Journal of Circadian Rhythms最新文献_第2页

Reflections on Several Landmark Advances in Circadian Biology 对昼夜节律生物学若干里程碑式进展的思考

Journal of Circadian Rhythms Pub Date : 2024-04-01 DOI: 10.5334/jcr.236

Sangeeta Chawla, Henrik Oster, Giles E. Duffield, Erik Maronde, Mario E Guido, Christopher Chabot, O. Dkhissi-Benyahya, Ignacio Provencio, Namni Goel, Shawn D. Youngstedt, Natalie Zi-Ching Mak, Mario Caba, Anjoom Nikhat, Shaon Chakrabarti, Lei Wang, Seth J. Davis

引用次数: 0

Abnormalities of Rest-Activity and Light Exposure Rhythms Associated with Cognitive Function in Patients with Mild Cognitive Impairment (MCI). 与轻度认知功能障碍（MCI）患者认知功能相关的休息-活动和光照节律异常。

Journal of Circadian Rhythms Pub Date : 2023-12-28 eCollection Date: 2023-01-01 DOI: 10.5334/jcr.227

Seong Jae Kim, Jung Hie Lee, Jae-Won Jang, Hee Seo Jung, In Bum Suh

{"title":"Abnormalities of Rest-Activity and Light Exposure Rhythms Associated with Cognitive Function in Patients with Mild Cognitive Impairment (MCI).","authors":"Seong Jae Kim, Jung Hie Lee, Jae-Won Jang, Hee Seo Jung, In Bum Suh","doi":"10.5334/jcr.227","DOIUrl":"10.5334/jcr.227","url":null,"abstract":"We aimed to examine the difference in rest-activity rhythm (RAR) and light exposure rhythm (LER) between patients with mild cognitive impairment (MCI) and normal controls (NC), and to verify their relationships with cognitive functions. The neuropsychological battery was administered to participants above 50 years old. The MCI diagnosis was made according to Petersen's criteria. Ten patients with MCI (77.90 ± 6.95 years) and eight NC (74.75 ± 5.06 years) were studied. Actigraphy (Actiwatch 2; Philips Respironics) was recorded at home for 5 days. RAR and LER variables, including interdaily stability (IS), intradaily variability (IV) and relative amplitude, were calculated using nonparametric analyses. The associations between cognitive performance and RAR and LER variables were explored using generalized linear models. There were no significant differences in RAR or LER variables between MCI and NC. There was a significant main effect of RAR-IS on the Stroop Color and Word Test (SCWT), indicating a positive relationship between RAR stability and SCWT performance. There was a significant group by RAR-IS interaction on Trail Making Test-A, indicating a negative relationship in MCI compared to NC. There was a significant group by LER-IV interaction on the Boston Naming Test, indicating a positive relationship in MCI compared to NC. There was no disruption in RAR and LER in patients with MCI. Our study showed that circadian rhythm abnormality was associated with a decline in executive function. However, circadian rhythm abnormality was not associated with declines in processing speed and language function in patients with MCI, implying an altered pathophysiology compared to NC.","PeriodicalId":15461,"journal":{"name":"Journal of Circadian Rhythms","volume":"21 ","pages":"4"},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10756154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139074180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Alarm Clock Against the Sun: Trends in Google Trends Search Activity Across the Transitions to and from Daylight Saving Time. 对抗太阳的闹钟：谷歌趋势搜索活动在夏令时与夏令时之间的过渡趋势。

Journal of Circadian Rhythms Pub Date : 2023-11-29 eCollection Date: 2023-01-01 DOI: 10.5334/jcr.230

Esther Dingena Domenie, Lisa Zarantonello, Chiara Mangini, Chiara Formentin, Gianluca Giusti, Domenico Ruggerini, Paola Cusumano, Alberto Biscontin, Rodolfo Costa, Sara Montagnese

