Journal of Carbohydrate Chemistry最新文献

Structural characterization, immune activity, and action mechanisms of fractionated polysaccharides from Athyrium multidentatum (Doll.) Ching 多齿胸草多糖的结构特征、免疫活性和作用机制京

IF 2.2 4区化学

Journal of Carbohydrate Chemistry Pub Date : 2025-07-24 DOI: 10.1080/07328303.2025.2527564

Ji-yu Chen , Ji-wen Sheng , Ting Wang , Yu-jie Yang , Jie Yang , Hong-wei Li , Han-tong Xiu , Xuan-chen Lu , Dong-mei Liu

{"title":"Structural characterization, immune activity, and action mechanisms of fractionated polysaccharides from Athyrium multidentatum (Doll.) Ching","authors":"Ji-yu Chen , Ji-wen Sheng , Ting Wang , Yu-jie Yang , Jie Yang , Hong-wei Li , Han-tong Xiu , Xuan-chen Lu , Dong-mei Liu","doi":"10.1080/07328303.2025.2527564","DOIUrl":"10.1080/07328303.2025.2527564","url":null,"abstract":"<div><div>A water-soluble polysaccharide (AFP) was extracted from <em>Athyrium Multidentatum</em> (Doll.) Ching by water extraction and alcohol precipitation method and purified by column chromatography. AFP was characterized by Fourier transform infrared (FT–IR) spectroscopy, ultraviolet-visible (UV–Vis) spectroscopy, circular dichroism (CD) spectroscopy, scanning electron microscopy (SEM), atomic force microscopy (AFM), Congo red (CR) binding assay, monosaccharide composition and molecular weight analyses. 1D and 2D nuclear magnetic resonance (NMR) studies revealed two structural components in AFP, which are →4-β-D-Man<em>p</em>-(1→4)-β-D-Xyl<em>p</em>-(1→4)-β-D-Xyl<em>p</em>-(1→2)-β-D-Gal<em>p</em>-(1→ and β-D-Glc<em>p</em>-(1→4)-β-D-Glc<em>p</em>-(1→4)-β-D-Glc<em>p</em>-(1→2)-β-D-Gal<em>p</em>-(1→. AFP exhibited significant immunological activities in both normal and immunosuppressed mice. Dectin-2/SYK/MAPK/non-classical NF-κB signaling pathways might play a crucial role in the immunomodulatory actions of AFP. Current results provided an important basis for the development of AFP as a natural immunoregulator.</div></div>","PeriodicalId":15311,"journal":{"name":"Journal of Carbohydrate Chemistry","volume":"44 4","pages":"Pages 196-230"},"PeriodicalIF":2.2,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145195919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The importance of glycotriazoles in medicinal chemistry – A narrative review 糖三唑在药物化学中的重要性——综述

IF 2.2 4区化学

Journal of Carbohydrate Chemistry Pub Date : 2025-07-24 DOI: 10.1080/07328303.2025.2488772

Rayssa de Cassia Alves Iemini , Dalila Junqueira Alvarenga , Ana Laura Marques Trinca , Guilherme Moreira Guidetti , Adriano Lucas da Luz Salgado , Isabela Darcie Pascoini , Jamie Anthony Hawkes , Diogo Teixeira Carvalho , Lucas Lopardi Franco

