Journal of cardiology最新文献

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Development of new anticoagulants targeting coagulation factor XI and prospects for clinical use. 以凝血因子XI为靶点的新型抗凝剂的研制及临床应用前景。
IF 2.5 3区 医学
Journal of cardiology Pub Date : 2025-02-14 DOI: 10.1016/j.jjcc.2025.02.013
Masahiro Ieko, Kazumasa Ohmura, Sumiyoshi Naito, Mika Yoshida, Osamu Kumano
{"title":"Development of new anticoagulants targeting coagulation factor XI and prospects for clinical use.","authors":"Masahiro Ieko, Kazumasa Ohmura, Sumiyoshi Naito, Mika Yoshida, Osamu Kumano","doi":"10.1016/j.jjcc.2025.02.013","DOIUrl":"10.1016/j.jjcc.2025.02.013","url":null,"abstract":"<p><p>Thrombosis is a potentially fatal condition for which various anticoagulant therapies have been used for prevention and treatment. However, bleeding events remain a concern with all anticoagulant drugs. Recent evidence suggests that inhibiting coagulation factor XI (FXI) and activated FXI (FXIa) plays a greater role in the formation of pathological thrombi in thrombosis than in normal hemostatic thrombi, allowing for the potential to address these two events separately. Consequently, FXI/XIa inhibition has become the focus of anticoagulant drug research, leading to the development of numerous FXI-targeting compounds with diverse mechanisms of action. Herein, we aimed to review FXI/FXIa inhibitors under development, discussing the role of FXI in the coagulation reaction and the advantages and disadvantages associated with its deficiency. The results of a Phase II study showed that FXI/XIa inhibitors provide efficacy comparable to that of low molecular weight heparin therapy while reducing clinically significant bleeding events. Additionally, in a study of patients with atrial fibrillation, FXI/XIa inhibitors reduced bleeding events compared to those with direct oral anticoagulants. Furthermore, when combined with antiplatelet therapy, FXI/XIa inhibitors did not significantly increase bleeding risk in non-cardioembolic stroke or acute coronary syndrome. However, conflicting trial results have also been reported, highlighting the difficulty in assessing the clinical benefit of FXI/XIa inhibitors in different clinical settings, such as atrial fibrillation and acute myocardial infarction. Future large, well-designed Phase III studies are needed to evaluate the safety and efficacy of FXI/XIa inhibitors across diverse populations requiring antithrombotic therapy.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitral regurgitation in atrial fibrillation: Is a simple repair enough to tackle a complex problem? 致编辑:心房颤动的二尖瓣返流:简单的修复足以解决一个复杂的问题吗?
IF 2.5 3区 医学
Journal of cardiology Pub Date : 2025-02-13 DOI: 10.1016/j.jjcc.2025.02.011
Hadisa Talpur, Ghulam Mustafa
{"title":"Mitral regurgitation in atrial fibrillation: Is a simple repair enough to tackle a complex problem?","authors":"Hadisa Talpur, Ghulam Mustafa","doi":"10.1016/j.jjcc.2025.02.011","DOIUrl":"10.1016/j.jjcc.2025.02.011","url":null,"abstract":"","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cognitive impairment in patients with heart failure: Physiopathology, clinical implications, and therapeutic considerations. 心力衰竭患者的认知障碍:生理病理、临床意义和治疗考虑。
IF 2.5 3区 医学
Journal of cardiology Pub Date : 2025-02-13 DOI: 10.1016/j.jjcc.2025.02.007
Meng Li, Junping Zhang, Yue Hu, Yue Zhang
{"title":"Cognitive impairment in patients with heart failure: Physiopathology, clinical implications, and therapeutic considerations.","authors":"Meng Li, Junping Zhang, Yue Hu, Yue Zhang","doi":"10.1016/j.jjcc.2025.02.007","DOIUrl":"10.1016/j.jjcc.2025.02.007","url":null,"abstract":"<p><p>Cognitive impairment (CI) is a significant comorbidity in individuals with heart failure (HF). A substantial number of patients with HF may experience CI, which can present as deficits in attention, memory, executive function, and processing speed. HF patients with CI tend to have reduced functional independence, self-care capabilities, medication adherence and decision-making ability, along with more frequent rehospitalizations, and an increased risk of mortality. Currently, there is no established gold standard diagnostic tool or follow-up strategy for assessing CI in patients with HF. There has been an increasing recognition of the complex bidirectional relationship between HF and CI. However, the exact pathological mechanisms of CI in HF need further in-depth investigation. This review aims to explore the current epidemiological status of CI in patients with HF, the relationship between HF and cognitive dysfunction, the pathological mechanisms involved, as well as the early screening, diagnosis, and management issues for HF patients with CI. It also discusses prevention and intervention strategies. The objective is to provide a scientific basis for the clinical diagnosis, management, and treatment of CI in HF, while proposing future research directions to advance this field.