Eligible participants had comprehensive assessments of cognition, ASL, Apolipoprotein E4 (APOE4) genotyping, Polygenic Hazard Score (PHS) calculation, and amyloidosis indices. Data<!--> <!-->were analyzed<!--> <!-->using IBM SPSS ver. 20, employing chi-square, ANOVA, and linear regression models, with a significance threshold of P &lt; 0.05.</div></div><div><h3>Results</h3><div>There were no statistically significant differences in demographic characteristics, including age, gender, and education level. Significant differences emerged in amyloid beta-protein 42 (Aβ42) levels, APOE4 status, and cognitive performance across groups. Four brain regions, including the left middle temporal, bilateral <em>para</em>-hippocampal, and right lingual cortex exhibited significant CBF differences (p &lt; 0.05). Clinical Dementia Rating (CDR) correlated strongly with various brain regions, particularly in MCI individuals. Moreover, CBF in multiple regions showed significant associations with Aβ variants and their ratios, especially Aβ42, even after adjusting for confounding factors.</div></div><div><h3>Conclusion</h3><div> <!-->ASL demonstrates potential in predicting brain amyloidosis and monitoring AD. Significant associations between CBF and amyloid-beta levels suggest that ASL can detect early perfusion deficits related to AD progression.</div></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"137 ","pages":"Article 111248"},"PeriodicalIF":1.9,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143904130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management, and outcomes of pediatric cerebral cavernous malformations across age groups: A systematic review and meta-analysis of the literature","authors":"Muhammad Ammar Haider ,&nbsp;Faraaz Azam ,&nbsp;Parker D. Smith ,&nbsp;Michael Farid ,&nbsp;Emerson Lout ,&nbsp;Soummitra Anand ,&nbsp;Abigail Jenkins ,&nbsp;Pooja Venkatesh ,&nbsp;Cesar Ramirez ,&nbsp;Kwadwo Darko ,&nbsp;Momodou G. Bah ,&nbsp;Anant Naik ,&nbsp;Umaru Barrie ,&nbsp;Bruno P. Braga ,&nbsp;Brett Whittemore","doi":"10.1016/j.jocn.2025.111289","DOIUrl":"10.1016/j.jocn.2025.111289","url":null,"abstract":"<div><h3>Objective</h3><div>Pediatric Cerebral Cavernous Malformations (CCM) are focal neuro-vascular lesions with highly variable symptomatic presentations and natural history. In this study, we explored clinical features, management decisions, and outcomes in specific pediatric CCM populations.</div></div><div><h3>Methods</h3><div>In accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, an exhaustive review of the literature was conducted using search strings on PubMed, SCOPUS, Google Scholar, Ovid Embase, and Cochrane databases to assess differences in patient demographics, treatment strategies and clinical outcomes specifically between National Institute of Health (NIH) and American Academic of Pediatrics (AAP)-defined age groups: infants (0–1 year), children (1–12 years), adolescents (12–17 years).</div></div><div><h3>Results</h3><div>Data from 630 individual pediatric cases from 94 publications was analyzed, yielding 45 infants (median: 0.3 years), 280 children (median: 7.0 years), and 305 adolescents (median: 15 years). Comparatively, infants were more likely to present with signs of elevated ICP and isolated lesions than both the children and adolescents’ group (p &lt; 0.05). Infants presenting with multiple lesions had higher rates of conservative management than surgery (46.2 % vs. 24.30 %, <em>p</em> &lt; 0.01). Children with isolated sensory deficits or asymptomatic at presentation were more likely to undergo conservative management (14.3 % vs. 3.70 %, <em>p</em> &lt; 0.05; 20.0 % vs. 0 %, <em>p</em> &lt; 0.001), while those who underwent surgery had higher rates of improvement (81.6 % vs. 51.4 %, <em>p</em> &lt; 0.001) and were more often symptom-free at follow-up (48.2 % vs. 25.7 %, <em>p</em> &lt; 0.05). In adolescents, seizures (47.1 % vs. 14.8 %, p &lt; 0.01), supratentorial lesions (64.6.0 % vs. 45.2 %, <em>p</em> &lt; 0.01), and isolated lesions (75.7 % vs. 53.8 %, <em>p</em> &lt; 0.05) favored surgical management. With increasing age, headaches were more likely (OR:1.05, 95 % CI:1.01–1.10, <em>p</em> &lt; 0.05), whereas motor deficits (OR:0.96, 95 % CI:0.93–0.99, <em>p</em> &lt; 0.05) and signs of elevated intracranial pressure (OR:0.91, 95 % CI:0.87–0.95, <em>p</em> &lt; 0.001) were less likely initial presentations. Furthermore, older patients were more likely to harbor multiple malformations (OR:1.04, 95 % CI:1.01–1.08, <em>p</em> &lt; 0.05). Regardless of management strategy, there was no difference in long-term outcomes between age groups (<em>p</em> &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>Although presenting symptoms, specific lesion characteristics and symptoms varied with the age of presentation in pediatric CCM patients, there was no significant difference noted in outcomes or long-term follow-up between age groups.