Journal of Attention Disorders最新文献_第10页

Methylphenidate and Sleep Difficulties in Children and Adolescents With ADHD: Results From the 2-Year Naturalistic Pharmacovigilance ADDUCE Study. 哌醋甲酯与多动症儿童和青少年的睡眠障碍：为期两年的自然药物警戒 ADDUCE 研究结果。

IF 3 3区医学

Journal of Attention Disorders Pub Date : 2024-03-01 Epub Date: 2024-02-22 DOI: 10.1177/10870547241232337

Alexander Häge, Kenneth K C Man, Sarah K Inglis, Jan Buitelaar, Sara Carucci, Marina Danckaerts, Ralf W Dittmann, Bruno Falissard, Peter Garas, Chris Hollis, Kerstin Konrad, Hanna Kovshoff, Elizabeth Liddle, Suzanne McCarthy, Antje Neubert, Peter Nagy, Eric Rosenthal, Edmund J S Sonuga-Barke, Alessandro Zuddas, Ian C K Wong, David Coghill, Tobias Banaschewski

{"title":"Methylphenidate and Sleep Difficulties in Children and Adolescents With ADHD: Results From the 2-Year Naturalistic Pharmacovigilance ADDUCE Study.","authors":"Alexander Häge, Kenneth K C Man, Sarah K Inglis, Jan Buitelaar, Sara Carucci, Marina Danckaerts, Ralf W Dittmann, Bruno Falissard, Peter Garas, Chris Hollis, Kerstin Konrad, Hanna Kovshoff, Elizabeth Liddle, Suzanne McCarthy, Antje Neubert, Peter Nagy, Eric Rosenthal, Edmund J S Sonuga-Barke, Alessandro Zuddas, Ian C K Wong, David Coghill, Tobias Banaschewski","doi":"10.1177/10870547241232337","DOIUrl":"10.1177/10870547241232337","url":null,"abstract":"Objective: Short-term RCTs have demonstrated that MPH-treatment significantly reduces ADHD-symptoms, but is also associated with adverse events, including sleep problems. However, data on long-term effects of MPH on sleep remain limited.Methods: We performed a 2-year naturalistic prospective pharmacovigilance multicentre study. Participants were recruited into three groups: ADHD patients intending to start MPH-treatment (MPH-group), those not intending to use ADHD-medication (no-MPH-group), and a non-ADHD control-group. Sleep problems were assessed with the Children's-Sleep-Habits-Questionnaire (CSHQ).Results: 1,410 participants were enrolled. Baseline mean CSHQ-total-sleep-scores could be considered clinically significant for the MPH-group and the no-MPH-group, but not for controls. The only group to show a significant increase in any aspect of sleep from baseline to 24-months was the control-group. Comparing the MPH- to the no-MPH-group no differences in total-sleep-score changes were found.Conclusion: Our findings support that sleep-problems are common in ADHD, but don't suggest significant negative long-term effects of MPH on sleep.","PeriodicalId":15237,"journal":{"name":"Journal of Attention Disorders","volume":" ","pages":"699-707"},"PeriodicalIF":3.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139931357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep Disordered Breathing and Risk for ADHD: Review of Supportive Evidence and Proposed Underlying Mechanisms. 睡眠呼吸紊乱与多动症风险：支持性证据和潜在机制综述》（Review of Supportive Evidence and Proposed Underlying Mechanisms）。

IF 3 3区医学

Journal of Attention Disorders Pub Date : 2024-03-01 Epub Date: 2024-02-14 DOI: 10.1177/10870547241232313

