Journal of biomedical nanotechnology最新文献_第10页

The Value of Near-Infrared Multifunctional Nanoprobe Combined with Artificial Intelligence Microsensor Technology in Molecular Diagnosis for Gastric Cancer 近红外多功能纳米探针与人工智能微传感器技术在胃癌分子诊断中的应用价值

IF 2.9 4区医学

Journal of biomedical nanotechnology Pub Date : 2024-02-01 DOI: 10.1166/jbn.2024.3769

Qiang Sun, Jun Yao, Shuxun Wei, Xinxing Li, Weijun Wang

{"title":"The Value of Near-Infrared Multifunctional Nanoprobe Combined with Artificial Intelligence Microsensor Technology in Molecular Diagnosis for Gastric Cancer","authors":"Qiang Sun, Jun Yao, Shuxun Wei, Xinxing Li, Weijun Wang","doi":"10.1166/jbn.2024.3769","DOIUrl":"https://doi.org/10.1166/jbn.2024.3769","url":null,"abstract":"Since the symptoms of early gastric cancer patients are not obvious, the majority of new gastric cancer cases are progressive gastric cancer every year. In this paper, we applied nanomedicine technology to design and prepare multifunctional nanoparticles for the diagnosis and treatment\u0000 of gastric cancer. Through targeted imaging of gastric cancer, combined with phototherapy and the prepared nanoprobes are applied to the ectopic transplantation tumor model of gastric cancer. Meanwhile, a fluorescent microsensor based on graphene oxide and deoxyribonuclease is constructed\u0000 in order to realize the rapid detection of gastric cancer exosomes. The near-infrared multifunctional nanoprobe is combined with artificial intelligence microsensor technology and applied to the molecular diagnosis of gastric cancer. The results shows that the P-P-I-M+ laser irradiation group\u0000 has the highest fluorescence intensity and its average fluorescence intensity is 2.04 times higher than that of the P-P-I+ laser irradiation group. The relative cell viability of P-P-M+ laser irradiation group, P-P-I+ laser irradiation group and P-P-I-M+ laser irradiation group are 62.5%,\u0000 41.9% and 19.3%, respectively. Therefore, the method in this paper can reduce the non-specific toxicity to other organs as well as exert the effect of combining the diagnosis and treatment of gastric cancer.","PeriodicalId":15260,"journal":{"name":"Journal of biomedical nanotechnology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139825069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Follistatin-Like Protein 1 Alleviates Renal Ischemia-Reperfusion Injury by Regulating MicroRNA-21 类花粉素蛋白 1 通过调节 MicroRNA-21 减轻肾缺血再灌注损伤

IF 2.9 4区医学

Journal of biomedical nanotechnology Pub Date : 2024-02-01 DOI: 10.1166/jbn.2024.3760

Guoxiong Lin, Shiquan Chai, Kaibo Mei, Guixiang Xiong, Fanglan Liu, Haifei Mao

{"title":"Follistatin-Like Protein 1 Alleviates Renal Ischemia-Reperfusion Injury by Regulating MicroRNA-21","authors":"Guoxiong Lin, Shiquan Chai, Kaibo Mei, Guixiang Xiong, Fanglan Liu, Haifei Mao","doi":"10.1166/jbn.2024.3760","DOIUrl":"https://doi.org/10.1166/jbn.2024.3760","url":null,"abstract":"A mouse renal ischemia-reperfusion injury (RIRI) model was used to investigate how follistatin-Like Protein 1 (FSTL1) provides renal protection post-RIRI by targeting inflammation, apoptosis, and microRNA (miRNA). RIRI was induced in 8-week-old male C57BL/6 mice, followed by FSTL1 recombinant\u0000 protein treatment. Inflammation and apoptosis in kidney tissues were assessed using ELISA and flow cytometry. A cellular RIRI model was created using hypoxia/reoxygenation (H/R) in HK-2 cells to validate FSTL1’s effects. miRNA-mediated mechanisms were explored using cell transfection\u0000 and dual-luciferase assays. RIRI mice exhibited elevated inflammation and apoptosis, while FSTL1 treatment mitigated these effects. Similarly, FSTL1 attenuated H/R-induced HK-2 cell damage. miR-21 expression decreased in H/R-treated HK-2 cells, which FSTL1 reversed. miR-21 mimic reduced H/R-induced\u0000 HK-2 cell damage, while its inhibition decreased FSTL1’s protection. Notably, miR-21 targeted caspase-7 and suppressed its activity. FSTL1 alleviated mouse RIRI by upregulating miR-21, thereby reducing inflammation and apoptosis in kidney tissues post-RIRI. This study highlights FSTL1’s\u0000 therapeutic potential through the miR-21-mediated regulation of inflammation and apoptosis in RIRI.","PeriodicalId":15260,"journal":{"name":"Journal of biomedical nanotechnology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139826206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liposome Nanoparticles Loaded with Paeoniflorin Protect Neuronal Damage in Parkinson’s Disease by Regulating miR-135a 负载芍药苷的脂质体纳米颗粒通过调节 miR-135a 保护帕金森病的神经元损伤

