Journal of Circadian Rhythms最新文献_第2页

Genes Relevant to Tissue Response to Cancer Therapy Display Diurnal Variation in mRNA Expression in Human Oral Mucosa. 与肿瘤治疗相关的组织反应基因在人口腔黏膜mRNA表达中显示出日变化。

Journal of Circadian Rhythms Pub Date : 2021-06-17 DOI: 10.5334/jcr.213

Fangyi Gu, Eduardo Cortes Gomez, Jianhong Chen, Matthew F Buas, Nicolas F Schlecht, Karen Hulme, Shweta Vishwas Kulkarni, Prashant K Singh, Richard O'Connor, Christine B Ambrosone, Anurag K Singh, Jianmin Wang

{"title":"Genes Relevant to Tissue Response to Cancer Therapy Display Diurnal Variation in mRNA Expression in Human Oral Mucosa.","authors":"Fangyi Gu, Eduardo Cortes Gomez, Jianhong Chen, Matthew F Buas, Nicolas F Schlecht, Karen Hulme, Shweta Vishwas Kulkarni, Prashant K Singh, Richard O'Connor, Christine B Ambrosone, Anurag K Singh, Jianmin Wang","doi":"10.5334/jcr.213","DOIUrl":"https://doi.org/10.5334/jcr.213","url":null,"abstract":"Background: To address a critical gap for application of cancer chronotherapy of when would be the best time(s) for treating an individual cancer patient, we conducted a pilot study to characterize diurnal variations of gene expression in oral mucosal tissue, which is vulnerable to damage from cancer therapies.Methods: We conducted RNA-seq assay on individual oral mucosal samples collected from 11 healthy volunteers every 4 hours (6 time points). Using a cosine-based method, we estimated the individual and average values of peak-time and amplitude for each gene. Correlations between gene expression peak-times and age was examined, adjusting for individual's sleep timing.Results: Among candidate gene pathways that are relevant to treatment response, 7 of 16 genes (PER3, CIART, TEF, PER1, PER2, CRY2, ARNTL) involved in circadian regulation and 1 of 118 genes (WEE1) involved in cell cycle regulation achieved p-value ≤ 0.1 and relative amplitude>0.1. The average peak times were approximately 10:15 for PER3, CIART and TEF, 10:45 for PER1, 13:00 for WEE1, PER2 and CRY2, and 19:30 for ARNTL. Ranges in peak times across individuals differed by gene (e.g., 8 hours for PER1; 16.7 hours for WEE1). Older people had later peak times for PER1 (r = 0.77, p = 0.03) and PER3 (r = 0.69, p-value = 0.06).Conclusion: In oral mucosa, expression of some genes relevant to treatment response displayed diurnal variation. These genes may be candidates for development of biomarkers for optimizing individual timing of cancer therapy using non-invasively collected oral mucosa.","PeriodicalId":15461,"journal":{"name":"Journal of Circadian Rhythms","volume":"19 ","pages":"8"},"PeriodicalIF":0.0,"publicationDate":"2021-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39081452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Changes in 24 h Rhythmicity of Spontaneous Locomotor Activity in the Triple Transgenic Mouse for Alzheimer's Disease (3xTg-AD) in a Jet Lag Protocol: Correlations with Retinal Sensitivity. 时差方案中阿尔茨海默病三重转基因小鼠(3xTg-AD) 24小时自发运动活动节律性的变化:与视网膜敏感性的相关性

Journal of Circadian Rhythms Pub Date : 2021-05-27 DOI: 10.5334/jcr.214

Irma Angélica González-Luna, Cinthia Juárez-Tapia, Azucena Aguilar-Vázquez, Edith Arnold, Sofia Díaz-Cintra, Manuel Miranda-Anaya, Mauricio Díaz-Muñoz