{"title":"The Alarm Clock Against the Sun: Trends in Google Trends Search Activity Across the Transitions to and from Daylight Saving Time.","authors":"Esther Dingena Domenie, Lisa Zarantonello, Chiara Mangini, Chiara Formentin, Gianluca Giusti, Domenico Ruggerini, Paola Cusumano, Alberto Biscontin, Rodolfo Costa, Sara Montagnese","doi":"10.5334/jcr.230","DOIUrl":"https://doi.org/10.5334/jcr.230","url":null,"abstract":"The human circadian timing system depends on the light/dark cycle as its main cue to synchronize with the environment, and thus with solar time. However, human activities depend also on social time, i.e. the set of time conventions and restrictions dictated by society, including Daylight Saving Time (DST), which adds an hour to any degree of desynchrony between social and solar time. Here, we used Google Trends as a data source to analyze diurnal variation, if any, and the daily peak in the relative search volume of 26 Google search queries in relation to the transitions to/from DST in Italy from 2015 to 2020. Our search queries of interest fell into three categories: sleep/health-related, medication and random non sleep/health-related. After initial rhythm and phase analysis, 11 words were selected to compare the average phase of the 15 days before and after the transition to/from DST. We observed an average phase advance after the transition to DST, and a phase delay after the transition to civil time, ranging from 25 to 60 minutes. Advances or delays shorter than 60 minutes, which were primarily observed in the sleep/health-related category, may suggest that search timing for these queries is at least partially driven by the endogenous circadian rhythm. Finally, a significant trend in phase anticipation over the years was observed for virtually all words. This is most likely related to an increase in age, and thus in earlier chronotypes, amongst Google users.","PeriodicalId":15461,"journal":{"name":"Journal of Circadian Rhythms","volume":"21 ","pages":"3"},"PeriodicalIF":0.0,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10705023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138804892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation Analysis Between Time Awareness and Morningness-Eveningness Preference. 时间意识与晨昏偏好的相关性分析。

Journal of Circadian Rhythms Pub Date : 2023-10-11 eCollection Date: 2023-01-01 DOI: 10.5334/jcr.225

Reimi Sogawa, Fuminori Ono, Masahiko Terao, Shunta Nagano, Junko Kawabe, Koichi Node, Makoto Akashi

{"title":"Correlation Analysis Between Time Awareness and Morningness-Eveningness Preference.","authors":"Reimi Sogawa, Fuminori Ono, Masahiko Terao, Shunta Nagano, Junko Kawabe, Koichi Node, Makoto Akashi","doi":"10.5334/jcr.225","DOIUrl":"10.5334/jcr.225","url":null,"abstract":"The circadian clock is adjusted by light inputs via the retinohypothalamic tract. Because environmental light is controllable for modern humans at the individual's preference although under social schedules, individual differences in time-related psychology and behavior may be associated with morningness-eveningness preference (M-E preference). To examine this hypothesis, we used the Time Management Scale and Time Anxiety Scale to quantify time-related psychology and behavior. These scales aim to evaluate \"awareness of effective time management and utilization\" and \"anxiety about uncontrollable time schedule and unexpected time-related outcome\", respectively. According to our correlation analysis using mid-sleep time as a marker for M-E preference, we obtained results supporting our hypothesis in the correlation between the M-E preference values and the Time Management Scale scores, with larger \"time estimation\" and \"taking each moment as it comes\" scores associated with more morningness and eveningness, respectively. Considering that modern humans likely become night owls under artificial light conditions, it appears plausible that lower awareness of time management leads to more eveningness.","PeriodicalId":15461,"journal":{"name":"Journal of Circadian Rhythms","volume":"21 ","pages":"2"},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10573578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41235716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circadian Oscillation Pattern of Endoplasmic Reticulum Quality Control (ERQC) Components in Human Embryonic Kidney HEK293 Cells. 人胚胎肾HEK293细胞内质网质量控制(ERQC)成分的昼夜振荡模式。

Journal of Circadian Rhythms Pub Date : 2023-01-01 DOI: 10.5334/jcr.219

Yalcin Erzurumlu, Deniz Catakli, Hatice Kubra Dogan

{"title":"Circadian Oscillation Pattern of Endoplasmic Reticulum Quality Control (ERQC) Components in Human Embryonic Kidney HEK293 Cells.","authors":"Yalcin Erzurumlu, Deniz Catakli, Hatice Kubra Dogan","doi":"10.5334/jcr.219","DOIUrl":"https://doi.org/10.5334/jcr.219","url":null,"abstract":"The circadian clock regulates the \"push-pull\" of the molecular signaling mechanisms that arrange the rhythmic organization of the physiology to maintain cellular homeostasis. In mammals, molecular clock genes tightly arrange cellular rhythmicity. It has been shown that this circadian clock optimizes various biological processes, including the cell cycle and autophagy. Hence, we explored the dynamic crosstalks between the circadian rhythm and endoplasmic reticulum (ER)-quality control (ERQC) mechanisms. ER-associated degradation (ERAD) is one of the most important parts of the ERQC system and is an elaborate surveillance system that eliminates misfolded proteins. It regulates the steady-state levels of several physiologically crucial proteins, such as 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) and the metastasis suppressor KAI1/CD82. However, the circadian oscillation of ERQC members and their roles in cellular rhythmicity requires further investigation. In the present study, we provided a thorough investigation of the circadian rhythmicity of the fifteen crucial ERQC members, including gp78, Hrd1, p97/VCP, SVIP, Derlin1, Ufd1, Npl4, EDEM1, OS9, XTP3B, Sel1L, Ufd2, YOD1, VCIP135 and FAM8A1 in HEK293 cells. We found that mRNA and protein accumulation of the ubiquitin conjugation, binding and processing factors, retrotranslocation-dislocation, substrate recognition and targeting components of ERQC exhibit oscillation under the control of the circadian clock. Moreover, we found that Hrd1 and gp78 have a possible regulatory function on Bmal1 turnover. The findings of the current study indicated that the expression level of ERQC components is fine-tuned by the circadian clock and major ERAD E3 ligases, Hrd1 and gp78, may influence the regulation of circadian oscillation by modulation of Bmal1 stability.","PeriodicalId":15461,"journal":{"name":"Journal of Circadian Rhythms","volume":"21 ","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10077977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9277955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Discovery and Visualization of Age-Dependent Patterns in the Diurnal Transcriptome of Drosophila. 果蝇昼夜转录组中年龄依赖模式的发现与可视化

