Elmma Khalid, Hannah B VanLandingham, Karen S Basurto, Amanda N Nili, Christopher Gonzalez, Janna L Guilfoyle, Gabriel P Ovsiew, Nicole M Durkin, Devin M Ulrich, Zachary J Resch, Neil H Pliskin, Jason R Soble, Brian M Cerny
{"title":"Exploring Subfactors of Adult Cognitive Disengagement Syndrome and Impact on Neuropsychological Performance.","authors":"Elmma Khalid, Hannah B VanLandingham, Karen S Basurto, Amanda N Nili, Christopher Gonzalez, Janna L Guilfoyle, Gabriel P Ovsiew, Nicole M Durkin, Devin M Ulrich, Zachary J Resch, Neil H Pliskin, Jason R Soble, Brian M Cerny","doi":"10.1177/10870547231218945","DOIUrl":"10.1177/10870547231218945","url":null,"abstract":"<p><strong>Objective: </strong>This study investigated subfactors of cognitive disengagement syndrome (CDS; previously referred as sluggish cognitive tempo) among adults referred for neuropsychological evaluation of attentiondeficit/hyperactivity disorder (ADHD).</p><p><strong>Method: </strong>Retrospective analyses of data from 164 outpatient neuropsychological evaluations examined associations between CDS subfactors and self-reported psychological symptoms and cognitive performance.</p><p><strong>Results: </strong>Factor analysis produced two distinct but positively correlated constructs: \"Cognitive Complaints'' and \"Lethargy.\" Both correlated positively with symptom reports (rs = 0.26-0.57). Cognitive Complaints correlated negatively with working memory, processing speed, and executive functioning performance (rs = -0.21 to -0.37), whereas Lethargy correlated negatively only with processing speed and executive functioning performance (rs = -0.26 to -0.42). Both predicted depression symptoms, but only Cognitive Complaints predicted inattention symptoms. Both subfactors demonstrated modest to nonsignificant associations with cognitive performance after accounting for estimated premorbid intelligence and inattention.</p><p><strong>Conclusion: </strong>Findings indicate a bidimensional conceptualization of CDS, with differential associations between its constituent subfactors, reported symptoms, and cognitive performance.</p>","PeriodicalId":15237,"journal":{"name":"Journal of Attention Disorders","volume":" ","pages":"957-969"},"PeriodicalIF":3.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139097935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P Douglas Callan, Stephanie Swanberg, Sarah K Weber, Kari Eidnes, Tara M Pope, Dustin Shepler
{"title":"Diagnostic Utility of Conners Continuous Performance Test-3 for Attention Deficit/Hyperactivity Disorder: A Systematic Review.","authors":"P Douglas Callan, Stephanie Swanberg, Sarah K Weber, Kari Eidnes, Tara M Pope, Dustin Shepler","doi":"10.1177/10870547231223727","DOIUrl":"10.1177/10870547231223727","url":null,"abstract":"<p><strong>Objective: </strong>To review the literature on the utility of the Conners CPT-3 in persons with ADHD.</p><p><strong>Methods: </strong>A systematic review was conducted. Six databases were searched using inclusion criteria: research studies, year 2000+, English, and ages 8+. Two raters independently screened 1,480 title/abstracts and subsequently reviewed 399 full texts. Data extraction and critical appraisal were conducted. Reflective thematic analysis through inductive coding identified qualitative themes.</p><p><strong>Results: </strong>Thirteen studies met inclusion criteria with five themes identified. Five studies found CPT-3 was a weak or poor predictor of ADHD diagnosis while two found it was an adequate predictor. Two studies found CPT-3 could differentiate clients with comorbid ADHD/anxiety from ADHD or ADHD from obsessive-compulsive disorder. One found CPT-3 could not differentiate ADHD from ASD or comorbid ADHD/ASD.</p><p><strong>Conclusions: </strong>Results revealed CPT-3 as a standalone measure is a weak or poor predictor of ADHD. Multiple measures for evaluating persons with ADHD are recommended.</p>","PeriodicalId":15237,"journal":{"name":"Journal of Attention Disorders","volume":" ","pages":"992-1007"},"PeriodicalIF":2.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139691945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vishal Madaan, Sailaja Bhaskar, Graeme A E Donnelly, Daniel J Cox