IF 2.9 4区医学

Journal of biomedical nanotechnology Pub Date : 2024-02-01 DOI: 10.1166/jbn.2024.3801

Pin Wang, Dongxia Xia, Yihe Wang, Yue Qu

{"title":"Liposome Nanoparticles Loaded with Paeoniflorin Protect Neuronal Damage in Parkinson’s Disease by Regulating miR-135a","authors":"Pin Wang, Dongxia Xia, Yihe Wang, Yue Qu","doi":"10.1166/jbn.2024.3801","DOIUrl":"https://doi.org/10.1166/jbn.2024.3801","url":null,"abstract":"Paeoniflorin (PAE) is an active ingredient extracted from peony. This study aimed to explore the mechanism by which liposome nanoparticles loaded with PAE protect neuronal damage in Parkinson’s disease. Model group, PAE group, PAE-Lips group, PAE-Lips+miR-135a agonist group, PAE-Lips+miR-135a\u0000 inhibitor group, PAE-Lips+BAY11-7085 group, PAE-Lips+SC75741 group were designed. PCR, learning and memory ability testing, pole climbing test, etc. were used to determine the mechanism of PAE-Lips on Parkinson’s disease and whether it exerts effects through regulating miR-135a. PAE-Lips\u0000 were successfully constructed. PAE-Lips improved Parkinson’s disease in rats and had a certain connection with miR-135a. Up-regulating miR-135a inhibited NF-κB pathway to a certain extent and improved Parkinson’s disease. It helped protect neurons. Further verification\u0000 using PAE-Lips+miR-135a agonists, SC75741, BAY11-7085, etc. showed that PAE-Lips upregulated the expression of miR-135 and inhibited NF-κB pathway, which has a good protective effect on neurons in Parkinson’s disease. PAE-Lips can promote miR-135a to inhibit the NF-κB\u0000 pathway, thereby protecting neuronal damage in Parkinson’s disease. This study will provide a new idea for the prevention and treatment of Parkinson’s disease, clarify the impact of PAE-Lips, miR-135a, NF-κB, BAY11-7085 and SC75741 on Parkinson’s disease, and\u0000 provide a basis for the combined use of these interventions. The possibility of treating Parkinson’s disease more effectively deserves further exploration and research and provides a theoretical basis for the development of related therapeutic drugs.","PeriodicalId":15260,"journal":{"name":"Journal of biomedical nanotechnology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139827609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlations of ADAMTS13 Expression with Kidney Injury and Inflammatory Cytokine Changes in Rats with Preeclampsia 子痫前期大鼠 ADAMTS13 表达与肾损伤和炎症细胞因子变化的相关性

IF 2.9 4区医学

Journal of biomedical nanotechnology Pub Date : 2024-02-01 DOI: 10.1166/jbn.2024.3759

Guixia Sun, Xiaohan Yu, Yan Zhou, Qinxue Cao, Dongle Zhang

{"title":"Correlations of ADAMTS13 Expression with Kidney Injury and Inflammatory Cytokine Changes in Rats with Preeclampsia","authors":"Guixia Sun, Xiaohan Yu, Yan Zhou, Qinxue Cao, Dongle Zhang","doi":"10.1166/jbn.2024.3759","DOIUrl":"https://doi.org/10.1166/jbn.2024.3759","url":null,"abstract":"This study investigated the altered expression of ADAMTS13 (a metalloproteinase) in a rat model of preeclampsia (PE)-induced kidney injury, along with its connection to inflammatory cytokines. Sprague-Dawley rats were divided into PE and Control groups. PE group rats were induced with\u0000 Nω-Nitro-L-arginine methyl ester hydrochloride (L-NAME) to simulate PE-induced kidney injury. Key indicators such as systolic and diastolic blood pressure and proteinuria were assessed to confirm PE model success. Kidney tissue changes were examined through histology and cell\u0000 apoptosis, while ADAMTS13 expression was studied using Western blotting and qRT-PCR. Plasma ADAMTS13 levels were correlated with interleukin-6 (IL-6) and IL-8 cytokines in PE rats. Elevated SBP, DBP, and proteinuria were evident in L-NAME-treated pregnant rats. Microscopic examination revealed\u0000 glomerulocystic changes, thickened basement membranes, and increased apoptotic cells. Compared to Controls, PE rats exhibited decreased ADAMTS13 expression in renal tissues and plasma. Plasma IL-6 and IL-8 levels were elevated, inversely proportional to ADAMTS13 concentration in PE rats. In\u0000 conclusion, PE-induced kidney injury reduced ADAMTS13 levels, correlating with heightened IL-6 and IL-8 concentrations, suggesting an interplay between ADAMTS13 and inflammatory cytokines.","PeriodicalId":15260,"journal":{"name":"Journal of biomedical nanotechnology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139830913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Mechanism of miR-223 Inhibiting Treg Differentiation in Autoimmune Encephalomyelitis by Targeting Forkhead box-O3-Forkhead box-P3 Using Nano-Albumin Particles as a Carrier 以纳米白蛋白颗粒为载体靶向叉头盒-O3-叉头盒-P3的miR-223抑制自身免疫性脑脊髓炎中Treg分化的机制

