Journal of cardiology最新文献

{"title":"Sacubitril/valsartan in older adults: interpreting hypotension, biomarkers, and dose trajectories in routine care","authors":"Beibei Wang MD, Yiqun Lou MD","doi":"10.1016/j.jjcc.2026.02.005","DOIUrl":"10.1016/j.jjcc.2026.02.005","url":null,"abstract":"","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":"88 3","pages":"Page 234"},"PeriodicalIF":3.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147306295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to letter to the editor","authors":"Beatriz Garcia, Daniela Pinheiro, Catarina Gregório, Daniel Caldeira, Fausto J. Pinto, Dulce Brito","doi":"10.1016/j.jjcc.2026.06.017","DOIUrl":"10.1016/j.jjcc.2026.06.017","url":null,"abstract":"","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":"88 3","pages":"Pages 229-230"},"PeriodicalIF":3.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148387633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A greater reduction in γ-GTP was associated with achieving BP <140/90 mmHg without antihypertensive medication among individuals who newly developed Grade I hypertension","authors":"Ryoichi Ohara MD,&nbsp;Fumiko Nakatsu PhD,&nbsp;Kazuma Iekushi MD, PhD,&nbsp;Sachiko Tanaka-Mizuno PhD,&nbsp;Hironori Nakagami MD, PhD,&nbsp;Koichi Yamamoto MD, PhD","doi":"10.1016/j.jjcc.2026.01.002","DOIUrl":"10.1016/j.jjcc.2026.01.002","url":null,"abstract":"<div><h3>Background</h3><div>Our previous multivariable analysis of hypertensive participants in Hiratsuka City identified younger age, grade I hypertension, absence of prior hypertension at the previous specific health check-up (SHC), and willingness to improve lifestyle as key determinants of achieving target blood pressure (BP). Building on these findings, we further characterized participants who achieved BP control without antihypertensive medications to identify responders for lifestyle guidance using decision-tree analysis.</div></div><div><h3>Methods</h3><div>The study included 5428 residents age 40–74 years with hypertension (BP ≥140/90 mmHg) but untreated at SHCs conducted from May 2016 to March 2023. Of these, 2468 participants started antihypertensive medications by their next SHC. Descriptive analysis and decision-tree analysis stratified by antihypertensive medication use were used to identify factors associated with achieving BP &lt;140/90 mmHg and to assess their relative importance.</div></div><div><h3>Results</h3><div>Among participants without antihypertensive medications, 55.9% achieved BP &lt;140/90 mmHg. Decision-tree analysis revealed that no history of hypertension at the previous SHC and lower BP grade were the primary predictors of success. Notably, a reduction in γ-glutamyl transpeptidase (γ-GTP) was the next most influential factor in the non-medication group. For individuals who initiated antihypertensive therapy, younger age was associated with higher achievement rates.</div></div><div><h3>Conclusion</h3><div>A greater reduction in γ-GTP was associated with achieving BP &lt;140/90 mmHg without antihypertensive medication, among individuals who newly developed Grade I hypertension, suggesting that effective lifestyle modification, reflected by improvements in metabolic markers, may play a pivotal role in BP control in this population.</div></div>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":"88 3","pages":"Pages 151-158"},"PeriodicalIF":3.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145998220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author's reply to “Comment on ‘Cardio-ankle vascular index as a screening tool for coronary artery disease in patients with metabolic dysfunction-associated steatotic liver disease’”","authors":"Mitsutaka Nakashima MD, PhD,&nbsp;Toru Miyoshi MD, PhD, FJCC","doi":"10.1016/j.jjcc.2026.06.010","DOIUrl":"10.1016/j.jjcc.2026.06.010","url":null,"abstract":"","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":"88 3","pages":"Page 227"},"PeriodicalIF":3.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148283894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical factors associated with increase in serum transthyretin levels at 1-year with tafamidis in wild-type transthyretin amyloid cardiomyopathy.","authors":"Koji Yoshie, Tsuneaki Yoshinaga, Masatoshi Minamisawa, Hirohiko Motoki, Takenori Aoki, Ken Nishikawa, Sho Suzuki, Yukari Okuma, Kazuhiro Kimura, Yoshiki Sekijima, Koichiro Kuwahara","doi":"10.1016/j.jjcc.2026.07.022","DOIUrl":"https://doi.org/10.1016/j.jjcc.2026.07.022","url":null,"abstract":"","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148860415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paradigm shift in hydrogen medicine: Target molecules and catalytic mechanisms elucidated at the atomic level.","authors":"Motoaki Sano, Masaki Shibuya, Hitoshi Uchinoumi, Yoshinori Katsumata, Kosuke Shirakawa, Zenzo Fujii, Takeshi Yamamoto","doi":"10.1016/j.jjcc.2026.08.007","DOIUrl":"10.1016/j.jjcc.2026.08.007","url":null,"abstract":"<p><p>Molecular hydrogen (H₂) has been shown to exert antioxidant and anti-inflammatory effects