Crucial Biological Roles of Long Noncoding RNA-Mediated Pyroptosis in Urological Tumors

Abstract

Urologic neoplasm is one of the most general neoplasms, including bladder neoplam, prostate neoplasm and renal neoplasm. Researches have shown that tumor formation is a very complicated process, and it is the result of cell proliferation that is seriously out of control. Long noncoding RNA (lncRNA) and pyroptosis act separately or together on the tumorigenesis, growth and metastasis of urinary tumors, and are related to their treatment and prognosis. In this review, we summarized existing studies and found that lncRNA-mediated pyroptosis can promote or inhibit the development of urinary tumors. Pyroptosis can be achieved by lncRNA-caspase-gasdermin axis. Abnormal lncRNA expression may cause uncontrolled pyroptosis, thus bringing tumor deterioration and adverse prognosis. Controlling pyroptosis of neoplasm cells by regulating pyroptosis-related lncRNAs may be a new entry for the treatment of urinary neoplasms.