Journal of Clinical Neuroscience最新文献

{"title":"Race/ethnicity-specific association between the American Heart Association’s new Life’s Essential 8 and stroke in US adults with nonalcoholic fatty liver disease: Evidence from NHANES 2005–2018","authors":"Nuo Xu ,&nbsp;Xiaowen Lu ,&nbsp;Cheng Luo ,&nbsp;Junchen Chen","doi":"10.1016/j.jocn.2024.111005","DOIUrl":"10.1016/j.jocn.2024.111005","url":null,"abstract":"<div><h3>Background</h3><div>The Life’s Essential 8 (LE8) is a recently introduced assessment of cardiovascular health (CVH) by the American Heart Association (AHA). Nonalcoholic fatty liver disease (NAFLD) is currently the most common chronic liver disease and is associated with an increased risk of stroke. We aimed to explore the association of LE8 with stroke in NAFLD using a national cross-sectional study.</div></div><div><h3>Methods</h3><div>Eligible participants with NAFLD aged 20–85 years in NHANES 2005–2018 were included. LE8 was assessed according to AHA criteria and categorized into metabolic and behavioral factors. US Fatty Liver Index (USFLI) ≥ 30 and exclusion of other chronic liver diseases suggested NAFLD. Stroke was diagnosed according to self-report on standardized questionnaires.</div></div><div><h3>Results</h3><div>After adjusting for all confounders, each point increase in LE8, LE8 metabolic factors, and LE8 behavioral factors was associated with a 4.4 %, 1.8 %, and 2.5 % reduction in stroke prevalence in NAFLD, respectively. Both moderate and high CVH assessed by LE8 and LE8 behavioral factors were associated with reduced odds of stroke compared with low CVH. Stroke prevalence declined progressively with increasing number of ideal LE8 components, with the lowest odds of stroke at 3 + ideal LE8 components for both LE8 metabolic and behavioral factors. Restricted cubic spline suggested dose–response associations. Race/ethnicity was a significant effect modifier, and this association was present only among non-Hispanic white population and other Hispanic population. FLI as a diagnostic indicator of NAFLD yielded generally consistent results.</div></div><div><h3>Conclusions</h3><div>Higher LE8 score, especially LE8 behavioral factors, was associated with reduced prevalence of stroke in NAFLD, especially among non-Hispanic white population and other Hispanic population. The odds of stroke declined progressively with increased ideal LE8 component number. These findings underscore the preventive value of adherence to high CVH for stroke prevention in NAFLD.</div></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"132 ","pages":"Article 111005"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of perioperative cerebral blood flow evaluation using arterial spin labeling in a patient undergoing carotid artery stenting","authors":"Tomohiro Iida ,&nbsp;Kentaro Yamashita ,&nbsp;Yuki Kato ,&nbsp;Rikiyoshi Yamamoto ,&nbsp;Koudai Uematsu ,&nbsp;Tatsuya Kuroda ,&nbsp;Satoru Murase ,&nbsp;Tsuyoshi Izumo","doi":"10.1016/j.jocn.2024.110974","DOIUrl":"10.1016/j.jocn.2024.110974","url":null,"abstract":"<div><h3>Background</h3><div>Hyperperfusion syndrome (HPS) is one of the most serious complications after carotid artery stenting (CAS). Arterial spin labeling (ASL) is a noninvasive method for assessing cerebral perfusion. This study aimed to evaluate the utility of ASL compared to that of SPECT in evaluating changes in intracranial blood flow during the perioperative period of CAS.</div></div><div><h3>Methods</h3><div>We retrospectively reviewed prospectively collected data from 49 cases of CAS conducted for symptomatic and asymptomatic carotid artery stenosis. We calculated the relative cerebral blood flow (rCBF) from ASL (post labeling delay [PLD] of 1500 ms and 2500 ms) and SPECT, both pre- and post-CAS. Cerebrovascular reactivity (CVR) was assessed using SPECT with an acetazolamide challenge. We defined the change rate from PLD 1500 ms to 2500 ms before CAS as ΔrASL.