{"title":"A Randomized, Phase 3, Double-Blind, Crossover Comparison of Multilayer, Extended-Release Methylphenidate (PRC-063), and Lisdexamfetamine in the Driving Performance of Young Adults With ADHD.","authors":"Vishal Madaan, Sailaja Bhaskar, Graeme A E Donnelly, Daniel J Cox","doi":"10.1177/10870547241226634","DOIUrl":"10.1177/10870547241226634","url":null,"abstract":"<p><strong>Objective: </strong>To compare PRC-063 (multilayer-release methylphenidate) and lisdexamfetamine dimesylate (LDX) on the driving performance of young adults with attention deficit hyperactivity disorder (ADHD) in a randomized, double-blind, crossover study.</p><p><strong>Method: </strong>Following up to 21 days of each treatment in each treatment course (PRC-063/LDX or LDX/PRC-063), subjects completed a 15-hour driving simulator laboratory assessment. The primary outcome measure was the Tactical Driving Quotient (TDQ) and the Clinical Global Impressions-Improvement (CGI-I) scale was a secondary outcome measure.</p><p><strong>Results: </strong>Forty-four subjects completed the study. PRC-063 and LDX had equivalent effects on driving performance through a 15-hour time period (least square mean difference -0.3 [standard error 1.08], 95% confidence interval [-2.4, 1.8], <i>p</i> = .793). Consistent improvement in CGI-I was observed. The incidence of treatment-emergent adverse events was similar for each treatment sequence.</p><p><strong>Conclusions: </strong>PRC-063 and LDX had comparable effects on driving performance, from 1 through 15 hours, the last time point measured.</p>","PeriodicalId":15237,"journal":{"name":"Journal of Attention Disorders","volume":" ","pages":"947-956"},"PeriodicalIF":3.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10981171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139972035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carlotta Rivella, Alice Bazzurro, Valeria Olla, Cristina Potente, Claudio Vio, Paola Viterbori, Maria Carmen Usai
{"title":"Impact of Distractors on Sustained Attention and Inhibition in Children With ADHD.","authors":"Carlotta Rivella, Alice Bazzurro, Valeria Olla, Cristina Potente, Claudio Vio, Paola Viterbori, Maria Carmen Usai","doi":"10.1177/10870547231218932","DOIUrl":"10.1177/10870547231218932","url":null,"abstract":"<p><strong>Objective: </strong>This study examines the impact of visual and auditory distractors on attention and inhibition in children with and without ADHD.</p><p><strong>Method: </strong>The study used the MOXO d-CPT child version. The sample consisted of 208 children aged 8 to 12 years, including 64 with ADHD and 144 controls.</p><p><strong>Results: </strong>Children with ADHD and controls differed in their reaction to distracting stimuli; visual distractors cause a higher decrease in sustained attention and inhibitory control in the ADHD group. Moreover, auditory distractors generate improved performance in the control group but not in the ADHD group. In addition, age-related effects were found in both sustained attention and inhibitory control in all children, regardless of whether the ADHD condition was present.</p><p><strong>Conclusions: </strong>The findings indicate that children with ADHD performed poorer compared to controls, and that distractors differently affected the performance of the two groups.</p>","PeriodicalId":15237,"journal":{"name":"Journal of Attention Disorders","volume":" ","pages":"970-981"},"PeriodicalIF":3.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139097936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Esen Yıldırım Demirdöğen, Mehmet Akif Akıncı, Abdullah Bozkurt, Bahadır Turan, İbrahim Selçuk Esin, Mehmet Ali Donbaloğlu, İsa Bingöl, Gülşah Tümüklü Özyer, Uğur Kılıç, Onur Burak Dursun
{"title":"Objective Parameters in Attention Deficit Hyperactivity Disorder: Eye and Head Movements.","authors":"Esen Yıldırım Demirdöğen, Mehmet Akif Akıncı, Abdullah Bozkurt, Bahadır Turan, İbrahim Selçuk Esin, Mehmet Ali Donbaloğlu, İsa Bingöl, Gülşah Tümüklü Özyer, Uğur Kılıç, Onur Burak Dursun","doi":"10.1177/10870547231221746","DOIUrl":"10.1177/10870547231221746","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to evaluate eye and head movements, which are objective parameters in ADHD. Method: While the children were watching the course video task, which included the relevant (teacher and smart board) and irrelevant (any regions outside the relevant area) areas of interest, their eye movements were evaluated through eye tracking, and video recordings were made simultaneous. Head position estimation was made using through video recordings. The proportion of total fixation duration on areas of interest (PFDAOI) and saccade count, amplitude, velocity for eye movements, number of total head movements and angular change of head movement in <i>x</i>-<i>y</i>-<i>z</i> axes for head movements were compared.</p><p><strong>Results: </strong>Children with ADHD had lower PFDAOI on the relevant area, and had more saccade and head movements The angular change of head movement in the x-axis was higher in the ADHD group.</p><p><strong>Conclusion: </strong>In the assessment of ADHD, the eye and head movements may be particulary useful.</p>","PeriodicalId":15237,"journal":{"name":"Journal of Attention Disorders","volume":" ","pages":"982-991"},"PeriodicalIF":3.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139424815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Israel Moses Gross, Yangfeifei Gao, Mary J Lee, Alison E Hipwell, Kate Keenan
