Journal of Clinical Pathology最新文献

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Molecular confirmation that fibrocartilaginous dysplasia is a variant of fibrous dysplasia. 分子证实纤维软骨发育不良是纤维性发育不良的一种变体。
IF 2.5 4区 医学
Journal of Clinical Pathology Pub Date : 2024-08-17 DOI: 10.1136/jcp-2024-209626
Juan Zhou, Xuling Su, Dingjun Hu, Li Zhang, Chunyan Chen, Keyang Sun, Huizhen Zhang, Zhiyan Liu
{"title":"Molecular confirmation that fibrocartilaginous dysplasia is a variant of fibrous dysplasia.","authors":"Juan Zhou, Xuling Su, Dingjun Hu, Li Zhang, Chunyan Chen, Keyang Sun, Huizhen Zhang, Zhiyan Liu","doi":"10.1136/jcp-2024-209626","DOIUrl":"https://doi.org/10.1136/jcp-2024-209626","url":null,"abstract":"<p><strong>Aims: </strong>Fibrocartilaginous dysplasia (FCD) is a subvariant of fibrous dysplasia (FD). This study aims to retrospectively elucidate the clinicopathological and separate genetic features of the cartilaginous and fibro-osseous components of FCD.</p><p><strong>Methods: </strong>In total, 24 patients (14 men and 10 women) with FCD were included in our cohort. The diagnosis was confirmed morphologically and immunohistochemically, and genetic features were determined via Sanger sequencing.</p><p><strong>Results: </strong>Five patients were polyostotic, and 19 were monostotic, predominantly concerning the femur. Radiography revealed a well-demarcated ground glass appearance with ring-like or scattered calcification. Histologically, the lesions were characterised by proliferative fibroblasts, immature woven bone and highly differentiated hyaline cartilage. The fibro-osseous components exhibited positive immunoreaction with SATB2 and a low Ki-67 proliferation index. The fibro-osseous and cartilaginous components shared mutations at codon 201 in exon 8 of the guanine nucleotide-binding protein/a-subunit (<i>GNAS)</i> gene, specifically CGT>CAT (p.R201H) in four patients and the wild-type isocitrate dehydrogenase (<i>IDH)1/IDH2</i> gene. Telomerase reverse transcriptase (<i>TERT)</i> promoter mutations (C288T and C229G) occurred in both fibro-osseous and cartilaginous components in two patients.</p><p><strong>Conclusions: </strong>FCD encompasses areas of conventional FD with additional cartilage. Importantly, the presence or absence of mutations in the <i>GNAS</i> gene and/or the <i>TERT</i> promoter is common between the fibro-osseous and cartilaginous components of the disease. These results further confirmed FCD as a variant of FD.</p>","PeriodicalId":15391,"journal":{"name":"Journal of Clinical Pathology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141995776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Laboratory investigation of peritoneal fluids: an updated practical approach based on the available evidence. 腹腔液的实验室检查:基于现有证据的最新实用方法。
IF 2.5 4区 医学
Journal of Clinical Pathology Pub Date : 2024-08-16 DOI: 10.1136/jcp-2023-209282
Giulia Colombo, Elena Aloisio, Mauro Panteghini
{"title":"Laboratory investigation of peritoneal fluids: an updated practical approach based on the available evidence.","authors":"Giulia Colombo, Elena Aloisio, Mauro Panteghini","doi":"10.1136/jcp-2023-209282","DOIUrl":"10.1136/jcp-2023-209282","url":null,"abstract":"<p><p>Even though analysis of peritoneal fluids (PF) is often requested to medical laboratories for biochemical and morphological tests, there is still no mutual agreement on what the most appropriate way is to manage PF samples and which tests should be appropriately executed. In this update, we tried to identify the most useful tests for PF analysis to establish best practice indications. We performed a literature review and examined available guidelines to select the most appropriate tests by an evidence-based approach. Accordingly, the basic PF profile should include (1) serum to effusion albumin gradient and (2) automated cell counts with differential analysis. This profile allows to determine the PF nature, differentiating between 'high-albumin gradient' and 'low-albumin gradient' effusions, which helps to identify the pathophysiological process causing the ascites formation. Restricted to specific clinical situations, additional tests can be requested as follows: PF lactate dehydrogenase (LDH) and glucose, to exclude (LDH) or confirm (glucose) secondary bacterial peritonitis; PF total protein, to differentiate ascites of cardiac origin from other causes; PF (pancreatic) amylase, for the identification of pancreatic ascites; PF bilirubin, when a choleperitoneum is suspected; PF triglycerides, in differentiating chylous from pseudochylous ascites and PF creatinine, to detect intraperitoneal urinary leakage.</p>","PeriodicalId":15391,"journal":{"name":"Journal of Clinical Pathology","volume":" ","pages":"579-585"},"PeriodicalIF":2.5,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140305767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NTRK gene alterations were enriched in hepatoid or enteroblastic differentiation type of gastric cancer. NTRK基因改变富集于肝样或肠样分化型胃癌。
