Journal of Clinical Neuroscience最新文献

{"title":"Unlocking therapeutic synergy: IDH inhibitors and immunotherapy combination in preclinical and clinical IDH mutant glioma models − A systematic review","authors":"Manjeera Ramadas ,&nbsp;Nikhitha Jacob ,&nbsp;Malaka Ameratunga ,&nbsp;Lucy Gately","doi":"10.1016/j.jocn.2025.111281","DOIUrl":"10.1016/j.jocn.2025.111281","url":null,"abstract":"<div><div>(1) Background: Over 80 % of low-grade gliomas have IDH mutations, leading to 2-hydroxyglutarate accumulation, an oncometabolite that promotes gliomagenesis by altering metabolism and impairing anti-tumour immunity. Previously, treatment options included surgical resection (debulking) with or without chemo/radiotherapy based on tumour risk. Vorasidenib, an IDH inhibitor (IDHi), demonstrates promising activity in IDH-mutant low-grade gliomas. While immunotherapy has succeeded in other solid tumours, its efficacy as a single agent in gliomas remains limited. This review explores potential synergies between IDHi and immunotherapy in IDH-mutant glioma across preclinical and clinical studies; (2) Methods: A systematic review (Prospero: CRD42024523861) was performed using Medline, Cochrane, EMBASE and <span><span>ClinicalTrials.Gov</span><svg><path></path></svg></span>. Findings were summarised using descriptive analysis without <em>meta</em>-analysis; (3) Results: This review included four preclinical murine and two clinical studies. Preclinical findings suggest that combining IDHi with immunotherapy enhances anti-tumour immunity and survival. Clinical trials are underway, but limitations include small sample sizes and treatment heterogeneity; (4) Conclusions: The high certainty of evidence and satisfactory risk of bias provide further rationale for future research investigating this combination, including larger randomised, blinded studies with standardised treatment regimens to validate preclinical findings and enhance translational relevance. Moreover, future preclinical studies should integrate multiple cell-line models, including patient-derived models.</div></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"136 ","pages":"Article 111281"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143890894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mibrain cystic pilocytic astrocytoma","authors":"Ali Alkhaibary ,&nbsp;Amani AbuHassan ,&nbsp;Moutasem Azzubi","doi":"10.1016/j.jocn.2025.111291","DOIUrl":"10.1016/j.jocn.2025.111291","url":null,"abstract":"<div><h3>Background</h3><div>Pilocytic astrocytoma is a well-circumscribed tumor of the central nervous system (CNS WHO grade I), commonly affecting children. Pilocytic astrocytoma frequently arises from the cerebellum or cerebrum. Pilocytic astrocytoma arising from the brainstem is rare, accounting for 10 % of the cases. We hereby report a patient with midbrain cystic pilocytic astrocytoma.</div></div><div><h3>Case description</h3><div>An 8-year-old girl presented with left-sided upper and lower limbs weakness, facial deviation, and multiple episodes of headache and vomiting for one week. The neurological examination revealed a left-sided hemiparesis (Power: 3/5) and facial weakness (House-Brackman II). Brain MRI showed an expansile cystic lesion with a mural nodule in the right side of the midbrain<strong>.</strong> The patient underwent stereotactic biopsy of the solid lesion and aspiration of the cystic component. The histopathological sections were compatible with pilocytic astrocytoma; CNS WHO grade 1. Post-operatively, the patient’s hemiparesis and facial asymmetry improved immediately. She was commenced on chemotherapy and discharged with periodic clinicoradiological follow-up.</div></div><div><h3>Conclusion</h3><div>Midbrain cystic pilocytic astrocytoma is rare and is considered a surgical challenge. The present article describes the clinical and radiological appearance of a patient with midbrain cystic pilocytic astrocytoma.