{"title":"Changes in 24 h Rhythmicity of Spontaneous Locomotor Activity in the Triple Transgenic Mouse for Alzheimer's Disease (3xTg-AD) in a Jet Lag Protocol: Correlations with Retinal Sensitivity.","authors":"Irma Angélica González-Luna, Cinthia Juárez-Tapia, Azucena Aguilar-Vázquez, Edith Arnold, Sofia Díaz-Cintra, Manuel Miranda-Anaya, Mauricio Díaz-Muñoz","doi":"10.5334/jcr.214","DOIUrl":"https://doi.org/10.5334/jcr.214","url":null,"abstract":"The progression of amyloid plaques and neurofibrillary tangles in different brain areas is associated with the effects of Alzheimer's disease (AD). In addition to cognitive impairment, circadian alterations in locomotor activity have also been detected, but they have not been characterized in a jet lag protocol. Therefore, the present study aimed to compare 3xTg-AD and non-transgenic mice in changes of 24 h cycles of spontaneous locomotor activity in a jet lag protocol, in an environment without a running wheel, at 3 different states of neuronal damage: early, intermediate and advanced (3, 8 and 13 months, respectively). The 3xTg-AD mice at 3 months presented differences in phase angle and acrophase, and differentially increased activity after advances more than after delays. At 13 months, a shortening of the free-running period in constant darkness was also noted. 3xTg-AD mice showed a significant increase (123%) in global activity at 8 to 13 months and in nighttime activity (153%) at 13 months. In the advance protocol (ADV), 3xTg-AD mice displayed a significant increase in global activity (171%) at 8 and 13 months. The differences in masking effect were evident at 8 months. To assess a possible retinal dysfunction that could interfere with photic entrainment as part of the neurodegenerative process, we compared electroretinogram recordings. The results showed early deterioration in the retinal response to light flashes in mesopic conditions, observed in the B-wave latency and amplitude. Thus, our study presents new behavioral and pathological characteristics of 3xTg-AD mice and reveals the usefulness of non-invasive tools in early diagnosis.","PeriodicalId":15461,"journal":{"name":"Journal of Circadian Rhythms","volume":"19 ","pages":"7"},"PeriodicalIF":0.0,"publicationDate":"2021-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8194968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39099538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Tubulin Polymerization Promoting Protein Affects the Circadian Timing System in C57Bl/6 Mice. 微管蛋白聚合促进蛋白影响C57Bl/6小鼠的昼夜节律系统。

Journal of Circadian Rhythms Pub Date : 2021-05-20 DOI: 10.5334/jcr.207

Eric Barbato, Rebecca Darrah, Thomas J Kelley

{"title":"Tubulin Polymerization Promoting Protein Affects the Circadian Timing System in C57Bl/6 Mice.","authors":"Eric Barbato, Rebecca Darrah, Thomas J Kelley","doi":"10.5334/jcr.207","DOIUrl":"https://doi.org/10.5334/jcr.207","url":null,"abstract":"The circadian timing system (CTS) is a complex set of cyclic cellular mechanisms which serve to synchronize discrete cell groups across multiple organ systems to adapt the bodys physiology to a (roughly) 24-hour clock. Many genes and hormones have been shown to be strongly associated with the CTS, some of which include the genes Bmal1, Period1, Period2, Cryptochrome1, and Cryptochrome2, and the hormone melatonin. Previous data suggest that microtubule dynamics play an important role in melatonin function as it relates to the CTS in vitro, though this relationship has never been explored in vivo. The purpose of this study was to determine whether disruption of microtubule regulation in C57Bl/6 mice results in measurable changes to the CTS. To study the potential effects of microtubule dynamics on the CTS in vivo, we utilized a mouse model of microtubule instability, knocked out for the tubulin polymerization promoting protein gene (Tppp -/-), comparing them to their wild type (WT) littermates in three categories: locomotor activity (in light/dark and dark/dark photoperiods), serial clock gene expression, and serial serum melatonin concentration. These comparisons showed differences in all three categories, including significant differences in locomotor characteristics under dark/dark conditions. Our findings support and extend previous reports that microtubule dynamics are a modulator of circadian rhythm regulation likely through a mechanism involving melatonin induced phase shifting.","PeriodicalId":15461,"journal":{"name":"Journal of Circadian Rhythms","volume":"19 ","pages":"5"},"PeriodicalIF":0.0,"publicationDate":"2021-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39040907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

A Functional Adenosine Deaminase Polymorphism Associates with Evening Melatonin Levels and Sleep Quality. 功能性腺苷脱氨酶多态性与晚间褪黑激素水平和睡眠质量有关。

