Journal of Computer Assisted Tomography最新文献

{"title":"Evaluation of Amide Proton Transfer Imaging Combined With Serum Squamous Cell Carcinoma Antigen for Grading Cervical Cancer.","authors":"Xiao-Yan Zhang, Chen Xu, Xing-Chen Wu, Qian-Qian Qu, Kai Deng","doi":"10.1097/RCT.0000000000001699","DOIUrl":"10.1097/RCT.0000000000001699","url":null,"abstract":"<p><strong>Objective: </strong>The aim of the study is to investigate the efficacy of amide proton transfer-weighted (APT) imaging combined with serum squamous cell carcinoma antigen (SCC-Ag) in grading cervical cancer.</p><p><strong>Methods: </strong>Sixty-three patients with surgically confirmed cervical SCC were enrolled and categorized into 3 groups: highly differentiated (G1), moderately differentiated (G2), and poorly differentiated (G3). The diagnostic efficacies of APT imaging and serum SCC-Ag, alone or in combination, for grading cervical SCC were compared.</p><p><strong>Results: </strong>The APT values measured by the 2 observers were in excellent agreement (intraclass correlation coefficient >0.75). Mean (± standard deviation) APT values for the high, moderate, and poor differentiation groups were 2.542 ± 0.215% (95% confidence interval [CI]: 2.423-2.677), 2.784 ± 0.175% (95% CI: 2.701-2.856), and 3.120 ± 0.221% (95% CI: 2.950-3.250), respectively. APT values for groups G2 and G3 were significantly higher than those for G1 ( P  < 0.05). APT values for identifying cervical SCC in groups G1 and G2, G2 and G3, and G1 and G3, had areas under the receiver operating characteristic curve, sensitivities, and specificities of 0.815 (95% confidence interval [CI]: 0.674-0.914), 82.1%, and 72.2%, 0.882 (95% CI: 0.751-0.959), 70.6%, and 92.7%, and 0.961 (95% CI: 0.835-0.998), 94.1%, and 94.4%, respectively. APT values were significantly and positively correlated with the histological grade of cervical SCC (Spearman's correlation [ rs ] = 0.731, P  < 0.01). Serum SCC-Ag levels for the high, moderate, and poor differentiation groups were 1.60 (0.88-4.63) ng/mL, 4.10 (1.85-6.98) ng/mL, and 26.10 (9.65-70.00) ng/mL, respectively. The differences were statistically significant only between groups G1 and G3 and G2 and G3 ( P  < 0.05), whereas the differences between groups G1 and G2 were not statistically significant ( P  > 0.05). Spearman's analysis revealed a positive correlation between SCC-Ag levels and the histological grade of cervical SCC ( rs  = 0.573, P  < 0.01). The diagnostic efficacy of APT imaging for the histological grading of cervical SCC was better than that of serum SCC-Ag, and the discriminatory efficacy of the combination of the 2 parameters was better than that of either alone.</p><p><strong>Conclusions: </strong>The diagnostic efficacy of APT imaging was better than that of serum SCC-Ag, and the combined diagnostic utility of APT and SCC-Ag was better than that of the individual parameters.</p>","PeriodicalId":15402,"journal":{"name":"Journal of Computer Assisted Tomography","volume":" ","pages":"399-406"},"PeriodicalIF":1.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of Local Tumor Progression After Thermal Ablation of Colorectal Cancer Liver Metastases Based on Magnetic Resonance Imaging Δ-Radiomics.","authors":"Xiucong Zhu, Jinke Zhu, Chenwen Sun, Fandong Zhu, Bing Wu, Jiaying Mao, Zhenhua Zhao","doi":"10.1097/RCT.0000000000001702","DOIUrl":"10.1097/RCT.0000000000001702","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to enhance the predictability of local tumor progression (LTP) postthermal ablation in patients with colorectal cancer liver metastases (CRLMs). A sophisticated approach integrating magnetic resonance imaging (MRI) Δ-radiomics and clinical feature-based modeling was employed.