Journal of cardiology最新文献

{"title":"Coronary anomalies in single ventricles: Insights from selective angiographic assessment.","authors":"Yuko Wakisaka, Kei Inai, Gen Harada, Seiji Asagai, Eriko Shimada","doi":"10.1016/j.jjcc.2025.02.009","DOIUrl":"10.1016/j.jjcc.2025.02.009","url":null,"abstract":"<p><strong>Background: </strong>Adults with congenital heart disease have a higher risk of coronary artery disease compared to the general population. However, there is limited information on coronary artery distribution in patients with a single ventricle (SV), which is important in understanding potential cardiovascular events. This study aimed to evaluate coronary artery morphology and anomalies in patients with SV based on selective coronary angiography (CAG).</p><p><strong>Methods: </strong>We performed a retrospective single-center study including 80 patients with SV [median age, 29 years (range 13-50); 54 % males] who underwent selective CAG at our institution between 2019 and 2023. Patients were classified into either single right or left ventricular (SRV and SLV) morphologies and categorized into D-, L-, and X-loops based on the rules of cardiovascular looping. Coronary artery morphology, dominance, and the abnormality of origin were evaluated.</p><p><strong>Results: </strong>Of the 80 SV patients, 56 had SRV and 24 had SLV. Patients with coronary artery looping surrounding the rudimentary chamber were more frequent in cases with D-loops. In patients with SV, right coronary artery dominance was observed in 70 %, and anomalous origins of coronary artery origins were found in 36.3 % of cases, with a higher frequency of L-loops. Overall, cardiovascular events were observed in patients with SV as follows: 46 % of patients had arrhythmias, 13 % had heart failure, and 8 % had thrombosis; there were no cardiovascular deaths. A single coronary artery was identified in 9 cases (11 %) of SV patients, exclusively in SRV, of which 2 cases (22 %) had arrhythmias and 1 case (11 %) had thrombus.</p><p><strong>Conclusion: </strong>Selective CAG revealed a high prevalence of coronary artery anomalies in patients with SV, emphasizing the importance of comprehensive assessment and long-term follow-up to manage cardiovascular risk in this patient population.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":"187-193"},"PeriodicalIF":2.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of gut microbiota in cardiovascular diseases and their potential as novel therapeutic targets.","authors":"Tomoya Yamashita","doi":"10.1016/j.jjcc.2025.05.002","DOIUrl":"10.1016/j.jjcc.2025.05.002","url":null,"abstract":"<p><p>Cardiovascular diseases (CVDs) including heart failure (HF) is a major health, medical and social issue that needs to be resolved in Japan's super-aged society. Recent clinical and basic studies suggest that the gut microbiota and their metabolites play critical roles in the onset and progression of CVDs. We explored changes in gut microbiota composition and metabolite levels among Japanese patients to investigate their association with CVDs. Changes in specific bacteria were observed, with a decrease in phylum Bacteroidetes and increases in order Lactobacillus or genus Streptococcus in coronary artery disease patients. For HF patients, a reduction in phylum Bacteroidetes and increases in phylum Actinobacteria (e.g. Bifidobacterium) and Proteobacteria (e.g. Escherichia, Shigella, and Klebsiella) were noted. Elevated levels of gut microbiota-associated metabolites, such as trimethylamine N-oxide (TMAO) and indoxyl sulfate, were observed in CVD patients, suggesting potential effects on organ functions. Many studies have linked higher plasma TMAO levels to worse prognoses in CVDs, including HF and renal failure. However, the clinical significance and therapeutic potential of these findings require further investigation. In this manuscript, the author aims to review the current status of research on gut microbiota in CVDs, with a primary focus on the microbes themselves and their related metabolites. Further research is essential to comprehensively understand these intricacies and establish clear cause-and-effect relationships, ultimately paving the way for the development of innovative therapies for CVDs.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":"141-147"},"PeriodicalIF":2.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author's reply.","authors":"Atsushi Yamamoto, Michinobu Nagao, Shuji Sakai, Junichi Yamaguchi","doi":"10.1016/j.jjcc.2025.06.002","DOIUrl":"10.1016/j.jjcc.2025.06.002","url":null,"abstract":"","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":"221"},"PeriodicalIF":2.