IF 2.5 4区 医学
Journal of Clinical Pathology Pub Date : 2024-08-16 DOI: 10.1136/jcp-2023-208865
Xiaohong Pu, Yao Fu, Qi Sun, Lin Li, Attigah Kwasi, Ziyan Ma, Xiangshan Fan, Beicheng Sun
{"title":"NTRK gene alterations were enriched in hepatoid or enteroblastic differentiation type of gastric cancer.","authors":"Xiaohong Pu, Yao Fu, Qi Sun, Lin Li, Attigah Kwasi, Ziyan Ma, Xiangshan Fan, Beicheng Sun","doi":"10.1136/jcp-2023-208865","DOIUrl":"10.1136/jcp-2023-208865","url":null,"abstract":"<p><p><b>Aims</b> Currently, the clinicopathological characteristics of gastric cancer (GC) with oncogenic NTRK alterations are not well known. Although NTRK fusion has been identified as prevalent in DNA mismatch repair protein deficient (dMMR) colorectal cancer (CRC), the relationship between NTRK alterations and dMMR protein expression in GC has not been previously explored.</p><p><strong>Methods: </strong>Our study comprised 51 cases of EBV(Epstein-barr virus)-associated gastric carcinomas, 94 cases of dMMR GC, 90 cases of gastric adenocarcinoma with hepatoid or enteroblastic differentiation (GAHED) and 256 cases of conventional GC. Furthermore, to investigate the connection between NTRK fusion and dMMR proteins, we collected dMMR tumours of various types, including 21 cases of duodenal adenocarcinomas, 46 endometrioid carcinomas and 82 CRCs. NTRK fusion and amplification were screened in GC and various types of dMMR tumours using fluorescence in situ hybridisation (FISH), while cases positive for FISH translocation underwent next-generation sequencing testing.</p><p><strong>Results: </strong>Our findings revealed the existence of two cases each of NTRK fusions and NTRK amplifications, which were all enriched in case of GAHED. Additionally, following an analysis of several types of cancers, we discovered that NTRK gene alterations were only present in dMMR CRC.</p><p><strong>Conclusions: </strong>Our results indicate that NTRK gene alterations are not enriched in GC with dMMR but are specifically enriched in cases of GAHED.</p>","PeriodicalId":15391,"journal":{"name":"Journal of Clinical Pathology","volume":" ","pages":"608-613"},"PeriodicalIF":2.5,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11474252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9841338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autopsy findings from patients diagnosed with COVID-19 demonstrate unique morphological patterns in bone marrow and lymph node. 确诊为 COVID-19 的患者的尸检结果显示骨髓和淋巴结有独特的形态模式。
IF 2.5 4区 医学
Journal of Clinical Pathology Pub Date : 2024-08-16 DOI: 10.1136/jcp-2023-208875
Ali AlJabban, Mark G Evans, Geoffrey G Fell, Jack P Guccione, Robert A Edwards, Geraldine S Pinkus, Robert F Padera, Olga Pozdnyakova, Annette S Kim
{"title":"Autopsy findings from patients diagnosed with COVID-19 demonstrate unique morphological patterns in bone marrow and lymph node.","authors":"Ali AlJabban, Mark G Evans, Geoffrey G Fell, Jack P Guccione, Robert A Edwards, Geraldine S Pinkus, Robert F Padera, Olga Pozdnyakova, Annette S Kim","doi":"10.1136/jcp-2023-208875","DOIUrl":"10.1136/jcp-2023-208875","url":null,"abstract":"<p><strong>Aims: </strong>The identification of haemophagocytosis in bone marrow (BM) is recurrently identified in patients with severe COVID-19. These initial COVID-19 autopsy studies have afforded valuable insight into the pathophysiology of this disease; however, only a limited number of case series have focused on lymphoid or haematopoietic tissues.