Journal of cardiology最新文献

{"title":"Gout is associated with the development of abdominal aortic aneurysm.","authors":"Gang Wang, Zhichun Liu","doi":"10.1016/j.jjcc.2025.01.019","DOIUrl":"10.1016/j.jjcc.2025.01.019","url":null,"abstract":"","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of left ventricular reverse remodeling in patients with heart failure with reduced ejection fraction using cardiopulmonary exercise testing.","authors":"Yoshihiro Hosoda, Ayumi Goda, Yoshiaki Yanagisawa, Yusuke Miura, Ryo Nakamaru, Sayaka Funabashi, Mika Tashiro, Tomoko Nishi, Shinsuke Takeuchi, Kyoko Soejima, Takashi Kohno","doi":"10.1016/j.jjcc.2025.01.021","DOIUrl":"10.1016/j.jjcc.2025.01.021","url":null,"abstract":"<p><strong>Background: </strong>With advances in the treatment of heart failure with reduced ejection fraction (HFrEF), the prediction of left ventricular reverse remodeling (LVRR) has become increasingly important. Cardiopulmonary exercise testing (CPET) is a non-invasive test recommended for prognostic risk assessment in HFrEF; however, it is not known whether it predicts LVRR. We aimed to investigate whether the parameters obtained from CPET are useful in predicting LVRR in HFrEF.</p><p><strong>Methods: </strong>We retrospectively evaluated 230 consecutive patients with HFrEF [left ventricular ejection fraction (LVEF) ≤40 %] hospitalized for acute heart failure (59 ± 14 years, 78 % males) who underwent CPET before discharge. We investigated whether the CPET parameters, peak oxygen consumption (VO₂), and the minute ventilation (VE) vs. carbon dioxide production (VCO₂) slope could predict LVRR within 1 year (LVEF >50 %).</p><p><strong>Results: </strong>Among 230 patients, 89 (39 %) exhibited LVRR. In multivariable logistic analysis, higher peak VO₂ [odds ratio (OR): 1.13, 95 % confidence interval (CI): 1.05-1.22, p < 0.001] and lower VE vs. VCO₂ slope (OR: 0.95, 95 % CI: 0.91-0.98, p < 0.001) were independently associated with LVRR. In receiver operating characteristic curve analysis, peak VO₂ [area under the curve (AUC): 0.657, p < 0.001, optimal cut-off: 15.5 mL/min/kg] and VE vs. VCO₂ slope (AUC: 0.663, p < 0.001, optimal cut-off: 35.8) were significant predictors of LVRR. Moreover, combining the peak VO₂ and VE vs. VCO₂ slope improved the predictive value (AUC: 0.682).</p><p><strong>Conclusions: </strong>CPET is a valuable test for the non-invasive detection of LVRR. The combination of peak VO₂ and the VE vs. VCO₂ slope is useful for predicting LVRR among hospitalized patients with HFrEF receiving pharmacological treatment.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular imaging of cardiovascular disease: Current status and future perspective.","authors":"Takehiro Nakahara, Shinichiro Fujimoto, Masahiro Jinzaki","doi":"10.1016/j.jjcc.2025.01.017","DOIUrl":"10.1016/j.jjcc.2025.01.017","url":null,"abstract":"<p><p>Advancements in knowledge of cardiovascular disease, pharmacology, and chemistry have led to the development of newer radiopharmaceuticals and targets for new and more suitable molecules. Molecular imaging encompasses multiple imaging techniques for identifying the characteristics of key components involved in disease. Despite its limitations in spatial resolution, the affinity for key molecules compensates for disadvantages in diagnosing diseases and elucidating their pathophysiology. This review introduce established molecular tracers involved in clinical practice and emerging tracers already applied in clinical studies, classifying the key component in A: artery, specifically those vulnerable plaque (A-I) inflammatory cells [¹⁸F-FDG]; A-II) lipid/fatty acid; A-III) hypoxia; A-IV) angiogenesis; A-V) protease [¹⁸F/⁶⁸Ga-FAPI]; A-VI) thrombus/hemorrhage; A-VII) apoptosis and A-VIII) microcalcification [¹⁸F-NaF]) and B: myocardium, including myocardial ischemia, infarction and myocardiopathy (B-I) myocardial ischemia; B-II) myocardial infarction (myocardial damage and fibrosis); B-III) myocarditis and endocarditis; B-IV) sarcoidosis; B-V) amyloidosis; B-VI) metabolism; B-VII) innervation imaging). In addition to cardiovascular-specific tracers tested in animal models, many radiotracers may have been developed in other areas, such as oncology imaging or neuroimaging. While this review does not cover all available tracers, some of them hold potential for future use assessing cardiovascular disease. Advances in molecular biology, pharmaceuticals, and imaging sciences will facilitate the identification of precise disease mechanisms, enabling precise diagnoses, better assessment of disease status, and enhanced therapeutic evaluation in this multi-modality era.