Journal of Clinical Pathology最新文献_第10页

GPT-4 and histopathological image detection and classification of colorectal adenomas. 大肠腺瘤的 GPT-4 和组织病理学图像检测与分类。

IF 2.5 4区医学

Journal of Clinical Pathology Pub Date : 2024-05-17 DOI: 10.1136/jcp-2024-209405

Hinpetch Daungsupawong, Viroj Wiwanitkit

引用次数: 0

PHOX2B: a diagnostic cornerstone in neurocristopathies and neuroblastomas. PHOX2B：神经坏死和神经母细胞瘤的诊断基石。

IF 3.4 4区医学

Journal of Clinical Pathology Pub Date : 2024-05-17 DOI: 10.1136/jcp-2023-209047

Mei-Lan Windels, Fleur Cordier, Jo Van Dorpe, Liesbeth Ferdinande, David Creytens

引用次数: 0

Clinicopathological features of CD5-positive splenic marginal zone lymphoma. CD5阳性脾边缘区淋巴瘤的临床病理特征。

IF 2.5 4区医学

Journal of Clinical Pathology Pub Date : 2024-05-17 DOI: 10.1136/jcp-2022-208603

Yunling Li, Guannan Wang, Enjie Liu, Dandan Zhang, Yanping Zhang, Xiangyu Jian, Wugan Zhao, Wencai Li

{"title":"Clinicopathological features of CD5-positive splenic marginal zone lymphoma.","authors":"Yunling Li, Guannan Wang, Enjie Liu, Dandan Zhang, Yanping Zhang, Xiangyu Jian, Wugan Zhao, Wencai Li","doi":"10.1136/jcp-2022-208603","DOIUrl":"10.1136/jcp-2022-208603","url":null,"abstract":"Aims: To investigate the clinicopathological features, immunophenotypes and differential diagnosis of CD5-positive splenic marginal zone lymphoma (SMZL).Methods: We retrospectively analysed 16 CD5-positive cases of SMZL. Assess their clinicopathological features and survival outcomes to evaluate their similarities and differences with a control group of 25 CD5-negative cases of SMZL.Results: Compared with CD5-negative patients, CD5-positive SMZL tends to be more prone to B symptoms, peripheral lymphadenopathy and extranodal infiltration, high Ann Arbor stage, high International Prognostic Index scores, high serum lactic dehydrogenase and high rates of bone marrow involvement. The 5-year survival rate was significantly shorter than that of the CD5-negative group (52.1% and 81.8%, respectively).Conclusions: There are many similarities between CD5-positive SMZL and classical CD5-negative SMZL in clinical presentations, morphology and immunohistochemistry, but the former may have a more aggressive clinical course with a poorer prognosis.","PeriodicalId":15391,"journal":{"name":"Journal of Clinical Pathology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9179498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence and impact of non-canonical JAK2 p.(Val617Phe) mutations in myeloproliferative neoplasm molecular diagnostics. 骨髓增生性肿瘤分子诊断中非典型 JAK2 p.(Val617Phe) 突变的发生率和影响。

IF 3.4 4区医学

Journal of Clinical Pathology Pub Date : 2024-05-17 DOI: 10.1136/jcp-2023-209276

Danielle Patchell, Clodagh Keohane, Susan O'Shea, Stephen E Langabeer

引用次数: 0

Unusual fusion gene rearrangements in patients with nodular fasciitis: a study of rare and novel USP6 fusion partners with a review of the literature. 结节性筋膜炎患者的异常融合基因重排：对罕见和新型 USP6 融合伙伴的研究及文献综述。