</div></div><div><h3>Results</h3><div>Hyperperfusion phenomenon was observed in four cases (8.2 %), with one case (2.0 %) resulting in cerebral hemorrhage and diagnosed as HPS. Positive correlations were noted between ASL and SPECT at both pre- and post-CAS (r = 0.42–0.65, p &lt; 0.01). A negative correlation was found between ΔrASL obtained from the two PLDs before CAS and CVR (r=-0.41, p &lt; 0.01).</div></div><div><h3>Conclusions</h3><div>ASL using two PLDs is a useful method for evaluating changes in CBF during the perioperative period of CAS.</div></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"132 ","pages":"Article 110974"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"C5 palsy following one- or two-level anterior cervical discectomy and fusion: Incidence and neurological recovery in a retrospective neurosurgical multicenter study","authors":"Yoshiki Fujikawa ,&nbsp;Naokado Ikeda ,&nbsp;Kosuke Sakai ,&nbsp;Ryokichi Yagi ,&nbsp;Ryo Hiramatsu ,&nbsp;Masahiro Kameda ,&nbsp;Naosuke Nonoguchi ,&nbsp;Motomasa Furuse ,&nbsp;Shinji Kawabata ,&nbsp;Kunio Yokoyama ,&nbsp;Masahiro Kawanishi ,&nbsp;Takahiro Fujishiro ,&nbsp;Yangtae Park ,&nbsp;Hideki Tanabe ,&nbsp;Toshihiro Takami ,&nbsp;Masahiko Wanibuchi","doi":"10.1016/j.jocn.2024.111000","DOIUrl":"10.1016/j.jocn.2024.111000","url":null,"abstract":"<div><h3>Background</h3><div>C5 palsy is a frequent complication following cervical spine surgery, particularly after posterior approaches. Although several risk factors have been proposed, the incidence of C5 palsy after anterior cervical discectomy and fusion (ACDF) remains less well understood. This study aims to elucidate the risk factors and neurological recovery associated with C5 palsy following ACDF.</div></div><div><h3>Methods</h3><div>A total of 330 patients who underwent one or two-level ACDF between January 2018 and December 2022 across three institutions within the neurosurgical training program were retrospectively included and analyzed. Demographic, surgical, and radiological data were collected.</div></div><div><h3>Results</h3><div>Sixteen (4.8 %) patients developed postoperative C5 palsy, with a significantly high incidence observed in patients exhibiting preoperative symptoms (radiculopathy or radiculomyelopathy) and undergoing two-level ACDF (p-values 0.008 and 0.018, respectively). No other demographic or radiological factors were associated with C5 palsy. Eleven of 16 (68.8 %) patients experienced C5 palsy within 1 day post-surgery (early-onset group), whereas the remaining five developed symptoms between 4 to 15 days post-surgery (late-onset group). At one year post-surgery, the late-onset group demonstrated superior recovery from C5 palsy compared to the recovery noted in the early-onset group (100 % vs 44.4 %).</div></div><div><h3>Conclusions</h3><div>Surgeons should be cognizant of the potential for C5 palsy following one- or two-level ACDF, despite generally favorable neurological outcomes. The timing of C5 palsy onset post-ACDF, potentially influenced by mechanisms such as direct injury and ischemia–reperfusion injury, could impact the recovery prognosis. Careful surgical procedure might be the key to success.</div></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"132 ","pages":"Article 111000"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe intracranial hypotension secondary to cerebrospinal-venous fistula in a patient with remote history of spinal decompression and fusion","authors":"Julia Greenberg ,&nbsp;Christina Kallik ,&nbsp;Benjamin Jadow ,&nbsp;Joseph Boonsiri ,&nbsp;Svetlana Kvint ,&nbsp;Eytan Raz ,&nbsp;Ariane Lewis","doi":"10.1016/j.jocn.2024.111007","DOIUrl":"10.1016/j.jocn.2024.111007","url":null,"abstract":"","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"132 ","pages":"Article 111007"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complete blood count and systemic inflammation indices in individuals with Alzheimer’s disease: A case-control study","authors":"Jéssica A.G. Tosatti ,&nbsp;Jessica D. Pereira ,&nbsp;Cristina M.G. Loures ,&nbsp;Vanêssa G. Fraga ,&nbsp;Carolina A. Magalhães ,&nbsp;Rafaela D.A.C. Eugênio ,&nbsp;Henrique C. Guimarães ,&nbsp;Elisa de P.F. Resende ,&nbsp;Leonardo C. de Souza ,&nbsp;Maria das G. Carvalho ,&nbsp;Paulo Caramelli ,&nbsp;Karina B. Gomes","doi":"10.1016/j.jocn.2024.111011","DOIUrl":"10.1016/j.jocn.2024.111011","url":null,"abstract":"<div><div>Alzheimer’s disease (AD) is the most common cause of dementia, characterized by progressive cognitive and functional decline and is associated with aging. Chronic inflammatory processes are also involved in its the etiology, as the consequence or cause of proteinopathy (amyloid and tau load in the brain). This study aimed to investigate the complete blood count and systemic inflammation indices in 61 individuals with AD, compared to 59 cognitively healthy individuals as controls. The diagnosis of AD dementia was based on the NIA-AA criteria and patients presented biomarkers in the cerebrospinal fluid compatible with the diagnosis of AD. The complete blood count (CBC) was conducted using an automated system. The neutrophil count (p = 0.011), neutrophil-to-lymphocyte ratio (p = 0.023), and Systemic Inflammation Response Index (SIRI) (p = 0.044) were significantly higher, whereas the lymphocyte count (p = 0.018) and platelet count (p = 0.038) were significantly lower in the AD group compared to the control group. After a multivariate<!--> <!-->generalized linear model analyses, neutrophils count and SIRI maintained significant difference between the groups, even after correcting for age, sex, body mass index and ApoE ε4 carrier status. The overall results suggest that AD is associated with a low-grade pro-inflammatory profile, characterized by alterations in blood inflammatory and immune cells, leading to a higher systemic inflammatory index. The CBC and its derived inflammatory indices, routinely obtained in clinical practice, have potential utility in the context of AD.</div></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"132 ","pages":"Article 111011"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of cannabis on brain activity in males: Quantitative electroencephalography and its relationship with duration, dosage, and age of onset","authors":"Neda Vahed ,&nbsp;Mohammad Bagher Saberizafarghandi ,&nbsp;Hamed Bashirpour ,&nbsp;Hamid Reza Ahmadkhaniha ,&nbsp;Reza Arezoomandan","doi":"10.1016/j.jocn.2024.110982","DOIUrl":"10.1016/j.jocn.2024.110982","url":null,"abstract":"<div><h3>Objective</h3><div>Brain function changes as a result of cannabis use. This study examined the brain activity of cannabis users compared to a healthy group and nicotine smokers, focusing on the age of onset, duration of use, and dosage.</div></div><div><h3>Method</h3><div>Demographic and quantitative electroencephalography (QEEG) data of 15 healthy individuals, 20 patients with chronic cannabis use, and 15 nicotine smokers were collected and recorded during the eyes-closed and eyes-open conditions in the resting state. The data were analyzed using MATLAB software and the EEGLAB toolbox.</div></div><div><h3>Results</h3><div>In the eyes-closed condition, cannabis users exhibited significantly elevated relative theta band power in widespread brain regions compared to both the healthy group and nicotine smokers. They showed decreased relative power in the beta and gamma bands in the parietal and occipital regions when compared to nicotine smokers. In the eyes-open condition, cannabis users displayed increased relative theta band power in widespread brain regions relative to both groups. Additionally, lower relative power in the beta and gamma bands was observed in cannabis users compared to the healthy group in the frontal region, as well as in various brain regions compared to nicotine smokers. A significant relationship was identified between gamma-band power, age of onset, and dosage of cannabis use.</div></div><div><h3>Conclusion</h3><div>These findings suggest that cannabis use leads to changes in brain wave patterns during the resting state, which may be linked to cognitive impairments affecting functions. Understanding these associations is essential for developing effective intervention programs aimed at mitigating cognitive deficits related to cannabis use.