</p><p><strong>Materials and methods: </strong>In this retrospective study, 37 patients with CRLM were included, encompassing a total of 57 tumors. Radiomics features were derived by delineating the images of lesions pretreatment and images of the ablation zones posttreatment. The change in these features, termed Δ-radiomics, was calculated by subtracting preprocedure values from postprocedure values. Three models were developed using the least absolute shrinkage and selection operators (LASSO) and logistic regression: the preoperative lesion model, the postoperative ablation area model, and the Δ model. Additionally, a composite model incorporating identified clinical features predictive of early treatment success was created to assess its prognostic utility for LTP.</p><p><strong>Results: </strong>LTP was observed in 20 out of the 57 lesions (35%). The clinical model identified, tumor size ( P  = 0.010), and ΔCEA ( P  = 0.044) as factors significantly associated with increased LTP risk postsurgery. Among the three models, the Δ model demonstrated the highest AUC value (T2WI AUC in training, 0.856; Delay AUC, 0.909; T2WI AUC in testing, 0.812; Delay AUC, 0.875), whereas the combined model yielded optimal performance (T2WI AUC in training, 0.911; Delay AUC, 0.954; T2WI AUC in testing, 0.847; Delay AUC, 0.917). Despite its superior AUC values, no significant difference was noted when comparing the performance of the combined model across the two sequences ( P  = 0.6087).</p><p><strong>Conclusions: </strong>Combined models incorporating clinical data and Δ-radiomics features serve as valuable indicators for predicting LTP following thermal ablation in patients with CRLM.</p>","PeriodicalId":15402,"journal":{"name":"Journal of Computer Assisted Tomography","volume":" ","pages":"377-384"},"PeriodicalIF":1.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142780222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Performance of Imaging Methods in Predicting Lung Cancer Metastases.","authors":"Murat Aşik, Zeynep Nihal Kazci","doi":"10.1097/RCT.0000000000001706","DOIUrl":"10.1097/RCT.0000000000001706","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the possibility of distant organ metastasis using an algorithm developed to evaluate the morphology and localization of lung masses.</p><p><strong>Methods: </strong>Patients diagnosed with lung cancer between 2016 and 2023 were included. The lesion's morphological characteristics, proximity to important structures, and maximum standardized uptake value were recorded. Six common metastatic sites were identified: the contralateral lung, liver, brain, adrenal glands, bone, and other regions. The relationship between the characteristics of the mass and the metastatic location was investigated.</p><p><strong>Results: </strong>A total of 383 patients (260 men, 68%) with malignant lung lesions with a mean ± SD age of 65.50 ± 12.34 years (range: 36-74 years) were included in the study. Among them, 242 were diagnosed with primary lung cancer, and 106 (43.8%) exhibited metastases to other organs with primary lung tumors. Distant organ metastases were most frequently detected in the bones (n = 45, 42.5%) and were more frequent in male patients and lesions adjacent to the ribs and bronchi, those involving mediastinal lymph nodes, irregular contours, and maximum standardized uptake values above 11.15 ± 5.67 (mean ± SD).</p><p><strong>Conclusions: </strong>Evaluating radiological imaging of malignant lesions in patients with lung cancer using an algorithm that considers morphological and neighborhood characteristics can provide predictive information regarding the possibility of metastasis of malignant lung lesions and the metastatic location.</p>","PeriodicalId":15402,"journal":{"name":"Journal of Computer Assisted Tomography","volume":" ","pages":"462-470"},"PeriodicalIF":1.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Impact of Pancreatic and Peripancreatic Hemorrhage Associated With Acute Pancreatitis.","authors":"Benjamin I Richter, Joseph H Weissbrot, Frank R Chung, Tamas A Gonda, Chenchan Huang","doi":"10.1097/RCT.0000000000001683","DOIUrl":"10.1097/RCT.0000000000001683","url":null,"abstract":"<p><strong>Purpose: </strong>The significance of pancreatitis-associated hemorrhage outside the context of a ruptured pseudoaneurysm remains unclear. This study aims to characterize the clinical significance of pancreatic hemorrhage during acute pancreatitis (AP).