Journal of cardiology最新文献

{"title":"Author's reply.","authors":"Atsushi Yamamoto, Michinobu Nagao, Shuji Sakai, Junichi Yamaguchi","doi":"10.1016/j.jjcc.2025.06.002","DOIUrl":"https://doi.org/10.1016/j.jjcc.2025.06.002","url":null,"abstract":"","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the intersectionality of race and gender and its impact on heart transplant equity, listing outcomes, and allocation policy.","authors":"Ahad Firoz, Huaqing Zhao, Xiaoning Lu, Eman Hamad","doi":"10.1016/j.jjcc.2025.06.007","DOIUrl":"https://doi.org/10.1016/j.jjcc.2025.06.007","url":null,"abstract":"<p><strong>Background: </strong>Although there are existing studies on the role of race- and gender-based disparities as one-dimensional elements in heart transplantation (HTx), few reports have examined the intersection of such identities. Our study investigates the intersectionality of race and gender, and its impact on HTx waitlist outcomes.</p><p><strong>Methods: </strong>Data from adult patients listed for orthotopic HTx between 2010 and 2023 were analyzed using the United Network for Organ Sharing database. Inclusion criteria included \"White\" and \"Black\" races. Exclusion criteria included missing data in race or gender, a previous history of HTx, or concurrent listing for other transplants. Four groups were created using a combination of race and gender. Waitlist outcomes of interest include transplantation and death using competing-risk models.</p><p><strong>Results: </strong>In total, 37,796 patients were included in this analysis, of which 55.1 % were White-male (M), 17.4 % White-female (F), 18.6 % Black-M, and 8.9 % Black-F. Relative to White-M, Black-M (HR = 0.86, p < 0.001) and Black-F (HR = 0.82, p < 0.001) had decreased odds of transplantation. In the survival models, both female groups had a decreased mortality risk compared to White-M (White-F: HR = 0.56, p = 0.001; Black-F: HR = 0.61, p = 0.008) and Black-M (White-F: HR = 0.60, p = 0.005; Black-F: HR = 0.64, p = 0.025). Following the 2018 policy changes, with reference to White-F, Black-M (0.94, p = 0.189) had comparable odds of HTx while Black-F (HR = 0.91, p = 0.618) had a similar pattern of survival.</p><p><strong>Conclusion: </strong>Disparities on the HTx waiting list continue to exist. Black patients had decreased odds of transplantation compared to White groups. Additionally, females had superior overall survival on the waitlist. Although outcomes appear to have improved marginally for some vulnerable groups in the new allocation system, further work is required to achieve equity on the heart transplant waiting list.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoparticle-driven drug delivery system for cardiovascular treatment.","authors":"Raj Patel, Dhruvi Patel, Unnati Dani, Ketan Kuperkar","doi":"10.1016/j.jjcc.2025.06.004","DOIUrl":"10.1016/j.jjcc.2025.06.004","url":null,"abstract":"<p><p>Cardiovascular disease (CVD) is the world's major concern affecting the heart, blood arteries, and the blood that flows through and between them, making it a significant obstacle to contemporary healthcare practices. Approximately one in three individuals has a CVD, and many of them have several, overlapping diseases that might eventually result in catastrophic events such as a heart attack or stroke. The previous century opened the door for progress of life-saving drugs and treatment modalities. Recent developments in nanomaterials provide novel approaches for the treatment of CVD. Due to their unique properties, which include increased target specificity, sensitivity, and both active and passive targeting of cardiac tissues, the use of nanoparticles as carriers has received a lot of attention in the field of cardiology. Drug delivery using heart-targeted nanocarriers is a safe, efficient method of treating heart-related conditions such as hypertension, atherosclerosis, and myocardial infarction. Here, we highlight significant clinical opportunities in the quickly emerging field of CVD nanomedicine. This review concentrates on the use of nanoparticle-based therapeutics in CVD and provides a key take away regarding the use of metal, lipid, and polymer-based nanoparticle in CVD treatment. In this review, we emphasize recent advances in the use of nanomedicine to treat CVD and the therapeutic potential of drug delivery via nanoparticles in clinical prospects.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Lean Mass Index with a risk of incident stroke: a Nationwide epidemiological cohort study.","authors":"Takuma Ishibashi, Hidehiro Kaneko, Yuta Suzuki, Toshiyuki Ko, Takahiro Jimba, Akira Okada, Katsuhito Fujiu, Norifumi Takeda, Hiroyuki Morita, Koichi Node, Hideo Yasunaga, Norihiko Takeda","doi":"10.1016/j.jjcc.2025.06.003","DOIUrl":"https://doi.org/10.1016/j.jjcc.2025.06.003","url":null,"abstract":"<p><strong>Background: </strong>Body compositions are closely related to stroke risk. Recently, lean mass index (LMI) has been demonstrated to be a precise indicator of cardiovascular disease (CVD) risk, and the newly proposed formula enabled the simple estimation of LMI without a computed tomography scan. However, little is known about its attribution to a risk of stroke. Using a large-scale epidemiological cohort, we sought to clarify the association of LMI with a subsequent risk of developing stroke.