</div></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"136 ","pages":"Article 111291"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143890891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical comparison of flow diversion and microsurgery for retreatment of intracranial aneurysms","authors":"Samer S. Hoz ,&nbsp;Li Ma ,&nbsp;Prateek Agarwal ,&nbsp;Rachel C. Jacobs ,&nbsp;Alhamza R. Al-Bayati ,&nbsp;Raul G. Nogueira ,&nbsp;Georgios A. Zenonos ,&nbsp;Paul A. Gardner ,&nbsp;Robert M. Friedlander ,&nbsp;Michael J. Lang ,&nbsp;Bradley A. Gross","doi":"10.1016/j.jocn.2025.111296","DOIUrl":"10.1016/j.jocn.2025.111296","url":null,"abstract":"<div><h3>Background</h3><div>The goal of aneurysm retreatment is effective, durable obliteration. Flow diversion (FD) and microsurgical clipping generally represent two aneurysm treatment options with high obliteration rates. However, their relative efficacy in aneurysm retreatment has been infrequently evaluated. We thus sought to compare the radiographic and neurological outcomes of microsurgery to FD for retreatment of intracranial aneurysms (IA)s.</div></div><div><h3>Method</h3><div>A single institution database was reviewed to identify patients undergoing retreatment for IAs over a two-year period via either FD or microsurgery. Obliteration rates and neurological outcomes were compared between the two retreatment modalities and across subgroups. Impact of retreatment modality was adjusted via multivariate logistic regression analyses.</div></div><div><h3>Results</h3><div>Sixty-seven retreatments were identified, 60 % via microsurgery and 40 % via FD. Microsurgery was more commonly performed for anterior communicating artery (Acomm) aneurysms (<em>p</em> = 0.04), residual size &lt; 10 mm (<em>p</em> = 0.02), and aneurysms initially treated endovascularly (<em>p</em> = 0.02). FD was more commonly performed for ICA aneurysms (<em>p</em> = 0.01) and residual size &gt; 10 mm (<em>p</em> = 0.02). Angiographic obliteration rates and neurological outcome were similar overall between the two retreatment modalities at a median follow-up of 26 months. Raymond I obliteration after 12-month follow-up was 94.9 % after microsurgery and 95.2 % after FD (<em>p</em> = 1.00). Good neurological outcome (mRS 0–2) was similar between FD and microsurgery (92.6 % versus 90 %, <em>p</em> = 1.00). Comparable outcomes were observed across several subgroups, including previously ruptured aneurysms and aneurysms requiring retreatment within 6 months. Compared with a 10 % major complication rate after microsurgery, no major events occurred after FD (<em>p</em> = 0.14).</div></div><div><h3>Conclusion</h3><div>FD is an appropriate endovascular option for IA retreatment, with comparable efficacy and neurological outcome to microsurgery at 2-year follow-up. Longer-term follow-up will be critical to more accurately determine therapeutic efficacy.</div></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"136 ","pages":"Article 111296"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143895620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A randomized controlled Trial of telerehabilitation intervention for acute ischemic stroke patients Post-Discharge","authors":"Shihao Sun ,&nbsp;Yu Li ,&nbsp;Gang Zhang ,&nbsp;Yong Zhang ,&nbsp;Jun Dong","doi":"10.1016/j.jocn.2025.111245","DOIUrl":"10.1016/j.jocn.2025.111245","url":null,"abstract":"<div><h3>Background</h3><div>The acute ischemic stroke (AIS) represents a significant contributor to global disability and mortality rates. Effective rehabilitation interventions play a critical role in enhancing patients’ functional recovery and overall quality of life. With the advancement of telemedicine technology, post-discharge telerehabilitation interventions are becoming increasingly feasible, yet their efficacy requires validation through randomized controlled trials (RCT). This study aimed to evaluate the efficacy of a 12-week telerehabilitation program compared to standard post-discharge care in AIS patients.</div></div><div><h3>Methods</h3><div>This study employed a randomized controlled design, enrolling 200 patients who had been discharged after an AIS. Participants were randomly assigned to either the intervention group or the control group in a 1:1 ratio. The intervention group received a 12-week telerehabilitation program, which included a personalized rehabilitation training plan, regular video consultations, and health education. The control group received standard post-discharge care, which consisted of a rehabilitation manual and biweekly outpatient follow-ups for up to 12 weeks. The primary outcome measure was the Barthel Index, assessing patients’ ability to perform activities of daily living. Secondary outcome measures included the modified Rankin Scale (mRS, assessing the degree of disability), Hamilton Depression Rating Scale (HAMD, assessing the patients’ mental health status), and World Health Organization Quality of Life-BREF (WHOQOL-BREF, assessing the patients’ quality of life).