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of left ventricular reverse remodeling in patients with heart failure with reduced ejection fraction using cardiopulmonary exercise testing.","authors":"Yoshihiro Hosoda, Ayumi Goda, Yoshiaki Yanagisawa, Yusuke Miura, Ryo Nakamaru, Sayaka Funabashi, Mika Tashiro, Tomoko Nishi, Shinsuke Takeuchi, Kyoko Soejima, Takashi Kohno","doi":"10.1016/j.jjcc.2025.01.021","DOIUrl":"10.1016/j.jjcc.2025.01.021","url":null,"abstract":"<p><strong>Background: </strong>With advances in the treatment of heart failure with reduced ejection fraction (HFrEF), the prediction of left ventricular reverse remodeling (LVRR) has become increasingly important. Cardiopulmonary exercise testing (CPET) is a non-invasive test recommended for prognostic risk assessment in HFrEF; however, it is not known whether it predicts LVRR. We aimed to investigate whether the parameters obtained from CPET are useful in predicting LVRR in HFrEF.</p><p><strong>Methods: </strong>We retrospectively evaluated 230 consecutive patients with HFrEF [left ventricular ejection fraction (LVEF) ≤40 %] hospitalized for acute heart failure (59 ± 14 years, 78 % males) who underwent CPET before discharge. We investigated whether the CPET parameters, peak oxygen consumption (VO₂), and the minute ventilation (VE) vs. carbon dioxide production (VCO₂) slope could predict LVRR within 1 year (LVEF >50 %).</p><p><strong>Results: </strong>Among 230 patients, 89 (39 %) exhibited LVRR. In multivariable logistic analysis, higher peak VO₂ [odds ratio (OR): 1.13, 95 % confidence interval (CI): 1.05-1.22, p < 0.001] and lower VE vs. VCO₂ slope (OR: 0.95, 95 % CI: 0.91-0.98, p < 0.001) were independently associated with LVRR. In receiver operating characteristic curve analysis, peak VO₂ [area under the curve (AUC): 0.657, p < 0.001, optimal cut-off: 15.5 mL/min/kg] and VE vs. VCO₂ slope (AUC: 0.663, p < 0.001, optimal cut-off: 35.8) were significant predictors of LVRR. Moreover, combining the peak VO₂ and VE vs. VCO₂ slope improved the predictive value (AUC: 0.682).</p><p><strong>Conclusions: </strong>CPET is a valuable test for the non-invasive detection of LVRR. The combination of peak VO₂ and the VE vs. VCO₂ slope is useful for predicting LVRR among hospitalized patients with HFrEF receiving pharmacological treatment.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":"164-171"},"PeriodicalIF":2.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating feasibility, health impact, and participant feedback of the Utah South Asian Cardiovascular Health Initiative (U-SACHI): A community-based screening and intervention program.","authors":"Kevin S Shah, Hafsa Zahid, Nagesh Gullapalli, Harini Krishnan, Korak Chakraborti, Elizabeth Dranow, Amy B Locke, Sarath Satheesan, Krishna M Sundar","doi":"10.1016/j.jjcc.2025.03.011","DOIUrl":"10.1016/j.jjcc.2025.03.011","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular disease (CVD) is the leading cause of death globally. In the United States, South Asians have a higher prevalence and earlier onset of atherosclerotic cardiovascular disease (ASCVD) compared to other ethnic groups. This study assessed the feasibility, health impact, and feedback of a community-based screening and intervention program focused on South Asians in Utah.</p><p><strong>Methods: </strong>We conducted a feasibility study of the Utah South Asian Cardiovascular Health Initiative (U-SACHI) using the University of Utah Wellness Bus to perform cardiovascular screenings at the India Cultural Center (ICC) in Utah. Participants were South Asian adults aged 30+ without known severe cardiovascular disease. The screening included measurements of waist circumference, LDL, HDL, hemoglobin A1c, and lipoprotein(A). A monthly intervention program was offered to those who had at least one increased risk marker on a monthly basis. Metrics were measured before and after the intervention, and qualitative input was obtained.</p><p><strong>Results: </strong>The combined screening events participant cohort consisted of 179 adults of South Asian descent. Based on desirable levels for South Asians as set out by the National Lipid Association, elevated waist circumference, BMI, LDL, and total cholesterol were confirmed in this cohort. At least one increased risk marker was present in 70 % of the subjects. The intervention program involved forty participants, of whom twenty-one finished most sessions. After completion, participants showed small improvements in some risk measures. Qualitative feedback highlighted that individuals reported more physical activity, made healthier food choices, and had higher levels of awareness.</p><p><strong>Conclusion: </strong>The U-SACHI program is a feasible and effective model for improving cardiovascular health in South Asians through community-based screenings and culturally tailored interventions. This approach enhances early detection of CVD risk factors and also encourages sustainable lifestyle changes. Further research is necessary to explore strategies for improving long-term outcomes.