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paradoxical outcomes in very severe aortic stenosis following TAVI. TAVI后非常严重主动脉狭窄的矛盾结果。
IF 2.5 3区 医学
Journal of cardiology Pub Date : 2025-02-13 DOI: 10.1016/j.jjcc.2025.02.014
Mesut Gitmez, Mehmet Kadri Akboga
{"title":"Paradoxical outcomes in very severe aortic stenosis following TAVI.","authors":"Mesut Gitmez, Mehmet Kadri Akboga","doi":"10.1016/j.jjcc.2025.02.014","DOIUrl":"10.1016/j.jjcc.2025.02.014","url":null,"abstract":"","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors involved in discontinuation or dose reduction of angiotensin receptor-neprilysin inhibitor: A retrospective analysis in 200 patients. 血管紧张素受体-奈普利素抑制剂停药或剂量减少的相关因素:200例患者的回顾性分析。
IF 2.5 3区 医学
Journal of cardiology Pub Date : 2025-02-12 DOI: 10.1016/j.jjcc.2025.02.006
Haruna Inoue, Kenzo Uzu, Yusuke Fukuyama, Yoshinori Nagasawa, Kiyohiro Hyogo, Yasushi Shimokawa, Hideaki Okubo, Hiroki Shimizu
{"title":"Factors involved in discontinuation or dose reduction of angiotensin receptor-neprilysin inhibitor: A retrospective analysis in 200 patients.","authors":"Haruna Inoue, Kenzo Uzu, Yusuke Fukuyama, Yoshinori Nagasawa, Kiyohiro Hyogo, Yasushi Shimokawa, Hideaki Okubo, Hiroki Shimizu","doi":"10.1016/j.jjcc.2025.02.006","DOIUrl":"10.1016/j.jjcc.2025.02.006","url":null,"abstract":"","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Imaging characteristics of patients with cardiac sarcoidosis who presented with ventricular arrhythmias. 伴有室性心律失常的心脏结节病患者的影像学特征。
IF 2.5 3区 医学
Journal of cardiology Pub Date : 2025-02-12 DOI: 10.1016/j.jjcc.2025.02.004
Noor K Albakaa, Kimi Sato, Naoto Kawamatsu, Masayoshi Yamamoto, Tomoko Machino-Ohtsuka, Yuki Komatsu, Akihiko Nogami, Masaki Ieda, Tomoko Ishizu
{"title":"Imaging characteristics of patients with cardiac sarcoidosis who presented with ventricular arrhythmias.","authors":"Noor K Albakaa, Kimi Sato, Naoto Kawamatsu, Masayoshi Yamamoto, Tomoko Machino-Ohtsuka, Yuki Komatsu, Akihiko Nogami, Masaki Ieda, Tomoko Ishizu","doi":"10.1016/j.jjcc.2025.02.004","DOIUrl":"10.1016/j.jjcc.2025.02.004","url":null,"abstract":"<p><strong>Background: </strong>Ventricular arrhythmia (VA) is an ominous manifestation of cardiac sarcoidosis (CS). Hence, identifying specific characteristics associated with VA in imaging modalities may enhance risk stratification.</p><p><strong>Methods: </strong>Fifty-nine patients diagnosed with CS were retrospectively studied and grouped based on presenting symptoms as the VA group (sustained ventricular tachycardia and ventricular fibrillation) and the non-VA group (atrioventricular block, heart failure, and other symptoms). Thirty-nine patients underwent comprehensive evaluation by cardiac magnetic resonance imaging and <sup>18</sup>F-fluorodeoxyglucose positron emission tomography (FDG-PET) for comparing cardiac involvement distribution.</p><p><strong>Results: </strong>The VA group (n = 15) showed higher prevalence of right bundle branch block, basal interventricular thinning, and left ventricle wall motion abnormality. In Cox analysis, VA at baseline (hazard ratio 4.75, p = 0.008) was associated with poor outcomes. The VA group showed a larger extent of late gadolinium enhancement than the non-VA group, especially in the left ventricular mid inferoseptal, right ventricular (RV) basal lateral to mid lateral, and RV apical anterior lesions. FDG-PET accumulation was prominent in the RV basal lateral to basal inferior, and mid anterior lesions in the VA group.</p><p><strong>Conclusions: </strong>Patients who presented with VA had worse outcomes and a larger cardiac involvement predominant to the RV and ventricular septum; RV predominant scar pattern may serve as a surrogate in patients with CS and explain possible correlation with electrophysiological abnormalities.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incidence, predictors, and sex differences in acute coronary syndrome overdiagnosis among patients presenting to the emergency department with acute chest pain. 急诊科急性胸痛患者急性冠状动脉综合征过度诊断的发生率、预测因素和性别差异
