{"title":"Gout is associated with the development of abdominal aortic aneurysm","authors":"Gang Wang MD, Zhichun Liu MD","doi":"10.1016/j.jjcc.2025.01.019","DOIUrl":"10.1016/j.jjcc.2025.01.019","url":null,"abstract":"","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":"86 1","pages":"Page 105"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Author's reply to the Letter to the Editor “How to demonstrate the causal relationship between sodium-glucose cotransporter 2 receptor and prevention of ventricular arrhythmia in heart failure cohorts”","authors":"Paolo Basile MD, Andrea Igoren Guaricci MD, PhD","doi":"10.1016/j.jjcc.2025.01.012","DOIUrl":"10.1016/j.jjcc.2025.01.012","url":null,"abstract":"","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":"86 1","pages":"Page 104"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Efficacy of sodium-glucose cotransporter 2 inhibitors on preventing atrial arrhythmia recurrences after atrial fibrillation ablation in patients with heart failure","authors":"Takashi Okajima MD , Shinji Ishikawa MD , Yusuke Uemura MD , Yuta Ozaki MD , Shogo Yamaguchi MD , Takayuki Mitsuda MD , Kenji Takemoto MD , Yasuya Inden MD, PhD , Toyoaki Murohara MD, PhD , Masato Watarai MD","doi":"10.1016/j.jjcc.2025.03.013","DOIUrl":"10.1016/j.jjcc.2025.03.013","url":null,"abstract":"<div><h3>Background</h3><div>Atrial fibrillation (AF) is frequently observed in patients with heart failure (HF), and the efficacy of catheter ablation for AF treatment has been established; however, recurrence of atrial arrhythmia is possible. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have been reported to suppress AF recurrence in patients with diabetes; however, the efficacy of SGLT2i after AF ablation in patients with HF has not been fully elucidated.</div></div><div><h3>Methods</h3><div>A total of 141 consecutive patients with HF aged ≤75 years who underwent AF ablation were analyzed. Patients with follow-up shorter than six months were excluded. The primary endpoint was atrial arrhythmia recurrence after a 3-month blanking period. The type of recurrence, incidence of hospitalization for HF, and mortality rates were also evaluated.</div></div><div><h3>Results</h3><div>Forty-five patients used SGLT2i, and the median follow-up period was 372 days. The incidence of atrial arrhythmia recurrence was significantly lower in patients taking SGLT2i than in those that were not taking SGLT2i (20.0 % vs. 38.5 %, <em>p</em> = 0.029; log-rank test, <em>p</em> = 0.034). In the multivariate analysis, intake of SGLT2i was associated with a low risk of atrial arrhythmia recurrence (hazard ratio: 0.38, 95 % confidence interval: 0.18–0.80, <em>p</em> = 0.010). The rate of AF recurrence was significantly lower than the rate of atrial tachycardia/flutter recurrence in the SGLT2i group (44.4 % vs. 83.8 %; <em>p</em> = 0.013). The incidence of hospitalization for HF and/or death was low in both groups (0 % in the SGLT2i group and 1.0 % in the non-SGLT2i group). In 24 propensity score-matched pairs, the SGLT2i group had a lower recurrence rate (16.7 % vs. 45.8 %, <em>p</em> = 0.029, log-rank test, <em>p</em> = 0.047) than the non-SGLT2i group.</div></div><div><h3>Conclusions</h3><div>SGLT2i use in patients with HF was associated with a lower atrial arrhythmia recurrence after AF ablation; hence, SGLT2i administration for patients with HF who will undergo AF ablation may be beneficial.</div></div>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":"86 1","pages":"Pages 95-96"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Optimal ablation pattern on intraprocedural echocardiography is associated with favorable clinical outcomes of alcohol septal ablation for hypertrophic obstructive cardiomyopathy","authors":"Junya Matsuda MD, PhD , Yukichi Tokita MD, PhD , Lisa Hoshika MD , Kentaro Koyama MD , Kakeru Ishihara MD, PhD , Serina Kobayashi MD , Saori Uchiyama MD , Yoichi Imori MD, PhD , Yoshiaki Kubota MD, PhD , Jun Nakata MD , Hideki Miyachi MD, PhD , Shuhei Tara MD, PhD , Takeshi Yamamoto MD, PhD, FJCC , Hitoshi Takano MD, PhD , Mitsunobu Kitamura MD, PhD , Morimasa Takayama MD, PhD, FJCC , Kuniya Asai MD, PhD","doi":"10.1016/j.jjcc.2025.01.007","DOIUrl":"10.1016/j.jjcc.2025.01.007","url":null,"abstract":"<div><h3>Background</h3><div>Alcohol septal ablation (ASA) is used to treat drug-refractory hypertrophic obstructive cardiomyopathy (HOCM). Intraprocedural echocardiography is essential for identifying the septal area perfused by each septal branch; however, its role in determining the procedural endpoint of ASA remains unclear. This retrospective study aimed to evaluate the impact of intraprocedural echocardiographic findings on clinical outcomes and left ventricular pressure gradient (LVPG) after ASA.