</div></div><div><h3>Results</h3><div>The mean score of the Barthel Index in the intervention group improved significantly from a baseline of 65.4 ± 12.3 to 88.7 ± 9.6, while the control group improved from 65.6 ± 12.1 to 74.9 ± 13.2 (P &lt; 0.001). The mRS showed that 75 patients (75 %) in the intervention group achieved scores of 0–2 (no symptoms or mild disability), compared to 62 patients (62 %) in the control group, with significant improvement in the intervention group (P = 0.003). The HAMD scores indicated a significant reduction from a baseline of 17.5 ± 4.2 to 9.6 ± 3.1 in the intervention group, compared to a reduction from 17.3 ± 4.0 to 13.2 ± 4.5 in the control group (P &lt; 0.001). The WHOQOL-BREF scores in the intervention group were significantly higher than those in the control group across all four domains: physical health, psychological health, social relationships, and environment (P &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>The findings of this study support telerehabilitation interventions as an effective rehabilitation method, significantly improving the rehabilitation outcomes and quality of life of patients discharged after mild AIS, and potentially reducing the risk of recurrence.</div></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"136 ","pages":"Article 111245"},"PeriodicalIF":1.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143890895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: Efficacy and tolerability of valproate versus topiramate in migraine prevention, a randomized controlled multi-center trial","authors":"Hafsa Shuja ,&nbsp;Umer Wamiq ,&nbsp;Hamida Memon","doi":"10.1016/j.jocn.2025.111286","DOIUrl":"10.1016/j.jocn.2025.111286","url":null,"abstract":"","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"136 ","pages":"Article 111286"},"PeriodicalIF":1.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143886346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical appraisal of “Association between admission serum hemoglobin concentration and the Black Hole Sign on cranial CT in ICH patients: A cross-sectional study”","authors":"Ahmed Mueed,&nbsp;Izaan Zaheer","doi":"10.1016/j.jocn.2025.111292","DOIUrl":"10.1016/j.jocn.2025.111292","url":null,"abstract":"","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"136 ","pages":"Article 111292"},"PeriodicalIF":1.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143886347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-based carotid plaque characteristics combined with dynamic cerebral autoregulation: An imaging biomarker for cerebral ischemic events in patients with severe carotid artery stenosis","authors":"Na Li ,&nbsp;Fubo Zhou ,&nbsp;Songwei Chen ,&nbsp;Liuping Cui ,&nbsp;Hongxiu Chen ,&nbsp;Yingqi Xing","doi":"10.1016/j.jocn.2025.111280","DOIUrl":"10.1016/j.jocn.2025.111280","url":null,"abstract":"<div><h3>Background</h3><div>Atherosclerotic stenosis of the carotid artery is a major cause of ischemic stroke. We aimed to identify extracranial and intracranial features associated with cerebral ischemic events in patients with severe carotid artery stenosis using carotid ultrasonography and transcranial Doppler.</div></div><div><h3>Methods</h3><div>We retrospectively enrolled 130 patients with severe carotid artery stenosis and 45 age- and sex-matched healthy controls. Extracranial carotid artery parameters included carotid plaque morphology, echogenicity, and the gray-scale median (GSM). Intracranial features, mainly dynamic cerebral autoregulation (dCA), were assessed using transfer function analysis. Correlations between extracranial and intracranial parameters and cerebral ischemic events were analyzed using univariate and multivariate logistic regression analyses. Receiver operating characteristic (ROC) curves were compared.