across a broad spectrum of disease models and clinical trials; however, its direct reaction rate with hydroxyl radicals (•OH) in aqueous solution is exceedingly slow, and the underlying mechanism of action has remained unresolved for many years as the \"hydrogen paradox\". The present review delineates a paradigm shift that resolves this enigma from three distinct perspectives. First, oxidized Fe-porphyrin \"hematin [Fe(III)-OH]\" has been identified as a redox-related biosensor for H₂, reducing •OH selectively to water through a catalytic cycle. Ab initio density functional theory calculations support the notion that H₂ does not interfere with normal ferrous heme, but intervenes exclusively in pathologically hyperoxidized heme. Second, we propose a novel mechanism whereby H₂ performs one-electron reduction of the high-valent ferryl iron intermediate Compound I [Fe(IV) = O·P•⁺] of myeloperoxidase during neutrophil extracellular trap formation, selectively arresting hypochlorous acid production and immunothrombosis without compromising normal bactericidal function. Third, we discuss how the identical concept of \"high-valent iron overheat protection\" applies to mitochondrial Complex IV, potentially explaining the maintenance of aerobic energy metabolism and the suppression of lactate accumulation. We present a unified paradigm shift in which H₂ functions as the ultimate biological fail-safe mechanism, exerting pinpoint control exclusively over the pathological \"runaway oxygen engine\" driven by oxidative stress, while leaving normal enzymatic activity entirely intact.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"External validation of the international ICI-myocarditis registry risk score in a Japanese multicenter registry.","authors":"Takuro Imaoka, Yudai Tamura, Nao Muraoka, Masaaki Shoji, Hirofumi Tomita, Yoshitaka Iso, Shiro Nakamori, Issei Komuro, Kazuko Tajiri, Yuichi Tamura","doi":"10.1016/j.jjcc.2026.08.005","DOIUrl":"10.1016/j.jjcc.2026.08.005","url":null,"abstract":"<p><strong>Background: </strong>The International ICI-myocarditis Registry Risk Score predicts major adverse cardiotoxic events (MACE), but Japanese validation is limited.</p><p><strong>Methods and results: </strong>In a retrospective multicenter Japanese registry (23 hospitals), 88 patients were analyzed. MACE occurred in 25 (28.4%) and increased stepwise with higher scores (0: 10%, 1: 13%, 2: 32%, 3: 50%, 4: 67%, 5: 100%; P < 0.001). Discrimination was preserved (AUC 0.76, 95% CI 0.65-0.88); a cutoff ≥2 yielded 80.0% sensitivity and 60.3% specificity.</p><p><strong>Conclusions: </strong>The score preserved discriminatory performance in Japanese cohort, but low scores did not exclude risk.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erythrocyte fatty acid compositional patterns and cardiovascular-kidney-metabolic stage burden.","authors":"Shanshan Chen, Pengyi Chen, Chiyuan Luo, Lianhui Chen","doi":"10.1016/j.jjcc.2026.08.003","DOIUrl":"10.1016/j.jjcc.2026.08.003","url":null,"abstract":"<p><strong>Background: </strong>Erythrocyte fatty acids (RBC-FAs) are objective biomarkers of longer-term fatty acid status, but their relationship with cardiovascular-kidney-metabolic (CKM) syndrome stage burden remains unclear. We aimed to derive biologically interpretable RBC-FA patterns and examine their associations with CKM stage burden.</p><p><strong>Methods: </strong>In this population-based cross-sectional study of US adults, isometric log-ratio principal component analysis was performed among 5118 eligible nonpregnant participants with complete 21-part RBC-FA profiles to derive RBC-FA pattern scores. Associations were then evaluated in 2427 participants with positive fasting subsample weights and classifiable CKM stage. Survey-weighted logistic regression was used for the primary outcome, defined as CKM stage ≥2, and survey-weighted linear regression was used for CKM stage modeled continuously from 0 to 4. Subgroup analyses were performed by age and sex.</p><p><strong>Results: </strong>Three retained principal components (PCs) explained 66.2% of total RBC-FA variance. PC1 represented an omega-3-enriched pattern, PC2 a saturated fatty acid/monounsaturated fatty acid-enriched and polyunsaturated fatty acid-depleted contrast, and PC3 a stearoyl-CoA desaturase-16/delta-6 desaturase-related desaturation proxy pattern. In fully adjusted models, PC1 was associated with lower odds of CKM stage ≥2 (OR: 0.66; 95% CI: 0.49-0.90), whereas PC3 was associated with higher odds (OR: 3.09; 95% CI: 1.61-5.92). PC2 showed no robust association. Secondary analyses using continuous CKM stage showed consistent directions, and no robust effect modification by age or sex was observed.</p><p><strong>Conclusion: </strong>Distinct RBC-FA patterns were differentially associated with CKM stage burden, suggesting that RBC-FA profiles may provide objective biomarker information on integrated CKM burden.