IF 3.4 4区医学

Journal of Clinical Pathology Pub Date : 2024-05-17 DOI: 10.1136/jcp-2023-208768

Jan Balko, Martin Stanek, Lenka Krskova, Josef Zamecnik

{"title":"Unusual fusion gene rearrangements in patients with nodular fasciitis: a study of rare and novel USP6 fusion partners with a review of the literature.","authors":"Jan Balko, Martin Stanek, Lenka Krskova, Josef Zamecnik","doi":"10.1136/jcp-2023-208768","DOIUrl":"10.1136/jcp-2023-208768","url":null,"abstract":"Aims: This retrospective non-randomised study aims to identify new and rare fusion partners with USP6 in the setting of nodular fasciitis. It has been proven, that nodular fasciitis can harbour different variants of USP6 fusions, which can be used in routine diagnostics and even determine the biological behaviour of the process.Methods: A total of 19 cases of nodular fasciitis examined between 2011 and 2022 at Motol University Hospital in Prague were included into this study. Next to the histopathological evaluation, all cases were assessed using immunohistochemistry, RT-PCR and Anchored multiplex RNA methods. Patient's main demographic characteristics and corresponding clinical data were also analysed.Results: This study presents one novel (KIF1A) and five rare examples (TMP4, SPARC, EIF5A, MIR22HG, COL1A2) of fusion partners with USP6 among 19 cases of nodular fasciitis.Conclusion: Identification of USP6 fusion partners in nodular fasciitis helps to understand the biology of such lesions. Moreover, it can be useful in routine histopathological practice of soft-tissues diagnostics, especially in preventing possible misdiagnosis of malignancy.","PeriodicalId":15391,"journal":{"name":"Journal of Clinical Pathology","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11103289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10819272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosis and clinical relevance of uncommon subtypes of colorectal carcinoma. 不常见亚型结直肠癌的诊断和临床意义。

IF 3.4 4区医学

Journal of Clinical Pathology Pub Date : 2024-05-17 DOI: 10.1136/jcp-2023-209046

Raul S Gonzalez

引用次数: 0

The difficulty with measuring the largest melanoma tumour diameter in sentinel lymph nodes. 测量前哨淋巴结最大黑色素瘤肿瘤直径的困难。

IF 3.4 4区医学

Journal of Clinical Pathology Pub Date : 2024-05-17 DOI: 10.1136/jcp-2023-209354

Annelien E Laeijendecker, Mary-Ann El Sharouni, Nikolaos Stathonikos, Clothaire P E Spoto, Bart A van de Wiel, Erik J E Eijken, Marijne Mulder, Antien L Mooyaart, Anna Szumera-Cieckiewicz, Daniela Mihic-Probst, Daniela Massi, Martin Cook, Senada Koljenovic, Llucia Alos, Paul J van Diest, Alexander C J van Akkooi, Willeke Blokx

{"title":"The difficulty with measuring the largest melanoma tumour diameter in sentinel lymph nodes.","authors":"Annelien E Laeijendecker, Mary-Ann El Sharouni, Nikolaos Stathonikos, Clothaire P E Spoto, Bart A van de Wiel, Erik J E Eijken, Marijne Mulder, Antien L Mooyaart, Anna Szumera-Cieckiewicz, Daniela Mihic-Probst, Daniela Massi, Martin Cook, Senada Koljenovic, Llucia Alos, Paul J van Diest, Alexander C J van Akkooi, Willeke Blokx","doi":"10.1136/jcp-2023-209354","DOIUrl":"10.1136/jcp-2023-209354","url":null,"abstract":"Identification of sentinel node (SN) metastases can set the adjuvant systemic therapy indication for stage III melanoma patients. For stage IIIA patients, a 1.0 mm threshold for the largest SN tumour diameter is used. Therefore, uniform reproducible measurement of its size is crucial. At present, the number of deposits or their microanatomical sites are not part of the inclusion criteria for adjuvant treatment. The goal of the current study was to show examples of the difficulty of measuring SN melanoma tumour diameter and teach how it should be measured. Histopathological slides of SN-positive melanoma patients were retrieved using the Dutch Pathology Registry (PALGA). Fourteen samples with the largest SN metastasis around 1.0 mm were uploaded via tele-pathology and digitally measured by 12 pathologists to reflect current practice of measurements in challenging cases. Recommendations as educational examples were provided. Microanatomical location of melanoma metastases was 1 subcapsular, 2 parenchymal and 11 combined. The smallest and largest difference in measurements were 0.24 mm and 4.81 mm, respectively. 11/14 cases (78.6%) showed no agreement regarding the 1.0 mm cut-off. The median discrepancy for cases ≤5 deposits was 0.5 mm (range 0.24-0.60, n=3) and 2.51 mm (range 0.71-4.81, n=11) for cases with ≥6 deposits. Disconcordance in measuring SN tumour burden is correlated with the number of deposits. Awareness of this discordance in challenging cases, for example, cases with multiple small deposits, is important for clinical management. Illustrating cases to reduce differences in size measurement are provided.","PeriodicalId":15391,"journal":{"name":"Journal of Clinical Pathology","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139912735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Russell body typhilitis: An unusual mimicker of malignancy! 罗素体斑疹伤寒：一种不寻常的恶性肿瘤假象！