IF 2.5 3区 医学
Journal of cardiology Pub Date : 2025-02-12 DOI: 10.1016/j.jjcc.2025.02.008
Giorgio Fiore, Giuseppe Pinto, Michele Oppizzi, Massimo Slavich, Carlo Gaspardone, Federico Furlan, Davide Valsecchi, Alberto Margonato, Gabriele Fragasso
{"title":"Incidence, predictors, and sex differences in acute coronary syndrome overdiagnosis among patients presenting to the emergency department with acute chest pain.","authors":"Giorgio Fiore, Giuseppe Pinto, Michele Oppizzi, Massimo Slavich, Carlo Gaspardone, Federico Furlan, Davide Valsecchi, Alberto Margonato, Gabriele Fragasso","doi":"10.1016/j.jjcc.2025.02.008","DOIUrl":"10.1016/j.jjcc.2025.02.008","url":null,"abstract":"<p><strong>Background: </strong>In the era of high-sensitivity troponin assays, overdiagnosis of acute coronary syndrome (ACS) has become increasingly common, overriding underdiagnosis and carrying a burden of healthcare issues. This study aimed to assess the incidence, predictors, and sex differences in ACS overdiagnosis among patients presenting with chest pain (CP) to the emergency department (ED).</p><p><strong>Methods: </strong>Consecutive CP patients presenting at the ED were included. Patients with other causes of CP, non-suspicious for ACS, were excluded. Six-month ACS rate was assessed in discharged patients. In ACS hospitalized patients, clinical records were analyzed to evaluate true-ACS incidence. Patients inappropriately hospitalized for ACS (ACS-overdiagnosis, false-positives) were compared to correctly discharged (true-negatives) and actual ACS patients (true-positives and false-negatives).</p><p><strong>Results: </strong>From 7040 CP patients, a random sample of 1025 was included. ACS was initially diagnosed in 237 (23.1 %) patients who were hospitalized, while 788 (76.9 %) were discharged from the ED. ACS misdiagnosis occurred in 30 (2.9 %) patients: 8 (1 %) discharged patients experienced ACS at follow-up (false-negatives) while 22 (9.3 %) hospitalized for ACS were considered not to have ACS (ACS-overdiagnosis). True incident ACS at 6 months was 223 (21.8 %). Independent predictors of ACS overdiagnosis were electrocardiographic alterations, troponin T > 99° percentile, and male sex, while women were older with lower pre-test likelihood of ACS according to ED physicians, with a higher rate of early discharge but similar outcomes.</p><p><strong>Conclusions: </strong>ACS overdiagnosis is more frequent than underdiagnosis, carrying potential issues for the healthcare system. Patients with ACS overdiagnosis were more commonly men with elevated high-sensitivity troponin, often indistinguishable from true-ACS patients according to standard care.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship between body mass index and traditional size-matching in heart transplantation. 心脏移植中体重指数与传统尺寸匹配的关系。
IF 2.5 3区 医学
Journal of cardiology Pub Date : 2025-02-08 DOI: 10.1016/j.jjcc.2025.02.001
Ahad Firoz, Huaqing Zhao, Eman Hamad
{"title":"Relationship between body mass index and traditional size-matching in heart transplantation.","authors":"Ahad Firoz, Huaqing Zhao, Eman Hamad","doi":"10.1016/j.jjcc.2025.02.001","DOIUrl":"10.1016/j.jjcc.2025.02.001","url":null,"abstract":"<p><strong>Background: </strong>Donor-recipient size matching is an important consideration for heart allocation, of which predicted heart mass (PHM) ratio has been found to be the most optimal metric. However, the PHM formula has not been validated in a cohort that included obese recipients. Therefore, our study seeks to add further granular data on this topic by investigating acute survival in PHM categories across multiple body mass index (BMI) groups.</p><p><strong>Methods: </strong>Adult heart transplant recipients were analyzed using the United Network for Organ Sharing database. BMI groups included: normal (18.5-24.9 kg/m<sup>2</sup>), overweight (25.0-29.9 kg/m<sup>2</sup>), obese class I (30.0-34.9 kg/m<sup>2</sup>), and obese class II+ (≥35.0 kg/m<sup>2</sup>). PHM ratio (PHMR) categories were: severely undersized (U2): <0.85, undersized (U1): 0.85-0.95, approximately equally sized (R): 0.95-1.05, oversized (O1): 1.05-1.25, and severely oversized (O2): ≥1.25. All-cause acute mortality was the primary outcome of interest.