</p><p><strong>Methods: </strong>This retrospective study included adult patients diagnosed with hemorrhagic pancreatitis (HP) from 2010 to 2021. HP was defined as a clinical diagnosis of AP and the presence of pancreatic or peripancreatic hemorrhage on cross-sectional imaging. Two radiologists assessed the pancreatitis type, degree of necrosis, hemorrhage location, peripancreatic collections, and peripancreatic vessels. Demographic and disease data, AP severity, and treatment decisions from admission to 3 months after discharge were extracted from hospital electronic health records.</p><p><strong>Results: </strong>The study included 36 patients, stratified by AP severity into 12 (33.3%) mild, 13 (36.1%) moderate-severe, and 11 (30.6%) severe cases. Six (16.6%) of the patients experienced clinically significant bleeding, which led to changes in clinical management such as further imaging, modifications to anticoagulation regimens, or both. Among these, 50% (3 of 6) demonstrated active bleeding on further imaging, with 33% (2 of 6) of the bleeding being intrapancreatic. In contrast, 83% (30 of 36) of HP patients did not have clinically significant bleeding, and all but one did not require changes in clinical management. AP-associated splanchnic vein thrombosis occurred in 30.6% (11 of 36) of patients, and anticoagulation in these patients did not result in clinically significant bleeding.</p><p><strong>Conclusions: </strong>HP without clinically significant bleeding does not necessitate changes in clinical management. However, hemorrhage may indicate more severe disease and is associated with a higher incidence of splanchnic vein thrombosis.</p>","PeriodicalId":15402,"journal":{"name":"Journal of Computer Assisted Tomography","volume":"49 3","pages":"343-347"},"PeriodicalIF":1.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IDEAL-IQ Magnetic Resonance Imaging Fat Fraction Quantification in Distinguishing Thymic Hyperplasia From Low-Risk Thymoma and Thymic Lymphoma in Adulthood: A Reliability and Efficacy Analysis.","authors":"Jie Zhang, Xiu-Long Feng, Yu-Hui Ma, Jiang-Tao Lan, Shu-Mei Wang, Guang Yang, Yu-Chuan Hu, Guang-Bin Cui","doi":"10.1097/RCT.0000000000001688","DOIUrl":"10.1097/RCT.0000000000001688","url":null,"abstract":"<p><strong>Objectives: </strong>Detection of fat content in thymic lesions is essential to differentiate thymic hyperplasia from thymic tumors. This study assesses the reliability and efficacy of \"iterative decomposition of water and fat with echo asymmetry and least-squares estimation quantization\" IDEAL-IQ magnetic resonance sequence in distinguishing thymic hyperplasia from low-risk thymoma and thymic lymphoma in adulthood.</p><p><strong>Methods: </strong>Thirty patients with thymic hyperplasia, 28 low-risk thymomas, and 13 thymic lymphomas were respectively enrolled. All subjects underwent conventional thorax magnetic resonance imaging and IDEAL-IQ sequence. The fat fraction (FF mean and FF total ), signal intensity index, and R2* values of the lesions were compared for differences among 3 groups by the Mann-Whitney U and Kruskal-Wallis tests. Receiver operating characteristic curve analysis was performed to determine the differentiating efficacy.</p><p><strong>Results: </strong>Both FF mean and FF total values in patients with thymic hyperplasia are significantly higher than those in patients with low-risk thymoma and thymic lymphoma (FF mean : 26.41% vs 1.78% and 1.93%, FF total : 27.67% vs 2.21% and 2.44%; both P  < 0.001), whereas there was no significant difference in these values between low-risk thymomas and thymic lymphomas (both P  > 0.05). Similarly, signal intensity index and R2* values of thymic hyperplasia were significantly higher than those of patients with low-risk thymoma and thymic lymphoma ( P  < 0.001). Receiver operating characteristic curve analysis showed that FF mean had an area under the curve of 0.998, with a cutoff of 4.78% yielding 95.12% sensitivity and 100% specificity, and FF total had an area under the curve of 0.994, with a cutoff of 8.57% yielding 97.56% sensitivity and 96.67% specificity in distinguishing thymic hyperplasia from tumors.