Journal of Carbohydrate Chemistry最新文献_第10页

Structural analyses and engineering of the pmHAS enzyme to improve its functional performance: An in silico study pmHAS酶的结构分析和工程设计以提高其功能性能:一项硅片研究

IF 1 4区化学

Journal of Carbohydrate Chemistry Pub Date : 2020-01-01 DOI: 10.1080/07328303.2020.1821041

Alireza Zakeri , Sepideh Khoshsorour , Mohsen Karami Fath , Navid Pourzardosht , Faezeh Fazeli , Saeed Khalili

引用次数: 1

Study on the activity of Mori Fructus polysaccharides and its derivatives against acute alcoholic liver injury in mice 桑多糖及其衍生物抗小鼠急性酒精性肝损伤活性的研究

IF 1 4区化学

Journal of Carbohydrate Chemistry Pub Date : 2020-01-01 DOI: 10.1080/07328303.2021.1895194

Xi Tan , Huaguo Chen , Xin Zhou

{"title":"Study on the activity of Mori Fructus polysaccharides and its derivatives against acute alcoholic liver injury in mice","authors":"Xi Tan , Huaguo Chen , Xin Zhou","doi":"10.1080/07328303.2021.1895194","DOIUrl":"10.1080/07328303.2021.1895194","url":null,"abstract":"<div>Four polysaccharides, MFPA1, MFPA2, MFPB1, and MFPB2, were isolated from Mori Fructus using DEAE-52 cellulose chromatography. MFPA1 (177 kDa) was composed of mannose, rhamnose, glucose, and xylose, and MFPB1 (165 kDa) was composed of mannose, rhamnose, galacturonic acid, glucose, and xylose, while MFPA2 (638 kDa) and MFPB2 (380 kDa) were consisted of mannose, rhamnose, glucuronic acid, galacturonic acid, glucose, xylose, and arabinose. These polysaccharides were sulfated to obtained Four sulfated polysaccharides, S-MFPA1, S-MFPA2, S-MFPB1, and S-MFPB2. The characteristic absorptive bands of purified polysaccharides and sulfated polysaccharides were determined by FT-IR. MFPA1, MFPB1, S-MFPA1, and S-MFPB1 showed excellent activities to activate alcohol dehydrogenase in vitro. Subsequently, it was found that MFPA1 had the strongest antiacute alcoholic liver injury activity through the experiments with acute alcoholic liver injury in mice. These results provide important scientific basis for Mori fructus polysaccharides as a potential therapeutic agent against acute alcoholic liver injury.</div>","PeriodicalId":15311,"journal":{"name":"Journal of Carbohydrate Chemistry","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/07328303.2021.1895194","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44486431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Comparison on structure, chain conformation, and antioxidant activity of polysaccharides extracted from Liriopes radix with hot water and ultrasound 热水法和超声法提取枳壳多糖的结构、链构象及抗氧化活性比较

IF 1 4区化学

Journal of Carbohydrate Chemistry Pub Date : 2020-01-01 DOI: 10.1080/07328303.2020.1746329

Xiaomei Wang , Shaobo Zhang , Zhixu Li , Miao Wang , Runguang Sun

引用次数: 5

Synthesis of glycoimmunogen Tn-Thr-PS A1 via hydrazone bond and stability optimization of PS A1 monosaccharide mimics under vaccine development conditions 酰腙键合成糖免疫原Tn-Thr-PS A1及PS A1单糖模拟物在疫苗制备条件下的稳定性优化

IF 1 4区化学

Journal of Carbohydrate Chemistry Pub Date : 2020-01-01 DOI: 10.1080/07328303.2019.1709975

F. Hossain , S. Nishat , S. Ghosh , S. Boga , G.T. Hymel , P.R. Andreana

{"title":"Synthesis of glycoimmunogen Tn-Thr-PS A1 via hydrazone bond and stability optimization of PS A1 monosaccharide mimics under vaccine development conditions","authors":"F. Hossain , S. Nishat , S. Ghosh , S. Boga , G.T. Hymel , P.R. Andreana","doi":"10.1080/07328303.2019.1709975","DOIUrl":"10.1080/07328303.2019.1709975","url":null,"abstract":"<div>Previously, our group constructed several immunogens utilizing oxime linkage to conjugate a T-cell stimulatory zwitterionic polysaccharide PS A1 and tumor associated carbohydrate antigens (TACAs) in acetate buffer. Here, a semi-synthetic immunogen was synthesized using hydrazone conjugation between PS A1 and a glycopeptide hydrazide (α-D-GalNAc-L-Thr-NH-NH2) with an excellent loading in PBS buffer. To get robust immune response, the retention of zwitterionic character of PS A1 under vaccine construction conditions is essential. In this regard, the stability of embedded pyruvate acetal moiety in tetrasaccharide repeating unit of PS A1 can validate the retention of the dual charges. Therefore, rather than utilizing this highly immunogenic PS A1 fully, stability studies were performed with synthetic 1-thiophenyl-4,6-O-pyruvate acetal-D-galactopyranose in varying acetate buffer pHs and time intervals. Furthermore, 1-propyl-D-galactofuranose was synthesized to mimick the D-Galf of PS A1 to examine regioselective hydrazone and oxime formation with α-D-GalNAc-L-Thr-NH-NH2 and α-D-GalNAc-ONH2 moieties respectively.</div>","PeriodicalId":15311,"journal":{"name":"Journal of Carbohydrate Chemistry","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/07328303.2019.1709975","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38987469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Glycosylation employing glycopyranosyl fluorides promoted by TiF4 under mild conditions 在温和条件下，TiF4促进甘氨酰氟的糖基化