</p><p><strong>Results: </strong>A total of 46,141 recipients were included in our analysis. The percentage of obese patients and donors increased over the years, from 21.5 % and 17.2 % in 2000 to 34.4 % and 33.1 % in 2022, respectively. Survival analysis found a stepwise reduction in mortality risk for severely undersized grafts as BMI increased (normal: HR = 1.59, p < 0.001; overweight: HR = 1.20, p = 0.029), until ultimately reaching insignificant levels in obese groups across all PHMR categories.</p><p><strong>Conclusion: </strong>Patients with a normal to overweight BMI were susceptible to increased mortality with a severely undersized graft. Conversely, obese groups appeared to be resistant to the hazards of organ size mismatching by PHMR. The clinical implications of this study may enable recruitment from a larger donor pool and improve challenges in transplantation for obese patients.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Challenging perspectives on the role of Impella in biventricular failure: A response to Matsushita et al. 关于Impella在双心室衰竭中的作用的挑战观点:对Matsushita等人的回应。
IF 2.5 3区 医学
Journal of cardiology Pub Date : 2025-02-08 DOI: 10.1016/j.jjcc.2025.02.002
Arif Albulushi
{"title":"Challenging perspectives on the role of Impella in biventricular failure: A response to Matsushita et al.","authors":"Arif Albulushi","doi":"10.1016/j.jjcc.2025.02.002","DOIUrl":"10.1016/j.jjcc.2025.02.002","url":null,"abstract":"","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structural instability of ryanodine receptor 2 causes endoplasmic reticulum (ER) dysfunction as well as sarcoplasmic reticulum (SR) dysfunction. Ryanodine受体2结构不稳定导致内质网(ER)功能障碍和肌浆网(SR)功能障碍。
IF 2.5 3区 医学
Journal of cardiology Pub Date : 2025-02-08 DOI: 10.1016/j.jjcc.2025.02.003
Hitoshi Uchinoumi, Yoshihide Nakamura, Takeshi Suetomi, Takashi Nawata, Masafumi Fujinaka, Shigeki Kobayashi, Takeshi Yamamoto, Masafumi Yano, Motoaki Sano
{"title":"Structural instability of ryanodine receptor 2 causes endoplasmic reticulum (ER) dysfunction as well as sarcoplasmic reticulum (SR) dysfunction.","authors":"Hitoshi Uchinoumi, Yoshihide Nakamura, Takeshi Suetomi, Takashi Nawata, Masafumi Fujinaka, Shigeki Kobayashi, Takeshi Yamamoto, Masafumi Yano, Motoaki Sano","doi":"10.1016/j.jjcc.2025.02.003","DOIUrl":"10.1016/j.jjcc.2025.02.003","url":null,"abstract":"<p><p>The type 2 ryanodine receptor (RyR2) is a giant Ca<sup>2+</sup> (Ca)-releasing channel on the sarcoplasmic reticulum (SR) membrane, with subunits composed of 5000 amino acids constituting a homotetrameric channel. The N-terminal (1-220) and central (2300-2500) domain interactions (inter-subunit zipping interfaces) within RyR2 are located in close proximity to each other between different neighboring subunits and play an important \"cornerstone\" role in maintaining the tetrameric structure of RyR2. External stress such as oxidative stress causes Ca leak by destabilizing RyR2 (instability of the tetrameric structure) due to domain unzipping between N-terminal (1-220) and central (2300-2500) domains, followed by dissociation of calmodulin (CaM: binds to the RyR2 and stabilize RyR2) from RyR2. Ca leak from SR causes arrhythmias and myocardial dysfunction. RyR2 is also present in the endoplasmic reticulum (ER), thus it is not surprising that undesired Ca release from RyR2 on the ER is closely associated with various diseases involving ER dysfunction such as neurodegenerative diseases, diabetes, metabolic dysfunction-associated steatotic liver disease, chronic kidney disease, and autoimmune diseases. Pharmacological or genetic (point mutations within RyR2 that increase CaM-RyR2 affinity: knock-in RyR2-V3599K) RyR2 structural stabilization has shown potential therapeutic effects not only for SR failure-related diseases (malignant hyperthermia, arrhythmia, and heart failure) but also for ER failure-related disease. RyR2-stabilizers may function as a panacea for aging-related diseases.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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