Journal of cardiology最新文献

{"title":"The efficacy of inspiratory muscle training in improving clinical outcomes in heart failure patients: An updated systematic review and meta-analysis","authors":"Ahmed Kamal Siddiqi MBBS ,&nbsp;Maryam Shahzad MBBS ,&nbsp;Akash Kumar MBBS ,&nbsp;Manahil Ahmed MBBS ,&nbsp;Lakshmi Sridharan MD ,&nbsp;Mahmoud H. Abdou MD ,&nbsp;Muhammad Naeem MD","doi":"10.1016/j.jjcc.2025.01.016","DOIUrl":"10.1016/j.jjcc.2025.01.016","url":null,"abstract":"<div><h3>Background</h3><div>Inspiratory muscle training (IMT) has shown improvements in clinical variables for heart failure (HF) patients. We conducted a meta-analysis to investigate if IMT can enhance respiratory muscle strength, quality of life (QoL), and reduce cardiac biomarker levels in HF patients.</div></div><div><h3>Methods</h3><div>PubMed, Cochrane Library, and Google Scholar databases were systematically searched up to July 8, 2024. Randomized controlled trials of IMT in HF patients were included. A random effects model was used to calculate weighted mean differences (WMDs) and 95 % confidence intervals. Outcomes analyzed included minute ventilation to carbon dioxide output slope (VE/VCO2), QoL, six-minute walk distance (6MWD), maximum expiratory pressure, maximum inspiratory pressure (MIP), N-terminal pro B-type natriuretic peptide (NT-pro-BNP), forced vital capacity, forced expiratory volume in one second, and metabolic equivalents.</div></div><div><h3>Results</h3><div>Seventeen studies involving 510 patients (252 in IMT group, 258 in control) were included. IMT significantly improved 6MWD [WMD: 72.72; 95 % CI: (16.65 to 128.78); p = 0.01], QoL [WMD: -15.27; 95 % CI: (−21.01 to −9.53); p &lt; 0.00001], VE/VCO2 [WMD: -5.09; 95 % CI: (−7.36 to −2.83); p &lt; 0.0001], MIP [WMD: 13.77; 95 % CI: (7.51 to 20.03); p &lt; 0.0001], and NT-pro-BNP levels [WMD: -659.66; 95 % CI: (−1212.87 to −106.46); p = 0.02].</div></div><div><h3>Conclusion</h3><div>IMT significantly improved respiratory muscle strength, QoL, and reduced cardiac biomarker levels in patients with both heart failure with preserved ejection fraction and heart failure with reduced ejection fraction. These findings suggest that IMT may be a promising exercise-based strategy for treating HF.</div></div>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":"85 5","pages":"Pages 374-385"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of artificial intelligence-based application to estimate nutrients in daily meals","authors":"Teruhiko Imamura MD, FJCC ,&nbsp;Nikhil Narang MD ,&nbsp;Koichiro Kinugawa MD, FJCC","doi":"10.1016/j.jjcc.2024.10.003","DOIUrl":"10.1016/j.jjcc.2024.10.003","url":null,"abstract":"<div><h3>Background</h3><div>Diet modification is a mainstay for the successful management of metabolic syndrome and potentially may reduce the risk of cardiovascular disease. Accurate estimation of essential nutrients in daily meals is currently challenging to quantify. HAKARIUM (AstraZeneca Co., Ltd., Osaka, Japan) is a recently introduced artificial intelligence (AI)-based application that can estimate each nutrient component through photographs, although its applicability to real-world practice remains unknown.</div></div><div><h3>Methods</h3><div>Lunchtime meals served for healthy individuals at a single university cooperative society between September 2023 and February 2024 were analyzed. Nutrient components, including energy in the form of calories, protein, and salts, were estimated by the HAKARIUM application and compared with the actual nutrient values that were officially calculated and presented by the university cooperative society.</div></div><div><h3>Results</h3><div>A total of 62 meals were included. Actual values of energy, protein, and salt content per meal were 382 (358, 431) kcal, 17.1 (13.9, 18.9) g, and 2.9 (2.6, 3.1) g, respectively. AI-estimated values of energy, protein, and salt content per meal were 636 (493, 835) kcal, 25.7 (19.7, 36.3) g, and 4.2 (3.5, 4.6) g, respectively. Most of the values were within the limits of agreement with significant correlations between the two variables, respectively (<em>r</em> &gt; 0.80, <em>p</em> &lt; 0.05 for all).