{"title":"The importance of glycotriazoles in medicinal chemistry – A narrative review","authors":"Rayssa de Cassia Alves Iemini , Dalila Junqueira Alvarenga , Ana Laura Marques Trinca , Guilherme Moreira Guidetti , Adriano Lucas da Luz Salgado , Isabela Darcie Pascoini , Jamie Anthony Hawkes , Diogo Teixeira Carvalho , Lucas Lopardi Franco","doi":"10.1080/07328303.2025.2488772","DOIUrl":"10.1080/07328303.2025.2488772","url":null,"abstract":"<div><div>Glycosides have gained increasing significance due to their roles in energy provision, structural function, and intercellular communication in living organisms. This recognition laid the foundation for advancements in glycobiology and pharmacology. This review traces the evolution of sugar modification methodologies to aglycones throughout the 20th century, culminating in the development of a groundbreaking coupling approach utilizing triazoles as molecular linkers. The “Click Chemistry,” an innovation in [2 + 3] cycloaddition, has allowed for the formation of glyco-compounds through energetically favorable reactions, and usually requires prior preparation of the terminal alkyne precursor and organic azide. This strategy has the significant benefit as a “synthetic structural access tool” – providing a way to achieve structures with regioselectivity that would not be accessible via other methods. This coupling method has emerged as a powerful tool in modern glyco-chemistry, enabling the synthesis of novel compounds with significant therapeutic potential. The triazole linkage can improve the stability (dependent on the individual molecules) and bioactivity of glycosides but also opens new venues for the development of drug candidates with enhanced efficacy and broader applications in medicinal chemistry. This review highlights the importance of glycotriazoles in advancing the field of medicinal chemistry and their potentials in future therapeutic development.</div></div>","PeriodicalId":15311,"journal":{"name":"Journal of Carbohydrate Chemistry","volume":"44 4","pages":"Pages 133-159"},"PeriodicalIF":2.2,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145195921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insight into interactions between cellulose model D-cellobiose and fourteen selected sodium salts using FT-IR, thermogravimetry, and computational analysis tools 深入了解纤维素模型d -纤维素二糖和14种选定的钠盐之间的相互作用，使用FT-IR，热重法和计算分析工具

IF 2.2 4区化学

Journal of Carbohydrate Chemistry Pub Date : 2025-07-24 DOI: 10.1080/07328303.2025.2530053

Ananda S. Amarasekara , Uchechukwu G. Ariwodo , Harshica Fernando

{"title":"Insight into interactions between cellulose model D-cellobiose and fourteen selected sodium salts using FT-IR, thermogravimetry, and computational analysis tools","authors":"Ananda S. Amarasekara , Uchechukwu G. Ariwodo , Harshica Fernando","doi":"10.1080/07328303.2025.2530053","DOIUrl":"10.1080/07328303.2025.2530053","url":null,"abstract":"<div><div>Understanding intermolecular interactions between cellulose and metal salts, and in particularly with anions, is crucial in development of cellulose composites and processing methods. Intermolecular interactions between cellulose model compound D-cellobiose and 14 sodium salts were evaluated using Fourier-Transform Infrared (FT-IR) spectroscopy, thermogravimetric (TG), and computational analysis tools. In FT-IR, shifts in 10 distinct bands in the D-cellobiose spectra were monitored to evaluate interactions between D-cellobiose and sodium salts. Na<sub>2</sub>B<sub>4</sub>O<sub>3</sub> and Na<sub>3</sub>PO<sub>4</sub> caused the highest total shifts of 61.85 and 34.08 cm<sup>−1</sup>, respectively. Mixing with salt caused lowering the initial decomposition temperatures in 10 out of the 14 salts. In density functional theory (DFT) study, Na<sub>2</sub>B<sub>4</sub>O<sub>7</sub> and D-cellobiose mixture showed negative binding energies of −11.18, −25.3, −30.9, and −12.2 kJ/mol in approaching α- and β-D-cellobiose from up and down faces. In addition, FT-IR data showed the strong interaction between borate anion and carbohydrate, where mixing Na<sub>2</sub>B<sub>4</sub>O<sub>7</sub> with D-cellobiose resulted in the largest total shift of 61.85 cm<sup>−1</sup> in the ten IR bands monitored. The strong interactions between Na<sub>2</sub>B<sub>4</sub>O<sub>7</sub> and D-cellobiose were explained as a result of Lewis acidity of boron, as well as multiple B and O atoms present in the anion and strong hydrogen bonding and dipolar interactions between B and O atoms.</div></div>","PeriodicalId":15311,"journal":{"name":"Journal of Carbohydrate Chemistry","volume":"44 4","pages":"Pages 179-195"},"PeriodicalIF":2.2,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145195887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An overview on marine bacterial exopolysaccharides and their industrial applications 海洋细菌胞外多糖及其工业应用综述

IF 2.2 4区化学

Journal of Carbohydrate Chemistry Pub Date : 2025-07-24 DOI: 10.1080/07328303.2025.2480564

Mohamed S. Amer , Khouloud M. Barakat , Hassan A. H. Ibrahim , Koichi Matsuo , Mohamed I. A. Ibrahim

