Journal of Computer Assisted Tomography最新文献

{"title":"Comparison of Radiation Dose and Image Quality in Pediatric Abdominopelvic Photon-Counting Versus Energy-Integrating Detector CT.","authors":"Marilyn J Siegel, Matthew Allan Thomas, Adeel Haq, Noah Seymore, Kushaljit Singh Sodhi, Andres Abadia","doi":"10.1097/RCT.0000000000001730","DOIUrl":"https://doi.org/10.1097/RCT.0000000000001730","url":null,"abstract":"<p><strong>Objective: </strong>Adoption of abdominal photon counting detector CT (PCD-CT) into clinical pediatric CT practice requires evidence that it provides diagnostic images at acceptable radiation doses. Thus, this study aimed to compare radiation dose and image quality of PCD-CT and conventional energy-integrating detector CT (EID-CT) in pediatric abdominopelvic CT.</p><p><strong>Materials and methods: </strong>This institutional review board-approved retrospective study included 147 children (median age 8.5 y; 80 boys, 67 girls) who underwent clinically indicated contrast-enhanced abdominopelvic PCD-CT between October 1, 2022 and April 30, 2023 and 147 children (median age 8.5 y; 74 boys, 73 girls) who underwent EID-CT between July 1, 2021 and January 1, 2022. Patients in the 2 groups were matched by age and effective diameter. Radiation dose parameters (CT dose index volume, CTDIvol; dose length product, DLP; size-specific dose estimate, SSDE) were recorded. In a subset of 25 matched pairs, subjective image quality was assessed on a scale of 1 to 4 (1=highest quality), and liver attenuation, dose-normalized noise, and contrast-to-noise ratio (CNR) were measured. Groups were compared using parametric and/or nonparametric testing.</p><p><strong>Results: </strong>Among the 147 matched pairs, there were no significant differences in sex (P=0.576), age (P=0.084), or diameter (P=0.668). PCD-CT showed significantly lower median CTDIvol, DLP, and SSDE (1.6 mGy, 63.8 mGy-cm, 3.1 mGy) compared with EID-CT (3.7 mGy, 155.3 mGy-cm, 6.0 mGy) (P<0.001). In the subset of 25 patients, PCD-CT and EID-CT showed no significant difference in overall image quality for reader 1 (1.0 vs. 1.0, P=0.781) or reader 2 (1.0 vs. 1.0, P=0.817), or artifacts for reader 1 (1.0 vs. 1.0, P=0.688) or reader 2 (1.0 vs. 1.0, P=0.219). After normalizing for radiation dose, image noise was significantly lower with PCD-CT (P<0.001), while CNR in the liver (P=0.244) and portal vein (P=0.079) were comparable to EID-CT.</p><p><strong>Conclusion: </strong>Abdominopelvic PCD-CT in children significantly reduces radiation dose while maintaining subjective image quality, and accounting for dose levels, has the potential to lower image noise and achieve comparable CNR to EID-CT. These data expand understanding of the capabilities of PCD-CT and support its routine use in children.</p>","PeriodicalId":15402,"journal":{"name":"Journal of Computer Assisted Tomography","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of a New CT Detector and Filtration Technology: Part 2-Image Quality in Phantoms, Cadavers, and Patients.","authors":"Izabella Barreto, Graham Stoddard, Anahita Heshmat, Tara Massini, Ibrahim Tuna, Lynn Rill, Manuel Arreola","doi":"10.1097/RCT.0000000000001711","DOIUrl":"https://doi.org/10.1097/RCT.0000000000001711","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this work was to evaluate the image quality of a commercial CT scanner equipped with a novel detector and filtration technology called PureVision Optics (PVO).</p><p><strong>Methods: </strong>CT number, noise, contrast-to-noise ratio (CNR), modulation transfer function (MTF), and noise power spectrum (NPS) were assessed using the ACR CT Accreditation phantom scanned with various acquisitions at 80 kV, 100 kV, 120 kV, and 135 kV, each with multiple CTDIvol values of 20 mGy, 40 mGy, and 65 mGy. Artifacts were evaluated in an anthropomorphic head phantom, a cadaver head, and in patient studies. Two neuroradiologists assessed image quality features in various patients who were examined with unenhanced brain CT on both scanners.