Journal of Cardiovascular Magnetic Resonance最新文献

{"title":"Hemodynamics of distal cerebral arteries are associated with functional outcomes in symptomatic ischemic stroke in middle cerebral artery territory: A four-dimensional flow cardiovascular magnetic resonance study.","authors":"Peirong Jiang, Lixin Liu, Xiuzhu Xu, Yanping Zheng, Jialin Chen, Huiyu Qiao, Lin Lin, Bin Sun, Xihai Zhao, He Wang, Zhensen Chen, Yunjing Xue","doi":"10.1016/j.jocmr.2025.101857","DOIUrl":"10.1016/j.jocmr.2025.101857","url":null,"abstract":"<p><strong>Background: </strong>Cerebrovascular hemodynamics are believed to play an important role in the development of ischemic stroke (IS). However, the relationships between hemodynamics and prognosis are not fully understood. Four-dimensional (4D) flow cardiovascular magnetic resonance (CMR) enables comprehensive characteristics of cerebrovascular hemodynamics. This study aims to investigate the associations of the different hemodynamics derived from 4D flow CMR with IS functional outcomes.</p><p><strong>Methods: </strong>Ninety-one patients (median age 64 years, 62 males) with unilateral IS in middle cerebral artery (MCA) territory were included. All subjects underwent a CMR scan, including 4D flow, three-dimensional (3D) time-of-flight magnetic resonance angiography, and 3D whole brain black-blood high-resolution vessel wall imaging of the MCA. Six hemodynamic parameters, including flow rate, velocity, pulsatility index, time-averaged wall shear stress (TAWSS), oscillatory shear index, and relative residence time (RRT), were calculated for the lesion site, pre-bifurcation M1 (pM1) segment, and the distal M1 and/or first branches of M2 (dM1/M2) segments. Vessel characteristics, such as lumen area, vessel area, wall area, maximum wall thickness, and the degree of stenosis, were calculated at the most stenotic lesion site. The modified Rankin Scale (mRS) scores were assessed at 90 days and 1 year, and an mRS >2 was considered as a poor functional outcome.</p><p><strong>Results: </strong>Lower segment-level TAWSS (odds ratio [OR]: 0.24, P = 0.006 and OR: 0.29, P = 0.014), higher RRT (OR: 2.74, P = 0.007 and OR: 2.40, P = 0.011) of dM1/M2 segments, and lower segment- and lesion-level velocity (OR: 0.40, P = 0.019 and OR: 0.41, P = 0.025; OR: 0.41, P = 0.030 and OR: 0.42, P = 0.040) of pM1 segment were observed to be associated with poor functional outcome at both 90 days and 1 year. Using the cut-off value of 3.58 Pa and 0.29, respectively, TAWSS and RRT of dM1/M2 segments showed moderate performance in distinguishing poor functional outcome from favorable outcome (area under the curve ranging from 0.642-0.687) both at 90 days and 1 year.</p><p><strong>Conclusion: </strong>Distal segmental TAWSS and RRT of dM1/M2 segments were associated with poor functional outcomes. Such alterations in hemodynamics might help in the identification of patients with potentially unfavorable prognosis.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101857"},"PeriodicalIF":4.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11987608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143407769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular magnetic resonance radiologic-pathologic correlation in radiomic analysis of myocardium in non-ischemic dilated cardiomyopathy.","authors":"Amine Amyar, Shiro Nakamori, Long Ngo, Masaki Ishida, Satoshi Nakamura, Taku Omori, Keishi Moriwaki, Naoki Fujimoto, Kyoko Imanaka-Yoshida, Hajime Sakuma, Kaoru Dohi, Warren J Manning, Reza Nezafat","doi":"10.1016/j.jocmr.2025.101881","DOIUrl":"10.1016/j.jocmr.2025.101881","url":null,"abstract":"<p><strong>Background: </strong>There is a growing interest in cardiovascular magnetic resonance (CMR) radiomic signatures as novel imaging biomarkers of cardiac disease. However, very little is known about pathological correlates of the radiomics signature of myocardium on CMR sequences. In this study, we sought to investigate the association between CMR myocardial radiomic signatures and histological features in patients with non-ischemic dilated cardiomyopathy (DCM).</p><p><strong>Methods: </strong>CMR images from DCM patients who underwent CMR followed by endomyocardial biopsy within 6 [2-15] days were used to investigate the association between myocardial radiomic signatures measured from native T₁, extra-cellular volume (ECV), late gadolinium enhancement (LGE) and histological features. Radiomic first-order and textural features were computed for each sequence from the mid-septal myocardium near the biopsy region. Hierarchical clustering was then applied to identify distinct radiomic clusters. A representative feature known as the \"medoid\" was identified within each cluster based on its minimal dissimilarity from other features. Logistic regression models were built using one medoid per model to evaluate the association between each medoid and histological feature. Association was determined using odds ratio (OR) with a 95% confidence interval.