Journal of Circadian Rhythms Pub Date : 2022-12-08 eCollection Date: 2022-01-01 DOI: 10.5334/jcr.218

Benjamin Sebastian, Rosalyn M Fey, Patrick Morar, Brittany Lasher, Jadwiga M Giebultowicz, David A Hendrix

{"title":"Discovery and Visualization of Age-Dependent Patterns in the Diurnal Transcriptome of Drosophila.","authors":"Benjamin Sebastian, Rosalyn M Fey, Patrick Morar, Brittany Lasher, Jadwiga M Giebultowicz, David A Hendrix","doi":"10.5334/jcr.218","DOIUrl":"10.5334/jcr.218","url":null,"abstract":"Many critical life processes are regulated by input from 24-hour external light/dark cycles, such as metabolism, cellular homeostasis, and detoxification. The circadian clock, which helps coordinate the response to these diurnal light/dark cycles, remains rhythmic across lifespan; however, rhythmic transcript expression is altered during normal aging. To better understand how aging impacts diurnal expression, we present an improved Fourier-based method for detecting and visualizing rhythmicity that is based on the relative power of the 24-hour period compared to other periods (RP24). We apply RP24 to transcript-level expression profiles from the heads of young (5-day) and old (55-day) Drosophila melanogaster, and reveal novel age-dependent rhythmicity changes that may be masked at the gene level. We show that core clock transcripts phase advance during aging, while most rhythmic transcripts phase delay. Transcripts rhythmic only in young flies tend to peak before lights on, while transcripts only rhythmic in old peak after lights on. We show that several pathways, including glutathione metabolism, gain or lose coordinated rhythmic expression with age, providing insight into possible mechanisms of age-onset neurodegeneration. Remarkably, we find that many pathways show very robust coordinated rhythms across lifespan, highlighting their putative roles in promoting neural health. We investigate statistically enriched transcription factor binding site motifs that may be involved in these rhythmicity changes.","PeriodicalId":15461,"journal":{"name":"Journal of Circadian Rhythms","volume":"20 ","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2022-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9733130/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10423563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Discovery and Visualization of Age-Dependent Patterns in the Diurnal Transcriptome of Drosophila 果蝇日转录组中年龄依赖模式的发现和可视化

Journal of Circadian Rhythms Pub Date : 2022-04-08 DOI: 10.1101/2022.04.06.487011

Benjamin Sebastian, Rosalyn M. Fey, Patrick Morar, Brittany Lasher, Eileen S. Chow, Jadwiga M. Geibultowicz, D. Hendrix