Journal of Circadian Rhythms Pub Date : 2021-04-28 DOI: 10.5334/jcr.209

Jaime L Tartar, Franklin S Hiffernan, Kristine E Freitas, Ana I Fins, Jonathan B Banks

{"title":"A Functional Adenosine Deaminase Polymorphism Associates with Evening Melatonin Levels and Sleep Quality.","authors":"Jaime L Tartar, Franklin S Hiffernan, Kristine E Freitas, Ana I Fins, Jonathan B Banks","doi":"10.5334/jcr.209","DOIUrl":"10.5334/jcr.209","url":null,"abstract":"Increased adenosine levels throughout the day promote sleepiness. A single nucleotide polymorphism (SNP) in the adenosine deaminase ADA gene (rs73598374) has been shown to affect sleep regulation. The extent to which lower ADA enzymatic activity is associated with the homeostatic sleep factor, melatonin, is uncertain. To test this possibility, we assessed the relationship between the ADA polymorphism and evening melatonin levels, as well as self-reported sleep behavior. Given the close relationship between mood and sleep behavior, we further tested the impact of ADA genotype on self-reported mood. We show that relative to the GG homozygotes, the A allele carriers (higher adenosine levels) had significantly higher evening melatonin levels as well as significantly better sleep quality. We further show the correlations between sleep and mood measures were altered by ADA genotype, with a stronger relationship observed in the GG (lower adenosine) group. Combined, these findings advance our understanding of the biochemistry of melatonin production by showing that there is a relationship between ADA genotype and melatonin levels. The differential relationships between sleep and psychological health between the genotype groups may reveal novel insights about the development of genotype-specific progression of various psychological disorders such as chronic anxiety and stress.","PeriodicalId":15461,"journal":{"name":"Journal of Circadian Rhythms","volume":"19 ","pages":"5"},"PeriodicalIF":0.0,"publicationDate":"2021-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8086720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38975952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Daily and Estral Regulation of RFRP-3 Neurons in the Female Mice. 雌性小鼠RFRP-3神经元的日、夜调控。

Journal of Circadian Rhythms Pub Date : 2021-04-15 DOI: 10.5334/jcr.212

Eleni Angelopoulou, Perrine Inquimbert, Paul Klosen, Greg Anderson, Andries Kalsbeek, Valérie Simonneaux

{"title":"Daily and Estral Regulation of RFRP-3 Neurons in the Female Mice.","authors":"Eleni Angelopoulou, Perrine Inquimbert, Paul Klosen, Greg Anderson, Andries Kalsbeek, Valérie Simonneaux","doi":"10.5334/jcr.212","DOIUrl":"https://doi.org/10.5334/jcr.212","url":null,"abstract":"Female reproductive success relies on proper integration of circadian- and ovarian- signals to the hypothalamic-pituitary-gonadal axis in order to synchronize the preovulatory LH surge at the end of the ovarian follicular stage with the onset of the main active period. In this study, we used a combination of neuroanatomical and electrophysiological approaches to assess whether the hypothalamic neurons expressing Arg-Phe amide-related peptide (RFRP-3), a gonadotropin inhibitory peptide, exhibit daily and estrous stage dependent variations in female mice. Furthermore, we investigated whether arginine vasopressin (AVP), a circadian peptide produced by the suprachiamatic nucleus regulates RFRP-3 neurons. The number of c-Fos-positive RFRP-3 immunoreactive neurons is significantly reduced at the day-to-night transition with no difference between diestrus and proestrus. Contrastingly, RFRP neuron firing rate is higher in proestrus as compared to diestrus, independently of the time of the day. AVP immunoreactive fibers contact RFRP neurons with the highest density observed during the late afternoon of diestrus and proestrus. Application of AVP increases RFRP neurons firing in the afternoon (ZT6-10) of diestrus, but not at the same time point of proestrus, indicating that AVP signaling on RFRP neurons may depend on circulating ovarian steroids. Together, these studies show that RFRP neurons integrate both daily and estrogenic signals, which downstream may help to properly time the preovulatory LH surge.","PeriodicalId":15461,"journal":{"name":"Journal of Circadian Rhythms","volume":"19 ","pages":"4"},"PeriodicalIF":0.0,"publicationDate":"2021-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38873531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Regional Differences in Height, Weight, and Body Composition may Result from Photoperiodic Responses: An Ecological Analysis of Japanese Children and Adolescents. 光周期反应可能导致身高、体重和身体成分的地区差异：日本儿童和青少年的生态分析》。