IF 2.9 4区医学

Journal of biomedical nanotechnology Pub Date : 2024-02-01 DOI: 10.1166/jbn.2024.3793

Ziming Tan, Jun Wang, Mei Zhang, Hongtao Zhu, Qiong Luo

{"title":"The Mechanism of miR-223 Inhibiting Treg Differentiation in Autoimmune Encephalomyelitis by Targeting Forkhead box-O3-Forkhead box-P3 Using Nano-Albumin Particles as a Carrier","authors":"Ziming Tan, Jun Wang, Mei Zhang, Hongtao Zhu, Qiong Luo","doi":"10.1166/jbn.2024.3793","DOIUrl":"https://doi.org/10.1166/jbn.2024.3793","url":null,"abstract":"Central nervous system (CNS) inflammatory demyelinating diseases target oligodendrocytes or supporting cells. Millions of patients worldwide suffer from a variety of symptoms including vision. Motor and sensory impairments are increasingly recognized in children, but treatments for\u0000 these disorders remain very limited. This study intends to assess the mechanism of miR-223 in inhibiting regulatory T cells differentiation in autoimmune encephalomyelitis. Electron microscopy revealed nanoparticle size. miR-223 expression in tissues was detected by mRNA. MTT method and flow\u0000 cytometry were used to detect Treg cell activity, proliferation and differentiation. We further studied the mechanism by which miR-223 inhibits Treg differentiation and experimental autoimmune encephalomyelitis by targeting FOXO3-FOXP3. Animal experiments were conducted on the therapeutic\u0000 potential of miR-223 antagonists to confirm whether miR-223 antagonists have an effect on Experimental allergic encephalomyelitis (EAE). In our previous studies, we found that the expression of miR-223 was up-regulated in EAE and children with MOG antibody-related demyelinating diseases. Through\u0000 bioinformatics analysis, we found that FOXO3 could be used as a target gene of miR-223. FOXO3 is targeted by miR-223. Using nano-albumin particles as the carrier, miR-223 mimic reduced cell activity while FOXP3 overexpression partially offset the inhibitory effect. Overexpression of FOXP3\u0000 restored the Treg induced by using nano-albumin particles as the carrier of miR-223 mimic. Our study shows that nano-albumin particles carrying miR-223 can inhibit Treg cell differentiation by targeting FOXO3. This study provides a theoretical basis for clinical research.","PeriodicalId":15260,"journal":{"name":"Journal of biomedical nanotechnology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139882381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MicroRNA-153 Restrains Cell Metastasis and Epithelial–Mesenchymal Transition in Cervical Carcinoma by Targeting SATB1 and Regulating Wnt/β-Catenin Pathway MicroRNA-153 通过靶向 SATB1 和调控 Wnt/β-Catenin 通路抑制宫颈癌的细胞转移和上皮-间质转化

IF 2.9 4区医学

Journal of biomedical nanotechnology Pub Date : 2024-02-01 DOI: 10.1166/jbn.2024.3761

Wenfeng Liu, Meng Zhang, Xiaojie Du, Min Zhang, Weiling Wang, Zhiying Zhang

引用次数: 0

Mechanism of miR-21 Lipid Nanoparticles Carrier in Restraining Biological Behavior in Breast Carcinoma Through Targeting of Wnt/β-Catenin Channel miR-21 脂质纳米颗粒载体通过靶向 Wnt/β-Catenin 通道抑制乳腺癌生物学行为的机制

IF 2.9 4区医学

Journal of biomedical nanotechnology Pub Date : 2024-02-01 DOI: 10.1166/jbn.2024.3779