IF 1 4区化学

Journal of Carbohydrate Chemistry Pub Date : 2020-01-01 DOI: 10.1080/07328303.2020.1837151

Joachim Thiem , Matthias Wiesner

引用次数: 0

Chemical synthesis and preliminary biological evaluation of C-6-O-methyl-1-deoxynojirimycin as a potent α-glucosidase inhibitor α-葡萄糖苷酶抑制剂c -6- o -甲基-1-脱氧诺吉霉素的化学合成及初步生物学评价

IF 1 4区化学

Journal of Carbohydrate Chemistry Pub Date : 2020-01-01 DOI: 10.1080/07328303.2019.1700995

Lin Wang , Tingting Liang , Zhijie Fang

引用次数: 1

A systematic review on the significant roles of cyclodextrins in the construction of supramolecular systems and their potential usage in various fields 综述了环糊精在超分子体系构建中的重要作用及其在各个领域的潜在应用

IF 1 4区化学

Journal of Carbohydrate Chemistry Pub Date : 2020-01-01 DOI: 10.1080/07328303.2020.1792919

R. Periasamy

引用次数: 10

2018 JCC Best Paper Award 2018年JCC最佳论文奖

IF 1 4区化学

Journal of Carbohydrate Chemistry Pub Date : 2019-11-06 DOI: 10.1080/07328303.2019.1685796

Guo Zhongwu

引用次数: 0

2018 T. Ogawa Young Investigator Award 2018 T.Ogawa青年调查员奖

IF 1 4区化学

Journal of Carbohydrate Chemistry Pub Date : 2019-11-04 DOI: 10.1080/07328303.2019.1685797

Zhongwu Guo

{"title":"2018 T. Ogawa Young Investigator Award","authors":"Zhongwu Guo","doi":"10.1080/07328303.2019.1685797","DOIUrl":"https://doi.org/10.1080/07328303.2019.1685797","url":null,"abstract":"I am delighted to announce that the winner of the 2018 T. Ogawa Young Investigator Award is Professor Qian Wan at Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, Hubei, China. T. Ogawa Young Investigator Award is established by the Journal of Carbohydrate Chemistry and is given annually to recognize a young principal investigator for his or her excellent contributions to carbohydrate chemistry. Prof. Wan received his B.S. degree in chemistry from Central China Normal University in 1997. In 2000, he completed his M.S. studies at the Paris-Sud University, supervised by Prof. Claudine Aug e. After receiving his PhD degree in 2004 from the Paris-Sud University under the supervision of Prof. Andr e Lubineau and Prof. Marie-Christine Scherrmann, he joined the group of Prof. Samuel J. Danishefsky at the Memorial SloanKettering Cancer Center as a postdoctoral fellow. From 2007 to 2011, Dr. Wan was a scientist at Amgen Inc. In 2012, he started his independent career as a Full Professor in Tongji School of Pharmacy at Huazhong University of Science and Technology. Dr. Wan’s major research interest has been focused on the development of novel and efficient strategies for the synthesis of biologically important oligosaccharides and the discovery of new free radical chemistry.","PeriodicalId":15311,"journal":{"name":"Journal of Carbohydrate Chemistry","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2019-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/07328303.2019.1685797","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46263802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An extensive review of studies on mycobacterium cell wall polysaccharide-related oligosaccharides – part II: Synthetic studies on complex arabinofuranosyl oligosaccharides carrying other functional motifs and related derivatives and analogs 分枝杆菌细胞壁多糖相关低聚糖研究综述——第二部分:携带其他功能基序的复合阿拉伯糖糠基低聚糖及其衍生物和类似物的合成研究

IF 1 4区化学

Journal of Carbohydrate Chemistry Pub Date : 2019-01-01 DOI: 10.1080/07328303.2019.1630840

Liwen Han , Lizhen Wang , Zhongwu Guo

{"title":"An extensive review of studies on mycobacterium cell wall polysaccharide-related oligosaccharides – part II: Synthetic studies on complex arabinofuranosyl oligosaccharides carrying other functional motifs and related derivatives and analogs","authors":"Liwen Han , Lizhen Wang , Zhongwu Guo","doi":"10.1080/07328303.2019.1630840","DOIUrl":"10.1080/07328303.2019.1630840","url":null,"abstract":"Abstract Lipoarabinomannan (LAM), mannosyl LAM (ManLAM), and mycolyl-arabinogalactan (mAG) are unique and ubiquitous cell wall constituents of Mycobacterium tuberculosis (M. tb), the bacterium causing tuberculosis (TB). It has been well documented that LAM, ManLAM, and mAG play an important role in mycobacterial infections and in the elicitation of specific immune responses against M. tb in the host. Therefore, LAM, ManLAM, mAG, and related molecules are attractive targets for the development of novel TB diagnostic and therapeutic strategies. Accordingly, numerous research groups have spent great effort on the chemical synthesis and biological studies of mycobacterium-related arabinofuranosyl oligosaccharides and their mimetics and conjugates. This article provides an extensive review about the progresses in this area. Due to the page limit of this journal, the review is published in three parts separately. This part (Part II) is focused on the synthesis of various ManLAM and mAG analogs containing mannose, galactose or galactosamine units and other natural structural motifs, as well as arabinofuranosyl oligosaccharide C-analogs and other derivatives. Graphical Abstract","PeriodicalId":15311,"journal":{"name":"Journal of Carbohydrate Chemistry","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/07328303.2019.1630840","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49308392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7