{"title":"脑动静脉畸形患者早期癫痫发作的相关因素。","authors":"Prut Koonalintip , Aurakoch Kanjana-opas , Jarudetch Wichaitum , Rujimas Khumtong , Suwanna Setthawatcharawanich , Pornchai Sathirapanya , Rattana Leelawattana , Pat Korathanakhun","doi":"10.1016/j.jocn.2025.111637","DOIUrl":null,"url":null,"abstract":"<div><div>This retrospective cohort study aimed to identify factors associated with early seizure (ES) in patients with cerebral arteriovenous malformations (AVMs). Patients diagnosed with cerebral AVMs between 2002 and 2023 were enrolled. Clinical and seizure characteristics, radiographic findings, and clinical outcomes were compared between the ES and non-seizure groups. Factors with p-values < 0.05 in univariate analyses were further analyzed using a multivariable logistic regression model to identify independent factors associated with ES. The incidence of ES was 39.81 % among 309 patients with cerebral AVMs. Focal seizure semiology was recorded in 77 patients (62.60 %), and the rest were considered motor tonic–clonic seizures with unknown onset. Long pial venous drainage (adjusted odds ratio [aOR] 12.015, 95 % confidence interval [CI] 5.325–30.018, p = 0.038) and adjacent cortical edema (aOR 3.112, 95 % CI 1.825–20.125, p = 0.014) were independent associated factors with ES, whereas the focal neurological deficit showed a reversed association (aOR 0.063, 95 % CI 0.011–0.202, p = 0.028). In conclusion, the long pial venous drainage and the adjacent cortical edema were independently associated with ES in patients with cerebral AVMs.</div></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"142 ","pages":"Article 111637"},"PeriodicalIF":1.8000,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Factors associated with early seizure in patients with cerebral arteriovenous malformations\",\"authors\":\"Prut Koonalintip , Aurakoch Kanjana-opas , Jarudetch Wichaitum , Rujimas Khumtong , Suwanna Setthawatcharawanich , Pornchai Sathirapanya , Rattana Leelawattana , Pat Korathanakhun\",\"doi\":\"10.1016/j.jocn.2025.111637\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>This retrospective cohort study aimed to identify factors associated with early seizure (ES) in patients with cerebral arteriovenous malformations (AVMs). Patients diagnosed with cerebral AVMs between 2002 and 2023 were enrolled. Clinical and seizure characteristics, radiographic findings, and clinical outcomes were compared between the ES and non-seizure groups. Factors with p-values < 0.05 in univariate analyses were further analyzed using a multivariable logistic regression model to identify independent factors associated with ES. The incidence of ES was 39.81 % among 309 patients with cerebral AVMs. Focal seizure semiology was recorded in 77 patients (62.60 %), and the rest were considered motor tonic–clonic seizures with unknown onset. Long pial venous drainage (adjusted odds ratio [aOR] 12.015, 95 % confidence interval [CI] 5.325–30.018, p = 0.038) and adjacent cortical edema (aOR 3.112, 95 % CI 1.825–20.125, p = 0.014) were independent associated factors with ES, whereas the focal neurological deficit showed a reversed association (aOR 0.063, 95 % CI 0.011–0.202, p = 0.028). In conclusion, the long pial venous drainage and the adjacent cortical edema were independently associated with ES in patients with cerebral AVMs.</div></div>\",\"PeriodicalId\":15487,\"journal\":{\"name\":\"Journal of Clinical Neuroscience\",\"volume\":\"142 \",\"pages\":\"Article 111637\"},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2025-09-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Clinical Neuroscience\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0967586825006101\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0967586825006101","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Factors associated with early seizure in patients with cerebral arteriovenous malformations
This retrospective cohort study aimed to identify factors associated with early seizure (ES) in patients with cerebral arteriovenous malformations (AVMs). Patients diagnosed with cerebral AVMs between 2002 and 2023 were enrolled. Clinical and seizure characteristics, radiographic findings, and clinical outcomes were compared between the ES and non-seizure groups. Factors with p-values < 0.05 in univariate analyses were further analyzed using a multivariable logistic regression model to identify independent factors associated with ES. The incidence of ES was 39.81 % among 309 patients with cerebral AVMs. Focal seizure semiology was recorded in 77 patients (62.60 %), and the rest were considered motor tonic–clonic seizures with unknown onset. Long pial venous drainage (adjusted odds ratio [aOR] 12.015, 95 % confidence interval [CI] 5.325–30.018, p = 0.038) and adjacent cortical edema (aOR 3.112, 95 % CI 1.825–20.125, p = 0.014) were independent associated factors with ES, whereas the focal neurological deficit showed a reversed association (aOR 0.063, 95 % CI 0.011–0.202, p = 0.028). In conclusion, the long pial venous drainage and the adjacent cortical edema were independently associated with ES in patients with cerebral AVMs.
期刊介绍:
This International journal, Journal of Clinical Neuroscience, publishes articles on clinical neurosurgery and neurology and the related neurosciences such as neuro-pathology, neuro-radiology, neuro-ophthalmology and neuro-physiology.
The journal has a broad International perspective, and emphasises the advances occurring in Asia, the Pacific Rim region, Europe and North America. The Journal acts as a focus for publication of major clinical and laboratory research, as well as publishing solicited manuscripts on specific subjects from experts, case reports and other information of interest to clinicians working in the clinical neurosciences.