</p><p><strong>Results: </strong>Compared with the conventional scanner, for the same CTDIvol, the PVO scanner produced 20.3% less image noise (P < 0.001), 18.9% higher CNR (P < 0.01), and 24.6% higher spatial resolution (P < 0.001). Streak artifacts were less severe with the PVO scanner for the phantom, cadaver, and patient scans (P < 0.05). Radiologists scored the PVO scanner as significantly better for visualization of the cerebrospinal fluid space over the cerebral sulci in high convexity, image noise in gray and white matter, and artifacts in the posterior fossa. They also significantly preferred the PVO scanner for visualization of the border between brain gray and white matter, cerebrospinal fluid space around the mesencephalon, and overall diagnostic acceptability.</p><p><strong>Conclusions: </strong>For matched CTDIvol values, the scanner equipped with PVO technology produced better objective and subjective image quality metrics in brain CT imaging compared with a conventional CT scanner without PVO. In clinical settings, PVO may allow for lower doses while enhancing imaging through dense areas, improving visualization of subtle details, and offering more effective options for examining obese patients.This research received financial support from Canon Medical Systems USA. The study design and data were fully controlled by the coauthors, of which none are employees or consultants of Canon Medical Systems USA.</p>","PeriodicalId":15402,"journal":{"name":"Journal of Computer Assisted Tomography","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Prototype \"Smart\" 3-Dimensionally Printed Model Showcasing Interactivity: Implementing Voice Command for the Ventricular and Cisternal Systems.","authors":"Cullen Fleming, Navid Mostaghni, Iman Elsayed, Sabrina Hsiao, Raheleh Taghvaei, Lauren Arsenault, Ramin Javan","doi":"10.1097/RCT.0000000000001695","DOIUrl":"https://doi.org/10.1097/RCT.0000000000001695","url":null,"abstract":"<p><strong>Abstract: </strong>The next step in the evolution of static 3-dimensionally (3D) printed models may be the creation of \"smart\" models, where subcomponents can be seamlessly interacted with through a feedback mechanism, with potential applications in trainee education and patient counseling. Considering the complexity of the ventricular and cisternal systems, they were chosen for segmentation, using Materialize InPrint with outward hollowing using 2.5-mm wall thickness. After 3D printing, dedicated holes were drilled for placement of wired light emitting diodes (LEDs) in anatomical landmarks and connected to an Arduino Uno microcontroller. This was coupled to a Bluetooth transceiver for communication via an Android cellular device. C++ was used to match each LED to a particular pin number on the Arduino board. When the user verbalizes a structure, the Bluetooth sends a command to the Arduino, where the code looks for the \"trigger word,\" subsequently sending a signal to illuminate the corresponding LED. The system requires wireless/cellular data for communication with the voice recognition engine on the Google server. The described method may serve as a prototype for when 3D printers are capable of simultaneously printing conductive material or wiring along with the main material within a model to allow for integration of feedback devices.</p>","PeriodicalId":15402,"journal":{"name":"Journal of Computer Assisted Tomography","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of a New CT Detector and Filtration Technology: Part 1 - X-ray Beam Characterization and Radiation Dosimetry.","authors":"Izabella Barreto, Nathalie Correa, Patricia Moser, Ibrahim Tuna, Tara Massini, Lynn Rill, Manuel Arreola","doi":"10.1097/RCT.0000000000001710","DOIUrl":"https://doi.org/10.1097/RCT.0000000000001710","url":null,"abstract":"<p><strong>Purpose: </strong>This study evaluated beam quality and radiation dosimetry of a CT scanner equipped with a novel detector and filtration technology called PureVision Optics (PVO). PVO features miniaturized electronics, a detector cut with microblade technology, and increased filtration in order to increase x-ray detection and reduce image noise.