Journal of cardiology最新文献

{"title":"Association between insomnia symptoms and risk of heart failure: A meta-analysis of prospective cohort studies.","authors":"Juan Gao, Hong-Shuai Cao, Le Han, Xiao-Qin Luo, Li-Yue Xu, Ying Zhou, Zhe-Xun Lian, Jing-Yi Ren","doi":"10.1016/j.jjcc.2025.10.001","DOIUrl":"https://doi.org/10.1016/j.jjcc.2025.10.001","url":null,"abstract":"<p><strong>Background: </strong>Insomnia, as one of the most prevalent sleep disorders, is frequently linked to heart failure (HF). However, the precise relationship and potential risk of HF events associated with insomnia and subtypes of symptoms necessitate further investigation. This meta-analysis aims to provide a comprehensive and current evaluation of the associations between insomnia symptoms and HF risk, including difficulty initiating sleep (DIS), difficulty maintaining sleep (DMS), early-morning awakening, and non-restorative sleep (NRS).</p><p><strong>Methods: </strong>A comprehensive literature search was conducted in PubMed, Web of Science, Embase, ProQuest and the Cochrane Library to identify prospective cohort studies from inception to October 31, 2024. Pooled hazard ratios (HRs) with 95 % confidence intervals (CIs) were calculated to assess the correlation between insomnia and the risk of HF. Funnel plots and Egger's tests were employed to assess publication bias.</p><p><strong>Results: </strong>A total of 177,008 patients from seven eligible prospective cohort studies were included. The pooled minimally adjusted HR for HF was 1.26 (p = 0.001), indicating that insomnia was associated with an increased risk of HF. Among the individual insomnia symptoms, only DIS showed a positive association with the risk of HF (p = 0.005). DMS and NRS had no significant effect on the risk of HF (p > 0.05). In the subgroup analysis including age, sex, and body mass index, there were no significant differences between groups.</p><p><strong>Conclusion: </strong>This meta-analysis confirms the link between insomnia and an increased risk of HF, particularly highlighting the importance of DIS as a potential predictor for HF.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiarrhythmic potential of SGLT2 inhibitors: Mechanistic insights and clinical evidence.","authors":"Shinya Fujiki","doi":"10.1016/j.jjcc.2025.09.018","DOIUrl":"10.1016/j.jjcc.2025.09.018","url":null,"abstract":"<p><p>Sodium-glucose cotransporter 2 (SGLT2) inhibitors were originally developed to treat type 2 diabetes by promoting glycosuria through inhibition of renal glucose reabsorption. However, their clinical utility has expanded rapidly following the demonstration of consistent cardiovascular and renal benefits in large-scale randomized controlled trials. These trials have shown that SGLT2 inhibitors significantly reduce adverse cardiovascular outcomes-including sudden cardiac death-in patients with diabetes, heart failure, or chronic kidney disease, irrespective of glycemic control. As clinical experience has accumulated, several unanticipated hypotheses have emerged-one of which is that SGLT2 inhibitors may exert antiarrhythmic effects. This review summarizes the current evidence for antiarrhythmic effects of SGLT2 inhibitors, from both mechanistic and clinical perspectives. Experimental studies suggest that these agents modulate arrhythmogenic substrates via multiple pathways: inhibition of sodium-hydrogen exchanger 1, suppression of the late sodium current, modulation of potassium currents, attenuation of sympathetic tone, hemodynamic improvement, and enhanced myocardial energy efficiency through increased ketone body utilization. These cellular and systemic changes may attenuate arrhythmogenic remodeling and reduce the risk of both atrial and ventricular arrhythmias. Clinically, post-hoc analyses and meta-analyses of major SGLT2 inhibitor trials have reported reductions in the incidence of atrial fibrillation/flutter and ventricular arrhythmias, although findings have been somewhat heterogeneous. A small number of prospective studies using implantable cardioverter defibrillators have also provided high-resolution evidence supporting this effect. While definitive large-scale trials with arrhythmia-specific endpoints are still lacking, the potential antiarrhythmic benefits of SGLT2 inhibitors represent a promising area for further research and may help explain their ability to reduce sudden cardiac death across a range of cardiovascular conditions.