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":"214-215"},"PeriodicalIF":2.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-invasive and quantitative evaluation of myocardial PET imaging: Next step for advanced therapy.","authors":"Atsushi Yamamoto, Michinobu Nagao, Kenji Fukushima, Junichi Yamaguchi","doi":"10.1016/j.jjcc.2025.04.001","DOIUrl":"10.1016/j.jjcc.2025.04.001","url":null,"abstract":"<p><p>Myocardial positron emission tomography (PET) is superior in detecting ischemia in patients with left main or multivessel disease, conditions that are challenging to assess using single-photon emission computed tomography (SPECT). Additionally, quantitative measurements of myocardial blood flow and myocardial flow reserve (MFR) have been established as significant prognostic indicators for patients with ischemic heart disease. Moreover, ¹³N-ammonia PET offers high temporal and spatial resolution, enabling the assessment of both left and right ventricular strain, a quantitative marker of regional myocardial wall motion. Ongoing research aims to translate these advanced PET-based methodologies into SPECT imaging. Furthermore, MFR has proven valuable for diagnosing and predicting cardiac allograft vasculopathy in heart transplant recipients. More recently, it has also been utilized to evaluate the efficacy of cardiac regeneration therapy in individuals with severe heart failure and reduced cardiac function. This review presents existing evidence and highlights recent advancements in myocardial PET.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":"134-140"},"PeriodicalIF":2.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polymer-free sirolimus- and probucol-eluting stents versus durable polymer-based everolimus-eluting stents for percutaneous coronary revascularization: A prospective multicenter randomized clinical trial.","authors":"Akihiro Ikuta, Junji Yajima, Shinya Okazaki, Taishi Yonetsu, Jiro Ando, Itaru Takamisawa, Yoshiaki Ito, Shigeru Saito, Masami Sakurada, Yukihiko Yoshida, Yukio Ozaki, Tetsuya Amano, Kenshi Fujii, Junya Shite, Koh Ono, Shigeru Nakamura, Tomofumi Takaya, Atsushi Hirohata, Koichi Kishi, Kenji Ando, Tomohiro Kawasaki, Yoshisato Shibata, Ken Kozuma, Yuji Ikari, Takafumi Ueno, Toshiya Muramatsu, Kiyoshi Hibi, Yoshihiro Morino, Kazushige Kadota","doi":"10.1016/j.jjcc.2025.01.018","DOIUrl":"10.1016/j.jjcc.2025.01.018","url":null,"abstract":"<p><strong>Background: </strong>Owing to the advent of new generation drug-eluting stents, percutaneous coronary intervention (PCI) outcomes are improving. However, the polymers, which have been the most common type of coatings used in drug-eluting stents, have some issues. The study aim was to evaluate the clinical outcomes of patients undergoing PCI with polymer-free sirolimus- and probucol-eluting stents (NP023).</p><p><strong>Methods: </strong>This clinical trial was a prospective multicenter single-blind noninferiority randomized study performed at 22 hospitals in Japan. We randomly assigned patients in a 2:1 ratio to undergo PCI with either NP023 or durable polymer-based everolimus-eluting stents (control stents) with a 5-year follow-up. The primary outcome was freedom from target lesion failure (TLF) at 9 months, defined as patient-oriented composite of cardiac death, ischemia-driven target vessel-related myocardial infarction, or ischemia-driven target lesion revascularization. The secondary outcome included adverse outcomes at 5 years following the index procedure.</p><p><strong>Results: </strong>Overall, 432 patients (463 lesions) were treated at 22 sites in Japan [mean age, 68 years; males, 345 (80 %); chronic coronary artery diseases, 322 (74.5 %)]. Of the participants, 91 % completed the 5-year follow-up. The Kaplan-Meier estimates of the percentages of patients who were free from TLF were 95.8 % and 97.3 % with NP023 and control stents, respectively (hazard ratio, 0.98; 95 % confidential interval, 0.80-1.21; p < 0.01 for noninferiority). At the 5-year follow-up, the secondary endpoint for safety was not different between the two groups.</p><p><strong>Conclusions: </strong>The results of this study showed similar outcomes for polymer-free sirolimus- and probucol-eluting stents and durable polymer-based everolimus-eluting stents regarding freedom from TLF at 9 months and other outcomes at 5 years among patients undergoing PCI.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":"148-154"},"PeriodicalIF":2.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor on association between complementary use of Goreisan and heart failure readmission: A nationwide propensity score-matched study.","authors":"Muhammad Ibrahim","doi":"10.1016/j.jjcc.2025.04.005","DOIUrl":"10.1016/j.jjcc.2025.04.005","url":null,"abstract":"","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":"216"},"PeriodicalIF":2.