</p><p><strong>Methods: </strong>We assessed the performance of two similar 320-detector CT scanners: one equipped with PVO and one without. Beam quality was measured by determining the half-value layer (HVL) and effective energy (Eeff) for both scanners using all tube voltages (80 kV, 100 kV, 120 kV, 135 kV) and bowtie filters (small, medium, large) available. Energy correction factors were identified for optically stimulated luminescent dosimeters (OSLDS) compared to a calibrated ionization chamber. Surface and internal doses were measured for an anthropomorphic CT angiography head phantom and a cadaver head scanned with CTDIvol matched as close as possible at the conventional (55.1 mGy) and PVO (55.4 mGy) CT scanners.</p><p><strong>Results: </strong>For all scan settings, the PVO scanner showed significantly higher HVL (range, 4.33-11.02 mm Al) and effective energy (range, 39.4-68.0 keV) values compared to the conventional scanner (HVL, 4.19-8.25 mm Al; effective energy, 38.4-55.2 keV). For equivalent CTDIvol values, the energy-corrected surface skin and lens doses were on average 6.7% lower with the PVO scanner than the conventional scanner (P < 0.01).</p><p><strong>Conclusions: </strong>PVO technology yielded higher HVL and effective energies and, for the same CTDIvol, resulted in lower surface organ doses, indicating a potential for reduced patient radiation exposure in clinical settings.</p>","PeriodicalId":15402,"journal":{"name":"Journal of Computer Assisted Tomography","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triangular Margin: Reliable Imaging Feature of Fibrous Dysplasia in Long Bones?","authors":"Amine El Kandoussi, Steven J Staffa, Emre Ömeroğlu, Yin P Hung, Fabian Bauer, Santiago Lozano-Calderon, Connie Y Chang","doi":"10.1097/RCT.0000000000001731","DOIUrl":"https://doi.org/10.1097/RCT.0000000000001731","url":null,"abstract":"<p><strong>Objective: </strong>To determine the utility of a triangular margin as an imaging diagnostic feature for fibrous dysplasia.</p><p><strong>Materials and methods: </strong>We retrospectively reviewed all surgically biopsied or managed benign and malignant bone tumors by a single orthopedic oncologist over 19 years (2003 to 2022). A musculoskeletal radiologist and an orthopedic oncologist, both with >10 years of experience, retrospectively evaluated all imaging in consensus. Groups were compared using the χ2 test.</p><p><strong>Results: </strong>There were a total of 152 subjects [mean age 49±21 (range 7.8 to 91) years]; 80 (53%) females and 72 (47%) males. There were 52 subjects with fibrous dysplasia, 31 subjects with other benign bone tumors, and 69 subjects with malignant bone tumors. The sensitivity and specificity of a triangular margin for distinguishing fibrous dysplasia from other benign or malignant bone tumors were 74% and 96% on radiographs, 73% and 100% on CT, and 78% and 91% on MRI, respectively. The triangular margin was more prevalent in fibrous dysplasia (85%) versus benign (16%) and malignant (1.6%) primary bone tumors in all 3 modalities (P<0.001). Multivariate analysis of the aggregated imaging data suggests that if a lesion has a triangular margin, it is 14 times more likely to be a fibrous dysplasia than another benign bone tumor (P=0.012).</p><p><strong>Conclusions: </strong>The presence of a triangular margin could increase a radiologist's confidence that a bone tumor is fibrous dysplasia.</p>","PeriodicalId":15402,"journal":{"name":"Journal of Computer Assisted Tomography","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative Plaque Characteristics/Pericoronary Fat Attenuation Index and Acute Coronary Syndrome in Patients With Stable Angina Pectoris.","authors":"Defu Li, Yujin Wang, Tingting Zhu","doi":"10.1097/RCT.0000000000001718","DOIUrl":"https://doi.org/10.1097/RCT.0000000000001718","url":null,"abstract":"<p><strong>Objective: </strong>Vascular inflammation affects acute coronary syndrome (ACS) occurrence in patients with stable angina. Coronary inflammation can be represented by the pericoronary fat attenuation index (FAI).This study investigated the quantitative prognostic value of plaque characteristics and FAI in patients with stable angina.</p><p><strong>Methods: </strong>Risk factors for ACS occurrence in patients with stable angina pectoris were retrospectively analyzed. The diagnostic value of FAI and plaque characteristics for ACS occurrence in these patients were determined; Kaplan-Meier curves were used to predict ACS event incidence.