Iliyan Ivanov, Ben Miraglia, Dana Prodanova, Jeffrey H Newcorn

{"title":"Sleep Disordered Breathing and Risk for ADHD: Review of Supportive Evidence and Proposed Underlying Mechanisms.","authors":"Iliyan Ivanov, Ben Miraglia, Dana Prodanova, Jeffrey H Newcorn","doi":"10.1177/10870547241232313","DOIUrl":"10.1177/10870547241232313","url":null,"abstract":"Background: Accumulating evidence suggests that sleep disordered breathing (SDB) is under-recognized in youth and adults with ADHD. SDB may contribute to exacerbating pre-existing ADHD symptoms and may play a role in the development of cognitive deficits that may mimic ADHD symptoms.Method: We conducted a focused review of publications on cross-prevalence, overlapping clinical and neurobiological characteristics and possible mechanisms linking SDB and ADHD.Results: Exiting studies suggest that co-occurrence of SDB and ADHD is as high as 50%, with frequent overlap of clinical symptoms such as distractibility and inattention. Mechanisms linking these conditions may include hypoxia during sleep, sleep fragmentation and activation of inflammation, all of which may affect brain structure and physiology to produce disturbances in attention.Conclusions: The relationship between SDB and ADHD symptoms appear well-supported and suggests that more research is needed to better optimize procedures for SDB assessment in youth being evaluated and/or treated for ADHD.","PeriodicalId":15237,"journal":{"name":"Journal of Attention Disorders","volume":" ","pages":"686-698"},"PeriodicalIF":3.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139729745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preclinical Models of Attention Deficit Hyperactivity Disorder: Neurobiology, Drug Discovery, and Beyond. 注意缺陷多动障碍的临床前模型：神经生物学、药物发现及其他》。

IF 3 3区医学

Journal of Attention Disorders Pub Date : 2024-03-01 Epub Date: 2023-12-12 DOI: 10.1177/10870547231215286

Deirdre M McCarthy, Thomas J Spencer, Pradeep G Bhide

{"title":"Preclinical Models of Attention Deficit Hyperactivity Disorder: Neurobiology, Drug Discovery, and Beyond.","authors":"Deirdre M McCarthy, Thomas J Spencer, Pradeep G Bhide","doi":"10.1177/10870547231215286","DOIUrl":"10.1177/10870547231215286","url":null,"abstract":"Objective: We offer an overview of ADHD research using mouse models of nicotine exposure.Method: Nicotine exposure of C57BL/6 or Swiss Webster mice occurred during prenatal period only or during the prenatal and the pre-weaning periods. Behavioral, neuroanatomical and neurotransmitter assays were used to investigate neurobiological mechanisms of ADHD and discover candidate ADHD medications.Results: Our studies show that norbinaltorphimine, a selective kappa opioid receptor antagonist is a candidate novel non-stimulant ADHD treatment and that a combination of methylphenidate and naltrexone has abuse deterrent potential with therapeutic benefits for ADHD. Other studies showed transgenerational transmission of ADHD-associated behavioral traits and demonstrated that interactions between untreated ADHD and repeated mild traumatic brain injury produced behavioral traits not associated with either condition alone.Conclusion: Preclinical models contribute to novel insights into ADHD neurobiology and are valuable tools for drug discovery and translation to benefit humans with ADHD.","PeriodicalId":15237,"journal":{"name":"Journal of Attention Disorders","volume":" ","pages":"880-894"},"PeriodicalIF":3.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138802816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stimulant Treatment and Potential Adverse Outcomes in Pediatric Populations With Bipolar Disorder: A Systematic Review of the Literature. 双相情感障碍儿童群体中的兴奋剂治疗和潜在不良后果：文献的系统回顾。

IF 2.7 3区医学

Journal of Attention Disorders Pub Date : 2024-03-01 Epub Date: 2023-12-29 DOI: 10.1177/10870547231218045

Hannah O'Connor, Chloe Hutt Vater, Maura DiSalvo, Stephen V Faraone, Janet Wozniak