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145228596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contemporary clinical implication of catheter ablation for atrial fibrillation in Japan.","authors":"Naoya Kataoka, Teruhiko Imamura","doi":"10.1016/j.jjcc.2025.09.020","DOIUrl":"10.1016/j.jjcc.2025.09.020","url":null,"abstract":"","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Right ventricular outflow tract reconstruction in cyanotic congenital heart disease: A single center comparison between homograft and handmade polytetrafluoroethylene tri-leaflet valved conduit.","authors":"Qi Liu, Shoujun Li, Keming Yang, Yang Wang, Qing Deng, Benqing Zhang","doi":"10.1016/j.jjcc.2025.09.019","DOIUrl":"https://doi.org/10.1016/j.jjcc.2025.09.019","url":null,"abstract":"<p><strong>Background: </strong>The comparative clinical outcomes of homograft (HG) and handmade polytetrafluoroethylene (PTFE) tri-leaflet valved conduit for right ventricular outflow tract reconstruction (RVOTR) in children with cyanotic congenital heart diseases remain unclear.</p><p><strong>Methods: </strong>We reviewed 265 consecutive patients (aged <14 years old) with cyanotic congenital heart diseases who underwent surgical intervention from 2015 to 2025 in our center (HG n = 141, PTFE n = 124). Competing risk analysis was performed for perioperative mortality, early reintervention, and re-operative conduit replacement during follow-up.</p><p><strong>Results: </strong>There were five early deaths (1.9 %). Multivariate analysis revealed a significant relationship between early mortality and preoperative left ventricular ejection fraction [hazard ratio (HR), 0.879; 95 % confidence interval (CI), 0.777-0.993; p = 0.039]. During a median follow-up of 45 months (range, 1-96), six patients (2.3 %) had reintervention on pulmonary artery by percutaneous balloon pulmonary dilation in the early postoperative period (average 7.8 months). Compared with HG conduit, patients in the PTFE group demonstrated longer conduit durability (p = 0.013) and lower reoperation rate (p = 0.049) during follow-up. Overall, freedom from reoperation for conduit dysfunction was no different for both conduits (p = 0.037). Freedom from re-operative conduit replacement at 3 and 5 years in the PTFE group was 95.2 % and 91.8 %; 90.3 % and 81.2 % in the HG group, respectively without significant difference (p = 0.37). Multivariate analysis revealed a significant relationship between reoperation and cardiopulmonary bypass time (HR, 0.989; 95 % CI, 0.979-0.999; p = 0.036), conduit size/body surface area > 25.77 mm/m² (HR, 0.152; 95 % CI, 0.038-0.614; p = 0.008) and PTFE conduit (HR, 0.350; 95 % CI, 0.127-0.964; p = 0.042). Patients aged >34 months were associated with longer freedom from reoperation (p = 0.013).</p><p><strong>Conclusion: </strong>We demonstrate excellent outcomes for RVOTR in pediatric patients with cyanotic congenital heart diseases. The handmade PTFE tri-leaflet valved conduit showed better results for reoperation and conduit durability. Younger age showed worse survival without reoperation for both conduits.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145228585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prognostic value of pre-implantation hyponatremia in pacemaker recipients: A population-based study.","authors":"Yuval Avidan, Dana Hadar, Hila Cohen, Ali Jihad, Amir Yahav, Asaf Danon, Sameer Kassem, Amir Aker","doi":"10.1016/j.jjcc.2025.09.016","DOIUrl":"10.1016/j.jjcc.2025.09.016","url":null,"abstract":"","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond acute survival: Addressing long-term implications of size mismatch in obese heart transplant patients.","authors":"Parth Aphale, Himanshu Shekhar, Shashank Dokania","doi":"10.1016/j.jjcc.2025.09.017","DOIUrl":"10.1016/j.jjcc.2025.09.017","url":null,"abstract":"","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145175570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient perceptions on cardiac rehabilitation participation following hospitalization for acute coronary syndrome.","authors":"Momoko Masuda, Kazuki Tobita, Ayumi Goda, Daisuke Fujisawa, Ryo Nakamaru, Shinsuke Takeuchi, Kohei Koyama, Syoichi Tashiro, Shin Yamada, Kyoko Soejima, Takashi Kohno","doi":"10.1016/j.jjcc.2025.09.014","DOIUrl":"10.1016/j.jjcc.2025.09.014","url":null,"abstract":"","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of direct oral anticoagulants versus vitamin K antagonist in patients with left ventricular thrombus: A meta-analysis of randomized controlled trials.","authors":"Tadashi Asanuma, Yuriko Hiruma, Atsuyuki Watanabe, Tomonari M Shimoda, Masao Iwagami, Kaveh Hosseini, Leandro Slipczuk, Jose Wiley, Alexandros Briasoulis, Hisato Takagi, Tadao Aikawa, Toshiki Kuno","doi":"10.1016/j.jjcc.2025.09.012","DOIUrl":"10.1016/j.jjcc.2025.09.012","url":null,"abstract":"<p><strong>Background: </strong>While vitamin K antagonist (VKA) has traditionally been the preferred treatment for left ventricle (LV) thrombus, the comparative efficacy and safety of direct oral anticoagulants (DOACs) with VKA in this setting remain unelucidated.