Journal of cardiology最新文献

{"title":"The effect of circumferential and longitudinal strain on left ventricle ejection fraction and myocardial surface area strain","authors":"Dimitrios Ntelios MD, PhD , Anastasia Erythropoulou-Kaltsidou MD, MSc , Efstathios Pagourelias MD, PhD , Georgios Efthimiadis MD, PhD , Olivia Mauromoustaki MD, PhD , Vassilios Vassilikos MD, PhD","doi":"10.1016/j.jjcc.2024.11.001","DOIUrl":"10.1016/j.jjcc.2024.11.001","url":null,"abstract":"","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":"85 5","pages":"Pages 426-427"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in the management of out-of-hospital cardiac arrest: A clinical review.","authors":"Kazuya Tateishi, Yuichi Saito, Yoshio Kobayashi","doi":"10.1016/j.jjcc.2025.04.010","DOIUrl":"https://doi.org/10.1016/j.jjcc.2025.04.010","url":null,"abstract":"<p><p>Despite considerable advances in the management, the prognosis of patients resuscitated from out-of-hospital cardiac arrest (OHCA) remains poor. To standardize clinical practice patterns and to improve outcomes, the guidelines provide scientific statements. It is challenging to develop and establish novel diagnostic and therapeutic strategies in randomized controlled trials in patients with OHCA. Nonetheless, important randomized data have been recently published in the field of resuscitation science. This review article provides an overview of updates on OHCA and resuscitation, focusing on key topics since 2020.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author's reply","authors":"Nobuyuki Kagiyama (MD, PhD),&nbsp;Takatoshi Kasai (MD, PhD, FJCC),&nbsp;Hiroyuki Daida (MD, PhD, FJCC)","doi":"10.1016/j.jjcc.2024.11.009","DOIUrl":"10.1016/j.jjcc.2024.11.009","url":null,"abstract":"","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":"85 5","pages":"Pages 430-431"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of FFR-CT before coronary angiography on the management of non-culprit lesions among high-risk NSTE-ACS patients.","authors":"Aurelia Zimmerli, David Meier, Adil Salihu, Quentin Liabot, Victor Weerts, Ioannis Skalidis, Daniele Andreini, Bernard Cosyns, Tatyana Storozhenko, Thabo Mahendiran, Emilio Assanelli, Jeroen Sonck, Bram Roosens, David C Rotzinger, Salah Dine Qanadli, Georgios Tzimas, Bernard De Bruyne, Carlos Collet, Olivier Muller, Stephane Fournier","doi":"10.1016/j.jjcc.2025.04.009","DOIUrl":"10.1016/j.jjcc.2025.04.009","url":null,"abstract":"<p><p>Recent data suggest that fractional flow reserve derived from coronary computed tomography (FFR-CT) can help select patients with high-risk non-ST-elevation acute coronary syndrome (NSTE-ACS) requiring invasive coronary angiography (ICA). Multiple stenoses are often observed in this population, and while a clear culprit is frequently identified, the management of intermediate lesions remains challenging. The information provided by FFR-CT prior to the ICA could theoretically assist in the management of these lesions. A prespecified post-hoc analysis of a multicenter, single-arm, double-blinded, core-laboratory adjudicated study was conducted to evaluate the potential of FFR-CT to assess the non-culprit lesions among patients with an identified culprit lesion on ICA and one additional vessel with a stenosis ≥30 %. The primary endpoint was the performance of FFR-CT in ruling out hemodynamically significant lesions in non-culprit vessels, with invasive FFR as gold standard. A total of 49 patients with 67 non-culprit lesions were included. FFR-CT classified 33 lesions (49 %) as non-significant and 34 (51 %) as significant. Among the 33 lesions deemed negative by FFR-CT, 31 were confirmed negative by invasive FFR, resulting in a negative predictive value of 94 %. Similarly, among the 34 lesions classified as significant by FFR-CT, 26 were confirmed as positive by invasive FFR, resulting in a positive predictive value of 93 %. In patients with high-risk NSTE-ACS, FFR-CT has the potential to not only reduce the number of unnecessary ICAs, but also to support early decision-making regarding the management of non-culprit lesions.