{"title":"Stimulant Treatment and Potential Adverse Outcomes in Pediatric Populations With Bipolar Disorder: A Systematic Review of the Literature.","authors":"Hannah O'Connor, Chloe Hutt Vater, Maura DiSalvo, Stephen V Faraone, Janet Wozniak","doi":"10.1177/10870547231218045","DOIUrl":"10.1177/10870547231218045","url":null,"abstract":"Objective: To explore outcomes of stimulant treatment for ADHD in pediatric populations with particular attention to bipolar disorder (BPD).Method: We conducted a literature search of PubMed articles published prior to August 25, 2022 that focused on BPD, mania, and psychosis prior to, or as result of, stimulant treatment. We excluded studies: (1) unrelated to stimulants, (2) general stimulant research, (3) articles older than 40 years, (4) study protocols, or (5) case reports.Results: A total of 11 articles met all inclusion/exclusion criteria. Some reports found stimulant treatment safe and well-tolerated in children with comorbid BPD and ADHD. Others found evidence of treatment-emergent mania (TEM), discontinuation, and other adverse events with stimulant treatment.Conclusion: Poor outcomes associated with stimulant treatment in pediatric populations with BPD necessitate work to identify patients at risk of serious stimulant-related adverse events. Our results were limited by automated search filters and a pediatric, primarily male sample.","PeriodicalId":15237,"journal":{"name":"Journal of Attention Disorders","volume":" ","pages":"740-750"},"PeriodicalIF":2.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139074222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ADHD in Adults: Does Age at Diagnosis Matter? 成人多动症：诊断年龄重要吗？

IF 3 3区医学

Journal of Attention Disorders Pub Date : 2024-03-01 Epub Date: 2024-01-02 DOI: 10.1177/10870547231218450

Chloe Hutt Vater, Maura DiSalvo, Alyssa Ehrlich, Haley Parker, Hannah O'Connor, Stephen V Faraone, Joseph Biederman

{"title":"ADHD in Adults: Does Age at Diagnosis Matter?","authors":"Chloe Hutt Vater, Maura DiSalvo, Alyssa Ehrlich, Haley Parker, Hannah O'Connor, Stephen V Faraone, Joseph Biederman","doi":"10.1177/10870547231218450","DOIUrl":"10.1177/10870547231218450","url":null,"abstract":"Objective: To provide additional information about clinical features associated with adult ADHD in patients diagnosed in childhood compared to those first diagnosed in adulthood.Method: We stratified a sample of adults with ADHD into patients diagnosed in childhood versus adulthood and compared demographic and clinical characteristics.Results: We found similar clinical features in adults diagnosed in childhood and adults diagnosed in adulthood. Among those diagnosed in adulthood, 95% reported symptom onset in youth. Our results do not support the hypothesis that ADHD diagnosed in adulthood is due to misinterpreting symptoms of other disorders as ADHD. They also suggest incorporating behavioral signs of executive dysfunction into diagnostic criteria for ADHD in adults may increase diagnostic sensitivity.Conclusion: These results support the validity of ADHD diagnoses in adulthood, as these adults show similar clinical profiles to those diagnosed in youth. Our results also suggest that if adult-onset ADHD exists, it is rare.","PeriodicalId":15237,"journal":{"name":"Journal of Attention Disorders","volume":" ","pages":"614-624"},"PeriodicalIF":3.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139080583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Introduction to a Special Issue: A Tribute to Dr. Joseph Biederman-Pioneering Insights in Child and Adult Psychiatry and Psychology. 特刊导言：向约瑟夫-比德曼博士致敬--儿童与成人精神病学和心理学的开拓性见解。

IF 3 3区医学

Journal of Attention Disorders Pub Date : 2024-03-01 Epub Date: 2024-01-30 DOI: 10.1177/10870547231225007

Sam Goldstein, Stephen V Faraone, Timothy E Wilens, Janet R Wozniak, Craig B Surman, Gagan Joshi, Thomas J Spencer

引用次数: 0

Childhood Clinical Features Preceding the Onset of Bipolar Versus Major Depressive Disorders During Adolescence. 青春期躁郁症与重度抑郁症发病前的童年临床特征。

IF 2.7 3区医学

Journal of Attention Disorders Pub Date : 2024-03-01 Epub Date: 2024-02-07 DOI: 10.1177/10870547231225819

Clotilde Guidetti, Giulia Serra, Massimo Apicella, Elisa Andracchio, Maria Elena Iannoni, Monia Trasolini, Giorgia Della Santa, Gino Maglio, Stefano Vicari