</p><p><strong>Results: </strong>After postpropensity score matching, data of 60 and 130 patients with and without ACS, respectively, were analyzed. Pericoronary FAI, lipid volume, and lipid percentage in the narrowest segment significantly improved ACS diagnosis in patients with stable angina. Luminal stenosis ≥50% and FAI >-88 Hounsfield units (HU) were independent risk factors for ACS occurrence in patients with stable angina. Perileft anterior descending artery (LAD) FAI >-88 HU better predicted ACS occurrence in patients with stable angina than did peri-LAD FAI ≤-88 HU.</p><p><strong>Conclusions: </strong>In patients with stable angina, lipid volume and percentage and pericoronary FAI improved the diagnostic ability of luminal stenosis for ACS occurrence. Furthermore, peri-LAD FAI >-88 HU could predict ACS occurrence.</p>","PeriodicalId":15402,"journal":{"name":"Journal of Computer Assisted Tomography","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary: Is Your Department Ready to Educate Generation Z?","authors":"Devrim Ersahin","doi":"10.1097/RCT.0000000000001728","DOIUrl":"https://doi.org/10.1097/RCT.0000000000001728","url":null,"abstract":"<p><p>It is estimated that Generation Z will outnumber the next closest generation, the Millennials (born between 1981 and 1996), by 2040.Only a small number of them are currently in residency training; however, they have already entered the workforce in other professions. Many companies have studied Generation Z and have recognized major differences compared with older generations. Medical professionals can learn from the work already done to adjust for a smooth transition to medical training and postgraduate practice.</p>","PeriodicalId":15402,"journal":{"name":"Journal of Computer Assisted Tomography","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Different Imaging Evaluating Performances Between Glymphatic System and Motor Symptoms and Levodopa Responsiveness of Parkinson Disease.","authors":"Jin-Huan Deng, Han-Wen Zhang, Xin-Xin Lan, Yu-Feng Liu, Xiao-Lei Liu, Hua-Zhen Deng, Si-Ping Luo, Gui-Zhi Yao, He-Lv Wu, Biao Huang, Fan Lin","doi":"10.1097/RCT.0000000000001720","DOIUrl":"https://doi.org/10.1097/RCT.0000000000001720","url":null,"abstract":"<p><strong>Background and purpose: </strong>Parkinson disease (PD) is defined by its unique motor symptoms, where responsiveness to levodopa (L-DOPA) is fundamental for management. Recent research has highlighted a significant relationship between PD symptoms and glymphatic dysfunction. This study endeavors to clarify the connection between glymphatic system functionality and initial motor symptoms in PD, utilizing imaging biomarkers to determine its predictive capacity for L-DOPA responsiveness (LR).</p><p><strong>Materials and methods: </strong>Retrospective study of 86 PD patients with 3.0-T MRI scans (July 2019 to March 2021), assessing the diffusion tensor image analysis along the perivascular space (DTI-ALPS) methods, enlarged perivascular spaces (ePVSs) load, and choroid plexus volume (CPV). Analyzed metrics versus the third part of the Unified Parkinson Disease Rating Scale (UPDRSIII) scores and %LR using linear regression, creating a %LR prediction model for the L-DOPA challenge. Explored relationships with age, sex, Hoehn and Yahr stage, Montreal Cognitive Assessment scores, and Mini-Mental State Examination score. Examined DTI-ALPS index, ePVSs, and CPV interrelations.</p><p><strong>Results: </strong>Pre-L-DOPA, UPDRSIII inversely correlated with DTI-ALPS index (P=0.049), positively with bilateral basal ganglia ePVSs (P<0.001). Age-adjusted BG-ePVSs-UPDRSIII link (P<0.001). Post-L-DOPA, UPDRSIII correlated similarly and CPV was positive. %LR positively linked to DTI-ALPS index (P<0.001), negatively to BG-ePVSs (P=0.04), CPV (P<0.001). Adjusted %LR-DTI-ALPS index positive (P=0.005), %LR-CPV negative (P=0.04). DTI-ALPS index, CPV predicted LCT outcomes (%LR ≥33%) with area under the curves 0.78, 0.79; accuracies 86.01%, 81.4%. The combined model area under the curve is 0.82, with an accuracy of 87.2%. Significant linear correlations were observed (CPV-DTI-ALPS, CPV-ePVSs, DTI-ALPS-ePVSs).