</div></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"137 ","pages":"Article 111289"},"PeriodicalIF":1.9,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143904131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two decades of trends in nontraumatic intracerebral hemorrhage care: A nationwide analysis","authors":"Andrea Loggini ,&nbsp;Faddi G. Saleh Velez ,&nbsp;James E. Towner ,&nbsp;Jonatan Hornik ,&nbsp;Shawn S. Wallery MD ,&nbsp;Denise Battaglini ,&nbsp;Amber Schwertman ,&nbsp;Sarmad Nomani ,&nbsp;Alejandro Hornik ,&nbsp;Adnan I Qureshi ,&nbsp;Victor J. Del Brutto","doi":"10.1016/j.jocn.2025.111300","DOIUrl":"10.1016/j.jocn.2025.111300","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aims to analyze the temporal trends of comorbidities, complications, and in-hospital mortality of non-traumatic intracerebral hemorrhages (ICH) over the past two decades using a nationwide inpatient sample.</div></div><div><h3>Methods</h3><div>The National Inpatient Sample database was screened to identify patients hospitalized with ICH from 2002 to 2022. Socio-demographic characteristics, comorbidities, complications (including ischemic stroke, seizures, aspiration pneumonia, and deep vein thrombosis/pulmonary embolism DVT/PE), neurosurgical procedures, tracheostomy, and percutaneous gastrostomy placement were reviewed. Length of hospital stay and in-hospital mortality were analyzed. Temporal trends were determined using linear logistic regression models for each predetermined variable. For dichotomous variables, the natural logarithm was calculated to achieve a harmonic linear trend. Pairwise comparison was used for subgroup analyses.</div></div><div><h3>Results</h3><div>A total of 467,117 patients with ICH were included in the study. From 2002 to 2022, there was a significant increase in comorbidities, including hypertension, diabetes, chronic kidney disease, obesity, and anticoagulant use, p &lt; 0.01 for all. Patients’ age progressively decreased over time (β:-0.104, 95 %CI: −0.124–0.085, p &lt; 0.01). Notably, a temporal increase in ischemic stroke (β:0.081, 95 %CI: 0.069–0.092, p &lt; 0.01) and seizures (β:0.012, 95 %CI: 0.001–0.008, p &lt; 0.01) was noted. Clot removal/decompression declined over the years (β:-0.039, 95 %CI: −0.057–0.022, p &lt; 0.01) while EVD/VPS placement increased (β:, 95 %CI: −0.057–0.022, p &lt; 0.01). Length of hospital stay increased yearly by 0.07 days (95 %CI: 0.04–0.08, p &lt; 0.01). The average annual mortality rate significantly decreased by 2.43 % per year (95 %CI: −2.21 %-2.65 %, p &lt; 0.01). In-hospital mortality rates declined more rapidly in urban areas compared to rural areas (0.99 % difference, 95 %CI: 0.5 %-1.48 %, p &lt; 0.01). No statistical difference was observed among sex, racial or income groups; however, there was a trend toward a slower decline in in-hospital mortality among lower-income compared to higher-income groups.</div></div><div><h3>Conclusion</h3><div>Despite increasing patient complexity, in-hospital mortality has steadily decreased in ICH patients over the last two decades. These improvements have come at the cost of longer hospital stays. Profound inequities remain in the mortality rate in rural areas.</div></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"137 ","pages":"Article 111300"},"PeriodicalIF":1.9,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143908061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluid and thermal dynamics in endoscopic spine surgery: What surgeons need to know","authors":"Dong Hun Kim ,&nbsp;Sang Don Kim ,&nbsp;Jin Young Kim ,&nbsp;Jae Taek Hong ,&nbsp;Jung Woo Hur","doi":"10.1016/j.jocn.2025.111287","DOIUrl":"10.1016/j.jocn.2025.111287","url":null,"abstract":"<div><div>Endoscopic spine surgery (ESS) has revolutionized minimally invasive spinal procedures by enhancing visualization and reducing tissue disruption. Despite these advantages, effective fluid and thermal management remains crucial for procedural safety. Proper irrigation facilitates visualization, hemostasis, debris clearance, and infection prevention; however, excessive pressure may lead to complications such as headaches and seizures. While some surgeons advocate for higher pressures (80–100 