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathophysiologic and prognostic relevance of mid-upper arm circumference index in heart failure with preserved ejection fraction.","authors":"Yuki Shimoya, Yuta Tani, Naoki Yuasa, Kazuki Kagami, Tomonari Harada, Fumitaka Murakami, Hidemi Sorimachi, Tsukasa Murakami, Takahiro Okuno, Naoki Wada, Hideki Ishii, Masaru Obokata","doi":"10.1016/j.jjcc.2025.04.007","DOIUrl":"https://doi.org/10.1016/j.jjcc.2025.04.007","url":null,"abstract":"<p><strong>Background: </strong>Malnutrition is common in heart failure with preserved ejection fraction (HFpEF). Despite the increasing awareness, nutritional assessment and intervention may be underutilized in practice, needing a simple screening tool to identify patients at high nutritional risk. This study sought to determine the association of mid-upper arm circumference indexed to height (MUACi) with nutritional measures, exercise capacity, and clinical outcomes in HFpEF.</p><p><strong>Methods: </strong>Patients with HFpEF (n = 247) and controls with no HF (n = 240) underwent ergometry exercise echocardiography with simultaneous expired gas analysis. Patients with HFpEF were divided into two groups based on the median value of MUACi.</p><p><strong>Results: </strong>Compared to controls and HFpEF_highMUACi (n = 124), HFpEF_lowMUACi (n = 123) had lower body mass index, waist circumference, and geriatric nutritional risk index. Despite similar cardiac structure and function at rest and during peak ergometry exercise, peak workload achieved and mechanical efficiency (peak workload relative to peak oxygen consumption) were more reduced in HFpEF_lowMUACi than controls and HFpEF_highMUACi. During a median observation period of 385 days, 25 composite outcomes of all-cause mortality, HF hospitalizations, unplanned visits requiring intravenous diuretics, and intensifications of oral diuretics occurred. HFpEF_lowMUACi had 11-fold and 2-fold increased risks of the outcome compared to controls and HFpEF_highMUACi, respectively [hazard ratio (HR) 10.8, 95 % confidence intervals (CI) 2.47-47.3, p = 0.002 and HR 2.54, 95 % CI 1.05-6.16].</p><p><strong>Conclusion: </strong>These data suggest that MUACi may be a useful screening metric to identify patients with HFpEF at malnutrition risk in clinical practice to help guide more specialized nutritional assessment.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel biomarkers related to mitochondrial permeability transition driven-necrosis in hypertrophic cardiomyopathy.","authors":"Wenqiang Qi, Linghua Fu, Qinghua Wu, Pingping Yang","doi":"10.1016/j.jjcc.2025.04.008","DOIUrl":"https://doi.org/10.1016/j.jjcc.2025.04.008","url":null,"abstract":"<p><strong>Background: </strong>The role of mitochondrial permeability transition driven necrosis-related genes (MPTDN-RGs) in hypertrophic cardiomyopathy (HCM) is unclear. This investigation combined transcriptomics and Mendelian randomization (MR) analysis to explore the association of MPTDN-RGs with HCM.</p><p><strong>Methods: </strong>GSE36961 (training set), GSE141910 (validation set), and GSE174691 (single-cell dataset) were retrieved from Gene Expression Omnibus (GEO) database. This study is based on scRNA-seq and transcriptome sequencing (mRNA Sequencing, mRNA-seq) data combined with MR, and use MPTDN-RGs to identify genes of HCM.</p><p><strong>Results: </strong>Based on 51 interaction genes overlapped by 250 module genes and 154 differentially expressed genes, the top 10 genes within protein-protein interaction (PPI) core network were regarded as candidate genes. ITGB2 and STAT3 were screened out as genes by multiple analysis methods. MR results revealed that ITGB2 was a risk factor, while STAT3 was a protective factor for HCM. Gene set enrichment analysis (GSEA) indicated that ITGB2 and STAT3 were involved in complement and coagulation cascade. Moreover, ITGB2 had the strongest positive and significant correlations with myeloid-derived suppressor cells and chemokine receptor. Single cell analysis showed that STAT3 was highly expressed in endothelial cells, while ITGB2 was significantly greater in dendritic cells. During the process of differentiation, the expression of ITGB2 and STAT3 were decreased, and dendritic cells gradually differentiated and matured to play a role in immune function.