</div></div><div><h3>Conclusion</h3><div>AI-based estimation of nutrient components had relatively good agreement with actually calculated values.</div></div>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":"85 5","pages":"Pages 424-425"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of circumferential and longitudinal strain on left ventricle ejection fraction and myocardial surface area strain","authors":"Dimitrios Ntelios MD, PhD ,&nbsp;Anastasia Erythropoulou-Kaltsidou MD, MSc ,&nbsp;Efstathios Pagourelias MD, PhD ,&nbsp;Georgios Efthimiadis MD, PhD ,&nbsp;Olivia Mauromoustaki MD, PhD ,&nbsp;Vassilios Vassilikos MD, PhD","doi":"10.1016/j.jjcc.2024.11.001","DOIUrl":"10.1016/j.jjcc.2024.11.001","url":null,"abstract":"","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":"85 5","pages":"Pages 426-427"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in the management of out-of-hospital cardiac arrest: A clinical review.","authors":"Kazuya Tateishi, Yuichi Saito, Yoshio Kobayashi","doi":"10.1016/j.jjcc.2025.04.010","DOIUrl":"https://doi.org/10.1016/j.jjcc.2025.04.010","url":null,"abstract":"<p><p>Despite considerable advances in the management, the prognosis of patients resuscitated from out-of-hospital cardiac arrest (OHCA) remains poor. To standardize clinical practice patterns and to improve outcomes, the guidelines provide scientific statements. It is challenging to develop and establish novel diagnostic and therapeutic strategies in randomized controlled trials in patients with OHCA. Nonetheless, important randomized data have been recently published in the field of resuscitation science. This review article provides an overview of updates on OHCA and resuscitation, focusing on key topics since 2020.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author's reply","authors":"Nobuyuki Kagiyama (MD, PhD),&nbsp;Takatoshi Kasai (MD, PhD, FJCC),&nbsp;Hiroyuki Daida (MD, PhD, FJCC)","doi":"10.1016/j.jjcc.2024.11.009","DOIUrl":"10.1016/j.jjcc.2024.11.009","url":null,"abstract":"","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":"85 5","pages":"Pages 430-431"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of FFR-CT before coronary angiography on the management of non-culprit lesions among high-risk NSTE-ACS patients.","authors":"Aurelia Zimmerli, David Meier, Adil Salihu, Quentin Liabot, Victor Weerts, Ioannis Skalidis, Daniele Andreini, Bernard Cosyns, Tatyana Storozhenko, Thabo Mahendiran, Emilio Assanelli, Jeroen Sonck, Bram Roosens, David C Rotzinger, Salah Dine Qanadli, Georgios Tzimas, Bernard De Bruyne, Carlos Collet, Olivier Muller, Stephane Fournier","doi":"10.1016/j.jjcc.2025.04.009","DOIUrl":"10.1016/j.jjcc.2025.04.009","url":null,"abstract":"<p><p>Recent data suggest that fractional flow reserve derived from coronary computed tomography (FFR-CT) can help select patients with high-risk non-ST-elevation acute coronary syndrome (NSTE-ACS) requiring invasive coronary angiography (ICA). Multiple stenoses are often observed in this population, and while a clear culprit is frequently identified, the management of intermediate lesions remains challenging. The information provided by FFR-CT prior to the ICA could theoretically assist in the management of these lesions. A prespecified post-hoc analysis of a multicenter, single-arm, double-blinded, core-laboratory adjudicated study was conducted to evaluate the potential of FFR-CT to assess the non-culprit lesions among patients with an identified culprit lesion on ICA and one additional vessel with a stenosis ≥30 %. The primary endpoint was the performance of FFR-CT in ruling out hemodynamically significant lesions in non-culprit vessels, with invasive FFR as gold standard. A total of 49 patients with 67 non-culprit lesions were included. FFR-CT classified 33 lesions (49 %) as non-significant and 34 (51 %) as significant. Among the 33 lesions deemed negative by FFR-CT, 31 were confirmed negative by invasive FFR, resulting in a negative predictive value of 94 %. Similarly, among the 34 lesions classified as significant by FFR-CT, 26 were confirmed as positive by invasive FFR, resulting in a positive predictive value of 93 %. In patients with high-risk NSTE-ACS, FFR-CT has the potential to not only reduce the number of unnecessary ICAs, but also to support early decision-making regarding the management of non-culprit lesions.