</p><p><strong>Conclusions: </strong>A study affirms the link between glymphatic impairment, motor symptoms, and L-DOPA responses in PD. As glymphatic function declines, symptoms worsen, and L-DOPA effectiveness diminishes. The DTI-ALPS index and CPV emerge as potential predictors of PD patient LCT outcomes.</p>","PeriodicalId":15402,"journal":{"name":"Journal of Computer Assisted Tomography","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spectrum of Otological Manifestations in Treacher Collins Syndrome: A Case Series of 9 Patients.","authors":"Shehbaz Ansari, Eric R Basappa, Peter C Markee, Chanae Dixon, Sudeep H Bhabad","doi":"10.1097/RCT.0000000000001715","DOIUrl":"https://doi.org/10.1097/RCT.0000000000001715","url":null,"abstract":"<p><p>Treacher Collins syndrome (TCS) is an uncommon congenital disorder predominantly involving craniofacial, orbital, and otological structures. The various ear malformations seen in 9 patients with TCS are described. TCS predominantly affects the external and middle ear structures, with inner ear structures being relatively spared, not unexpected given the dual embryological origin of the human ear. The external and middle ear malformations were categorized and graded as those involving the ear pinna, external auditory canal, tympanic cavity, ossicles, facial nerve canal, oval window, and bony labyrinth for all 9 patients. The ear malformations were symmetric in the majority, and the patients with higher grades of microtia were found to have a more severe category of other otological malformations.</p>","PeriodicalId":15402,"journal":{"name":"Journal of Computer Assisted Tomography","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic Contrast-enhanced MRI Processing Comparison for Distinguishing True Progression From Pseudoprogression in High-grade Glioma.","authors":"Ahmad Amer, Shehbaz Ansari, Apollo Krayyem, Suprateek Kundu, Swapnil Khose, Halyna Pokhylevych, Susana Calle, Chirag B Patel, Zixi Yang, Ho-Ling Anthony Liu, Jason M Johnson","doi":"10.1097/RCT.0000000000001716","DOIUrl":"https://doi.org/10.1097/RCT.0000000000001716","url":null,"abstract":"<p><strong>Background: </strong>Treatment-related changes may occur due to radiation and temozolomide in glioblastoma and can mimic tumor progression on conventional MRI. DCE-MRI enables quantification of the extent of blood-brain barrier (BBB) disruption, providing information about areas of suspicious postcontrast T1 enhancement. We compared DCE-MRI processing methods for distinguishing true disease progression from pseudoprogression in high-grade gliomas (HGGs).</p><p><strong>Methods: </strong>We identified 110 patients with HGG treated with surgery and chemoradiation who underwent DCE-MRI to further interrogate areas of new/increasing enhancement. All patients had confirmatory surgery/biopsy with pathology-confirmed progression or pseudoprogression. Scans were performed at 3T and analyzed using nordicICE. The MCA, SSS, and Parker models are three standardized processing methodologies used to create ktrans maps, a parameter that quantifies BBB permeability. Three equal regions of interest were placed at sites of peak contrast enhancement within each lesion. Data from each method was processed for mean and maximum ktrans. We conducted several rounds of analysis and finalized a strategy on penalized support vector machines based on engineered features with bootstrap sampling.</p><p><strong>Results: </strong>The Parker method was significant for ktrans maximum in the combined pathology and clinical as well as the pathology-only data sets. MCA and SSS did not perform well under the SVM classifier for pathology only. For clinical follow-up subjects, the Parker method yielded statistically significant results for maximum and mean ktrans.</p><p><strong>Conclusions: </strong>The Parker method was effective in distinguishing PD and PsP for pathology and clinical data sets. MCA and SSS techniques were effective for the clinical data set.</p>","PeriodicalId":15402,"journal":{"name":"Journal of Computer Assisted Tomography","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}