</p><p><strong>Methods: </strong>BM and lymph node (LN) specimens were obtained from adult autopsies performed between 1 April 2020 and 1 June 2020, for which the decedent had tested positive for SARS-CoV-2. Tissue sections (H&E, CD3, CD20, CD21, CD138, CD163, MUM1, kappa/lambda light chains in situ hybridisation) were examined by two haematopathologists, who recorded morphological features in a blinded fashion. Haemophagocytic lymphohistiocytosis (HLH) was assessed based on HLH 2004 criteria.</p><p><strong>Results: </strong>The BM demonstrated a haemophagocytic pattern in 9 out of 25 patients (36%). The HLH pattern was associated with longer hospitalisation, BM plasmacytosis, LN follicular hyperplasia and lower aspartate aminotransferase (AST), as well as ferritin at demise. LN examination showed increased plasmacytoid cells in 20 of 25 patients (80%). This pattern was associated with a low absolute monocyte count at diagnosis, lower white cell count and lower absolute neutrophil count at demise, and lower ferritin and AST at demise.</p><p><strong>Conclusions: </strong>Autopsy results demonstrate distinct morphological patterns in BM, with or without haemophagocytic macrophages, and in LN, with or without increased plasmacytoid cells. Since only a minority of patients met diagnostic criteria for HLH, the observed BM haemophagocytic macrophages may be more indicative of an overall inflammatory state.</p>","PeriodicalId":15391,"journal":{"name":"Journal of Clinical Pathology","volume":" ","pages":"622-627"},"PeriodicalIF":2.5,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9967395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How many mislabelled samples go unidentified? Results of a pilot study to determine the occult mislabelled sample rate. 有多少贴错标签的样本未被发现?一项旨在确定隐性误标样本率的试点研究结果。
IF 2.5 4区 医学
Journal of Clinical Pathology Pub Date : 2024-08-16 DOI: 10.1136/jcp-2024-209544
Caitlin Raymond, Liesel Dell'Osso, David Guerra, Julia Hernandez, Leonel Rendon, Donna Fuller, Alejandro Villasante-Tezanos, JuanDavid Garcia, Peter McCaffrey, Christopher Zahner
{"title":"How many mislabelled samples go unidentified? Results of a pilot study to determine the occult mislabelled sample rate.","authors":"Caitlin Raymond, Liesel Dell'Osso, David Guerra, Julia Hernandez, Leonel Rendon, Donna Fuller, Alejandro Villasante-Tezanos, JuanDavid Garcia, Peter McCaffrey, Christopher Zahner","doi":"10.1136/jcp-2024-209544","DOIUrl":"10.1136/jcp-2024-209544","url":null,"abstract":"<p><strong>Background: </strong>Specimens with incorrect patient information are both a critical safety error and difficult to identify. Estimates of sample mislabelling rely on subjective identification of mislabelling, with the possibility that not all mislabelled samples are being caught.</p><p><strong>Methods: </strong>We determined the blood type of two or more complete blood count specimens with the same patient label and assessed for discrepancies. We additionally determined the rate of identified sample mislabelling for the study period.</p><p><strong>Results: </strong>We found a rate of 3.17 per 1000 discrepancies over the study period. These discrepancies most likely represent occult, or unidentified, mislabelled samples. In contrast, the rate of identified sample mislabelling was 1.15 per 1000.</p><p><strong>Conclusions: </strong>This study suggests that specimens identified as, or known to be, mislabelled represent only a fraction of those mislabelled. These findings are currently being confirmed in our laboratory and are likely generalisable to other institutions.</p>","PeriodicalId":15391,"journal":{"name":"Journal of Clinical Pathology","volume":" ","pages":"647-650"},"PeriodicalIF":2.5,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141070056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enteroblastic gastric cancer subtype holds therapeutic clues. 肠细胞性胃癌亚型蕴含治疗线索
IF 2.5 4区 医学
Journal of Clinical Pathology Pub Date : 2024-08-16 DOI: 10.1136/jcp-2023-209346
Vikram Deshpande, Munita Bal
{"title":"Enteroblastic gastric cancer subtype holds therapeutic clues.","authors":"Vikram Deshpande, Munita Bal","doi":"10.1136/jcp-2023-209346","DOIUrl":"10.1136/jcp-2023-209346","url":null,"abstract":"","PeriodicalId":15391,"journal":{"name":"Journal of Clinical Pathology","volume":" ","pages":"605-607"},"PeriodicalIF":2.5,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140305766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Learning at a distance: results of an international survey on the adoption of virtual conferences and whole slide imaging by pathologists. 远程学习:病理学家采用虚拟会议和全切片成像技术的国际调查结果。