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to indicate left atrial posterior wall isolation adjunctive to conventional pulmonary vein isolation in patients with atrial fibrillation.","authors":"Naoya Kataoka, Teruhiko Imamura","doi":"10.1016/j.jjcc.2025.01.020","DOIUrl":"10.1016/j.jjcc.2025.01.020","url":null,"abstract":"","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polymer-free sirolimus- and probucol-eluting stents versus durable polymer-based everolimus-eluting stents for percutaneous coronary revascularization: A prospective multicenter randomized clinical trial.","authors":"Akihiro Ikuta, Junji Yajima, Shinya Okazaki, Taishi Yonetsu, Jiro Ando, Itaru Takamisawa, Yoshiaki Ito, Shigeru Saito, Masami Sakurada, Yukihiko Yoshida, Yukio Ozaki, Tetsuya Amano, Kenshi Fujii, Junya Shite, Koh Ono, Shigeru Nakamura, Tomofumi Takaya, Atsushi Hirohata, Koichi Kishi, Kenji Ando, Tomohiro Kawasaki, Yoshisato Shibata, Ken Kozuma, Yuji Ikari, Takafumi Ueno, Toshiya Muramatsu, Kiyoshi Hibi, Yoshihiro Morino, Kazushige Kadota","doi":"10.1016/j.jjcc.2025.01.018","DOIUrl":"10.1016/j.jjcc.2025.01.018","url":null,"abstract":"<p><strong>Background: </strong>Owing to the advent of new generation drug-eluting stents, percutaneous coronary intervention (PCI) outcomes are improving. However, the polymers, which have been the most common type of coatings used in drug-eluting stents, have some issues. The study aim was to evaluate the clinical outcomes of patients undergoing PCI with polymer-free sirolimus- and probucol-eluting stents (NP023).</p><p><strong>Methods: </strong>This clinical trial was a prospective multicenter single-blind noninferiority randomized study performed at 22 hospitals in Japan. We randomly assigned patients in a 2:1 ratio to undergo PCI with either NP023 or durable polymer-based everolimus-eluting stents (control stents) with a 5-year follow-up. The primary outcome was freedom from target lesion failure (TLF) at 9 months, defined as patient-oriented composite of cardiac death, ischemia-driven target vessel-related myocardial infarction, or ischemia-driven target lesion revascularization. The secondary outcome included adverse outcomes at 5 years following the index procedure.</p><p><strong>Results: </strong>Overall, 432 patients (463 lesions) were treated at 22 sites in Japan [mean age, 68 years; males, 345 (80 %); chronic coronary artery diseases, 322 (74.5 %)]. Of the participants, 91 % completed the 5-year follow-up. The Kaplan-Meier estimates of the percentages of patients who were free from TLF were 95.8 % and 97.3 % with NP023 and control stents, respectively (hazard ratio, 0.98; 95 % confidential interval, 0.80-1.21; p < 0.01 for noninferiority). At the 5-year follow-up, the secondary endpoint for safety was not different between the two groups.</p><p><strong>Conclusions: </strong>The results of this study showed similar outcomes for polymer-free sirolimus- and probucol-eluting stents and durable polymer-based everolimus-eluting stents regarding freedom from TLF at 9 months and other outcomes at 5 years among patients undergoing PCI.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of American Heart Association's Life's Essential 8 and mortality among US adults with and without cardiovascular disease.","authors":"Ofer Kobo, Gurleen Kaur, Jacqueline E Tamis-Holland, Sarah Zaman, Renée P Bullock-Palmer, Kamala Tamirisa, Martha Gulati, Mamas A Mamas","doi":"10.1016/j.jjcc.2025.01.015","DOIUrl":"10.1016/j.jjcc.2025.01.015","url":null,"abstract":"<p><strong>Background: </strong>Differences in the American Heart Association's Life's Essential 8 (LE8) score and its association with mortality based on the presence of clinically prevalent cardiovascular disease (CVD) has not been assessed previously.