壳聚糖及硫代壳聚糖纳米颗粒的制备方法及医药应用

IF 1.2 4区 化学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Zoya Saifi , Tanya Ralli , Divya Vohora , Showkat R. Mir , Saima Amin
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引用次数: 0

摘要

有效的口服药物递送是非常理想的,以控制药物释放使用各种聚合物。在不同的聚合物中,壳聚糖被认为是一种安全、无毒的材料,是一种有效的药物载体。它具有生物相容性,可生物降解性,可通过水解几丁质的氨基乙酰基获得。壳聚糖在结构上不含任何巯基,而是通过化学修饰在其结构上加入游离巯基。这种衍生化使其成为具有黏附性和药物渗透性等特性的理想载体。最近,由于其表面的过量电荷有助于其与带电表面的结合,它已被用于免疫调节和骨吸收。因此,目前的研究彻底评估了壳聚糖和硫代壳聚糖纳米颗粒在医学口服给药方面的功效,特别是在骨质疏松症治疗的骨组织再生方面。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Formulation approaches and pharmaceutical applications of chitosan and thiolated chitosan nanoparticles
Effective oral drug delivery is highly desirable for a controlled drug release using various polymers. Among different polymers, chitosan is known to be a safe, nontoxic material that has served as an efficient drug carrier. It is biocompatible, biodegradable, and obtained by hydrolyzing the amino acetyl groups of chitins. Structurally chitosan does not possess any thiol group but is modified chemically to add free thiol groups to its structure. This derivatization makes it an ideal carrier with properties such as mucoadhesion and permeation of drugs. Recently it has been used for immune modulation and bone resorption because of the excessive charge on its surface that helps its binding with the charged surfaces. As a result, the current research thoroughly assesses the efficacy of chitosan and thiolated chitosan nanoparticles for oral drug administration in medicine, particularly in bone tissue regeneration for osteoporosis treatment.
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来源期刊
Journal of Carbohydrate Chemistry
Journal of Carbohydrate Chemistry 化学-生化与分子生物学
CiteScore
2.10
自引率
0.00%
发文量
20
审稿时长
1 months
期刊介绍: The Journal of Carbohydrate Chemistry serves as an international forum for research advances involving the chemistry and biology of carbohydrates. The following aspects are considered to fall within the scope of this journal: -novel synthetic methods involving carbohydrates, oligosaccharides, and glycoconjugates- the use of chemical methods to address aspects of glycobiology- spectroscopic and crystallographic structure studies of carbohydrates- computational and molecular modeling studies- physicochemical studies involving carbohydrates and the chemistry and biochemistry of carbohydrate polymers.
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