IF 2.5 4区 医学
Journal of Clinical Pathology Pub Date : 2024-08-16 DOI: 10.1136/jcp-2023-208912
Thiyaphat Laohawetwanit, Raul S Gonzalez, Andrey Bychkov
{"title":"Learning at a distance: results of an international survey on the adoption of virtual conferences and whole slide imaging by pathologists.","authors":"Thiyaphat Laohawetwanit, Raul S Gonzalez, Andrey Bychkov","doi":"10.1136/jcp-2023-208912","DOIUrl":"10.1136/jcp-2023-208912","url":null,"abstract":"<p><strong>Aims: </strong>This study presents the findings of a global survey of pathologists' views of online conferences and digital pathology.</p><p><strong>Methods: </strong>An online anonymous survey consisting of 11 questions focusing on pathologists' perceptions of virtual conferences and digital slides was distributed to practising pathologists and trainees across the globe using the authors' social media accounts and professional society connections. Participants were asked to rank their preference for various aspects of pathology meetings on a 5-point Likert scale.</p><p><strong>Results: </strong>There were 562 respondents from 79 countries. Several advantages of virtual meetings were recognised, including that they are less expensive to attend than in-person meetings (mean 4.4), more convenient to attend remotely (mean 4.3) and more efficient due to no loss of time for travel (mean 4.3). The lack of networking was reported as the main disadvantage of virtual conferences (mean 4.0). Most respondents (n=450, 80.1%) preferred hybrid or virtual meetings. About two-thirds (n=356, 63.3%) had no concern regarding the use of virtual slides for educational purposes and viewed them as an acceptable substitute for glass slides.</p><p><strong>Conclusions: </strong>Online meetings and whole slide imaging are viewed as valuable tools in pathology education. Virtual conferences allow affordable registration fees and flexibility for participants. However, networking opportunities are limited, meaning in-person meetings cannot be entirely replaced by virtual conferences. Hybrid meetings may be a solution to maximise the benefits of both virtual and in-person meetings.</p>","PeriodicalId":15391,"journal":{"name":"Journal of Clinical Pathology","volume":" ","pages":"632-638"},"PeriodicalIF":2.5,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9482862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HER2/ERBB2 overexpression in advanced gallbladder carcinoma: comprehensive evaluation by immunocytochemistry and fluorescence in situ hybridisation on fine-needle aspiration cytology samples. 晚期胆囊癌中的 HER2/ERBB2 过度表达:通过免疫细胞化学和荧光原位杂交对细针穿刺细胞学样本进行综合评估。
IF 2.5 4区 医学
Journal of Clinical Pathology Pub Date : 2024-08-16 DOI: 10.1136/jcp-2023-208940
Pragya Verma, Parikshaa Gupta, Nalini Gupta, Radhika Srinivasan, Pankaj Gupta, Usha Dutta, Shelly Sharma, Radha Uppal, Ritambhra Nada, Anupam Lal
{"title":"HER2/ERBB2 overexpression in advanced gallbladder carcinoma: comprehensive evaluation by immunocytochemistry and fluorescence in situ hybridisation on fine-needle aspiration cytology samples.","authors":"Pragya Verma, Parikshaa Gupta, Nalini Gupta, Radhika Srinivasan, Pankaj Gupta, Usha Dutta, Shelly Sharma, Radha Uppal, Ritambhra Nada, Anupam Lal","doi":"10.1136/jcp-2023-208940","DOIUrl":"10.1136/jcp-2023-208940","url":null,"abstract":"<p><strong>Aims: </strong>Advanced gallbladder carcinoma (AGBC) carries a poor prognosis with dismal survival. There are no data regarding HER2/ERBB2 expression in AGBC. This study evaluated the overexpression of HER2/ERBB2 in cytological aspirates from AGBCs to identify potential patients for whom anti-HER2 targeted therapies can benefit.</p><p><strong>Methods: </strong>This prospective, case-control study was performed on 50 primary AGBC cases. A detailed cytomorphological assessment, followed by immunocytochemistry (ICC) for HER2/ERBB2, was performed on AGBC cell blocks. A similar number of age-matched and gender-matched resected chronic cholecystitis specimens were included as controls. Fluorescence in situ hybridisation (FISH) was performed in equivocal cases.