{"title":"Discovery and Visualization of Age-Dependent Patterns in the Diurnal Transcriptome of Drosophila","authors":"Benjamin Sebastian, Rosalyn M. Fey, Patrick Morar, Brittany Lasher, Eileen S. Chow, Jadwiga M. Geibultowicz, D. Hendrix","doi":"10.1101/2022.04.06.487011","DOIUrl":"https://doi.org/10.1101/2022.04.06.487011","url":null,"abstract":"Many critical life processes are regulated by input from 24-hour external light/dark cycles, such as metabolism, cellular homeostasis, and detoxification. The circadian clock, which helps coordinate the response to these diurnal light/dark cycles, remains rhythmic across lifespan; however, rhythmic transcript expression is altered during normal aging. To better understand how aging impacts diurnal expression, we present an improved Fourier-based method for detecting and visualizing rhythmicity that is based on the relative power of the 24-hour period compared to other periods (RP24). We apply RP24 to transcript-level expression profiles from the heads of young (5-day) and old (55-day) Drosophila melanogaster, and reveal novel age-dependent rhythmicity changes that may be masked at the gene level. We show that core clock transcripts phase advance during aging, while most rhythmic transcripts phase delay. Transcripts rhythmic only in young flies tend to peak before lights on, while transcripts only rhythmic in old peak after lights on. We show that several pathways including glutathione metabolism, gain or lose coordinated rhythmic expression with age providing insight into possible mechanisms of age-onset neurodegeneration. Remarkably, we find that many pathways show very robust coordinated rhythms across lifespan, highlighting their putative roles in promoting neural health. We investigate statistically enriched transcription factor binding site motifs that may be involved in these rhythmicity changes.","PeriodicalId":15461,"journal":{"name":"Journal of Circadian Rhythms","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45535355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Day-Night Variations in the Concentration of Neurotransmitters in the Rat Lumbar Spinal Cord. 大鼠腰脊髓神经递质浓度的昼夜变化

Journal of Circadian Rhythms Pub Date : 2021-07-19 eCollection Date: 2021-01-01 DOI: 10.5334/jcr.215

Beatriz Shantal Jiménez-Zárate, Celia Piña-Leyva, Marina Rodríguez-Sánchez, Benjamín Florán-Garduño, Luis Antonio Jiménez-Zamudio, Ismael Jiménez-Estrada

{"title":"Day-Night Variations in the Concentration of Neurotransmitters in the Rat Lumbar Spinal Cord.","authors":"Beatriz Shantal Jiménez-Zárate, Celia Piña-Leyva, Marina Rodríguez-Sánchez, Benjamín Florán-Garduño, Luis Antonio Jiménez-Zamudio, Ismael Jiménez-Estrada","doi":"10.5334/jcr.215","DOIUrl":"10.5334/jcr.215","url":null,"abstract":"The purpose of this study was to analyze the light-dark variations in the concentrations of several neurotransmitters in the lumbar spinal cord of rats. Six groups of male Wistar rats were exposed to a 12 h light-12 h dark cycle for 70 days. At different time points of the experimental day (8, 12, 16, 20, 24 and 4 h), one of the groups of rats was randomly selected to be sacrificed, and the spinal cords were removed. The gamma-aminobutyric acid (GABA), glutamate (GLU), dopamine, serotonin, epinephrine (E), and norepinephrine (NE) levels in each extracted spinal cord were measured with high-pressure liquid chromatography (HPLC)-EQ and HPLC-fluorescence systems. Our results indicate that the spinal concentrations of GABA and GLU showed sinusoidal variation in a 24 h cycle, with the highest peak in the dark period (~20 h). Dopamine and serotonin also fluctuated in concentration but peaked in the light period (between 8 and 12 h), while E and NE concentrations showed no significant fluctuations. The possible relationship between neurotransmitter spinal concentration and sensitivity to pain and locomotor activity is discussed. It was concluded that most of the neurotransmitter levels in the lumbar spinal cord showed circadian fluctuations coupled to a light-dark cycle.","PeriodicalId":15461,"journal":{"name":"Journal of Circadian Rhythms","volume":"19 ","pages":"9"},"PeriodicalIF":0.0,"publicationDate":"2021-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8300578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39265494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genes Relevant to Tissue Response to Cancer Therapy Display Diurnal Variation in mRNA Expression in Human Oral Mucosa. 与肿瘤治疗相关的组织反应基因在人口腔黏膜mRNA表达中显示出日变化。

Journal of Circadian Rhythms Pub Date : 2021-06-17 DOI: 10.5334/jcr.213

Fangyi Gu, Eduardo Cortes Gomez, Jianhong Chen, Matthew F Buas, Nicolas F Schlecht, Karen Hulme, Shweta Vishwas Kulkarni, Prashant K Singh, Richard O'Connor, Christine B Ambrosone, Anurag K Singh, Jianmin Wang