</p><p><strong>Conclusions: </strong>IDEAL-IQ sequence provides accurate fat quantitative parameters and can differentiate thymic hyperplasia from thymic neoplasms with robust efficacy and reliability.</p>","PeriodicalId":15402,"journal":{"name":"Journal of Computer Assisted Tomography","volume":"49 3","pages":"431-439"},"PeriodicalIF":1.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12071501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Clinical Trial Efficiency: The Impact of a Dual Digital Alert System on Quantitative Imaging Report Turnaround Time.","authors":"Rucha Bhalde, Ceylan Altintas Taslicay, Mayur Virarkar, Jia Sun, Sean Michael Burke, Anish Nayak, Sujaya Rao, Sadhale Mayuresh, Ajaykumar Morani, Priya Bhosale","doi":"10.1097/RCT.0000000000001692","DOIUrl":"10.1097/RCT.0000000000001692","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to assess the effectiveness of a dual digital alert system and automatic radiologist reassignment in improving the efficiency of quantitative imaging report delivery for clinical trials.</p><p><strong>Materials and methods: </strong>Assessing tumor metrics is critical to oncologic disease management, informed treatment planning, and for monitoring therapeutic response and even more so in cancer clinical research trials. A collaborative effort with the Institutional Research Information Systems division led to developing a web-based system with a Java backend, tested using Agile methodology to improve patient care with improved turnaround time (TAT) of quantitative reports. The system sent dual digital alerts including a page and an email notification to the radiologist based on the last submitted date and time for each QIAC report and autoreassigned radiologists till report finalization. Data was extracted from the Quantitative Imaging Analysis Core database for comparing the TAT, calculated as time difference between the submission of preliminary reports by Imaging Research Specialists and the finalization by radiologists before and after the digital alert system implementation.</p><p><strong>Results: </strong>Implementing the dual digital alert system significantly increased the number of cases finalized within 6 hours to 50%. For nonexpedited cases, the mean TAT decreased by 57.2% from 85.9 hours to 36.8 hours ( P < 0.001). Expedited cases saw a reduction in mean TAT by 63.7% from 44.9 hours to 16.3 hours ( P  = 0.022). Baseline and follow-up cases also showed significantly reduced mean and median TAT after deployment ( P < 0.001).</p><p><strong>Conclusions: </strong>The dual digital alert system and automatic radiologist reassignment significantly improved the TAT for quantitative imaging reports in clinical trials. This enhancement in report delivery efficiency led to better therapeutic decision making and increased patient satisfaction in clinical settings.</p>","PeriodicalId":15402,"journal":{"name":"Journal of Computer Assisted Tomography","volume":" ","pages":"471-479"},"PeriodicalIF":1.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Prototype \"Smart\" 3-Dimensionally Printed Model Showcasing Interactivity: Implementing Voice Command for the Ventricular and Cisternal Systems.","authors":"Cullen Fleming, Navid Mostaghni, Iman Elsayed, Sabrina Hsiao, Raheleh Taghvaei, Lauren Arsenault, Ramin Javan","doi":"10.1097/RCT.0000000000001695","DOIUrl":"10.1097/RCT.0000000000001695","url":null,"abstract":"<p><strong>Abstract: </strong>The next step in the evolution of static 3-dimensionally (3D) printed models may be the creation of \"smart\" models, where subcomponents can be seamlessly interacted with through a feedback mechanism, with potential applications in trainee education and patient counseling. Considering the complexity of the ventricular and cisternal systems, they were chosen for segmentation, using Materialize InPrint with outward hollowing using 2.5-mm wall thickness. After 