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathophysiologic and prognostic relevance of mid-upper arm circumference index in heart failure with preserved ejection fraction.","authors":"Yuki Shimoya, Yuta Tani, Naoki Yuasa, Kazuki Kagami, Tomonari Harada, Fumitaka Murakami, Hidemi Sorimachi, Tsukasa Murakami, Takahiro Okuno, Naoki Wada, Hideki Ishii, Masaru Obokata","doi":"10.1016/j.jjcc.2025.04.007","DOIUrl":"https://doi.org/10.1016/j.jjcc.2025.04.007","url":null,"abstract":"<p><strong>Background: </strong>Malnutrition is common in heart failure with preserved ejection fraction (HFpEF). Despite the increasing awareness, nutritional assessment and intervention may be underutilized in practice, needing a simple screening tool to identify patients at high nutritional risk. This study sought to determine the association of mid-upper arm circumference indexed to height (MUACi) with nutritional measures, exercise capacity, and clinical outcomes in HFpEF.</p><p><strong>Methods: </strong>Patients with HFpEF (n = 247) and controls with no HF (n = 240) underwent ergometry exercise echocardiography with simultaneous expired gas analysis. Patients with HFpEF were divided into two groups based on the median value of MUACi.</p><p><strong>Results: </strong>Compared to controls and HFpEF_highMUACi (n = 124), HFpEF_lowMUACi (n = 123) had lower body mass index, waist circumference, and geriatric nutritional risk index. Despite similar cardiac structure and function at rest and during peak ergometry exercise, peak workload achieved and mechanical efficiency (peak workload relative to peak oxygen consumption) were more reduced in HFpEF_lowMUACi than controls and HFpEF_highMUACi. During a median observation period of 385 days, 25 composite outcomes of all-cause mortality, HF hospitalizations, unplanned visits requiring intravenous diuretics, and intensifications of oral diuretics occurred. HFpEF_lowMUACi had 11-fold and 2-fold increased risks of the outcome compared to controls and HFpEF_highMUACi, respectively [hazard ratio (HR) 10.8, 95 % confidence intervals (CI) 2.47-47.3, p = 0.002 and HR 2.54, 95 % CI 1.05-6.16].</p><p><strong>Conclusion: </strong>These data suggest that MUACi may be a useful screening metric to identify patients with HFpEF at malnutrition risk in clinical practice to help guide more specialized nutritional assessment.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel biomarkers related to mitochondrial permeability transition driven-necrosis in hypertrophic cardiomyopathy.","authors":"Wenqiang Qi, Linghua Fu, Qinghua Wu, Pingping Yang","doi":"10.1016/j.jjcc.2025.04.008","DOIUrl":"https://doi.org/10.1016/j.jjcc.2025.04.008","url":null,"abstract":"<p><strong>Background: </strong>The role of mitochondrial permeability transition driven necrosis-related genes (MPTDN-RGs) in hypertrophic cardiomyopathy (HCM) is unclear. This investigation combined transcriptomics and Mendelian randomization (MR) analysis to explore the association of MPTDN-RGs with HCM.</p><p><strong>Methods: </strong>GSE36961 (training set), GSE141910 (validation set), and GSE174691 (single-cell dataset) were retrieved from Gene Expression Omnibus (GEO) database. This study is based on scRNA-seq and transcriptome sequencing (mRNA Sequencing, mRNA-seq) data combined with MR, and use MPTDN-RGs to identify genes of HCM.