{"title":"Genes Relevant to Tissue Response to Cancer Therapy Display Diurnal Variation in mRNA Expression in Human Oral Mucosa.","authors":"Fangyi Gu, Eduardo Cortes Gomez, Jianhong Chen, Matthew F Buas, Nicolas F Schlecht, Karen Hulme, Shweta Vishwas Kulkarni, Prashant K Singh, Richard O'Connor, Christine B Ambrosone, Anurag K Singh, Jianmin Wang","doi":"10.5334/jcr.213","DOIUrl":"https://doi.org/10.5334/jcr.213","url":null,"abstract":"Background: To address a critical gap for application of cancer chronotherapy of when would be the best time(s) for treating an individual cancer patient, we conducted a pilot study to characterize diurnal variations of gene expression in oral mucosal tissue, which is vulnerable to damage from cancer therapies.Methods: We conducted RNA-seq assay on individual oral mucosal samples collected from 11 healthy volunteers every 4 hours (6 time points). Using a cosine-based method, we estimated the individual and average values of peak-time and amplitude for each gene. Correlations between gene expression peak-times and age was examined, adjusting for individual's sleep timing.Results: Among candidate gene pathways that are relevant to treatment response, 7 of 16 genes (PER3, CIART, TEF, PER1, PER2, CRY2, ARNTL) involved in circadian regulation and 1 of 118 genes (WEE1) involved in cell cycle regulation achieved p-value ≤ 0.1 and relative amplitude>0.1. The average peak times were approximately 10:15 for PER3, CIART and TEF, 10:45 for PER1, 13:00 for WEE1, PER2 and CRY2, and 19:30 for ARNTL. Ranges in peak times across individuals differed by gene (e.g., 8 hours for PER1; 16.7 hours for WEE1). Older people had later peak times for PER1 (r = 0.77, p = 0.03) and PER3 (r = 0.69, p-value = 0.06).Conclusion: In oral mucosa, expression of some genes relevant to treatment response displayed diurnal variation. These genes may be candidates for development of biomarkers for optimizing individual timing of cancer therapy using non-invasively collected oral mucosa.","PeriodicalId":15461,"journal":{"name":"Journal of Circadian Rhythms","volume":"19 ","pages":"8"},"PeriodicalIF":0.0,"publicationDate":"2021-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39081452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Changes in 24 h Rhythmicity of Spontaneous Locomotor Activity in the Triple Transgenic Mouse for Alzheimer's Disease (3xTg-AD) in a Jet Lag Protocol: Correlations with Retinal Sensitivity. 时差方案中阿尔茨海默病三重转基因小鼠(3xTg-AD) 24小时自发运动活动节律性的变化:与视网膜敏感性的相关性

Journal of Circadian Rhythms Pub Date : 2021-05-27 DOI: 10.5334/jcr.214

Irma Angélica González-Luna, Cinthia Juárez-Tapia, Azucena Aguilar-Vázquez, Edith Arnold, Sofia Díaz-Cintra, Manuel Miranda-Anaya, Mauricio Díaz-Muñoz

{"title":"Changes in 24 h Rhythmicity of Spontaneous Locomotor Activity in the Triple Transgenic Mouse for Alzheimer's Disease (3xTg-AD) in a Jet Lag Protocol: Correlations with Retinal Sensitivity.","authors":"Irma Angélica González-Luna, Cinthia Juárez-Tapia, Azucena Aguilar-Vázquez, Edith Arnold, Sofia Díaz-Cintra, Manuel Miranda-Anaya, Mauricio Díaz-Muñoz","doi":"10.5334/jcr.214","DOIUrl":"https://doi.org/10.5334/jcr.214","url":null,"abstract":"The progression of amyloid plaques and neurofibrillary tangles in different brain areas is associated with the effects of Alzheimer's disease (AD). In addition to cognitive impairment, circadian alterations in locomotor activity have also been detected, but they have not been characterized in a jet lag protocol. Therefore, the present study aimed to compare 3xTg-AD and non-transgenic mice in changes of 24 h cycles of spontaneous locomotor activity in a jet lag protocol, in an environment without a running wheel, at 3 different states of neuronal damage: early, intermediate and advanced (3, 8 and 13 months, respectively). The 3xTg-AD mice at 3 months presented differences in phase angle and acrophase, and differentially increased activity after advances more than after delays. At 13 months, a shortening of the free-running period in constant darkness was also noted. 3xTg-AD mice showed a significant increase (123%) in global activity at 8 to 13 months and in nighttime activity (153%) at 13 months. In the advance protocol (ADV), 3xTg-AD mice displayed a significant increase in global activity (171%) at 8 and 13 months. The differences in masking effect were evident at 8 months. To assess a possible retinal dysfunction that could interfere with photic entrainment as part of the neurodegenerative process, we compared electroretinogram recordings. The results showed early deterioration in the retinal response to light flashes in mesopic conditions, observed in the B-wave latency and amplitude. Thus, our study presents new behavioral and pathological characteristics of 3xTg-AD mice and reveals the usefulness of non-invasive tools in early diagnosis.","PeriodicalId":15461,"journal":{"name":"Journal of Circadian Rhythms","volume":"19 ","pages":"7"},"PeriodicalIF":0.0,"publicationDate":"2021-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8194968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39099538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2