{"title":"Childhood Clinical Features Preceding the Onset of Bipolar Versus Major Depressive Disorders During Adolescence.","authors":"Clotilde Guidetti, Giulia Serra, Massimo Apicella, Elisa Andracchio, Maria Elena Iannoni, Monia Trasolini, Giorgia Della Santa, Gino Maglio, Stefano Vicari","doi":"10.1177/10870547231225819","DOIUrl":"10.1177/10870547231225819","url":null,"abstract":"Objective: To identify childhood psychopathological features that predict the onset of adolescent Bipolar (BD) versus Unipolar Major Depressive Disorder (UD) during adolescence.Method: We analyzed clinical data from 495 juveniles diagnosed with DSM-5 UD (n = 359), and BD (n = 136), using bivariate analysis and multivariate logistic regression model.Results: BD subjects exhibited earlier onset of any psychiatric feature compared to UD. Antecedents associated with later BD were: oppositional defiant > specific phobias > ADHD > obsessive compulsive (OCD). Antecedents selectively associated with later UD were: social anxiety and separation anxiety. Factors significantly and independently associated with later BD diagnosis were: [a] emotional dysregulation at onset of the mood disorder; [b] first depressive episode with mixed features; [c] antecedent ADHD; [d] antecedent OCD, and [e] antecedent oppositional-defiance.Conclusion: Identifying developmental differences in BD and UD symptoms can aid clinicians in early identification and treatment planning for bipolar disorder in youth.","PeriodicalId":15237,"journal":{"name":"Journal of Attention Disorders","volume":" ","pages":"648-663"},"PeriodicalIF":2.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11421195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139702645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Single-Blind, Placebo Controlled Trial of Triple Beaded Mixed Amphetamine Salts in DSM-5 Adults With ADHD Assessing Effects Throughout the Day. 针对 DSM-5 多动症成人的三珠混合安非他明盐单盲安慰剂对照试验，评估全天效果。

IF 3 3区医学

Journal of Attention Disorders Pub Date : 2024-03-01 Epub Date: 2024-01-12 DOI: 10.1177/10870547231222260

Lenard A Adler, Deepti Anbarasan, Taylor Sardoff, Terry Leon, Richard Gallagher, Caleb A Massimi, Stephen V Faraone

{"title":"A Single-Blind, Placebo Controlled Trial of Triple Beaded Mixed Amphetamine Salts in DSM-5 Adults With ADHD Assessing Effects Throughout the Day.","authors":"Lenard A Adler, Deepti Anbarasan, Taylor Sardoff, Terry Leon, Richard Gallagher, Caleb A Massimi, Stephen V Faraone","doi":"10.1177/10870547231222260","DOIUrl":"10.1177/10870547231222260","url":null,"abstract":"Objective: To examine the effects of triple beaded mixed amphetamine salts (TB MAS) on ADHD and executive dysfunction symptoms throughout the day in adults with DSM-5 ADHD.Method: This was a 6 week, single-blind, placebo-lead in trial of TB MAS (12.5-37.5 mg/day); all participants received 2 weeks of single-blind placebo); one individual was a placebo responder and was discontinued. One of these 18 dropped after 1 week on 12.5 mg/day, while all others completed the trial and received 37.5 mg/day TB MAS.Results: There were significant effects of TB MAS on all clinical measures, including investigator overall symptoms (AISRS); self-report overall (ASRS), time-sensitive ADHD (TASS) scores throughout the day, impairment (CGI) and executive function scores (BRIEF-A). TB MAS was generally well tolerated.Conclusions: This study extends prior findings of TB MAS to adults with DSM-5 ADHD; it further re-validates findings of efficacy of TB MAS throughout the day.","PeriodicalId":15237,"journal":{"name":"Journal of Attention Disorders","volume":" ","pages":"810-819"},"PeriodicalIF":3.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139424902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Association Between Repeated Measured Febrile Episodes During Early Childhood and Attention Deficit Hyperactivity Disorder: A Large-Scale Population-Based Study. 幼儿期反复测量的发热与注意力缺陷多动障碍之间的关系：大规模人群研究》。