{"title":"The ADHD Phenotype in Black and White Girls From Childhood to Adolescence: Results From the Community-Based Pittsburgh Girls Study.","authors":"Israel Moses Gross, Yangfeifei Gao, Mary J Lee, Alison E Hipwell, Kate Keenan","doi":"10.1177/10870547231215281","DOIUrl":"10.1177/10870547231215281","url":null,"abstract":"<p><strong>Objective: </strong>The goal of the present study is to describe the ADHD phenotype from childhood to adolescence in Black and White girls in a community sample.</p><p><strong>Method: </strong>Primary caregivers enrolled in the population-based, longitudinal Pittsburgh Girls Study reported on girls' ADHD symptoms and impairment from ages 7 to 17; diagnostic subtypes were estimated based on meeting symptom criteria.</p><p><strong>Results: </strong>The prevalence of any subtype of ADHD ranged from 6.4 to 9.2% and from 2.3 to 6.4% for Black and White girls respectively; the inattentive subtype was most endorsed. A relatively equal number of new diagnoses at each age was observed. Persistence of ADHD diagnoses was typically 1 to 2 years.</p><p><strong>Conclusions: </strong>ADHD in the community is relatively common, with the inattentive subtype as the most common phenotype for Black and White girls. Research on developmentally sensitive periods for symptom exacerbation or new onset of ADHD in girls is needed.</p>","PeriodicalId":15237,"journal":{"name":"Journal of Attention Disorders","volume":" ","pages":"589-599"},"PeriodicalIF":2.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138802837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elisabeth F Callen, Tarin Clay, Jillian Alai, David W Goodman, Lenard A Adler, Stephen V Faraone
{"title":"The Role of Age in Adult ADHD Quality Care: A Longitudinal Analysis of Electronic Health Record Data.","authors":"Elisabeth F Callen, Tarin Clay, Jillian Alai, David W Goodman, Lenard A Adler, Stephen V Faraone","doi":"10.1177/10870547231218042","DOIUrl":"10.1177/10870547231218042","url":null,"abstract":"<p><strong>Objective: </strong>Several studies have shown that Adult ADHD presents differently in younger and older adults. We sought to assess the difference in care between these two groups using previously identified quality measures (QMs).</p><p><strong>Methods: </strong>Using electronic health record data, we matched a younger group of ADHD patients to an older group. We then assessed the achievement of the QMs using probit models with and without interaction terms.</p><p><strong>Results: </strong>The majority of QMs shown an increase in achievement for both groups over time. However, significant differences in quality of care between younger and older adult ADHD patients persisted. By the end of the study period, with the exception of three QMs, younger patients achieved the QMs more.</p><p><strong>Conclusion: </strong>While, in general, the quality of care for adult ADHD increased from 2010 to 2020, there were still differences in care between younger and older adult ADHD patients.</p>","PeriodicalId":15237,"journal":{"name":"Journal of Attention Disorders","volume":" ","pages":"913-922"},"PeriodicalIF":3.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139074223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dr. Joseph Biederman's Enduring Legacy: Illuminating the Path to Addressing Autistic Traits in Attention Deficit Hyperactivity Disorder With Transcranial Photobiomodulation.","authors":"Tolga Atilla Ceranoglu, Chloe Hutt Vater","doi":"10.1177/10870547231222599","DOIUrl":"10.1177/10870547231222599","url":null,"abstract":"<p><strong>Objective: </strong>To review the existing literature on transcranial photobiomodulation (tPBM) treatment effects on Autism Spectrum Disorder (ASD), in search for an effective treatment of a symptom cluster identified largely by contributions from late Dr. Biederman who asserted that they frequently present with Attention Deficit Hyperactivity Disorder (ADHD).</p><p><strong>Method: </strong>A survey of two databases, PubMed and PsycINFO, for clinical trials reporting on tPBM treatment in ASD was performed. Identified manuscripts that met eligibility criteria were then reviewed.