{"title":"An overview on marine bacterial exopolysaccharides and their industrial applications","authors":"Mohamed S. Amer , Khouloud M. Barakat , Hassan A. H. Ibrahim , Koichi Matsuo , Mohamed I. A. Ibrahim","doi":"10.1080/07328303.2025.2480564","DOIUrl":"10.1080/07328303.2025.2480564","url":null,"abstract":"<div><div>Exopolysaccharides (EPSs) are sugar-based biopolymers produced by bacteria in response to environmental stress. Bacterial EPSs (BEPSs) have attracted attention across multiple industries due to their biodegradable and nontoxic nature. Their large-scale production and ease of purification make BEPSs more favorable than other intracellular and cell wall polysaccharides. Two key approaches are used to enhance BEPS yields: metabolic engineering and the utilization of low-cost materials for eco-friendly production. Despite ongoing efforts to isolate and classify new marine BEPSs, only a few have been industrially utilized. The discovery of BEPSs with novel sugar compositions or structural modifications could unlock new applications. Currently, marine BEPSs are used as thickeners, stabilizers, and gelling agents in the food industry and show potential in cosmetics, biotechnology, wastewater treatment, petroleum recovery, and textiles. While their use is still in the early stage, BEPSs hold significant promise as versatile biomaterials. This review highlights bacterial sources of marine EPSs and explores their industrial potential.</div></div>","PeriodicalId":15311,"journal":{"name":"Journal of Carbohydrate Chemistry","volume":"44 4","pages":"Pages 95-132"},"PeriodicalIF":2.2,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145195920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemoselective acetonation and one-pot glycosylation/acetylation of free sugars under ultrasonic green energy source 超声波绿色能源下游离糖的化学选择性乙酰化和一锅糖基化/乙酰化

IF 2.2 4区化学

Journal of Carbohydrate Chemistry Pub Date : 2025-07-24 DOI: 10.1080/07328303.2025.2527571

Nitin Kumar , Ankit Yadav , Saurabh Saini , Sudhir Kashyap

引用次数: 0

Molecular mechanisms underlying endoplasmic reticulum stress-triggered apoptosis induced by Trichoderma pseudokoningii exopolysaccharide in WEHI-3 mouse myeloid leukemic cells 假康宁木霉胞外多糖诱导WEHI-3小鼠髓性白血病细胞内质网应激引发凋亡的分子机制

IF 2.2 4区化学

Journal of Carbohydrate Chemistry Pub Date : 2025-07-24 DOI: 10.1080/07328303.2025.2528127

Jingbo Lu , Xianfeng Zhang , Kaoshan Chen

{"title":"Molecular mechanisms underlying endoplasmic reticulum stress-triggered apoptosis induced by Trichoderma pseudokoningii exopolysaccharide in WEHI-3 mouse myeloid leukemic cells","authors":"Jingbo Lu , Xianfeng Zhang , Kaoshan Chen","doi":"10.1080/07328303.2025.2528127","DOIUrl":"10.1080/07328303.2025.2528127","url":null,"abstract":"<div><div>In this work, the anticancer activities of an exopolysaccharide (EPS) from <em>Trichoderma pseudokoningii</em>, as well as its influence on WEHI-3 mouse myeloid leukemia cells, were investigated. This EPS not only inhibited the proliferation of WEHI-3 cells in a time- and concentration-dependent manner but also altered the morphology of WEHI-3 cells in a manner similar to that of apoptotic cells, as demonstrated by fluorescence staining experiments. Moreover, flow cytometry analysis also revealed that the EPS induced apoptosis in WEHI-3 cells. Additionally, the results indicated that the endoplasmic reticulum (ER) stress may be involved in this apoptotic process. Apoptotic factors related to the ER pathway were assessed subsequently. The results revealed that after treatment with the EPS for 48 h, the concentration of intracellular calcium in WEHI-3 cells increased. Exposure of WEHI-3 cells to different concentrations of the EPS (0.25, 0.50, and 1.0 mg/mL) resulted in decreased GRP78 mRNA transcription and increased CHOP mRNA expression in relation to the ER pathway. In addition, the Western blot results revealed that EPS significantly increased the p-PERK/PERK ratio, decreased the protein levels of GRP78 and Bcl-2, and increased the protein levels of CHOP and Bax. Caspase activity analysis also revealed that EPS treatment of WEHI-3 cells resulted in a dose-dependent increase in the activities of caspase-4 and caspase-3. Taking all together, these results provide evidence that the endoplasmic reticulum pathway is one of the potential pathways for the EPS-induced apoptosis in WEHI-3 cells.</div></div>","PeriodicalId":15311,"journal":{"name":"Journal of Carbohydrate Chemistry","volume":"44 4","pages":"Pages 231-251"},"PeriodicalIF":2.2,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145195918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulation approaches and pharmaceutical applications of chitosan and thiolated chitosan nanoparticles 壳聚糖及硫代壳聚糖纳米颗粒的制备方法及医药应用