</p><p><strong>Methods: </strong>This retrospective observational cohort study included 1,410,568 participants in Japan without a history of CVD or kidney replacement therapy from the DeSC Database between 2014 and 2022. The median age was 62 years (IQR, 48-67), and 642,343 participants (45.5 %) were men. Using age, sex, height, weight, and waist circumference, LMI was estimated, with a median of 14.9 (13.2-17.0). Participants were categorized into quintiles based on LMI. The primary endpoint was overall stroke, comprising ischemic and hemorrhagic stroke.</p><p><strong>Results: </strong>During a mean follow-up period of 1372 ± 793 days, 35,210 stroke events were recorded. Cox regression analysis modeling a restricted cubic spline showed monotonously inverse correlation between LMI and stroke occurrence, with hazard ratios of 1.23 and 0.82 at the lowest and highest LMI quintile, respectively, compared to the middle quintile. This inverse association was consistent across ischemic and hemorrhagic strokes and observed in men and women.</p><p><strong>Conclusions: </strong>The high LMI was associated with a lower risk of developing stroke, suggesting the importance of maintaining adequate muscle mass from the perspective of stroke prevention.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of weekend catch-up sleep, sleep durations and cardiometabolic multimorbidity: based on NHANES.","authors":"Yu Han, Xin Li, Yan Liu, Jing Zhao, Yuqi Gao, Xiaotong Li, Fengdan Wang, Ying Zhu, Sitong Xin, Bo Li, Zhigang Liu","doi":"10.1016/j.jjcc.2025.06.005","DOIUrl":"https://doi.org/10.1016/j.jjcc.2025.06.005","url":null,"abstract":"<p><strong>Background: </strong>Cardiometabolic multimorbidity (CMM) is defined as the coexistence of two or more cardiometabolic diseases, including hypertension, diabetes, stroke, and cardiovascular disease. Weekend catch-up sleep (WCS) is an effective repayment of sleep debt, and the association between WCS and CMM, and between WCS and CMM under the influence of average sleep duration, weekday sleep duration, and weekend sleep duration is unknown. The aim of this study was to determine the association between WCS and CMM and their association under different sleep durations.</p><p><strong>Methods: </strong>A cross-sectional study was conducted using the 2017-2018 US National Health and Nutrition Examination Survey dataset (N = 3431). Weighted multivariate logistic regression models estimated the odds ratio (OR) and their 95 % confidence interval (95%CI) between WCS and CMM, associations between WCS and CMM under different sleep duration stratifications were examined. A restricted cubic spline plot was used to describe the relationship between various sleep durations, WCS durations, and the prevalence of CMM.</p><p><strong>Results: </strong>WCS made a statistically significant difference between those with CMM and no-CMM (p < 0.001). After adjusting for covariates, WCS was found to be a protective factor for CMM with OR of 0.531 (0.360, 0.784). After stratified analyses with different sleep durations, it was found that WCS remained a protective factor for CMM in those with different sleep durations <8 h.</p><p><strong>Conclusion: </strong>There was an association between WCS and CMM. WCS was a protective factor for CMM. WCS remained a protective factor for CMM across different sleep durations <8 h.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic stratification using the clinical frailty scale and geriatric nutritional risk index in patients after percutaneous coronary intervention: Sub-analysis of the SAKURA PCI2 antithrombotic registry.","authors":"Masatsugu Miyagawa, Nobuhiro Murata, Riku Arai, Keisuke Kojima, Michiaki Matsumoto, Naoya Matsumoto, Tomoyuki Morikawa, Wataru Atsumi, Eizo Tachibana, Hironori Haruta, Takaaki Kogo, Yasunari Ebuchi, Kazumiki Nomoto, Masaru Arai, Ken Arima, Takashi Mineki, Yutaka Koyama, Koji Oiwa, Yasuo Okumura","doi":"10.1016/j.jjcc.2025.06.006","DOIUrl":"https://doi.org/10.1016/j.jjcc.2025.06.006","url":null,"abstract":"<p><strong>Background: </strong>Although clinical frailty and nutritional status are associated with adverse events in patients after percutaneous coronary intervention (PCI), those two factors are closely interrelated. This study evaluated the prognostic utility of the Geriatric Nutritional Risk Index (GNRI), a nutritional risk assessment tool, in stratifying outcomes in patients with and without frailty.