</p><p><strong>Results: </strong>Three original manuscripts reporting findings on a heterogenous group of study methods met the eligibility criteria. Despite the heterogenous nature of study designs, findings from all three studies reported tPBM treatment to be associated with improvements in ASD symptoms. No serious or treatment limiting adverse events were reported.</p><p><strong>Conclusions: </strong>A nascent body of research suggests further clinical studies investigating efficacy of tPBM in treatment of ASD symptoms should be supported.</p>","PeriodicalId":15237,"journal":{"name":"Journal of Attention Disorders","volume":" ","pages":"664-668"},"PeriodicalIF":3.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139702647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Timothy E Wilens, Mira Stone, Sylvia Lanni, Amy Berger, Ronan L H Wilson, Melis Lydston, Craig B Surman
{"title":"Treating Executive Function in Youth With Attention Deficit Hyperactivity Disorder: A Review of Pharmacological and Non-Pharmacological Interventions.","authors":"Timothy E Wilens, Mira Stone, Sylvia Lanni, Amy Berger, Ronan L H Wilson, Melis Lydston, Craig B Surman","doi":"10.1177/10870547231218925","DOIUrl":"10.1177/10870547231218925","url":null,"abstract":"<p><strong>Introduction: </strong>Executive function (EF) deficits are common in youth with ADHD and pose significant functional impairments. The extent and effect of interventions addressing EF in youth with ADHD remain unclear.</p><p><strong>Methods: </strong>We conducted a systematic literature review using PRISMA guidelines. Included studies were randomized controlled trials of interventions to treat EF in youth with ADHD.</p><p><strong>Results: </strong>Our search returned 136 studies representing 11,443 study participants. We identified six intervention categories: nonstimulant pharmacological (<i>N</i> = 3,576 participants), neurological (<i>N</i> = 1,935), psychological (<i>N</i> = 2,387), digital (<i>N</i> = 2,416), physiological (<i>N</i> = 680), and combination (<i>N</i> = 366). The bulk of the evidence supported pharmacological interventions as most effective in mitigating EF, followed by psychological and digital interventions.</p><p><strong>Conclusion: </strong>A breadth of treatments exists for EF in youth with ADHD. Pharmacological, psychotherapeutic, and digital interventions had the most favorable, replicable outcomes. A lack of outcome standardization across studies limited treatment comparison. More data on the persistence of intervention effects are necessary.</p>","PeriodicalId":15237,"journal":{"name":"Journal of Attention Disorders","volume":" ","pages":"751-790"},"PeriodicalIF":2.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139097937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jillian Alai, Elisabeth F Callen, Tarin Clay, David W Goodman, Lenard A Adler, Stephen V Faraone
{"title":"Differences in Primary Care Management of Patients With Adult Attention Deficit Hyperactivity Disorder (ADHD) Based on Race and Ethnicity.","authors":"Jillian Alai, Elisabeth F Callen, Tarin Clay, David W Goodman, Lenard A Adler, Stephen V Faraone","doi":"10.1177/10870547231218038","DOIUrl":"10.1177/10870547231218038","url":null,"abstract":"<p><strong>Objective: </strong>Examine differences in care patterns around adult ADHD between race (White/Non-White) and ethnic (Hispanic/Non-Hispanic) groups utilizing existing quality measures (QMs), concerning diagnosis, treatment, and medication prescribing.</p><p><strong>Methods: </strong>The AAFP National Research Network in partnership with SUNY Upstate Medical used an EHR dataset to evaluate achievement of 10 ADHD QMs. The dataset was obtained from DARTNet Institute and includes 4 million patients of 873 behavioral and primary care practices with at least 100 patients from 2010 to 2020. Patients 18-years or older with adult ADHD were included in this analysis.</p><p><strong>Results: </strong>White patients and Non-Hispanic/Latinx patients were more likely to achieve these QMs than Non-White patients and Hispanic/Latinx patients, respectively. Differences between groups concerning medication and monitoring demonstrate a disparity for Non-White and Hispanic/Latinx populations.</p><p><strong>Conclusions: </strong>Using QMs in EHR data can help identify gaps in ADHD research. There is a need to continue investigating disparities of quality adult ADHD care.</p>","PeriodicalId":15237,"journal":{"name":"Journal of Attention Disorders","volume":" ","pages":"923-935"},"PeriodicalIF":3.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139424813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}