</p><p><strong>Methods: </strong>Data from the National Health and Nutrition Examination Survey 2009-2018 were utilized to calculate LE8 scores among adult patients, stratified by the presence of existing CVD. Health metrics were further divided into health behaviors and health factors. Scores were also evaluated based on sex, age, race/ethnicity, and socioeconomic status. Cox proportional hazard models were used to evaluate the association between the levels of cardiovascular health (CVH), estimated using LE8 score, and risk of all-cause and cardiovascular mortality.</p><p><strong>Results: </strong>25,359 patients were included in the analysis, of which 10.2 % had CVD. Individuals with known CVD had lower overall CVH (55.9 vs. 65.8, p < 0.001), health behaviors (60.6 vs. 67.9, p < 0.001), and health factors (51.3 vs. 63.8, p < 0.001) scores. The lower CVH scores in those with prior CVD persisted after stratification by sex, age, race/ethnicity, and socioeconomic status. When assessing the association of CVH metrics with mortality, for every 10-point increase in LE8 score, there was a significant reduction (17 %-27 %) in all-cause and CV mortality in those with and without CVD.</p><p><strong>Conclusions: </strong>Individuals with known CVD have lower CVH metric scores. Overall, the LE8 score is able to predict future CV outcomes in both individuals with and without CVD and highlights the importance of effective implementation strategies that target health factors and behaviors in primary and secondary prevention populations.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of inspiratory muscle training in improving clinical outcomes in heart failure patients: An updated systematic review and meta-analysis.","authors":"Ahmed Kamal Siddiqi, Maryam Shahzad, Akash Kumar, Manahil Ahmed, Lakshmi Sridharan, Mahmoud H Abdou, Muhammad Naeem","doi":"10.1016/j.jjcc.2025.01.016","DOIUrl":"10.1016/j.jjcc.2025.01.016","url":null,"abstract":"<p><strong>Background: </strong>Inspiratory muscle training (IMT) has shown improvements in clinical variables for heart failure (HF) patients. We conducted a meta-analysis to investigate if IMT can enhance respiratory muscle strength, quality of life (QoL), and reduce cardiac biomarker levels in HF patients.</p><p><strong>Methods: </strong>PubMed, Cochrane Library, and Google Scholar databases were systematically searched up to July 8, 2024. Randomized controlled trials of IMT in HF patients were included. A random effects model was used to calculate weighted mean differences (WMDs) and 95 % confidence intervals. Outcomes analyzed included minute ventilation to carbon dioxide output slope (VE/VCO2), QoL, six-minute walk distance (6MWD), maximum expiratory pressure, maximum inspiratory pressure (MIP), N-terminal pro B-type natriuretic peptide (NT-pro-BNP), forced vital capacity, forced expiratory volume in one second, and metabolic equivalents.</p><p><strong>Results: </strong>Seventeen studies involving 510 patients (252 in IMT group, 258 in control) were included. IMT significantly improved 6MWD [WMD: 72.72; 95 % CI: (16.65 to 128.78); p = 0.01], QoL [WMD: -15.27; 95 % CI: (-21.01 to -9.53); p < 0.00001], VE/VCO2 [WMD: -5.09; 95 % CI: (-7.36 to -2.83); p < 0.0001], MIP [WMD: 13.77; 95 % CI: (7.51 to 20.03); p < 0.0001], and NT-pro-BNP levels [WMD: -659.66; 95 % CI: (-1212.87 to -106.46); p = 0.02].</p><p><strong>Conclusion: </strong>IMT significantly improved respiratory muscle strength, QoL, and reduced cardiac biomarker levels in patients with both heart failure with preserved ejection fraction and heart failure with reduced ejection fraction. These findings suggest that IMT may be a promising exercise-based strategy for treating HF.