冠状动脉钙化作为一种增量预测风险：初级预防的研究视角。

IF 2.5 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of cardiology Pub Date : 2025-06-01 DOI:10.1016/j.jjcc.2024.12.005

Alberto Cereda MD , Antonio G. Franchina MD , Lorenzo Tua MD , Matteo Rocchetti MD , Davide Garattini MD , Emilia D'Elia PhD , Stefano Lucreziotti MD

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引用次数: 0

摘要

冠状动脉钙（CAC）评分是一种被忽视的生物标志物，可以从非心脏胸部计算机断层扫描中获得，并代表动脉粥样硬化的替代品。我们创建了一个模拟模型，使用来自傅立叶试验的人群中MESA冠状动脉风险评分中不同的CAC评分值。CAC评分可以调节心血管一级和二级预防试验的样本量，为高危受试者提供新的一级预防治疗方法，治疗人数合理，可与二级预防试验相媲美。

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Coronary artery calcification as an incremental predictive risk: Research perspectives in primary prevention

Coronary artery calcium (CAC) score is a neglected biomarker that can be derived from non-cardiac chest computed tomography scan and represents a surrogate for atherosclerosis. We created a simulation model using different CAC score values in the MESA coronary artery risk score in a population derived from the Fourier Trial. CAC score could modulate the sample sizes of cardiovascular trials in primary and secondary prevention and offer new primary prevention treatments to high-risk subjects with reasonable numbers needed to treat comparable to secondary prevention trials.

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来源期刊

Journal of cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

4.90

自引率

8.00%

发文量

202

审稿时长

29 days

期刊介绍： The official journal of the Japanese College of Cardiology is an international, English language, peer-reviewed journal publishing the latest findings in cardiovascular medicine. Journal of Cardiology (JC) aims to publish the highest-quality material covering original basic and clinical research on all aspects of cardiovascular disease. Topics covered include ischemic heart disease, cardiomyopathy, valvular heart disease, vascular disease, hypertension, arrhythmia, congenital heart disease, pharmacological and non-pharmacological treatment, new diagnostic techniques, and cardiovascular imaging. JC also publishes a selection of review articles, clinical trials, short communications, and important messages and letters to the editor.