Journal of Circadian Rhythms Pub Date : 2021-02-22 DOI: 10.5334/jcr.198

Masana Yokoya, Aki Terada

{"title":"Regional Differences in Height, Weight, and Body Composition may Result from Photoperiodic Responses: An Ecological Analysis of Japanese Children and Adolescents.","authors":"Masana Yokoya, Aki Terada","doi":"10.5334/jcr.198","DOIUrl":"10.5334/jcr.198","url":null,"abstract":"This ecological study examined whether geographical differences in the physique of Japanese children and adolescents can be explained from the perspective of photoperiodicity induced by effective day length (light duration exceeding a certain threshold of illuminance) using prefecture-level anatomical data and Mesh Climatic Data. Multiple regression analysis for height prediction demonstrated that when controlled by weight, effective day lengths of the longest and shortest months were inversely correlated with height distribution. Conversely, for weight prediction, when controlled by height, the effective day lengths of the longest and shortest months were positively correlated with weight distribution. The regression coefficients were greater for the effective day length of the shortest month in both height and weight prediction. This phenomenon where the same two explanatory variables are negatively correlated with height and positively correlated with weight in a significant manner is rare, and there may be no physiological interpretation of this phenomenon other than one based on changes in thyroid hormone signaling. These distribution characteristics are common to the photoperiodicity by which seasonal breeding vertebrates reciprocally switch thyroid hormone signaling according to prior photoperiodic history through epigenetic functions. From these perspectives, thyroid hormone signaling in a certain region was assumed to be activated in summer according to the prior shorter winter day length and inactivated in winter according to the prior longer summer day length. Regarding the prevalence of obesity, the coexistence of longer summer and winter day lengths was thought to set body composition to be short and fat in early adolescence.","PeriodicalId":15461,"journal":{"name":"Journal of Circadian Rhythms","volume":"19 ","pages":"3"},"PeriodicalIF":0.0,"publicationDate":"2021-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7908924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25439339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metastasis of Breast Cancer Promoted by Circadian Rhythm Disruption due to Light/Dark Shift and its Prevention by Dietary Quercetin in Mice. 小鼠明暗转换引起的昼夜节律紊乱促进乳腺癌转移及槲皮素预防

Journal of Circadian Rhythms Pub Date : 2021-02-18 DOI: 10.5334/jcr.203

Minoru Numata, Akane Hirano, Yukika Yamamoto, Michiko Yasuda, Nobuhiko Miura, Kazutoshi Sayama, Masa-Aki Shibata, Tomohiro Asai, Naoto Oku, Noriyuki Miyoshi, Kayoko Shimoi

{"title":"Metastasis of Breast Cancer Promoted by Circadian Rhythm Disruption due to Light/Dark Shift and its Prevention by Dietary Quercetin in Mice.","authors":"Minoru Numata, Akane Hirano, Yukika Yamamoto, Michiko Yasuda, Nobuhiko Miura, Kazutoshi Sayama, Masa-Aki Shibata, Tomohiro Asai, Naoto Oku, Noriyuki Miyoshi, Kayoko Shimoi","doi":"10.5334/jcr.203","DOIUrl":"https://doi.org/10.5334/jcr.203","url":null,"abstract":"Epidemiological studies have indicated that a disturbed circadian rhythm resulting from night-shift work is a potential risk factor for breast cancer. However, the mechanism of increased risk of breast cancer by night-shift work remains unclear, and there have been few in vivo studies conducted to definitively associate the two factors. In this study, BJMC3879Luc2 mouse breast cancer cells were transplanted into BALB/c mice. Mice were maintained under lighting conditions that modeled the two-shift system and were investigated for the effect of light/dark cycle disruption on tumor growth and lymph node metastasis. Circadian dysfunction, which was confirmed by measuring circadian locomotor activities using a nano tag device in our light/dark shift model, did not affect tumor growth. However, a significant increase in the number of lymph nodes with distant metastasis was observed. Neutrophil-to-lymphocyte ratio, which is an adverse prognostic factor of breast cancer and also indicator of inflammation, also increased. It has been demonstrated that a chronic inflammatory response is associated with cancer malignancy and poor prognosis in various cancers. These results suggest that night-shift work may also affect distant metastasis and prognosis. In addition, we investigated whether dietary quercetin has anti-metastatic activity against light/dark shift-induced metastasis. A diet containing 0.3 % quercetin significantly inhibited distant lymph node metastasis, particularly metastasis to the iliac and kidney lymph nodes. Our results contribute to our understandings of the effects of the external light environment on breast cancer metastasis and provide a glimpse into potential protective effects of dietary quercetin on light/dark disturbance-induced metastasis.","PeriodicalId":15461,"journal":{"name":"Journal of Circadian Rhythms","volume":"19 ","pages":"2"},"PeriodicalIF":0.0,"publicationDate":"2021-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7894366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25405626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Sleep, Circadian Rhythmicity and Response to Chronotherapy in University Students: Tips from Chronobiology Practicals. 大学生睡眠、昼夜节律和对时间疗法的反应:来自时间生物学实践的提示。