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atrial structural remodeling and atrial fibrillation substrate: A histopathological perspective","authors":"Takanori Yamaguchi MD, PhD","doi":"10.1016/j.jjcc.2024.05.007","DOIUrl":"10.1016/j.jjcc.2024.05.007","url":null,"abstract":"<div><div>Atrial fibrillation (AF) substrate progresses with the advancement of atrial structural remodeling, resulting in AF perpetuation and recurrence. Although fibrosis is considered a hallmark of atrial structural remodeling, the histological background has not been fully elucidated because obtaining atrial specimens is difficult, especially in patients not undergoing open-heart surgery. Bipolar voltage reduction evaluated using electroanatomic mapping during AF ablation is considered a surrogate marker for the progression of structural remodeling; however, histological validation is lacking. We developed an intracardiac echocardiography-guided endomyocardial atrial biopsy technique to evaluate atrial structural remodeling in patients undergoing catheter ablation for nonvalvular AF. The histological factors associated with a decrease in bipolar voltage were interstitial fibrosis, as well as an increase in myocardial intercellular space preceding fibrosis, myofibrillar loss, and a decrease in cardiomyocyte nuclear density, which is a surrogate marker for cardiomyocyte density. Cardiomyocyte hypertrophy is closely associated with a decrease in cardiomyocyte nuclear density, suggesting that hypertrophic changes compensate for cardiomyocyte loss. Electron microscopy also revealed that increased intercellular spaces indicated the leakage of plasma components owing to increased vascular permeability. Additionally, amyloid deposition was observed in 4 % of biopsy cases. Only increased intercellular space and interstitial fibrosis were significantly higher for long-standing persistent AF than for paroxysmal AF and associated with recurrence after AF ablation, suggesting that this interstitial remodeling is the AF substrate. An increase in intercellular space that occurs early in AF formation is a therapeutic target for the AF substrate, which prevents irreversible interstitial degeneration due to collagen accumulation. This endomyocardial atrial biopsy technique will allow the collection of atrial tissue from a wide variety of patients and significantly facilitate the elucidation of the mechanisms of atrial cardiomyopathy, structural remodeling, and AF substrates.</div></div>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":"85 2","pages":"Pages 47-55"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141175778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benefit of prehospital electrocardiogram on door-to-device time in ST-segment elevation myocardial infarction with cardiogenic shock: Data from the Kanagawa Acute Cardiovascular Registry","authors":"Jin Kirigaya MD, PhD ,&nbsp;Yasushi Matsuzawa MDs, PhD ,&nbsp;Toshiaki Ebina MD, PhD ,&nbsp;Takeru Abe PhD ,&nbsp;Noriaki Iwahashi MD, PhD, FJCC ,&nbsp;Kazuki Fukui MD, PhD ,&nbsp;Atsuo Maeda MD, PhD, FJCC ,&nbsp;Yoshihiro Akashi MD, PhD, FJCC ,&nbsp;Junya Ako MD, PhD, FJCC ,&nbsp;Yuji Ikari MD, PhD, FJCC ,&nbsp;Atsuo Namiki MD, PhD ,&nbsp;Ichiro Michishita MD, PhD, FJCC ,&nbsp;Teruyasu Sugano MD, PhD ,&nbsp;Kouichi Tamura MD, PhD, FJCC ,&nbsp;Kiyoshi Hibi MD, PhD, FJCC ,&nbsp;Kazuo Kimura MD, PhD, FJCC ,&nbsp;Hiroshi Suzuki MD, PhD, FJCC","doi":"10.1016/j.jjcc.2024.08.004","DOIUrl":"10.1016/j.jjcc.2024.08.004","url":null,"abstract":"<div><h3>Background</h3><div>The benefit of prehospital 12‑lead electrocardiogram (PH-ECG) performed by emergency medical service personnel at the site of first medical contact (FMC) in patients with ST-segment elevation myocardial infarction (STEMI) with cardiogenic shock (CS-STEMI) remains unclear. This study aimed to investigate the effect of PH-ECG on door-to-device time in patients with CS-STEMI.</div></div><div><h3>Methods</h3><div>This study enrolled CS-STEMI (Killip class IV) patients who were transferred directly to hospitals by ambulance (n = 517) from the Kanagawa Acute Cardiovascular Registry database. Patients were divided into PH-ECG (+) (n = 270) and PH-ECG (−) (n = 247) groups. Patients who experienced out-of-hospital cardiac arrest, who did not undergo emergent coronary intervention, or whose data were missing were excluded. Patient characteristics, FMC-to-door time, door-to-device time, and in-hospital mortality were compared between the groups.