</p><p><strong>Conclusion: </strong>To our knowledge, this is the first study to identify the novel genes related to MPTDN in HCM by combining transcriptomics and MR analysis. Two key genes play a critical role in HCM. ITGB2 and STAT3 deserve further investigation as potential therapeutic targets for HCM.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor on association between complementary use of Goreisan and heart failure readmission: A nationwide propensity score-matched study.","authors":"Muhammad Ibrahim","doi":"10.1016/j.jjcc.2025.04.005","DOIUrl":"https://doi.org/10.1016/j.jjcc.2025.04.005","url":null,"abstract":"","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between oral anticoagulants continuation on thromboembolism and bleeding events in patients with CHADS₂ score 0-2 points after catheter ablation for persistent atrial fibrillation.","authors":"Tomoaki Nakano, Takafumi Oka, Keita Okayama, Nobuaki Tanaka, Masaharu Masuda, Tetsuya Watanabe, Hitoshi Minamiguchi, Yasuyuki Egami, Miwa Miyoshi, Masato Okada, Yasuhiro Matsuda, Masato Kawasaki, Koichi Inoue, Shungo Hikoso, Akihiro Sunaga, Tomoharu Dohi, Katsuki Okada, Daisaku Nakatani, Yohei Sotomi, Yasushi Sakata","doi":"10.1016/j.jjcc.2025.04.004","DOIUrl":"https://doi.org/10.1016/j.jjcc.2025.04.004","url":null,"abstract":"<p><strong>Background: </strong>Guidelines state that oral anticoagulants (OACs) should be continued after catheter ablation for atrial fibrillation (AF) based on thromboembolic risk stratification, regardless of procedural results. However, whether OACs could be discontinued in low-thromboembolic-risk patients remains unclear.</p><p><strong>Methods: </strong>This was a retrospective follow-up study from the EARNEST-PVI (NCT03514693) trial, which compared the efficacy of pulmonary vein isolation (PVI)-alone and PVI-plus strategies for persistent AF ablation. A total of 427 patients with CHADS₂ score of ≤2 points were divided into two groups: OAC continuation throughout the overall period (group C, n = 205) and OAC discontinuation within 1 year after ablation (group D, n = 222). The incidence of thromboembolic and bleeding events was analyzed.</p><p><strong>Results: </strong>AF recurrence (33 % vs. 17 %, p < 0.001), thromboembolic events (1.39 % vs. 0 % per year, p = 0.005), and overall bleeding event rates (7.54 % vs. 3.32 % per year, p = 0.003) were higher in group C than in group D. There was no significant difference in major bleeding event rates between the C and D groups (0.51 % vs. 0.67 % per year, p = 0.686). However, a higher number of overall bleeding events, including major and clinically relevant non-major events, was observed in group C (adjusted hazards ratio: 2.04, 95 % confidence interval: 1.14-3.65, p = 0.016).</p><p><strong>Conclusions: </strong>Thromboembolic events and overall bleeding events were fewer in the OAC discontinuation group compared with the OAC continuation group. Discontinuation of OACs might be considered in patients with low CHADS₂ score after catheter ablation of persistent AF.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender disparities in acute coronary syndrome management and prognosis: National multicenter retrospective cohort study.","authors":"António Rocha de Almeida, Marta Paralta Figueiredo, Rafael Viana, Kisa Congo, Manuel Trinca, Lino Patrício","doi":"10.1016/j.jjcc.2025.04.006","DOIUrl":"https://doi.org/10.1016/j.jjcc.2025.04.006","url":null,"abstract":"<p><strong>Background: </strong>Gender disparity in the management of cardiovascular disease (CVD) is still significant, leading to suboptimal treatment of acute coronary syndromes (ACS) in women. This study evaluates differences in the management and prognosis of ACS between women and men.</p><p><strong>Methods: </strong>A multicenter retrospective cohort of 6000 patients with ACS was divided according to the patient's gender. CV risk factors, time to first medical care (FMC), and to electrocardiogram (ECG), coronary angiography (CAG), and percutaneous coronary intervention (PCI) were evaluated. The outcomes assessed were major adverse cardiac events (MACE), in-hospital and follow-up death, referral to cardiac rehabilitation, and hospital readmission.