Journal of Circadian Rhythms Pub Date : 2021-01-21 DOI: 10.5334/jcr.202

Sara Montagnese, Lisa Zarantonello, Chiara Formentin, Christian Zancato, Maria Beatrice Bonetto, Alberto Biscontin, Paola Cusumano, Rodolfo Costa

{"title":"Sleep, Circadian Rhythmicity and Response to Chronotherapy in University Students: Tips from Chronobiology Practicals.","authors":"Sara Montagnese, Lisa Zarantonello, Chiara Formentin, Christian Zancato, Maria Beatrice Bonetto, Alberto Biscontin, Paola Cusumano, Rodolfo Costa","doi":"10.5334/jcr.202","DOIUrl":"https://doi.org/10.5334/jcr.202","url":null,"abstract":"Chronobiology is not routinely taught to biology or medical students in most European countries. Here we present the results of the chronobiology practicals of a group of students of the University of Padova, with a view to highlight some interesting features of this group, and to share a potentially interesting cross-faculty teaching experience. Thirty-eight students (17 males; 22.9 ± 1.6 yrs) completed a set of self-administered electronic sleep quality [Pittsburgh Sleep Quality Index (PSQI)], chronotype and sleepiness [Epworth Sleepiness Scale (ESS)] questionnaires. They then went on to complete sleep diaries for two weeks. Sixteen also wore an actigraph, 8 wore wireless sensors for skin temperature, and 8 underwent a course of chronotherapy aimed at anticipating their sleep-wake timing. Analyses were performed as practicals, together with the students. Average PSQI score was 5.4 ± 1.9, with 15 (39%) students being poor sleepers. Average ESS score was 6.5 ± 3.3, with 3 (8%) students exhibiting excessive daytime sleepiness. Seven classified themselves as definitely/moderately morning, 25 as intermediates, 6 as moderately/definitely evening. Students went to bed/fell asleep significantly later on weekends, it took them less to fall asleep and they woke up/got up significantly later. Diary-reported sleep onset time coincided with the expected decrease in proximal skin temperature. Finally, during chronotherapy they took significantly less time to fall asleep. In conclusion, significant abnormalities in the sleep-wake patterns of a small group of university students were observed, and the students seemed to benefit from chronotherapy. We had a positive impression of our teaching experience, and the chronobiology courses obtained excellent student feedback.","PeriodicalId":15461,"journal":{"name":"Journal of Circadian Rhythms","volume":"19 ","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25341905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Peripheral Circadian Clock and Exercise: Lessons from Young and Old Mice. 外周生物钟和运动:来自年轻和年老小鼠的经验教训。

Journal of Circadian Rhythms Pub Date : 2020-12-16 DOI: 10.5334/jcr.201

Danielle R Bruns, Musharraf Yusifova, Nicholas A Marcello, Carly J Green, Whitney J Walker, Emily E Schmitt