</p><p><strong>Results: </strong>132 DCM patients (71% male, 94/132; 54 ± 15 years) were included in the study. Clustering analysis unveiled two radiomic clusters for each sequence. For native T₁, the medoids were textural features. The first medoid was associated with fibrosis, inflammation, myocyte hypertrophy, vacuolization, and fat replacement (OR = 2.84 [1.62-5.46]; OR = 2.05 [1.15-4.03]; OR = 2.39 [1.01-6.62]; OR = 2.03 [1.22-3.60]; OR = 0.35 [0.12-0.86]; respectively). The second medoid was associated with nuclear generation (OR = 0.55 [0.31-0.91]). ECV medoids included first-order and textural features. The first-order medoid was associated with fibrosis (OR = 2.97 [1.75-5.46]), myocyte hypertrophy (OR = 3.20 [1.17-10.37]), and nuclear degeneration (OR = 1.66 [1.02-2.89]), while medoid 2 (texture) was associated with fibrosis (OR = 4.44 [2.26-10.00]). LGE medoid 1 (texture) was associated with myocyte hypertrophy (OR = 0.31 [0.10-0.77]), while medoid 2 (texture) was associated with fibrosis (OR = 2.40 [1.38-4.66]) and vacuolization (OR = 2.00 [1.16-3.72]).</p><p><strong>Conclusions: </strong>In DCM patients, CMR radiomic signatures were associated with myocardial tissue composition, as assessed by invasive biopsy.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101881"},"PeriodicalIF":4.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12138411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and rationale of MYOFLAME-19 randomised controlled trial: MYOcardial protection to reduce post-COVID inFLAMmatory heart disease using cardiovascular magnetic resonance Endpoints.","authors":"Valentina O Puntmann, Dietrich Beitzke, Andreas Kammerlander, Inga Voges, Dominik D Gabbert, Marcus Doerr, Bishwas Chamling, Biykem Bozkurt, Juan Carlos Kaski, Erica Spatz, Eva Herrmann, Gernot Rohde, Philipp DeLeuw, Lenka Taylor, Christine Windemuth-Kieselbach, Cornelia Harz, Marta Santiuste, Laura Schoeckel, Juliana Hirayama, Peter C Taylor, Colin Berry, Eike Nagel","doi":"10.1016/j.jocmr.2024.101121","DOIUrl":"10.1016/j.jocmr.2024.101121","url":null,"abstract":"<p><strong>Background: </strong>Cardiac symptoms due to postacute inflammatory cardiac involvement affect a broad segment of previously well people with only mild acute coronavirus disease 2019 (COVID-19) illness and without overt structural heart disease. Cardiovascular magnetic resonance (CMR) imaging can identify the underlying subclinical disease process, which is associated with chronic cardiac symptoms. Specific therapy directed at reducing postacute cardiac inflammatory involvement before development of myocardial injury and impairment is missing.</p><p><strong>Methods: </strong>Prospective multicenter randomized placebo-controlled study of myocardial protection therapy (combined immunosuppressive/antiremodeling) of low-dose prednisolone and losartan. Consecutive symptomatic individuals with a prior COVID-19 infection, no pre-existing significant comorbidities or structural heart disease, undergo standardized assessments with questionnaires, CMR imaging, and cardiopulmonary exercise testing (CPET). Eligible participants fulfilling the criteria of subclinical post-COVID inflammatory heart involvement on baseline CMR examination are randomized to treatment with either verum or placebo for a total of 16 weeks (W16). Participants and investigators remain blinded to the group allocation throughout the study duration. The primary efficacy endpoint is the absolute change of left ventricular ejection fraction to baseline at W16, measured by CMR, between the verum treatment and placebo group by absolute difference, using unpaired t-test confirmatively at a significance level of 0.05 significance level. Secondary endpoints include assessment of changes of symptoms, CMR parameters, and CPET after W16, and frequency of major adverse cardiac events after 1 year. Safety data will be analyzed for frequency, severity, and types of adverse events (AEs) for all treatment groups. The proportion of AEs related to the contrast agent gadobutrol will also be analyzed. A calculated sample size is a total of 280 participants (accounting for 22 subjects (8%) drop out), randomized in 1:1 fashion to 140 in the verum and 140 placebo groups.</p><p><strong>Conclusion: </strong>Myoflame-19 study will examine the efficacy of a myocardial protection therapy in symptomatic participants with post-COVID inflammatory cardiac involvement determined by CMR. The aim of the intervention is to reduce the symptoms and inflammatory myocardial injury, improve exercise tolerance, and preclude the development of cardiac impairment.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101121"},"PeriodicalIF":4.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11697771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-, body surface area-, and sex-specific reference values for cardiovascular magnetic resonance imaging derived ventricular and atrial size and function for Chinese healthy children.","authors":"Ke Xu, Wei Bai, Zhi Yang, Rong Xu, Lin-Jun Xie, Ling-Yi Wen, Chuan Fu, Jie-Qian Zheng, Xin-Mao Ma, Hang Fu, Zhong-Qin Zhou, Cheng-Cheng Zhu, Xiao-Yue Zhou, Hua-Yan Xu, Ying-Kun Guo","doi":"10.1016/j.jocmr.2025.101885","DOIUrl":"10.1016/j.jocmr.2025.101885","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular magnetic resonance (CMR) is crucial for the diagnosis and prognosis of heart disease. However, normal reference values for CMR-derived morphology parameters have not been established for Chinese children. We sought to establish reference values for ventricular and atrial size and function parameters using CMR in healthy Chinese children across a broad age range.