mmHg) to ensure adequate visualization in select cases, irrigation pressures of 30–40 mmHg are generally sufficient to achieve effective bleeding control and maintain a clear surgical field. The Venturi effect plays a significant role in pressure dynamics, necessitating careful regulation through pressure-controlled pumps. Thermal management is equally critical when using radiofrequency (RF) energy for tissue manipulation. To prevent neural tissue damage—which may occur at temperatures exceeding 60 °C—continuous irrigation should accompany RF application. Power settings of 7–13 W are typically used with steerable RF probes for coagulation, 15–40 W for more demanding hemostasis, and up to 60 W with 90-degree RF probes for tissue dissection. Short, intermittent RF bursts further reduce thermal spread. This review synthesizes current evidence on fluid and thermal control in ESS, emphasizing proper pressure regulation and precise RF application. Future research should focus on standardized protocols and long-term outcomes. Advances in automated irrigation systems and real-time monitoring promise to enhance surgical precision and patient safety.</div></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"136 ","pages":"Article 111287"},"PeriodicalIF":1.9,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143904544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of intraoperative ultrasound in identifying pituitary adenoma hidden behind a cystic lesion in Cushing’s disease","authors":"Min Ho Lee,&nbsp;Tae-Kyu Lee","doi":"10.1016/j.jocn.2025.111279","DOIUrl":"10.1016/j.jocn.2025.111279","url":null,"abstract":"<div><div>Cushing’s disease with inconclusive MRI findings presents a significant diagnostic and surgical challenge due to the difficulty in localizing the causative pituitary adenoma. This case report highlights the use of intraoperative ultrasound as an adjunct for tumor detection and successful resection in a Cushing disease patient with hidden adenoma. A 55-year-old female with a history of hypertension, diabetes, and a recent cerebral infarction presented with clinical and biochemical features of Cushing’s disease. Brain MRI revealed a 10 mm non-enhancing cystic lesion in the sella, making it difficult to confirm the underlying pathology. Inferior petrosal sinus sampling suggested a right-sided lesion, leading to an endoscopic endonasal transsphenoidal surgery. Intraoperatively, ultrasound was employed to assess the sellar region, initially identifying a cystic structure consistent with a Rathke’s cleft cyst. Following fluid drainage, ultrasound revealed an <em>iso</em>-echoic lesion with a distinct margin, which was subsequently resected and confirmed as a pituitary adenoma on histopathological examination. The patient experienced postoperative biochemical remission, with normalization of ACTH levels and resolution of hypertension and diabetes. This case demonstrates that intraoperative ultrasound can be a valuable tool for tumor localization in suspicious MRI-negative Cushing’s disease. By aiding in the identification of adenomas obscured by cystic lesions or surrounding structures, intraoperative ultrasound may improve surgical outcomes. Further studies are warranted to validate its efficacy in routine clinical practice.</div></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"136 ","pages":"Article 111279"},"PeriodicalIF":1.9,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143904545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Main clinical findings and their frequency in cortical-subcortical areas tested in awake brain mapping for diffuse low-grade glioma","authors":"Lucas Alverne F. Albuquerque ,&nbsp;Leonardo José Monteiro de Macêdo Filho ,&nbsp;Cicera Jairlly Veras Rocha ,&nbsp;Gabryella S. Diógenes ,&nbsp;Fátima C. Pessoa ,&nbsp;Felipe Silva Borges ,&nbsp;João Paulo Almeida ,&nbsp;Andrei F. Joaquim","doi":"10.1016/j.jocn.2025.111290","DOIUrl":"10.1016/j.jocn.2025.111290","url":null,"abstract":"<div><h3>Background</h3><div>The main objective of awake surgery for brain gliomas is to achieve maximum tumor removal while safeguarding cognitive functions. This approach offers a unique chance to gain deeper insights into brain function. This study aims to detail the clinical findings and their relationship, frequency and probability of occurring in cortical and subcortical anatomical structures at both hemispheres.</div></div><div><h3>Methods</h3><div>This series represents our initial series of 51 consecutive diffuse low-grade gliomas (DLGG) treated with awake surgery.