IF 3.4 4区医学

Journal of Clinical Pathology Pub Date : 2024-05-17 DOI: 10.1136/jcp-2023-209308

Devika Chauhan, Surbhi Goyal, Puja Sakhuja, Ujjwal Sonika

引用次数: 0

Plasma viscosity, immunoglobulins and risk of cardiovascular disease and mortality: new data and meta-analyses. 血浆粘度、免疫球蛋白与心血管疾病和死亡风险：新数据和荟萃分析。

IF 3.4 4区医学

Journal of Clinical Pathology Pub Date : 2024-05-17 DOI: 10.1136/jcp-2022-208223

Gordon D O Lowe, Katie Harris, Wolfgang Koenig, Yoav Ben-Shlomo, Barbara Thorand, Annette Peters, Christa Meisinger, Armin Imhof, Hugh Tunstall-Pedoe, Sanne A E Peters, Mark Woodward

{"title":"Plasma viscosity, immunoglobulins and risk of cardiovascular disease and mortality: new data and meta-analyses.","authors":"Gordon D O Lowe, Katie Harris, Wolfgang Koenig, Yoav Ben-Shlomo, Barbara Thorand, Annette Peters, Christa Meisinger, Armin Imhof, Hugh Tunstall-Pedoe, Sanne A E Peters, Mark Woodward","doi":"10.1136/jcp-2022-208223","DOIUrl":"10.1136/jcp-2022-208223","url":null,"abstract":"Aims: Associations of plasma viscosity and plasma Ig levels (a determinant of viscosity) with incident coronary heart disease (CHD) events; and with CHD, cardiovascular disease (CVD: CHD and stroke) and all-cause mortalities.Methods: Meta-analysis of plasma viscosity levels from the MONitoring of trends and determinants of CArdiovascular (MONICA)/Cooperative Health Research in the Region of Augsburg, MONICA Glasgow and Speedwell Studies; and five other published studies. Meta-analysis of IgA, IgG and IgM levels from the Augsburg, Glasgow and Speedwell studies; and one other published study.Results: Over median follow-up periods of 14-26 years, there were 2270 CHD events, and 4220 all cause deaths in 28 605 participants with baseline plasma viscosity measurements. After adjustment for major risk factors, (HRs; 95% CIs) for a 1 SD increase in viscosity were 1.14 (1.09 to 1.20) for CHD events; and 1.21 (1.17 to 1.25) for all-cause mortality. 821 CHD events and 2085 all-cause deaths occurred in 8218 participants with baseline Ig levels. For CHD events, adjusted HRs for 1 SD increases in IgA, IgG and IgM were, respectively, 0.97 (0.89 to 1.05); 0.95(0.76 to 1.17) and 0.90 (0.79 to 1.03). Corresponding adjusted HRs for all-cause mortality were 1.08 (95% CI 1.02 to 1.13), 1.03 (95% CI 0.94 to 1.14) and 1.01 (95% CI 0.96 to 1.06).Conclusions: After risk factor adjustment, plasma viscosity was significantly associated with risks of CHD events; and with CHD, CVD and all-cause mortalities. We found no significant association of IgA, IgG or IgM levels with incident CHD events or mortality, except for a borderline association of IgA with all-cause mortality.","PeriodicalId":15391,"journal":{"name":"Journal of Clinical Pathology","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10768452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Practical guide to the use of digital slides in histopathology education. 在组织病理学教学中使用数字幻灯片的实用指南。

IF 3.4 4区医学

Journal of Clinical Pathology Pub Date : 2024-05-17 DOI: 10.1136/jcp-2024-209415

Bethany Jill Williams

引用次数: 0