Yang Zhang, Jianglun Shen, Ning Li, Fen Hu, Faming Tian, Yiming Yang, Jinyin Yan, Haifeng Cai

{"title":"Mechanism of miR-21 Lipid Nanoparticles Carrier in Restraining Biological Behavior in Breast Carcinoma Through Targeting of Wnt/β-Catenin Channel","authors":"Yang Zhang, Jianglun Shen, Ning Li, Fen Hu, Faming Tian, Yiming Yang, Jinyin Yan, Haifeng Cai","doi":"10.1166/jbn.2024.3779","DOIUrl":"https://doi.org/10.1166/jbn.2024.3779","url":null,"abstract":"This study assessed the mechanism of miR-21 with lipid nanoparticles carrier in restraining biological behavior of breast carcinoma cells through targeting of Wnt/β-catenin channel. Breast carcinoma cells were collected and divided into blank set, miR-21 set, agonist set\u0000 and inhibitor set. We observed expressions of miR-21 cyclinD1, Bcl-2, Bax and Caspases-3. Also, quantity of cells through basement membrane, expression of factors related with Wnt/β-catenin signal channel, and targeting correlation between miR-21 and Wnt were also observed. The\u0000 expression of miR-21 in MCF-7 cells was lowest, while the ratio of active cells in blank set was highest. The expressions of Bax and Caspase-3 and quantity of cells through basement membrane in the blank and agonist sets were highest. The expressions of cyclinD1 and Bcl-2 were lowest. The\u0000 apoptotic rate in the blank and agonist sets was lowest and invasive rate was highest. The expressions of Wnt and β-catenin in the blank and agonist sets were highest. There was direct targeting correlation between miR-21 and Wnt while Wnt/β-catenin activity was restrained\u0000 by miR-21. The expressions of Bax and Caspase-3 also increased and apoptosis was induced and invasion and proliferation of breast carcinoma cells were restrained.","PeriodicalId":15260,"journal":{"name":"Journal of biomedical nanotechnology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139878003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blocking Runx2 Inhibits the Caspase-1 Dependent Pyroptosis in Lipopolysaccharide-Treated Chondrocyte 阻断 Runx2 可抑制脂多糖处理软骨细胞中 Caspase-1 依赖性热凋亡

IF 2.9 4区医学

Journal of biomedical nanotechnology Pub Date : 2024-02-01 DOI: 10.1166/jbn.2024.3765

Libo Yuan, Ling Yao, Xianzhen Ren, Xusheng Chen, Kaiqiang Kang, Yongqing Xu, Tao Jin

{"title":"Blocking Runx2 Inhibits the Caspase-1 Dependent Pyroptosis in Lipopolysaccharide-Treated Chondrocyte","authors":"Libo Yuan, Ling Yao, Xianzhen Ren, Xusheng Chen, Kaiqiang Kang, Yongqing Xu, Tao Jin","doi":"10.1166/jbn.2024.3765","DOIUrl":"https://doi.org/10.1166/jbn.2024.3765","url":null,"abstract":"Pyroptosis is a new type of cell death in the development of osteoarthritis (OA), but the underlying mechanism is not fully understood. This study aimed to investigate the role of Runx2 in the pyroptosis of chondrocyte (CH) and explore its effect on Caspase-1 expression. Human knee\u0000 tissues from the fracture patients without OA history were collected. Human CHs isolated from the tissue were treated by lipopolysaccharide (LPS) to establish the model of OA. siRNA and CADD522 were used to block the function of Runx2. The cell viability was tested by MTT. The expression levels\u0000 of Runx2, Caspase1/4/5/11, GSDMD, collagen-II, aggrecan, IL-1β, IL-8, and MMP3/9 were detected by RT-PCR, immunofluorescence, or western blot. Besides, the transcriptional association between Runx2 and Caspase-1 was confirmed by DNA immunoprecipitation and luciferase reporter assay.\u0000 Runx2 and Caspase-1 expression were increased in LPS-treated CHs. Runx2 bound to the promoter of Caspase-1 and activated its expression. Moreover, silencing Runx2 or disrupting the DNA-binding ability of Runx2 attenuated the LPS-induced pyroptotic phenotype, containing Caspase-1 activation,\u0000 collagen-II and aggrecan degradation, viability suppression, IL-1β and IL-8 upregulation. Blocking the expression or function of Runx2 alleviated the LPS-caused pyroptosis in CHs in the Caspase-1 manner, indicating a novel understanding of the pathology of OA.","PeriodicalId":15260,"journal":{"name":"Journal of biomedical nanotechnology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139884140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Polystyrene Targeting Nanoparticles on Lung Injury in Severe Acute Pancreatitis and NOX2/ROS/NF-κB Pathway 聚苯乙烯靶向纳米粒子对重症急性胰腺炎肺损伤及 NOX2/ROS/NF-κB 通路的影响