</p><p><strong>Methods: </strong>A comprehensive literature search of PubMed and Google Scholar was conducted through May 7, 2025, to identify randomized controlled trials (RCTs) comparing DOACs with VKA in patients with LV thrombus. The primary endpoint was complete resolution of LV thrombus. Secondary endpoints included stroke, systemic embolism, the composite of both stroke and systemic embolism, major bleeding, and all-cause mortality. Both pairwise and network meta-analyses were performed using a random-effects model to synthesize the effect estimates.</p><p><strong>Results: </strong>Eight RCTs comprising a total of 576 patients were included. Collectively, 88.9 % of the patients treated with DOACs and 81.7 % of those receiving VKA experienced LV thrombus resolution, with a synthesized risk ratio (RR) of 1.01 [95 % confidence interval (CI), 0.94 to 1.07]. No significant differences were observed between the two groups for stroke (RR, 0.75; 95 % CI, 0.25 to 2.19), systemic embolism (RR, 0.21; 95 % CI, 0.01 to 4.58), the composite of stroke and systemic embolism (RR, 0.64; 95 % CI, 0.17 to 2.32), major bleeding (RR, 0.43; 95 % CI, 0.16 to 1.19), or all-cause mortality (RR, 0.92; 95 % CI, 0.36 to 2.31). A network meta-analysis showed no statistically significant differences across the anticoagulants in any clinical endpoint.</p><p><strong>Conclusion: </strong>DOACs showed comparable efficacy and safety to VKA in managing LV thrombus, supporting their potential role as a viable alternative anticoagulation strategy.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of night-time onset on neurologically favourable survival between patients with and without bystander cardiopulmonary resuscitation.","authors":"Kazuya Tateishi, Yuichi Saito, Yuki Shiko, Kohei Takahashi, Hideki Kitahara, Yoshio Kobayashi, Naohiro Yonemoto, Tetsuya Matoba, Yoshio Tahara","doi":"10.1016/j.jjcc.2025.09.015","DOIUrl":"10.1016/j.jjcc.2025.09.015","url":null,"abstract":"<p><strong>Background: </strong>Patients with out-of-hospital cardiac arrest (OHCA) during the night tend to have worse outcomes than those with OHCA during the day. One possible explanation for poorer outcomes in patients with night-time onset is the lower quality of bystander cardiopulmonary resuscitation (CPR), although the exact cause has not been fully clarified. This study evaluated the differences between day and night-time-OHCA onset on neurologically favourable survival for patients with and without bystander CPR.</p><p><strong>Methods: </strong>A cohort of 118,822 patients with witnessed OHCA and prehospital return of spontaneous circulation was obtained from a nationwide OHCA registry database in Japan. The primary endpoint was neurologically favourable survival at 1 month. We also investigated the impact of night-time bystander CPR presence or absence as a sub-analysis.</p><p><strong>Results: </strong>The neurologically favourable survival rate was significantly lower for patients with night-time than those with daytime OHCA onset (30.7 % vs. 31.8 %, p < 0.001). The multivariable analysis determined night-time OHCA onset was a significant negative factor associated with neurologically favourable survival at 1-month [odds ratio (OR) 0.95; 95 % confidence interval (CI) 0.92-0.98, p = 0.002]. This negative effect of night-time onset compared to daytime was more pronounced for patients with bystander CPR from a citizen (OR 0.91; 95 % CI 0.87-0.95, p < 0.001). In contrast, this negative effect was attenuated in patients without bystander CPR (OR 1.00; 95 % CI 0.95-1.04, p = 0.836).</p><p><strong>Conclusion: </strong>These results suggest that the insufficient quality of bystander CPR may be one of the causes for the negative impact of night-time OHCA compared to daytime on patients.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Residual tricuspid regurgitation after edge-to-edge repair versus annuloplasty: Implications for device selection.","authors":"Muhammad Mohid Haroon","doi":"10.1016/j.jjcc.2025.09.013","DOIUrl":"10.1016/j.jjcc.2025.09.013","url":null,"abstract":"","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}