3D printing, dedicated holes were drilled for placement of wired light emitting diodes (LEDs) in anatomical landmarks and connected to an Arduino Uno microcontroller. This was coupled to a Bluetooth transceiver for communication via an Android cellular device. C++ was used to match each LED to a particular pin number on the Arduino board. When the user verbalizes a structure, the Bluetooth sends a command to the Arduino, where the code looks for the \"trigger word,\" subsequently sending a signal to illuminate the corresponding LED. The system requires wireless/cellular data for communication with the voice recognition engine on the Google server. The described method may serve as a prototype for when 3D printers are capable of simultaneously printing conductive material or wiring along with the main material within a model to allow for integration of feedback devices.</p>","PeriodicalId":15402,"journal":{"name":"Journal of Computer Assisted Tomography","volume":" ","pages":"502-508"},"PeriodicalIF":1.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Usefulness of Dual-Energy CT for Differentiating Hemorrhage From Iodine Extravasation in Meningiomas After Preoperative Embolization.","authors":"Ryutaro Uchimura, Zaw Aung Khant, Hidetaka Hayashi, Yasunori Nagayama, Hiroyuki Uetani, Yasuyuki Kaku, Tatsuhiro Nagatomo, Yoshitaka Tamura, Kiyotaka Yokogami, Akitake Mukasa, Hiro Kiyosue, Minako Azuma, Toshinori Hirai","doi":"10.1097/RCT.0000000000001685","DOIUrl":"10.1097/RCT.0000000000001685","url":null,"abstract":"<p><strong>Objective: </strong>Discriminating between hemorrhage and iodine extravasation can pose challenges in conventional computed tomography (CCT) images following preoperative embolization for meningioma. This study aimed to assess the efficacy of dual-energy computed tomography (DECT) in differentiating hemorrhage from iodine extravasation after preoperative embolization for meningioma.</p><p><strong>Methods: </strong>Twenty-one consecutive meningioma patients who underwent CCT before and DECT immediately after preoperative embolization were included in this study. Two independent observers conducted qualitative assessments on CCT and virtual noncontrast (VNC) images and iodine maps (IMs) to differentiate between hemorrhage and iodine extravasation. One observer recorded CT values of hemorrhage and iodine extravasation on CCT and VNC images. The ratio of maximum attenuation to minimum attenuation on VNC images was defined as the VNC ratio. Statistical analysis included Kappa ( κ ) statistics, unpaired t tests, and receiver operating characteristic (ROC) analysis.</p><p><strong>Results: </strong>Interobserver agreement for qualitative assessment was fair ( κ  = 0.231) for CCT alone and good ( κ  = 0.723) for CCT plus VNC imaging and IM. The addition of VNC imaging and IM to CCT improved differential confidence in 16 (76%) and 18 (86%) cases of the two observers, respectively, increasing the area under the receiver operating characteristic curve (AUROC) from 0.868 to 0.895 and 0.658 to 0.947, respectively. At a cutoff value of 1.527, the VNC ratio was significantly higher for hemorrhage than iodine extravasation ( P  < 0.05), with the highest diagnostic performance (AUROC, 1).</p><p><strong>Conclusions: </strong>DECT with VNC imaging and IM is useful for differentiating hemorrhage from iodine extravasation in meningiomas with preoperative embolization.</p>","PeriodicalId":15402,"journal":{"name":"Journal of Computer Assisted Tomography","volume":"49 3","pages":"493-501"},"PeriodicalIF":1.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Accuracy of Four-Dimensional Computed Tomography in Preoperative Localization of Primary Hyperparathyroidism After Negative or Inconclusive Sestamibi: A Systematic Review and Meta-analysis.","authors":"Karen Smayra, Shahid Miangul, Joseph Nasr, Alma Sato, Sum-Yu C Lee, Liranne Bitton, Nour El Ghazal, Kyle G Alexander, Hayato Nakanishi, Christian A Than, Raman Uberoi","doi":"10.1097/RCT.0000000000001689","DOIUrl":"10.1097/RCT.0000000000001689","url":null,"abstract":"<p><strong>Objective: </strong>The aim of the study is to assess the diagnostic accuracy of 4-dimensional computed tomography (4D-CT) scans for patients with primary hyperparathyroidism (pHPT) after negative or inconclusive Technetium-99m sestamibi single-photon emission computed tomography scan.