{"title":"The Peripheral Circadian Clock and Exercise: Lessons from Young and Old Mice.","authors":"Danielle R Bruns, Musharraf Yusifova, Nicholas A Marcello, Carly J Green, Whitney J Walker, Emily E Schmitt","doi":"10.5334/jcr.201","DOIUrl":"https://doi.org/10.5334/jcr.201","url":null,"abstract":"Critical biological processes are under control of the circadian clock. Disruption of this clock, e.g. during aging, results in increased risk for development of chronic disease. Exercise is a protective intervention that elicits changes in both age and circadian pathologies, yet its role in regulating circadian gene expression in peripheral tissues is unknown. We hypothesized that voluntary wheel running would restore disrupted circadian rhythm in aged mice. We analyzed wheel running patterns and expression of circadian regulators in male and female C57Bl/6J mice in adult (~4 months) and old (~18 months) ages. As expected, young female mice ran further than male mice, and old mice ran significantly less than young mice. Older mice of both sexes had a delayed start time in activity which likely points to a disrupted diurnal running pattern and circadian disruption. Voluntary wheel running rescued some circadian dysfunction in older females. This effect was not present in older males, and whether this was due to low wheel running distance or circadian output is not clear and warrants a future study. Overall, we show that voluntary wheel running can rescue some circadian dysfunction in older female but not male mice; and these changes are tissue dependent. While voluntary running was not sufficient to fully rescue age-related changes in circadian rhythm, ongoing studies will determine if forced exercise (e.g. treadmill) and/or chrono-timed exercise can improve age-related cardiovascular, skeletal muscle, and circadian dysfunction.","PeriodicalId":15461,"journal":{"name":"Journal of Circadian Rhythms","volume":"18 ","pages":"7"},"PeriodicalIF":0.0,"publicationDate":"2020-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38770579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Healthcare Shift Workers' Temporal Habits for Eating, Sleeping, and Light Exposure: A Multi-Instrument Pilot Study. 医疗轮班工作者进食、睡眠和光照的时间习惯:一项多仪器试点研究。

Journal of Circadian Rhythms Pub Date : 2020-10-21 DOI: 10.5334/jcr.199

Chiahui Chen, Taha ValizadehAslani, Gail L Rosen, Laura M Anderson, Carla R Jungquist

{"title":"Healthcare Shift Workers' Temporal Habits for Eating, Sleeping, and Light Exposure: A Multi-Instrument Pilot Study.","authors":"Chiahui Chen, Taha ValizadehAslani, Gail L Rosen, Laura M Anderson, Carla R Jungquist","doi":"10.5334/jcr.199","DOIUrl":"https://doi.org/10.5334/jcr.199","url":null,"abstract":"Background: Circadian misalignment can impair healthcare shift workers' physical and mental health, resulting in sleep deprivation, obesity, and chronic disease. This multidisciplinary research team assessed eating patterns and sleep/physical activity of healthcare workers on three different shifts (day, night, and rotating-shift). To date, no study of real-world shift workers' daily eating and sleep has utilized a largely-objective measurement.Method: During this fourteen-day observational study, participants wore two devices (Actiwatch and Bite Technologies counter) to measure physical activity, sleep, light exposure, and eating time. Participants also reported food intake via food diaries on personal mobile devices.Results: In fourteen (5 day-, 5 night-, and 4 rotating-shift) participants, no baseline difference in BMI was observed. Overall, rotating-shift workers consumed fewer calories and had less activity and sleep than day- and night-shift workers. For eating patterns, compared to night- and rotating-shift, day-shift workers ate more frequently during work days. Night workers, however, consumed more calories at work relative to day and rotating workers. For physical activity and sleep, night-shift workers had the highest activity and least sleep on work days.Conclusion: This pilot study utilized primarily objective measurement to examine shift workers' habits outside the laboratory. Although no association between BMI and eating patterns/activity/sleep was observed across groups, a small, homogeneous sample may have influenced this. Overall, shift work was associated with 1) increased calorie intake and higher-fat and -carbohydrate diets and 2) sleep deprivation. A larger, more diverse sample can participate in future studies that objectively measure shift workers' real-world habits.","PeriodicalId":15461,"journal":{"name":"Journal of Circadian Rhythms","volume":"18 ","pages":"6"},"PeriodicalIF":0.0,"publicationDate":"2020-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38649198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6