</p><p><strong>Results: </strong>Based on 51 interaction genes overlapped by 250 module genes and 154 differentially expressed genes, the top 10 genes within protein-protein interaction (PPI) core network were regarded as candidate genes. ITGB2 and STAT3 were screened out as genes by multiple analysis methods. MR results revealed that ITGB2 was a risk factor, while STAT3 was a protective factor for HCM. Gene set enrichment analysis (GSEA) indicated that ITGB2 and STAT3 were involved in complement and coagulation cascade. Moreover, ITGB2 had the strongest positive and significant correlations with myeloid-derived suppressor cells and chemokine receptor. Single cell analysis showed that STAT3 was highly expressed in endothelial cells, while ITGB2 was significantly greater in dendritic cells. During the process of differentiation, the expression of ITGB2 and STAT3 were decreased, and dendritic cells gradually differentiated and matured to play a role in immune function.</p><p><strong>Conclusion: </strong>To our knowledge, this is the first study to identify the novel genes related to MPTDN in HCM by combining transcriptomics and MR analysis. Two key genes play a critical role in HCM. ITGB2 and STAT3 deserve further investigation as potential therapeutic targets for HCM.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor on association between complementary use of Goreisan and heart failure readmission: A nationwide propensity score-matched study.","authors":"Muhammad Ibrahim","doi":"10.1016/j.jjcc.2025.04.005","DOIUrl":"https://doi.org/10.1016/j.jjcc.2025.04.005","url":null,"abstract":"","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between oral anticoagulants continuation on thromboembolism and bleeding events in patients with CHADS₂ score 0-2 points after catheter ablation for persistent atrial fibrillation.","authors":"Tomoaki Nakano, Takafumi Oka, Keita Okayama, Nobuaki Tanaka, Masaharu Masuda, Tetsuya Watanabe, Hitoshi Minamiguchi, Yasuyuki Egami, Miwa Miyoshi, Masato Okada, Yasuhiro Matsuda, Masato Kawasaki, Koichi Inoue, Shungo Hikoso, Akihiro Sunaga, Tomoharu Dohi, Katsuki Okada, Daisaku Nakatani, Yohei Sotomi, Yasushi Sakata","doi":"10.1016/j.jjcc.2025.04.004","DOIUrl":"https://doi.org/10.1016/j.jjcc.2025.04.004","url":null,"abstract":"<p><strong>Background: </strong>Guidelines state that oral anticoagulants (OACs) should be continued after catheter ablation for atrial fibrillation (AF) based on thromboembolic risk stratification, regardless of procedural results. However, whether OACs could be discontinued in low-thromboembolic-risk patients remains unclear.</p><p><strong>Methods: </strong>This was a retrospective follow-up study from the EARNEST-PVI (NCT03514693) trial, which compared the efficacy of pulmonary vein isolation (PVI)-alone and PVI-plus strategies for persistent AF ablation. A total of 427 patients with CHADS₂ score of ≤2 points were divided into two groups: OAC continuation throughout the overall period (group C, n = 205) and OAC discontinuation within 1 year after ablation (group D, n = 222). The incidence of thromboembolic and bleeding events was analyzed.</p><p><strong>Results: </strong>AF recurrence (33 % vs. 17 %, p < 0.001), thromboembolic events (1.39 % vs. 0 % per year, p = 0.005), and overall bleeding event rates (7.54 % vs. 3.32 % per year, p = 0.003) were higher in group C than in group D. There was no significant difference in major bleeding event rates between the C and D groups (0.51 % vs. 0.67 % per year, p = 0.686). However, a higher number of overall bleeding events, including major and clinically relevant non-major events, was observed in group C (adjusted hazards ratio: 2.04, 95 % confidence interval: 1.14-3.65, p = 0.016).</p><p><strong>Conclusions: </strong>Thromboembolic events and overall bleeding events were fewer in the OAC discontinuation group compared with the OAC continuation group. Discontinuation of OACs might be considered in patients with low CHADS₂ score after catheter ablation of persistent AF.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}