</p><p><strong>Methods: </strong>A literature search of several databases was conducted from inception to August 2023. Eligible studies reported adult patients (>18 years old) who underwent 4D-CT after negative or inconclusive sestamibi results. The pooled proportions were analyzed using a random-effects model. This review was registered in PROSPERO (CRD42023446285).</p><p><strong>Results: </strong>From 208 initial studies screened, 10 met the eligibility criteria, with a total of 335 patients with a diagnosis of pHPT who underwent 4D-CT scans and subsequent surgical exploration. Nine of the studies reported a pooled sensitivity of localization of 71% (0.71; 95% confidence interval [CI]: 0.610, 0.811, I2  = 72%). The pooled specificity of localization across 5 studies was calculated at 47% (0.47; 95% CI: -0.111, 1.059, I2  = 99%). Seven of the included studies reported a pooled positive predictive value of 81% (0.81; 95% CI: 0.708, 0.917, I2  = 70%), and 6 of the studies reported a negative predictive value of 28% (0.28; 95% CI: -0.114, 0.683, I2  = 98%).</p><p><strong>Conclusions: </strong>For pHPT patients with inconclusive sestamibi scans, 4D-CT demonstrates promising results with good diagnostic accuracy for the localization of pHPT. Additional studies evaluating larger groups of patients may provide further support for the use of 4D-CT in this population.</p>","PeriodicalId":15402,"journal":{"name":"Journal of Computer Assisted Tomography","volume":"49 3","pages":"509-518"},"PeriodicalIF":1.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Value of Whole-Volume Radiomics Machine Learning Model Based on Multiparametric MRI in Predicting Triple-Negative Breast Cancer.","authors":"Tingting Xu, Xueli Zhang, Huan Tang, Ting Hua Bd, Fuxia Xiao, Zhijun Cui, Guangyu Tang, Lin Zhang","doi":"10.1097/RCT.0000000000001691","DOIUrl":"10.1097/RCT.0000000000001691","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the value of radiomics analysis in the precise diagnosis of triple-negative breast cancer (TNBC) based on breast dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and apparent diffusion coefficient (ADC) maps.</p><p><strong>Methods: </strong>This retrospective study included 326 patients with pathologically proven breast cancer (TNBC: 129, non-TNBC: 197). The lesions were segmented using the ITK-SNAP software, and whole-volume radiomics features were extracted using a radiomics platform. Radiomics features were obtained from DCE-MRI and ADC maps. The least absolute shrinkage and selection operator regression method was employed for feature selection. Three prediction models were constructed using a support vector machine classifier: Model A (based on the selected features of the ADC maps), Model B (based on the selected features of DCE-MRI), and Model C (based on the selected features of both combined). Receiver operating characteristic curves were used to evaluate the diagnostic performance of the conventional MR image model and the 3 radiomics models in predicting TNBC.</p><p><strong>Results: </strong>In the training dataset, the AUCs for the conventional MR image model and the 3 radiomics models were 0.749, 0.801, 0.847, and 0.896. The AUCs for the conventional MR image model and 3 radiomics models in the validation dataset were 0.693, 0.742, 0.793, and 0.876, respectively.</p><p><strong>Conclusions: </strong>Radiomics based on the combination of whole volume DCE-MRI and ADC maps is a promising tool for distinguishing between TNBC and non-TNBC.</p>","PeriodicalId":15402,"journal":{"name":"Journal of Computer Assisted Tomography","volume":" ","pages":"407-416"},"PeriodicalIF":1.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142780234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}