</p><p><strong>Methods: </strong>We used data from a prospective multicenter registry (SAKURA PCI2 Antithrombotic Registry) from June 2020 until September 2022. This study included 973 patients who underwent PCI [age: 72 (61, 79) years] and had available data. The patients were stratified into four groups based on the Clinical Frailty Scale (CFS) scores (CFS ≥4 defined as vulnerable frailty) and GNRI values (GNRI <92 defined as a high nutritional risk).</p><p><strong>Results: </strong>Of the total patients, 67 (6.9 %) had vulnerable frailty and GNRI <92, 115 (11.8 %) vulnerable frailty and GNRI ≥92, 98 (10.1 %) non-frailty and GNRI <92, and 693 (71.2 %) non-frailty and GNRI ≥92. During a median follow-up of 737 (565-956) days, a Kaplan-Meier curve revealed that patients with a GNRI <92 had higher rates of composite adverse events, including all-cause death, non-fatal myocardial infarctions, stent thromboses, hospitalizations for heart failure, Bleeding Academic Research Consortium 3 or 5 bleeding events, strokes, and venous thromboembolisms, regardless of the frailty status (log-rank, p < 0.05 for both). After adjusting for potential confounding factors, the vulnerable frailty group with a GNRI <92 had the highest composite adverse event rates, with a hazard ratio of 2.51 (95 % confidence interval 1.59-3.95, p < 0.001) compared to the non-frailty group with a GNRI ≥92.</p><p><strong>Conclusions: </strong>Both frailty and malnutrition were significantly linked to adverse outcomes in post-PCI patients, with malnutrition exerting an influence regardless of the frailty status. The GNRI, in particular, served as a valuable prognostic tool, enhancing the risk stratification among frail patients following PCI.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RNF213 and cardiovascular disease: A review of histopathological, genetic perspectives, and potential molecular mechanisms.","authors":"Toshinaru Kawakami, Masamichi Ito, Takayuki Isagawa, Takahiro Kuchimaru, Norihiko Takeda","doi":"10.1016/j.jjcc.2025.06.001","DOIUrl":"10.1016/j.jjcc.2025.06.001","url":null,"abstract":"<p><p>The ring finger protein 213 (RNF213) gene, identified in 2011 as a susceptibility gene for moyamoya disease (MMD), has since been recognized as a key factor in a broader spectrum of vascular disorders. The p.R4810K mutation in RNF213 is particularly common among Japanese MMD patients, although a smaller percentage of healthy individuals also carry the mutation, indicating that environmental factors, alongside genetic predisposition, likely influence disease onset. RNF213, a large E3 ubiquitin ligase, plays essential roles in vascular homeostasis, immune response, and endoplasmic reticulum stress reaction. Its mutation disrupts normal angiogenesis, contributing to abnormal vascular remodeling in conditions such as pulmonary hypertension and coronary artery disease. This review examines the multifaceted role of RNF213 and its p.R4810K mutation in the pathogenesis of MMD and other vascular conditions, collectively referred to as RNF213-associated vascular diseases. While research has begun to clarify the mutation's effects on angiogenesis and the involved pathways, the roles of RNF213 and its mutation in vascular integrity remain unclear. This comprehensive overview underscores the complex interaction between genetic and environmental factors in RNF213-related vascular diseases and calls for further research to elucidate these mechanisms and develop targeted therapeutic interventions.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144284437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of left ventricular volumes and ejection fraction using high-intensity echo band as a landmark: Comparison between two-dimensional echocardiography and cardiac magnetic resonance imaging.","authors":"Takaya Higuchi, Yasuyuki Chiba, Nobuaki Yoshino, Kenichi Matsubara, Mashiro Taniguchi, Yuki Ogino, Toshihiro Shimizu, Toshihisa Anzai","doi":"10.1016/j.jjcc.2025.05.017","DOIUrl":"10.1016/j.jjcc.2025.05.017","url":null,"abstract":"<p><strong>Background: </strong>The trace line for left ventricular (LV) volumes and ejection fraction (EF) measurements in 2-dimensional echocardiography (2DE) are often based on the empirical judgment of the examiner. We evaluated whether trace lines along the inner side of the high-intensity echo band that characterized LV endocardial boundary is useful for accurate measurements, with cardiac magnetic resonance (CMR) imaging as reference.