</div></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"132 ","pages":"Article 110982"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative pupillometry as a potential biomarker in early concussion assessment","authors":"Moez M.I. Bashir ,&nbsp;DaiWai M. Olson ,&nbsp;Natassia T. Miller ,&nbsp;Stephen C. Bunt ,&nbsp;C. Munro Cullum","doi":"10.1016/j.jocn.2024.111003","DOIUrl":"10.1016/j.jocn.2024.111003","url":null,"abstract":"<div><h3>Background</h3><div>There are limited objective methods when it comes to identifying and diagnosing concussion. Pupil assessment is performed routinely as a standard-of-care following traumatic brain injury (TBI). Unlike the highly subjective and limited reliability of pupil assessment using penlights and flashlights, Quantitative pupillometry (QP) is an established, valid, and reliable method of pupillary assessment. This study aims to investigate the use of QP values in concussion evaluation.</div></div><div><h3>Methods</h3><div>This observational study analyzed data collected by the North Texas Concussion Registry (ConTex). ConTex enrolls subjects who are &gt;5-years of age and clinically diagnosed with concussion. Subjects are excluded if they had moderate or severe traumatic brain injury, spinal cord injury with an American Spinal Injury Association score of C or worse, or if the injury occurred &gt; 6 months from enrollment. Data included demographics, medical history, time since concussion, the Sport Concussion Assessment Tool (SCAT5©) post-concussion symptom scale (PCSS), and QP assessment using the PLR3000® (Neuroptics Inc.) hand-held pupillometer. This study identified all subjects clinically diagnosed with concussion who had completed QP assessment, totaling 162. We created tertiles to describe the lowest (0–20), middle (21–43), and the highest (44–113) symptom score groupings to examine QP data.</div></div><div><h3>Results</h3><div>Of 162 subjects, 88 were female (54.3%), with a mean age of 15.8 (SD=6.9) years. Most (49.4%) occurrences were sport-related injuries. The mean time since injury was 21 (SD=28.6) days. The mean SCAT5 PCSS score was 37.3 (SD=25.6). A significant difference within average and maximum constriction velocities (p=.041 and 0.034, respectively) was found between subjects seen early (&lt;2weeks) versus late (&gt;2weeks) after injury. Pupillometry values were statistically different across SCAT5 PCSS tertiles for anisocoria after light exposure (p=.046).</div></div><div><h3>Conclusions</h3><div>This exploratory study is among the first to show that certain QP values — latency of constriction, constriction velocity, and average dilation velocity — may be useful in providing objective metrics when evaluating more symptomatic concussion.</div></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"132 ","pages":"Article 111003"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating single-level vs. multi-level lateral lumbar interbody fusion: Clinical outcomes and complications","authors":"Akihiko Hiyama,&nbsp;Daisuke Sakai,&nbsp;Hiroyuki Katoh,&nbsp;Masato Sato,&nbsp;Masahiko Watanabe","doi":"10.1016/j.jocn.2025.111082","DOIUrl":"10.1016/j.jocn.2025.111082","url":null,"abstract":"<div><h3>Objective</h3><div>Lateral Lumbar Interbody Fusion (LLIF) treats lumbar degenerative diseases (LDD) with spinal alignment and decompression advantages but can cause sensory and motor disturbances, especially in multilevel procedures. This study compares single-level and multi-level LLIF focusing on sensory and motor disturbances, surgical duration, and quality of life (QOL).</div></div><div><h3>Methods</h3><div>A retrospective review of 139 patients (84 males, 55 females; average age 70 years) with LDD who underwent LLIF and posterior fixation between May 2018 and January 2023 was conducted. Patients were divided into two groups: 89 patients who underwent single-level LLIF and 50 patients who underwent multi-level LLIF (two or more levels). Data on demographics, surgical details, perioperative complications, and clinical outcomes, including pain scores (Numeric Rating Scales: NRS) and QOL assessments (Japanese Orthopaedic Association Back Pain Evaluation Questionnaire: JOABPEQ), were collected preoperatively and one year postoperatively. Statistical analysis was performed to compare the outcomes between the two groups.