</div></div><div><h3>Results</h3><div>The patient backgrounds of the PH-ECG (+) and PH-ECG (−) groups were comparable. The peak creatinine kinase level was greater in the PH-ECG (+) group than in the PH-ECG (−) group [2756 (1292–6009) IU/ml vs. 2270 (957–5258) IU/ml, <em>p</em> = 0.048]. The FMC-to-door time was similar between the two groups [25 (20−33) min vs. 27 (20–35) min, <em>p</em> = 0.530], while the door-to-device time was significantly shorter in the PH-ECG group [74 (52–103) min vs. 83 (62–111) min, <em>p</em> = 0.007]. In-hospital mortality did not differ between the two groups (18 % vs. 21 %, <em>p</em> = 0.405). Multivariable logistic regression analyses revealed that PH-ECG (+) was independently associated with a door-to-device time &lt; 60 min [odds ratio (95 % confidence intervals): 1.88 (1.24–2.83), <em>p</em> = 0.003].</div></div><div><h3>Conclusions</h3><div>PH-ECG was significantly associated with shorter door-to-device times in patients with CS-STEMI. Further studies with larger populations and more defined protocols are required to evaluate the utility of PH-ECG in patients with CS-STEMI.</div></div>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":"85 2","pages":"Pages 108-114"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141995768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does previous valve replacement affect short-term coronary artery bypass grafting outcomes? A population-based National Inpatient Sample study from 2015 to 2020","authors":"Renxi Li BS ,&nbsp;Stephen J. Huddleston MD, PhD ,&nbsp;Deyanira J. Prastein MD","doi":"10.1016/j.jjcc.2024.08.005","DOIUrl":"10.1016/j.jjcc.2024.08.005","url":null,"abstract":"<div><h3>Background</h3><div>Coronary artery disease (CAD) and valvular disease frequently coexist due to similar pathophysiology. Effort has been dedicated to comprehending the outcomes of concomitant coronary revascularization and valve replacement procedures. However, the understanding of how prior valve replacement affects the outcomes of coronary artery bypass grafting (CABG) remains limited. Thus, this study aimed to conduct a population-based examination of the in-hospital outcomes in patients with previous valve replacement in CABG.</div></div><div><h3>Methods</h3><div>Patients who underwent CABG were identified in the National Inpatient Sample in the USA from Q4 2015–2020. Patients with age &lt; 18 years and concomitant procedures were excluded. A 1:3 propensity-score matching was used to address differences in demographics, socioeconomic status, primary payer status, hospital characteristics, comorbidities, and transfer/admission status between patients with and without previous valve replacement. In-hospital postoperative outcomes were assessed.</div></div><div><h3>Results</h3><div>There were 514 patients with previous valve replacement who underwent CABG, who were matched to 1588 out of 167,668 controls. After matching, patients with valve replacement had mostly comparable in-hospital outcomes except for a higher risk of vascular complications (1.75 % vs 0.57 %, <em>p</em> = 0.02), a longer length of stay (10.90 ± 7.04 days vs 9.95 ± 6.53 days, <em>p</em> = 0.01), and higher hospital charges (275,465 ± 229,088 US dollars vs 231,648 ± 189,938 US dollars, <em>p</em> &lt; 0.01).</div></div><div><h3>Conclusion</h3><div>For short-term outcomes, CABG is generally safe for patients who have undergone previous valve replacement, although there is an increased risk of vascular complications that may warrant additional attention. The findings of this study can be valuable for preoperative risk assessment of patients who have had valve replacement and are considering CABG.</div></div>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":"85 2","pages":"Pages 96-97"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}