</div></div><div><h3>Methods</h3><div>Overall, 120 patients with HOCM who underwent ASA at a single center were divided into two groups based on the presence of optimal ablation. Optimal ablation was defined as the ablated area fully covering the targeted septal myocardium from the point of contact with the onset of the accelerated flow to the basal septum and dense acoustic shadowing accompanying the ablated area. Clinical outcomes and LVPG changes were evaluated using inverse probability of treatment weighting.</div></div><div><h3>Results</h3><div>Significantly more patients showed a New York Heart Association (NYHA) functional class improvement of ≥2 stages or achievement of class I in the optimal ablation group (<em>n</em> = 74) than in the non-optimal ablation group (94 % vs. 62 %; <em>p</em> < 0.001). The optimal ablation group had a significantly greater percentage reduction in LVPG at 1-year after ASA (82 ± 18 % vs. 64 ± 18 %; <em>p</em> = 0.001). Multivariate analyses revealed that optimal ablation was an independent predictor of a NYHA functional class improvement of ≥2 stages or achievement of class I (odds ratio, 11.3; 95 % confidence interval, 3.43–39.1; <em>p</em> < 0.001) and a percentage reduction in LVPG (<em>p</em> = 0.001).</div></div><div><h3>Conclusions</h3><div>Intraprocedural echocardiographic findings of optimal ablation were associated with favorable clinical outcomes and a significant reduction in LVPG.</div></div>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":"86 1","pages":"Pages 64-72"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mitral regurgitation in atrial fibrillation: Is a simple repair enough to tackle a complex problem?","authors":"Hadisa Talpur MBBS , Ghulam Mustafa MBBS","doi":"10.1016/j.jjcc.2025.02.011","DOIUrl":"10.1016/j.jjcc.2025.02.011","url":null,"abstract":"","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":"86 1","pages":"Page 111"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Recent advances and clinical implications of intravascular imaging","authors":"Masahiko Noguchi MD, PhD , Tomotaka Dohi MD, PhD, FJCC","doi":"10.1016/j.jjcc.2025.03.001","DOIUrl":"10.1016/j.jjcc.2025.03.001","url":null,"abstract":"<div><div>Coronary artery disease (CAD) remains a major contributor to the global mortality rate. Accurate and detailed evaluation of atherosclerotic plaque characteristics is essential for effective risk assessment and treatment planning. Although conventional coronary angiography excels at quantifying luminal stenosis, information on plaque composition and structure remains limited. Recent advances in intravascular imaging (IVI) have bridged this gap by enabling high-resolution visualization of the vessel wall and plaque morphology, thereby enhancing treatment strategies and facilitating comprehensive risk stratification. Among the principal IVI modalities, intravascular ultrasound (IVUS), optical coherence tomography (OCT), and near-infrared spectroscopy (NIRS) provide distinct benefits. IVUS accurately measures vessel diameter and plaque burden, offering critical guidance for managing complex lesions and left main artery disease. The extremely high spatial resolution of OCT allows precise identification of high-risk plaque features, such as thin fibrous caps. NIRS complements these techniques by quantitatively assessing lipid components within plaques, making it particularly useful in predicting future cardiovascular events. In this review, we summarize the latest evidence on applying IVI modalities to the evaluation and treatment of CAD. We focus on the assessment of plaque morphology, identification of high-risk lesions, and the role of IVI-guided percutaneous coronary intervention (PCI). The continued development of hybrid imaging systems and artificial intelligence-based image analysis may produce more precise and safer PCI approaches. Consequently, IVI is poised to become indispensable in managing CAD, paving the way for more personalized treatment strategies tailored to the specific lesion characteristics of each patient.