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of FFR-CT before coronary angiography on the management of non-culprit lesions among high-risk NSTE-ACS patients.","authors":"Aurelia Zimmerli, David Meier, Adil Salihu, Quentin Liabot, Victor Weerts, Ioannis Skalidis, Daniele Andreini, Bernard Cosyns, Tatyana Storozhenko, Thabo Mahendiran, Emilio Assanelli, Jeroen Sonck, Bram Roosens, David C Rotzinger, Salah Dine Qanadli, Georgios Tzimas, Bernard De Bruyne, Carlos Collet, Olivier Muller, Stephane Fournier","doi":"10.1016/j.jjcc.2025.04.009","DOIUrl":"10.1016/j.jjcc.2025.04.009","url":null,"abstract":"<p><p>Recent data suggest that fractional flow reserve derived from coronary computed tomography (FFR-CT) can help select patients with high-risk non-ST-elevation acute coronary syndrome (NSTE-ACS) requiring invasive coronary angiography (ICA). Multiple stenoses are often observed in this population, and while a clear culprit is frequently identified, the management of intermediate lesions remains challenging. The information provided by FFR-CT prior to the ICA could theoretically assist in the management of these lesions. A prespecified post-hoc analysis of a multicenter, single-arm, double-blinded, core-laboratory adjudicated study was conducted to evaluate the potential of FFR-CT to assess the non-culprit lesions among patients with an identified culprit lesion on ICA and one additional vessel with a stenosis ≥30 %. The primary endpoint was the performance of FFR-CT in ruling out hemodynamically significant lesions in non-culprit vessels, with invasive FFR as gold standard. A total of 49 patients with 67 non-culprit lesions were included. FFR-CT classified 33 lesions (49 %) as non-significant and 34 (51 %) as significant. Among the 33 lesions deemed negative by FFR-CT, 31 were confirmed negative by invasive FFR, resulting in a negative predictive value of 94 %. Similarly, among the 34 lesions classified as significant by FFR-CT, 26 were confirmed as positive by invasive FFR, resulting in a positive predictive value of 93 %. In patients with high-risk NSTE-ACS, FFR-CT has the potential to not only reduce the number of unnecessary ICAs, but also to support early decision-making regarding the management of non-culprit lesions.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":"211-213"},"PeriodicalIF":2.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of American Heart Association's Life's Essential 8 and mortality among US adults with and without cardiovascular disease.","authors":"Ofer Kobo, Gurleen Kaur, Jacqueline E Tamis-Holland, Sarah Zaman, Renée P Bullock-Palmer, Kamala Tamirisa, Martha Gulati, Mamas A Mamas","doi":"10.1016/j.jjcc.2025.01.015","DOIUrl":"10.1016/j.jjcc.2025.01.015","url":null,"abstract":"<p><strong>Background: </strong>Differences in the American Heart Association's Life's Essential 8 (LE8) score and its association with mortality based on the presence of clinically prevalent cardiovascular disease (CVD) has not been assessed previously.</p><p><strong>Methods: </strong>Data from the National Health and Nutrition Examination Survey 2009-2018 were utilized to calculate LE8 scores among adult patients, stratified by the presence of existing CVD. Health metrics were further divided into health behaviors and health factors. Scores were also evaluated based on sex, age, race/ethnicity, and socioeconomic status. Cox proportional hazard models were used to evaluate the association between the levels of cardiovascular health (CVH), estimated using LE8 score, and risk of all-cause and cardiovascular mortality.</p><p><strong>Results: </strong>25,359 patients were included in the analysis, of which 10.2 % had CVD. Individuals with known CVD had lower overall CVH (55.9 vs. 65.8, p < 0.001), health behaviors (60.6 vs. 67.9, p < 0.001), and health factors (51.3 vs. 63.8, p < 0.001) scores. The lower CVH scores in those with prior CVD persisted after stratification by sex, age, race/ethnicity, and socioeconomic status. When assessing the association of CVH metrics with mortality, for every 10-point increase in LE8 score, there was a significant reduction (17 %-27 %) in all-cause and CV mortality in those with and without CVD.</p><p><strong>Conclusions: </strong>Individuals with known CVD have lower CVH metric scores. Overall, the LE8 score is able to predict future CV outcomes in both individuals with and without CVD and highlights the importance of effective implementation strategies that target health factors and behaviors in primary and secondary prevention populations.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":"155-163"},"PeriodicalIF":2.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}