</div></div><div><h3>Results</h3><div>The surgeries were evenly distributed between the left hemisphere (LH, n = 26 − all right-handed) and the right hemisphere (RH, n = 25 − one left-handed and one ambidextrous). In the LH, the main clinical findings during cortical mapping were positive motor responses (51 times; 33.3 % of clinical findings), followed by speech arrest (26; 16.9 %) and semantic paraphasia (19; 12.4 %). For LH subcortical responses: semantic paraphasia (36; 36.7 %), anomia (16; 16.3 %) and speech perseveration (13; 13.2 %). In the RH the main clinical findings during cortical mapping were positive motor responses (46; 38 % of clinical findings), negative motor responses (21; 17.3 %) and speech arrest (18; 14.8 %). For RH subcortical responses: negative motor responses (9; 21.9 %), positive motor responses (7; 17 %), and semantic paraphasia (5; 11.1 %).</div><div>The cortical anatomical structures with the highest average functional findings per exposure were the precentral gyrus (average of 2.1 findings per evaluation), vPMC (ventral premotor cortex) (1.5) and postcentral gyrus (1.2); and in the subcortical area: IFOF (Inferior Fronto-Occipital Fasciculus) (1.2), corticospinal tract (1.0) and somatic sensory fibers (1.0).</div></div><div><h3>Conclusion</h3><div>The clinical findings in each hemisphere are extremely important information for all neuro-oncological approaches. We highlight the brain regions most likely to have intraoperative findings. We emphasize the importance of functional findings in the RH, which, in addition to motor function, sensitivity, eye movement, visual alteration, social cognition, spatial awareness, and attention, also includes significant language findings.</div></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"136 ","pages":"Article 111290"},"PeriodicalIF":1.9,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143895734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors influencing outcomes of simultaneous hypoglossal-facial and cervical-hypoglossal nerve anastomoses for facial palsy","authors":"Xiaomin Cai ,&nbsp;Mengshu Qian ,&nbsp;Yiman Shen ,&nbsp;Yan Yuan ,&nbsp;Xuan Zheng ,&nbsp;Tingting Ying ,&nbsp;Jun Zhong ,&nbsp;Zhongding Zhang ,&nbsp;Hua Zhao ,&nbsp;Yinda Tang ,&nbsp;Ya Zhao ,&nbsp;Shiting Li","doi":"10.1016/j.jocn.2025.111288","DOIUrl":"10.1016/j.jocn.2025.111288","url":null,"abstract":"<div><h3>Objective</h3><div>The hypoglossal-facial and cervical-hypoglossal nerve anastomoses (HFCHA) technique addresses severe facial palsy after cerebellopontine angle (CPA) tumor resection. However, postoperative facial function recovery and tongue dysfunction vary significantly among patients. This study identifies prognostic factors influencing these outcomes.</div></div><div><h3>Methods</h3><div>We retrospectively followed up on 43 patients with facial palsy who underwent HFCHA for CPA tumor resection (July 2019–December 2022). The patients were divided into two groups based on their recovery of facial function or tongue function: the good recovery group and the poor recovery group; or the tongue dysfunction group and the normal tongue function group. Potential prognostic factors were evaluated using univariate and multivariable analyses.</div></div><div><h3>Results</h3><div>Patients with a duration of facial palsy less than 10.75 months may exhibit an increased likelihood of achieving improved facial function recovery following surgical intervention. Compared to individuals who engaged in longer postoperative tongue rehabilitation exercises, patients whose exercise duration was shorter than 4.5 months demonstrated a tendency towards experiencing tongue dysfunction after surgery.</div></div><div><h3>Conclusions</h3><div>A shorter time interval between facial nerve injury and surgery helps with the recovery of facial palsy. Longer postoperative tongue rehabilitation exercises may also potentially alleviate tongue dysfunction.</div></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"136 ","pages":"Article 111288"},"PeriodicalIF":1.9,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary suprasellar melanocytoma with leptomeningeal melanomatosis","authors":"Madhusudhan Nagesh ,&nbsp;Manish Beniwal ,&nbsp;Andiperumal R. Prabhuraj ,&nbsp;Sathyakumar Rima ,&nbsp;Amudhakumar Janani","doi":"10.1016/j.jocn.2025.111294","DOIUrl":"10.1016/j.jocn.2025.111294","url":null,"abstract":"","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"136 ","pages":"Article 111294"},"PeriodicalIF":1.9,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143895621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}