</div></div><div><h3>Results</h3><div>Patients who underwent multi-level LLIF had significantly longer operative times (145.1 min vs. 98.9 min, <em>p</em> &lt; 0.001) and higher estimated blood loss (126.5 mL vs. 62.9 mL, <em>p</em> &lt; 0.001) compared with the single-level group. Both groups significantly improved pain intensity and QOL, including NRS and JOABPEQ score, with no significant differences in perioperative complication rates (cage subsidence, motor paralysis, thigh pain/numbness) or revision rates (4 % vs. 8 %, <em>p</em> = 0.396).</div></div><div><h3>Conclusions</h3><div>Short-term clinical outcomes suggested that both single-level and multi-level LLIF effectively improved pain and QOL outcomes in patients with LDD.</div></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"134 ","pages":"Article 111082"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is time perception Different in focal vs. Generalized Epilepsy?","authors":"Prateek Kumar Panda,&nbsp;Indar Kumar Sharawat","doi":"10.1016/j.jocn.2025.111047","DOIUrl":"10.1016/j.jocn.2025.111047","url":null,"abstract":"","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"132 ","pages":"Article 111047"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endovascular thrombectomy for large vessel occlusion in acute ischemic stroke patients with concomitant intracranial hemorrhage","authors":"Mohamed Elfil ,&nbsp;Lilian Maria Godeiro Coelho ,&nbsp;Haneen Sabet ,&nbsp;Ahmed Bayoumi ,&nbsp;Abdallah Abbas ,&nbsp;Tiffany Eatz ,&nbsp;Mohammad Aladawi ,&nbsp;Zaid Najdawi ,&nbsp;Priya Nidamanuri ,&nbsp;Sidra Saleem ,&nbsp;Lisa Surowiec ,&nbsp;Amer Malik","doi":"10.1016/j.jocn.2025.111093","DOIUrl":"10.1016/j.jocn.2025.111093","url":null,"abstract":"<div><h3>Background</h3><div>Endovascular thrombectomy (EVT) is the gold standard for acute ischemic stroke (AIS) with large vessel occlusion (LVO). However, concomitant intracranial hemorrhage (ICH) might render AIS-LVO patients ineligible for EVT in real-life practice.</div></div><div><h3>Objective</h3><div>To provide robust evidence regarding the outcomes of EVT in AIS-LVO patients with concomitant ICH.</div></div><div><h3>Methods</h3><div>We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and the Cochrane Handbook for Systematic Reviews of Interventions. Data analysis was performed using OpenMetaAnalyst software. We assessed the pooled incidence rate with a 95 % confidence interval (CI) for qualitative data and analyzed the pooled mean difference (MD) with a 95 % CI for continuous data. The pooled effect size for all outcomes was calculated using the DerSimonian and Laird random-effects model.</div></div><div><h3>Results</h3><div>Six studies were included in the <em>meta</em>-analysis. The overall incidence rate of successful revascularization was 85.3 % (95 % CI: 75.8 %-94.7 %), with rates of 76.1 % for ipsilateral hemorrhages and 66.1 % for contralateral hemorrhages. Functional independence was achieved in 20 % of patients (95 % CI: 4.8 %-36.8 %), with rates of 23 % for ipsilateral and 27.7 % for contralateral hemorrhages. Mortality was reported at 52 % (95 % CI: 34.9 %-69 %), with a higher rate of 52.6 % for ipsilateral hemorrhages compared to 36.8 % for contralateral hemorrhages.</div></div><div><h3>Conclusion</h3><div>This <em>meta</em>-analysis indicates that EVT is feasible in AIS patients with concurrent ICH, yet it is associated with poor functional outcomes and high mortality rates. Careful patient selection is essential to optimize the outcomes, and further research is needed to enhance outcomes for these high-risk patients.</div></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"134 ","pages":"Article 111093"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}