</div></div>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":"86 1","pages":"Pages 1-11"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Efficacy and safety of leadless cardiac resynchronization therapy: An updated meta-analysis","authors":"Konstantinos Kolokathis MD, MSc, Ioannis Doundoulakis MD, PhD, Dimitrios Tsiachris MD, PhD, Athanasios Kordalis MD, Konstantinos Tsioufis MD, PhD","doi":"10.1016/j.jjcc.2025.03.010","DOIUrl":"10.1016/j.jjcc.2025.03.010","url":null,"abstract":"<div><h3>Background</h3><div>The WiSE cardiac resynchronization therapy (CRT) system (EBR Systems Inc., Sunnyvale, CA, USA) is an innovative technique consisting of an electrode implanted in the endocardium of the left ventricle as an alternative to the conventional CRT for symptomatic patients with heart failure and reduced ejection fraction (EF) despite optimal medical treatment. The objective of this study was to evaluate the efficacy of the Wise CRT.</div></div><div><h3>Methods</h3><div>We searched two electronic databases from inception until November 2024.The primary outcomes were defined as the mean difference (MD) of left ventricular (LV) EF (%) and QRS (milliseconds) from baseline to 6 months post-procedure.</div></div><div><h3>Results</h3><div>Our analysis included six studies (<em>n</em> = 281 patients). A meta-analysis was performed with the primary endpoints being the MD between baseline LVEF and 6-month follow-up and b) the MD between baseline QRS and 6-month follow-up. There was a mean increase in LVEF of 5.78 % (MD 5.78 %; CI 4.37–7.19; <em>p</em> < 0.01) and a mean reduction in QRS duration of 37.08 ms (MD −37.08 ms; CI −45.72 to −28.44; <em>p</em> < 0.01).</div></div><div><h3>Conclusion</h3><div>The WiSE CRT showed impressive electrocardiographic and echocardiographic responses in high-risk patients for whom conventional CRT implantation was impossible or resulted in suboptimal treatment.</div></div>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":"86 1","pages":"Pages 93-94"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association between delirium severity and prognosis following Transcatheter aortic valve implantation","authors":"Tomohiro Suenaga MD , Kenichi Ishizu MD , Shinichi Shirai MD , Satoru Yoshida MD , Hayashi Wakugawa MD , Katsunori Miyahara MD , Ko Yamamoto MD, PhD , Akira Otani MD, PhD , Norihisa Miyawaki MD , Kenji Nakano MD , Euihong Ko MD , Yu Yoshino MD , Yasuo Tsuru MD , Miho Nakamura MD , Toru Morofuji MD , Masaomi Hayashi MD , Akihiro Isotani MD , Nobuhisa Ohno MD , Shinichi Kakumoto MD , Kenji Ando MD","doi":"10.1016/j.jjcc.2025.01.004","DOIUrl":"10.1016/j.jjcc.2025.01.004","url":null,"abstract":"<div><h3>Background</h3><div>Delirium is associated with patient prognosis after transcatheter aortic valve implantation (TAVI). However, the prognostic impact of subsyndromal delirium, described as an intermediate stage between delirium and normal cognition, is uncertain. The present study aimed to investigate the prognostic impact of delirium severity in patients undergoing TAVI.</div></div><div><h3>Methods and results</h3><div>We prospectively assessed the delirium status of 1617 consecutive patients who underwent TAVI at Kokura Memorial Hospital using the Intensive Care Delirium Screening Checklist (ICDSC). The patients were divided into the following three groups: no-delirium [ICDSC score 0, <em>n</em> = 1035 (64.0 %)], subsyndromal delirium [ICDSC 1–3, <em>n</em> = 348 (21.5 %)], and delirium [ICDSC 4–8, <em>n</em> = 234 (14.5 %)] groups. A worse delirium status was associated with older age, higher degree of frailty, and higher prevalence of comorbidities, including atrial fibrillation, dementia, and peripheral arterial disease. At 2 years post-procedure with a clinical follow-up rate of 92.6 %, the cumulative all-cause mortality rate was significantly higher in the subsyndromal delirium (21.8 %) (<em>p</em> < 0.001) and delirium (29.1 %) (<em>p</em> < 0.001) groups than in the no-delirium group (11.9 %). After adjusting for pre- and post-procedural confounders, subsyndromal delirium and delirium were associated with an increased mortality risk [adjusted hazard ratio (HR) for subsyndromal delirium, 1.38; 95 % CI, 1.00–1.90; <em>p</em> = 0.049; adjusted HR for delirium, 1.61; 95 % CI, 1.15–2.17; <em>p</em> = 0.006].</div></div><div><h3>Conclusions</h3><div>Delirium conditions, including delirium and subsyndromal delirium, occurred in more than one-third of patients who had undergone TAVI and were associated with increased mortality.</div></div>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":"86 1","pages":"Pages 38-47"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}