Irene Campos-Sánchez, Eva María Navarrete-Muñoz, Dries S Martens, Isolina Riaño-Galán, Aitana Lertxundi, Sabrina Llop, Mónica Guxens, Cristina Rodríguez-Dehli, Nerea Lertxundi, Raquel Soler-Blasco, Martine Vrijheid, Tim S Nawrot, John Wright, Tiffany C Yang, Rosie McEachan, Kristine Bjerve Gützkow, Vaia Lida Chatzi, Marina Vafeiadi, Mariza Kampouri, Regina Grazuleviciene, Sandra Andrusaityte, Johanna Lepeule, Desirée Valera-Gran
{"title":"6-12岁儿童端粒长度与注意缺陷和多动障碍症状的关系","authors":"Irene Campos-Sánchez, Eva María Navarrete-Muñoz, Dries S Martens, Isolina Riaño-Galán, Aitana Lertxundi, Sabrina Llop, Mónica Guxens, Cristina Rodríguez-Dehli, Nerea Lertxundi, Raquel Soler-Blasco, Martine Vrijheid, Tim S Nawrot, John Wright, Tiffany C Yang, Rosie McEachan, Kristine Bjerve Gützkow, Vaia Lida Chatzi, Marina Vafeiadi, Mariza Kampouri, Regina Grazuleviciene, Sandra Andrusaityte, Johanna Lepeule, Desirée Valera-Gran","doi":"10.1177/10870547251314923","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To explore the association between telomere length (TL) and attention deficit hyperactivity disorder (ADHD) symptoms in children at 6-12 years.</p><p><strong>Method: </strong>Data from 1,759 children belonging to the HELIX project cohorts and the Asturias, Gipuzkoa and Valencia cohorts of INMA project were included. TL was determined by blood sample using a PCR protocol. ADHD symptoms were described by parents using the Conners' Parent Rating Scale-Revised: Short Form. Multiple negative binomial regression models adjusted for potential confounders were used to estimate associations.</p><p><strong>Results: </strong>Overall estimates showed no associations between TL and ADHD symptoms. However, we observed that a longer TL was significantly associated with a lower risk of presenting hyperactivity symptoms in children belonging to the HELIX project (IRR = 0.93, 95% CI [0.87, 0.99]; <i>p</i> = .022).</p><p><strong>Conclusion: </strong>While our study did not find a consistent association between TL and ADHD symptoms across all cohorts, the significant association found within the HELIX cohort suggests that longer TL may be linked to a lower risk of hyperactivity symptoms. Further research is needed to explore this association in more detail.</p>","PeriodicalId":15237,"journal":{"name":"Journal of Attention Disorders","volume":" ","pages":"474-485"},"PeriodicalIF":2.7000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Telomere Length and Symptoms of Attention Deficit and Hyperactivity Disorder in Children at 6-12 Years.\",\"authors\":\"Irene Campos-Sánchez, Eva María Navarrete-Muñoz, Dries S Martens, Isolina Riaño-Galán, Aitana Lertxundi, Sabrina Llop, Mónica Guxens, Cristina Rodríguez-Dehli, Nerea Lertxundi, Raquel Soler-Blasco, Martine Vrijheid, Tim S Nawrot, John Wright, Tiffany C Yang, Rosie McEachan, Kristine Bjerve Gützkow, Vaia Lida Chatzi, Marina Vafeiadi, Mariza Kampouri, Regina Grazuleviciene, Sandra Andrusaityte, Johanna Lepeule, Desirée Valera-Gran\",\"doi\":\"10.1177/10870547251314923\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To explore the association between telomere length (TL) and attention deficit hyperactivity disorder (ADHD) symptoms in children at 6-12 years.</p><p><strong>Method: </strong>Data from 1,759 children belonging to the HELIX project cohorts and the Asturias, Gipuzkoa and Valencia cohorts of INMA project were included. TL was determined by blood sample using a PCR protocol. ADHD symptoms were described by parents using the Conners' Parent Rating Scale-Revised: Short Form. Multiple negative binomial regression models adjusted for potential confounders were used to estimate associations.</p><p><strong>Results: </strong>Overall estimates showed no associations between TL and ADHD symptoms. However, we observed that a longer TL was significantly associated with a lower risk of presenting hyperactivity symptoms in children belonging to the HELIX project (IRR = 0.93, 95% CI [0.87, 0.99]; <i>p</i> = .022).</p><p><strong>Conclusion: </strong>While our study did not find a consistent association between TL and ADHD symptoms across all cohorts, the significant association found within the HELIX cohort suggests that longer TL may be linked to a lower risk of hyperactivity symptoms. Further research is needed to explore this association in more detail.</p>\",\"PeriodicalId\":15237,\"journal\":{\"name\":\"Journal of Attention Disorders\",\"volume\":\" \",\"pages\":\"474-485\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2025-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Attention Disorders\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/10870547251314923\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/29 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Attention Disorders","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/10870547251314923","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/29 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"PSYCHIATRY","Score":null,"Total":0}
Telomere Length and Symptoms of Attention Deficit and Hyperactivity Disorder in Children at 6-12 Years.
Objective: To explore the association between telomere length (TL) and attention deficit hyperactivity disorder (ADHD) symptoms in children at 6-12 years.
Method: Data from 1,759 children belonging to the HELIX project cohorts and the Asturias, Gipuzkoa and Valencia cohorts of INMA project were included. TL was determined by blood sample using a PCR protocol. ADHD symptoms were described by parents using the Conners' Parent Rating Scale-Revised: Short Form. Multiple negative binomial regression models adjusted for potential confounders were used to estimate associations.
Results: Overall estimates showed no associations between TL and ADHD symptoms. However, we observed that a longer TL was significantly associated with a lower risk of presenting hyperactivity symptoms in children belonging to the HELIX project (IRR = 0.93, 95% CI [0.87, 0.99]; p = .022).
Conclusion: While our study did not find a consistent association between TL and ADHD symptoms across all cohorts, the significant association found within the HELIX cohort suggests that longer TL may be linked to a lower risk of hyperactivity symptoms. Further research is needed to explore this association in more detail.
期刊介绍：
Journal of Attention Disorders (JAD) focuses on basic and applied science concerning attention and related functions in children, adolescents, and adults. JAD publishes articles on diagnosis, comorbidity, neuropsychological functioning, psychopharmacology, and psychosocial issues. The journal also addresses practice, policy, and theory, as well as review articles, commentaries, in-depth analyses, empirical research articles, and case presentations or program evaluations.
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