</p><p><strong>Methods: </strong>We compared the accuracy of LV volumes [end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV)] and EF in 73 patients, using CMR imaging as a reference. Protocol 1: 10 patients were compared by two examiners using the biplane disk summation method with trace line based on the empirical judgment of the examiner (before-learning) and trace line along the inner side of the high-intensity echo band (after-learning), and inter- and intra-observer variabilities were calculated. Protocol 2: the accuracy of LV volumes and EF was compared in 73 patients using the after-learning method. Bland-Altman analysis were used to compare with 2DE and CMR. The coefficient of variation was used for inter- and intra-observer variabilities.</p><p><strong>Results: </strong>Protocol 1: For examiner 1, EDV (-16 ml vs 1 ml, p = 0.001), ESV (-9 ml vs 1 ml, p = 0.004), and SV (-7 ml vs 0 ml, p = 0.037) after learning compared with before learning were significantly approximated CMR measurements. For examiner 2, no significant differences were noted between before and after learning. The variability in measurements was smaller for all items by both examiners. Inter-observer variability after learning was improved compared with before learning, and intra-observer variability was also better. Protocol 2: LV volumes and EF measurements after learning were almost as accurate as CMR.</p><p><strong>Conclusions: </strong>LV volumes and EF using after-learning trace approximated CMR measurements. Having landmark on trace line may contribute to quality control.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world safety of sacubitril/valsartan in Japanese patients with chronic heart failure: A post-marketing surveillance study.","authors":"Jiro Arita, Tomomi Ohishi, Takayoshi Sasajima, Daisuke Yarimizu, Katsuya Onishi","doi":"10.1016/j.jjcc.2025.05.020","DOIUrl":"10.1016/j.jjcc.2025.05.020","url":null,"abstract":"<p><strong>Background: </strong>This study evaluated the safety of sacubitril/valsartan for up to 52 weeks in Japanese patients with chronic heart failure (CHF) in real-world settings.</p><p><strong>Methods: </strong>This was an uncontrolled, multicenter, observational study conducted at 120 sites in Japan. Adult patients on standard of care for CHF and newly initiated on sacubitril/valsartan were included. The primary outcome was the exposure-adjusted incidence rate (EAIR: patients/100 patient-years) of adverse drug reactions (ADRs) and adverse events of interest (related to hypotension, hyperkalemia, renal impairment, and dehydration). The impact of patient risk factors on ADRs and clinical outcomes (EAIR of the composite endpoint [cardiovascular (CV) death or first hospitalization due to heart failure], and its components) were also assessed.</p><p><strong>Results: </strong>Overall, 682 patients (median age: 78.0 years, male: 61.4 %, age 75 years: 61.9 %) were assessed. Sacubitril/valsartan was typically initiated at 50 mg twice daily and up-titrated to 100 mg or 200 mg sequentially at 2- to 4-week intervals. Dose adjustments were made in 57.2 % of patients. EAIRs of ADRs related to hypotension, hyperkalemia, renal impairment, and dehydration were 7.776, 0.606, 0.913, and 0.151, respectively. The incidence of ADRs was 9.7 %, with hypotension (4.7 %) and decreased blood pressure (1.8 %) being the most common ADRs. Patients with systolic blood pressure (SBP) of ≤120 mmHg at sacubitril/valsartan initiation had a higher risk of ADRs than those in other SBP groups. EAIRs for composite endpoints, CV death, and first hospitalization for heart failure were 9.404, 2.269, and 8.150, respectively.</p><p><strong>Conclusions: </strong>This study did not show notable differences from the known safety profile of sacubitril/valsartan, and no new safety concerns were identified in Japanese patients with CHF. The EAIR of the composite endpoint of CV death or first hospitalization due to heart failure was lower than that in patients enrolled in clinical studies at the time of approval.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronary artery calcification as an incremental predictive risk: Research perspectives in primary prevention","authors":"Alberto Cereda MD ,&nbsp;Antonio G. Franchina MD ,&nbsp;Lorenzo Tua MD ,&nbsp;Matteo Rocchetti MD ,&nbsp;Davide Garattini MD ,&nbsp;Emilia D'Elia PhD ,&nbsp;Stefano Lucreziotti MD","doi":"10.1016/j.jjcc.2024.12.005","DOIUrl":"10.1016/j.jjcc.2024.12.005","url":null,"abstract":"<div><div>Coronary artery calcium (CAC) score is a neglected biomarker that can be derived from non-cardiac chest computed tomography scan and represents a surrogate for atherosclerosis. We created a simulation model using different CAC score values in the MESA coronary artery risk score in a population derived from the Fourier Trial. CAC score could modulate the sample sizes of cardiovascular trials in primary and secondary prevention and offer new primary prevention treatments to high-risk subjects with reasonable numbers needed to treat comparable to secondary prevention trials.</div></div>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":"85 6","pages":"Pages 502-504"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}