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myocardial degeneration precedes fibrosis: The role of myocardial autophagy and its pathological evaluation.","authors":"Tsunenori Saito","doi":"10.1016/j.jjcc.2026.08.006","DOIUrl":"10.1016/j.jjcc.2026.08.006","url":null,"abstract":"<p><p>Dilated cardiomyopathy (DCM) is characterized by progressive ventricular dilation and systolic dysfunction, yet the cellular damage that precedes intercellular fibrosis remains incompletely defined. Electron microscopy has long revealed autophagic vacuoles and myofilament lysis in cardiomyopathy, but their pathological significance has been debated for decades. Recent advances in ultrastructural analysis, including LC3 immunoelectron microscopy, have enabled more precise characterization of these changes and have renewed interest in the role of autophagy in cardiomyopathy. In this review, we integrate ultrastructural findings from a large cohort of patients with DCM with contemporary clinical imaging data to clarify the sequence of myocardial damage. Myofilament lysis consistently appears as the earliest structural abnormality, preceding intercellular fibrosis and ventricular remodeling. Autophagic vacuoles are frequently observed at sites of lysis, suggesting activation of a conserved cellular repair response rather than a mechanism of cell death. This interpretation is supported by external evidence, including LC3-based analyses demonstrating associations between autophagy and reverse remodeling, as well as experimental studies showing that sodium-glucose cotransporter 2 inhibitors enhance stress-adaptive pathways and mitochondrial energetics even in models with impaired mitophagy. By integrating electron microscopy with late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging, we further demonstrate that autophagic activity provides prognostic information beyond conventional tissue characterization. In LGE-negative myocardium, the presence of autophagic vacuoles identifies a subgroup with a lower risk of heart-failure recurrence, whereas myofilament lysis alone shows limited prognostic value. These findings highlight the importance of distinguishing structural damage from cellular repair activity when evaluating cardiomyopathy. Collectively, the evidence supports a refined framework in which myofilament lysis precedes intercellular fibrosis, and autophagy represents an adaptive response that modulates clinical outcomes. Understanding these ultrastructural processes may inform future diagnostic strategies and therapeutic approaches for cardiomyopathy.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond plaque and stenosis: Coronary inflammation imaging with the fat attenuation index.","authors":"Masahiro Hoshino, Taishi Yonetsu, Tsunekazu Kakuta, Tetsuo Sasano","doi":"10.1016/j.jjcc.2026.08.004","DOIUrl":"10.1016/j.jjcc.2026.08.004","url":null,"abstract":"<p><p>Pericoronary adipose tissue (PCAT) imaging has emerged as a promising noninvasive marker of coronary inflammation and an adjunctive risk-stratification tool beyond conventional coronary computed tomography angiography (CCTA) findings such as luminal stenosis and plaque morphology. The fat attenuation index (FAI), derived from CCTA, quantifies phenotypic changes in pericoronary fat driven by vascular inflammation. The CRISP-CT study demonstrated that elevated FAI around the right coronary artery independently predicted cardiac mortality. The ORFAN study further established that the FAI-Score-an artificial intelligence-adjusted derivative of raw PCAT attenuation-predicts cardiac events even in the absence of obstructive coronary artery disease. Multiple meta-analyses have consistently demonstrated that elevated PCAT attenuation is associated with an increased risk of major adverse cardiovascular events. It should be emphasized, however, that current evidence supports FAI/FAI-Score primarily as a prognostic marker; trial-level evidence that FAI-guided management decisions improve patient outcomes is not yet available. Beyond established prognostic applications, investigational uses include the identification of functionally significant lesions, acute coronary syndrome mechanism characterization, vasospastic angina prediction, assessment of myocardial infarction with nonobstructive coronary arteries, treatment-response monitoring, and risk stratification in diabetic populations; these emerging applications require prospective validation. The fat radiomic profile, a machine-learning-derived extension, captures structural remodeling in pericoronary fat that persists beyond the acute inflammatory changes detected by FAI alone. However, substantial technical challenges remain. Reconstruction algorithms and tube voltage introduce substantial measurement variability, underscoring the need for protocol standardization. This review provides an overview of the biological rationale, measurement methodology, prognostic evidence, emerging and investigational applications, and current limitations of PCAT-based coronary inflammation imaging.</p>","PeriodicalId":15223,"journal":{"name":"Journal of cardiology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148840173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}