IF 3 3区医学

Journal of Attention Disorders Pub Date : 2024-03-01 Epub Date: 2024-01-28 DOI: 10.1177/10870547231215289

Ariel Israel, Eugene Merzon, Beth Krone, Stephen V Faraone, Ilan Green, Avivit Golan Cohen, Shlomo Vinker, Shira Cohen, Shai Ashkenazi, Eli Magen, Abraham Weizman, Iris Manor

{"title":"The Association Between Repeated Measured Febrile Episodes During Early Childhood and Attention Deficit Hyperactivity Disorder: A Large-Scale Population-Based Study.","authors":"Ariel Israel, Eugene Merzon, Beth Krone, Stephen V Faraone, Ilan Green, Avivit Golan Cohen, Shlomo Vinker, Shira Cohen, Shai Ashkenazi, Eli Magen, Abraham Weizman, Iris Manor","doi":"10.1177/10870547231215289","DOIUrl":"10.1177/10870547231215289","url":null,"abstract":"Objective: We examined the association between the number, magnitude, and frequency of febrile episodes during the 0 to 4 years of life and subsequent diagnosis of ADHD.Methods: This population-based case-control study in an Israeli HMO, Leumit Health Services (LHS), uses a database for all LHS members aged 5 to 18 years between 1/1/2002 and 1/30/2022. The number and magnitude of measured fever episodes during the 0 to 4 years were recorded in individuals with ADHD (N = 18,558) and individually matched non-ADHD controls in a 1:2 ratio (N = 37,116).Results: A significant, independent association was found between the number and magnitude of febrile episodes during the 0 to 4 years and the probability of a later diagnosis of ADHD. Children who never had a measured temperature >37.5°C had a significantly lower rate of ADHD (OR = 0.834, 95% CI [0.802, 0.866], p < .0001).Conclusions: Febrile episodes during 0 to 4 years are associated with a significantly increased rate of a later diagnosis of ADHD in a doseresponse relationship.","PeriodicalId":15237,"journal":{"name":"Journal of Attention Disorders","volume":" ","pages":"677-685"},"PeriodicalIF":3.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139569810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metagenomic Analysis Reveals Difference of Gut Microbiota in ADHD. 元基因组分析揭示多动症患者肠道微生物群的差异

IF 3 3区医学

Journal of Attention Disorders Pub Date : 2024-03-01 Epub Date: 2024-02-07 DOI: 10.1177/10870547231225491

Ning Wang, Haibin Wang, Yu Bai, Yilu Zhao, Xiangyu Zheng, Xuping Gao, Zifeng Zhang, Li Yang

{"title":"Metagenomic Analysis Reveals Difference of Gut Microbiota in ADHD.","authors":"Ning Wang, Haibin Wang, Yu Bai, Yilu Zhao, Xiangyu Zheng, Xuping Gao, Zifeng Zhang, Li Yang","doi":"10.1177/10870547231225491","DOIUrl":"10.1177/10870547231225491","url":null,"abstract":"Objective: Although ADHD is highly heritable, some environmental factors contribute to its development. Given the growing evidence that gut microbiota was involved in psychiatric disorders, we aimed to identify the characteristic composition of the gut microbiota in ADHD.Methods: We recruited 47 medication-naive children and adolescents with ADHD, and 60 healthy controls (HCs). We used shotgun metagenomics to measure the structure of the gut microbiota and analyzed the difference in bacterial taxa between ADHD and HCs.Results: Significant differences were found between the ADHD and HC groups in both alpha diversity indices (Simpson index, p = .025 and Shannon index, p = .049) and beta diversity indices (Euclidean distance, Bray-Curtis distance, and JSD distance, p < 2.2e-16). Nine representative species best explain the difference.Conclusion: Patients with ADHD showed significant differences in the composition of the gut microbiota compared with HCs. These results may help identify potential biomarkers of ADHD.","PeriodicalId":15237,"journal":{"name":"Journal of Attention Disorders","volume":" ","pages":"872-879"},"PeriodicalIF":3.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139702650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0