IF 2.9 4区医学

Journal of biomedical nanotechnology Pub Date : 2024-02-01 DOI: 10.1166/jbn.2024.3783

Changbo Liu, Liya Luo, Shuzhen Suo, Yongkang Song

{"title":"Effect of Polystyrene Targeting Nanoparticles on Lung Injury in Severe Acute Pancreatitis and NOX2/ROS/NF-κB Pathway","authors":"Changbo Liu, Liya Luo, Shuzhen Suo, Yongkang Song","doi":"10.1166/jbn.2024.3783","DOIUrl":"https://doi.org/10.1166/jbn.2024.3783","url":null,"abstract":"Relationship between polyethylene targeting nanoparticles and key components of the NOX2/ROS/NF-κB signaling pathway has not yet been fully clarified, and their regulatory role in lung injury in severe acute pancreatitis has not yet been confirmed. In this study, severe\u0000 acute pancreatitis lung injury cells were exposed to polyethylene targeting nanoparticles and MTT method was used to detect cell proliferation. Cell cycle and apoptosis rate were detected using flow cytometry and the expression of NOX2/ROS/NF-κB pathway was detected. The compound\u0000 polyethylene targeting nanoparticles inhibited proliferation of lung-damaged cells in severe acute pancreatitis dose-dependently (5, 10 and 20 μmol/L), induced G2/M phase arrest, and increased cell apoptosis. In addition, it reduced the expression of NOX2, ROS, and NF-κB,\u0000 indicating that NOX2/ROS/NF-κB pathway may be inhibited. Polystyrene targeting nanoparticles reduced the expression of IL-6, TNF-α, JAK, STAT, and IL-10. As a targeted drug delivery system, nano-drug-carrying systems help to dissolve drugs that are difficult to dissolve\u0000 in the drug solution and intervene in the corresponding tissues and cells in a targeted manner. The results of this study showed that polymer-targeted nano-drug systems could regulate the growth of lung-damaged cells in severe acute pancreatitis. Polyethylene targeting nanoparticles may be\u0000 effective in inhibiting inflammation in lung-damaged cells in severe acute pancreatitis via regulation of NOX2/ROS/NF-κB pathway.","PeriodicalId":15260,"journal":{"name":"Journal of biomedical nanotechnology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139891310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Simvastatin-Loaded Nanoliposome Delivery System for Sepsis-Induced Acute Lung Injury 治疗脓毒症诱发的急性肺损伤的辛伐他汀载体纳米脂质体输送系统

IF 2.9 4区医学

Journal of biomedical nanotechnology Pub Date : 2024-02-01 DOI: 10.1166/jbn.2024.3805

Jianhai Yang, Yue Yue

{"title":"A Simvastatin-Loaded Nanoliposome Delivery System for Sepsis-Induced Acute Lung Injury","authors":"Jianhai Yang, Yue Yue","doi":"10.1166/jbn.2024.3805","DOIUrl":"https://doi.org/10.1166/jbn.2024.3805","url":null,"abstract":"To enhance the treatment of acute lung injury (ALI) induced by sepsis and optimize the clinical efficacy of simvastatin (SV), we develop SV-loaded nanoliposomes (SV/NLC) as a novel drug delivery system. The NLCs exhibited a particle size of approximately 165 nm, which increased to around\u0000 195 nm upon SV loading. NLCs significantly prolonged the half-life of SV by nearly five-fold and improved its penetration into EA.hy926 cells, demonstrating excellent biocompatibility and targeted delivery for ALI therapy. In the rat model of ALI, the SV/NLC effectively reduced the lung wet/dry\u0000 ratio and the levels of inflammatory factor and albumin in the alveoli, thus improving the alveolar gas exchange function and blood oxygenation. The SV/NLC group demonstrated superior suppression of oxidative stress within lung tissues compared to other groups. Notably, treatment with SV reduction\u0000 in TLR4, MyD88, and NF-κB P65 levels in lung tissues from ALI rat models. This effect was particularly pronounced in the SV/NLC group. Furthermore, SV can effectively mitigate inflammatory responses and oxidative stress in ALI treatment by modulating the TLR4/NF-κB\u0000 signaling pathway. In conclusion, our findings suggest that SV can exert therapeutic effects against sepsis-induced ALI through inhibition of the TLR4/NF-κ and mitigate inflammatory response and oxidative stress.","PeriodicalId":15260,"journal":{"name":"Journal of biomedical nanotechnology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139881938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0