</div></div><div><h3>Results</h3><div>Sixty-six patients (50.8 %) experienced cerebral ischemic events upon admission. Extracranial features (proportion of ulcerated plaques and echogenicity classification) significantly differed between the asymptomatic and symptomatic groups. The mean GSM of carotid plaques (48.9 ± 17.3 vs. 62.1 ± 18.3, <em>P &lt;</em> 0.001) and intracranial parameters were significantly lower in the symptomatic group. Plaque ulceration, hypoechoic plaques, and impaired dCA [lower ipsilateral phase at very-low frequency (VLF)] were independently associated with cerebral ischemic events in patients with severe carotid artery stenosis. The combined GSM and ipsilateral phase at VLF had the highest area under the ROC curve (0.784).</div></div><div><h3>Conclusions</h3><div>Combined extracranial and intracranial assessments may help predict cerebral ischemic events in patients with severe carotid artery stenosis. Ultrasound-based carotid plaque characteristics, combined with dynamic cerebral autoregulation, could be imaging biomarkers of cerebral ischemic events in patients with severe carotid artery stenosis.</div></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"136 ","pages":"Article 111280"},"PeriodicalIF":1.9,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143886345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing Intracranial Aneurysm Detection: A Comprehensive Systematic Review and Meta-analysis of Deep Learning Models Performance, Clinical Integration, and Future Directions","authors":"Niloufar Delfan ,&nbsp;Fatemeh Abbasi ,&nbsp;Negar Emamzadeh ,&nbsp;Amirmohammad Bahri ,&nbsp;Mansour Parvaresh Rizi ,&nbsp;Alireza Motamedi ,&nbsp;Behzad Moshiri ,&nbsp;Arad Iranmehr","doi":"10.1016/j.jocn.2025.111243","DOIUrl":"10.1016/j.jocn.2025.111243","url":null,"abstract":"<div><h3>Background</h3><div>Cerebral aneurysms pose a significant risk to patient safety, particularly when ruptured, emphasizing the need for early detection and accurate prediction. Traditional diagnostic methods, reliant on clinician-based evaluations, face challenges in sensitivity and consistency, prompting the exploration of deep learning (DL) systems for improved performance.</div></div><div><h3>Methods</h3><div>This systematic review and meta-analysis assessed the performance of DL models in detecting and predicting intracranial aneurysms compared to clinician-based evaluations. Imaging modalities included CT angiography (CTA), digital subtraction angiography (DSA), and time-of-flight MR angiography (TOF-MRA). Data on lesion-wise sensitivity, specificity, and the impact of DL assistance on clinician performance were analyzed. Subgroup analyses evaluated DL sensitivity by aneurysm size and location, and interrater agreement was measured using Fleiss’ κ.</div></div><div><h3>Results</h3><div>DL systems achieved an overall lesion-wise sensitivity of 90 % and specificity of 94 %, outperforming human diagnostics. Clinician specificity improved significantly with DL assistance, increasing from 83 % to 85 % in the patient-wise scenario and from 93 % to 95 % in the lesion-wise scenario. Similarly, clinician sensitivity also showed notable improvement with DL assistance, rising from 82 % to 96 % in the patient-wise scenario and from 82 % to 88 % in the lesion-wise scenario. Subgroup analysis showed DL sensitivity varied with aneurysm size and location, reaching 100 % for aneurysms larger than 10 mm. Additionally, DL assistance improved interrater agreement among clinicians, with Fleiss’ κ increasing from 0.668 to 0.862.</div></div><div><h3>Conclusions</h3><div>DL models demonstrate transformative potential in managing cerebral aneurysms by enhancing diagnostic accuracy, reducing missed cases, and supporting clinical decision-making. However, further validation in diverse clinical settings and seamless integration into standard workflows are necessary to fully realize the benefits of DL-driven diagnostics.</div></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"136 ","pages":"Article 111243"},"PeriodicalIF":1.9,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal alterations induced by amyotrophic lateral sclerosis: An analysis using optical coherence tomography","authors":"Yue Bu ,&nbsp;Yanchun Yuan ,&nbsp;Fan Hu ,&nbsp;Qianqian Zhao ,&nbsp;Cailin He ,&nbsp;Linxin Tang ,&nbsp;Yongchao Li ,&nbsp;Ziqin Liu ,&nbsp;Ling Weng ,&nbsp;Juan Du ,&nbsp;Jifeng Guo ,&nbsp;Lu Shen ,&nbsp;Jianming Li ,&nbsp;Jiping Yi ,&nbsp;Wenfeng Cao ,&nbsp;Renshi Xu ,&nbsp;Beisha Tang ,&nbsp;Junling Wang","doi":"10.1016/j.jocn.2025.111268","DOIUrl":"10.1016/j.jocn.2025.111268","url":null,"abstract":"<div><h3>Objective</h3><div>In this study, we aimed to investigate retinal changes in a large cohort of amyotrophic lateral sclerosis (ALS) patients and healthy controls (HCs) to further elucidate their relationship with ALS.