</p><p><strong>Results: </strong>Of the 6000 patients, 30 % (n = 1784) were female. Women were significantly older (73 ± 13 years vs. 65 ± 13 years, p < 0.001). The time to FMC was longer in women (10.6 h vs. 9.5 h, p < 0.001), and the median time to ECG was similar (101 min vs. 110 min, p = 0.9). Non-ST segment elevation ACS was higher in women [65 % vs 61 % p < 0.001, OR 1.2 (1.1;1.4)]. Women were less likely to undergo CAG [68 % vs. 79 %, p < 0.001, OR 0.6 (0.5;0.7)] and PCI than men [82 % vs. 86 % p < 0.001, OR 0.7 (0.6;0.8)]. Still, unfavorable anatomy cases were comparable (63 % vs 66 %, p = 0.5). Women had less multivessel disease (12 % vs 18 % p < 0.001). Successful PCI was similar among groups (95 % p = 0.9). Women were associated with higher in-hospital death and MACE than men [12 % vs 7 % p < 0.001 OR 1.8 (1.5;2.2) and 7 % vs 5 % p = 0.005, OR 1.5 (1.1;2)]. Women were associated with fewer cardiac rehabilitation referrals [33 % vs 38 % p < 0.001 OR 0.8 (0.7;0.9)]. During the follow-up of 16 ± 7 months, women had a significant association with mortality during follow-up [15 % vs 11 % p < 0.001, OR 1.5 (1.2;1.7)]. Also, women were significantly associated with more hospital readmissions [28 % vs 24 % p = 0.004, OR 1.2 (1.1;1.4)].</p><p><strong>Conclusion: </strong>Despite enhanced awareness, CVD in women remains underestimated. Women take longer to seek medical care and are less likely to undergo CAG and PCI. This ends in a worse early and long-term prognosis, with higher mortality and MACE on follow-up.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The difference of gas exchange pulmonary arterial capacitance with postural change between chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension.","authors":"Shota Soma, Nobuhiro Yaoita, Taijyu Satoh, Kotaro Nochioka, Saori Yamamoto, Haruka Sato, Hiroyuki Takahama, Hideaki Suzuki, Masashi Takeuchi, Satoru Ebihara, Satoshi Yasuda","doi":"10.1016/j.jjcc.2025.04.003","DOIUrl":"https://doi.org/10.1016/j.jjcc.2025.04.003","url":null,"abstract":"<p><strong>Background: </strong>Pulmonary artery compliance (PAC), which could be estimated with gas exchange pulmonary arterial capacitance (GXcap), reflects the elasticity of the pulmonary vessels, and it is known that PAC is changed by pulmonary perfusion. GXcap could be measured using ventilatory gas analysis and is calculated using O₂ pulse × peak end-tidal CO₂ pressure. Moreover, it is known that pulmonary perfusion by postural changes is different between chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary arterial hypertension (PAH). However, it was unclear whether GXcap could estimate PAC in CTEPH and PAH. Furthermore, it was unclear that change in GXcap with postural change (ΔGXcap) [Δ (Sitting - Supine)] was different between CTEPH and PAH.</p><p><strong>Methods: </strong>Patients with suspected pulmonary hypertension who underwent right heart catheterization (RHC) from May 2022 to February 2023 in our institution were prospectively enrolled. Ventilatory gas analysis was performed before RHC in both the supine and sitting positions and calculated. Moreover, PAC was calculated with RHC. The diagnosis of PAH and CTEPH was based on the European Society of Cardiology/European Respiratory Society 2022 guidelines.</p><p><strong>Results: </strong>Forty patients (CTEPH, n = 18; PAH, n = 22) were enrolled in this study. GXcap was positively related to PAC in these patients (R = 0.62, p < 0.001). Furthermore, PAC was significantly lower in CTEPH patients compared to PAH patients (median 1.63 mL/mmHg vs 2.05 mL/mmHg, p = 0.013). Moreover, GXcap was increased in CTEPH patients with postural change, while GXcap was decreased in PAH patients with postural change. Thus, ΔGXcap was significantly higher in CTEPH patients compared to PAH patients (median 5.8 mL × mmHg vs -2.6 mL × mmHg, p = 0.005).</p><p><strong>Conclusions: </strong>It was suggested that PAC could be moderately estimated using GXcap in PAH and CTEPH patients. Moreover, it was suggested that ΔGXcap was higher in CTEPH patients compared with PAH patients.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}