IF 1.2 4区化学

Journal of Carbohydrate Chemistry Pub Date : 2025-03-24 DOI: 10.1080/07328303.2025.2451825

Zoya Saifi , Tanya Ralli , Divya Vohora , Showkat R. Mir , Saima Amin

引用次数: 0

Supramolecular assembly of antibody-rhamnose complex to enhance the complement-dependent cytotoxicity for cancer immunotherapy 抗体-鼠李糖复合物的超分子组装增强补体依赖性细胞毒性用于癌症免疫治疗

IF 1.2 4区化学

Journal of Carbohydrate Chemistry Pub Date : 2025-03-24 DOI: 10.1080/07328303.2024.2418526

Haofei Hong , Kun Zhou , Han Lin , Zhimeng Wu

引用次数: 0

Ring opening of cyclopropylmethylidene with trimethylaluminum: Synthesis of 1-cyclopropylethyl ether as an acid labile protecting group for hydroxyl Protection and carbohydrate synthesis 环丙基甲基乙烯与三甲基铝开环：1-环丙基乙醚的合成，作为羟基保护和碳水化合物合成的酸不稳定保护基团

IF 1.2 4区化学

Journal of Carbohydrate Chemistry Pub Date : 2025-03-24 DOI: 10.1080/07328303.2025.2471354

Madhav Poudel , Zainab Bustani , Xiaohua Li , Jianglong Zhu

引用次数: 0

Inhibition of lipopolysaccharide layer by plant-derived molecules: A novel approach to combat Helicobacter pylori 植物源性分子抑制脂多糖层：一种对抗幽门螺杆菌的新方法

IF 1.2 4区化学

Journal of Carbohydrate Chemistry Pub Date : 2025-03-24 DOI: 10.1080/07328303.2025.2459914

Abhishek Sharma , Pragati Mahur , Amit Kumar Singh , Jayaraman Muthukumaran , Monika Jain

{"title":"Inhibition of lipopolysaccharide layer by plant-derived molecules: A novel approach to combat Helicobacter pylori","authors":"Abhishek Sharma , Pragati Mahur , Amit Kumar Singh , Jayaraman Muthukumaran , Monika Jain","doi":"10.1080/07328303.2025.2459914","DOIUrl":"10.1080/07328303.2025.2459914","url":null,"abstract":"<div><div>The WHO classifies <em>H. pylori</em> as a critical public health issue. <em>H. pylori</em> is a gram-negative bacterium that causes infections in the stomach lining, contributing to conditions such as gastritis, peptic ulcers, and gastric cancer. The emergence of multidrug resistance in <em>H. pylori</em> presents a major obstacle in treatment, resulting in ineffective therapies and prolonged infections. The lipopolysaccharide biosynthesis pathway plays a crucial role in the survival of <em>H. pylori</em>. UDP-3-<em>O</em>-acyl-<em>N</em>-acetylglucosamine deacetylase (LpxC) is an essential enzyme, and its crucial role in disease pathogenesis has positioned LpxC as a highly promising druggable target for targeting <em>H. pylori</em> infection. In this study, we utilized structure-based virtual high-throughput screening of phytochemicals to discover potential inhibitors of LpxC. The selection of hits was initially based on their compliance with the Lipinski rule of 5, along with their toxicological, pharmacokinetic properties, and other drug-like attributes. This was followed by 100 ns molecular dynamics simulations in triplicate and MM/PBSA based binding free energy calculations. These findings indicated that Panicutine interacts strongly and enhances the stability of the LpxC structure, suggesting it as potential inhibitor of LpxC. The outcomes point to future studies to enhance their effectiveness as innovative and cost-effective treatments for <em>H. pylori</em> infections.</div></div>","PeriodicalId":15311,"journal":{"name":"Journal of Carbohydrate Chemistry","volume":"44 1","pages":"Pages 43-62"},"PeriodicalIF":1.2,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143716020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0