</div></div><div><h3>Methods</h3><div>This was a cross-sectional observational study. We evaluated retinal layer thickness in 134 ALS patients and 66 HCs using optical coherence tomography (OCT). Particularly, we focused on the macular region and peripapillary retinal nerve fiber layer (p-RNFL).</div></div><div><h3>Results</h3><div>The examination of retinal layers in ALS patients revealed a significant change in the inner nuclear layer (INL), with a pattern of initial thickening followed by thinning, which correlated with disease stages, most notably in the inner nasal quadrant. Moreover, the p-RNFL in the temporal quadrant was thinner in ALS patients compared to HCs. In addition, ALS patients who developed bulbar symptoms exhibited marginally thinner p-RNFL in the temporal quadrant compared to those without bulbar symptoms. Interestingly, a thinner p-RNFL in the temporal quadrant did not correlate with faster disease progression.</div></div><div><h3>Conclusion</h3><div>This study reveals notable changes in the INL and p-RNFL thickness in ALS patients, highlighting the intricate relationship between retinal changes and ALS progression. Despite these retinal alterations, no correlation with disease progression rate was observed. These findings suggest that while OCT shows potential in monitoring ALS, its role in predicting disease course requires further investigation with long-term longitudinal studies and diverse patient cohorts.</div></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"136 ","pages":"Article 111268"},"PeriodicalIF":1.9,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Same-day mask-based gamma-knife stereotactic radiosurgery: workflow analysis and impact","authors":"Mark Mizrachi ,&nbsp;Iñigo L. Sistiaga ,&nbsp;Benjamin Hartley ,&nbsp;Eric Hintz ,&nbsp;Jessica S. Jung ,&nbsp;Emel Calugaru ,&nbsp;Anuj Goenka ,&nbsp;Michael Schulder","doi":"10.1016/j.jocn.2025.111277","DOIUrl":"10.1016/j.jocn.2025.111277","url":null,"abstract":"<div><h3>Objective</h3><div>Over the last 30 years, there has been a steady move towards the use of mask immobilization in SRS. Benefits of masks include the ability to hypofractionate SRS and improved patient comfort. However, there has been criticism that it eliminates the possibility of same-day, “wheels in to wheels out” treatments, as mask fixation is traditionally done on a separate day. This study evaluates the feasibility of doing mask fabrication and SRS treatment on the same day.</div></div><div><h3>Methods</h3><div>Patients who underwent SRS from September 2020 to June 2021 were reviewed. Leksell Gamma Knife (LGK) console data were processed, and operator reports were analyzed for treatment time, number of pauses, alarms, and pause durations.</div></div><div><h3>Results</h3><div>A total of 100 patients met the inclusion criteria. 52 patients underwent same-day fabrication and treatment, and 48 patients were treated at least one day following mask fabrication. Same-day patients had more frequent pauses and longer average pause durations than different-day patients. However, there were no significant differences in predicted vs. actual treatment times or the number of treatment alarms between groups.</div></div><div><h3>Conclusion</h3><div>Mask-based SRS can be done safely and efficiently in a single day, mirroring the approach of frame-based treatments. There is an increased number of pauses in the same-day group; however, it does not result in a significant prolongation of treatment time. The reduction in the number of visits to a GK facility for SRS may impact the overall subjective experience, increasing patient satisfaction.</div></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"136 ","pages":"Article 111277"},"PeriodicalIF":1.9,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143874216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}