</p><p><strong>Results: </strong>A total of 10 (20%) cases showed positive (3+), 19 (38%) equivocal (2+) expression and 21 (42%) were negative on HER2/ERBB2 ICC. None of the equivocal cases demonstrated HER2 amplification by FISH. Among the controls, none showed positive (3+) immunoexpression, 23 (46%) demonstrated equivocal expression and 27 (54%) were negative. On statistical analysis, HER2/ERBB2 overexpression was significantly associated with AGBC compared with the controls. Of all the clinical, radiological and cytomorphological parameters, the predominant papillary or acinar arrangements of the tumour cells were significantly associated with HER2/ERBB2 overexpression.</p><p><strong>Conclusions: </strong>This is the first study to evaluate the expression of HER2/ERBB2 on cytological aspirates in AGBC using ICC and FISH. HER2/ERBB2 overexpression(20%) was significantly associated with AGBC. Furthermore, predominant papillary or acinar arrangements of tumour cells in the cytological smears were significantly associated with HER2/ERBB2 overexpression. They can serve as potential predictors of HER2/ERBB2 overexpression to select AGBC patients for anti-HER2 targeted therapies.</p>","PeriodicalId":15391,"journal":{"name":"Journal of Clinical Pathology","volume":" ","pages":"614-621"},"PeriodicalIF":2.5,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9512291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Accuracy and validity of determined cause of death and manner of death following forensic autopsy prosection. 法医解剖后确定死因和死亡方式的准确性和有效性。
IF 2.5 4区 医学
Journal of Clinical Pathology Pub Date : 2024-08-16 DOI: 10.1136/jcp-2023-208876
Armaan Shergill, Peter Conner, Machelle Wilson, Bennet Omalu
{"title":"Accuracy and validity of determined cause of death and manner of death following forensic autopsy prosection.","authors":"Armaan Shergill, Peter Conner, Machelle Wilson, Bennet Omalu","doi":"10.1136/jcp-2023-208876","DOIUrl":"10.1136/jcp-2023-208876","url":null,"abstract":"<p><strong>Aims: </strong>The purpose of this study is to evaluate the accuracy and validity of the determination of cause of death (COD) and manner of death (MOD) at the completion of the forensic autopsy prosection.</p><p><strong>Methods: </strong>We analysed 952 autopsy cases conducted from 2019 to 2020 and compared every patient's COD, other significant contributing factors to death (OSC), and MOD after prosection to their COD, OSC and MOD after completion of the final autopsy report.</p><p><strong>Results: </strong>We found that 83% of cases (790 patients) did not have an unexpected change and 17% of cases (162 patients) exhibited a true change in their final diagnosis; the relationship between age and changes in COD and MOD was significant.</p><p><strong>Conclusions: </strong>Our findings indicate that in the majority of forensic autopsy cases, medical professionals can reasonably complete death certification after the autopsy prosection. In addition to improving the accuracy of COD and MOD, advances in this field will enhance timely decedent affairs management, timely investigations of crimes and timely closure to families who have lost loved ones. We recommend implementing combined interventional education and consultation with expert pathologists, and a well-followed structured method of death classification as the best course of practice.</p>","PeriodicalId":15391,"journal":{"name":"Journal of Clinical Pathology","volume":" ","pages":"628-631"},"PeriodicalIF":2.5,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11347210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9622280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sudden cardiac death with morphologically normal heart: always do toxicology. 心脏形态正常的心脏性猝死:一定要做毒理学检查。
IF 2.5 4区 医学
Journal of Clinical Pathology Pub Date : 2024-08-16 DOI: 10.1136/jcp-2023-209351
Davide Radaelli, Joseph Westaby, Gherardo Finocchiaro, Gianfranco Sinagra, Stefano D'Errico, Mary N Sheppard
{"title":"Sudden cardiac death with morphologically normal heart: always do toxicology.","authors":"Davide Radaelli, Joseph Westaby, Gherardo Finocchiaro, Gianfranco Sinagra, Stefano D'Errico, Mary N Sheppard","doi":"10.1136/jcp-2023-209351","DOIUrl":"10.1136/jcp-2023-209351","url":null,"abstract":"","PeriodicalId":15391,"journal":{"name":"Journal of Clinical Pathology","volume":" ","pages":"645-646"},"PeriodicalIF":2.5,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11347233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140158179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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