</p><p><strong>Methods: </strong>3T CMR scans were performed in 191 healthy children, aged 4-18 years. We used balanced steady-state free precession sequence for analyzing chamber size and function. Reference percentile curves and tables were generated using the generalized additive model for location scale and shape. A meta-analysis was conducted to compare our results with those of relevant previously published studies.</p><p><strong>Results: </strong>Boys generally had greater ventricular volumes and masses after normalization for body surface area (BSA) compared with girls. However, in the youngest age group (4-8 years), differences in volumes or masses between sexes were not found. Additionally, differences were not observed in left ventricular and right ventricular ejection fractions between sexes upon stratifying subjects based on age groups. However, after normalizing for BSA, only the maximal right atrial volume remained significantly greater in boys than that in girls. Age-specific and BSA-specific reference curves revealed non-linear relationships between age/BSA and cardiac parameters. Asian children exhibited significantly smaller chamber sizes compared to those seen in Caucasian children.</p><p><strong>Conclusion: </strong>We report normative CMR ventricular and atrial volume and function in Chinese children based on BSA, age, and sex, which can serve as a reference for future studies and clinical practice.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101885"},"PeriodicalIF":4.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12182818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Society for Cardiovascular Magnetic Resonance reference values (\"normal values\") in cardiovascular magnetic resonance: 2025 update.","authors":"Nadine Kawel-Boehm, Scott J Hetzel, Bharath Ambale-Venkatesh, Gabriella Captur, Calvin W L Chin, Christopher J François, Michael Jerosch-Herold, Judy M Luu, Zahra Raisi-Estabragh, Jitka Starekova, Michael Taylor, Max van Hout, David A Bluemke","doi":"10.1016/j.jocmr.2025.101853","DOIUrl":"10.1016/j.jocmr.2025.101853","url":null,"abstract":"<p><p>Quantitative assessment of morphological and functional cardiac parameters by cardiovascular magnetic resonance (CMR) is essential for research and routine clinical practice. Beyond established parameters of chamber size and function, tissue properties such as relaxation times play an increasing role. Normal reference ranges are required for interpretation of results obtained by quantitative CMR. Since the last publication of the \"normal values review\" in 2020 many new publications related to CMR reference values have been published, which were integrated in this update. The larger sample size provides greater statistical confidence in the estimates of upper and lower limits, and enables further partitioning, e.g., by age and ethnicity for several parameters. Previous topics were expanded by new sections.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101853"},"PeriodicalIF":4.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12159681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"True- and pseudo-mitral annular disjunction in patients undergoing cardiovascular magnetic resonance.","authors":"Kamil Stankowski, Federica Catapano, Dario Donia, Renato Maria Bragato, Pedro Lopes, João Abecasis, António Ferreira, Leandro Slipczuk, Pier-Giorgio Masci, Gianluigi Condorelli, Marco Francone, Stefano Figliozzi","doi":"10.1016/j.jocmr.2024.101413","DOIUrl":"10.1016/j.jocmr.2024.101413","url":null,"abstract":"<p><strong>Background: </strong>Mitral annular disjunction (MAD) is a controversial entity. Recently, a distinction between pseudo-MAD, present in systole and secondary to juxtaposition of the billowing posterior leaflet on the left atrial wall, and true-MAD, where the insertion of the posterior leaflet is displaced on the atrial wall both in diastole or in systole, has been proposed. We investigated the prevalence of pseudo-MAD and true-MAD.</p><p><strong>Methods: </strong>This was a retrospective study, including consecutive patients referred to cardiovascular magnetic resonance (CMR). MAD was defined as a ≥1 mm displacement between the left atrial wall-mitral valve leaflet junction hinge and the top of the left ventricular wall, measured from cine-CMR images in the three long-axis views. Pseudo-MAD and true-MAD were defined as the presence of MAD only in systole or both in systole and diastole, respectively.</p><p><strong>Results: </strong>Two hundred and ninety patients (59 [47-71] years; 181/290 men, 62%) were included. Mitral valve prolapse (MVP) and MAD were found in 24/290 (8%) and 145/290 (50%) patients, of which 100/290 (35%) with true-MAD and 45/290 (16%) with pseudo-MAD. In all measurements, systolic MAD extent (2.3 [1.7-3.0] mm) resulted equal to or greater than diastolic MAD extent (2.0 [1.5-2.9] mm). The most frequent MAD location was the inferior wall (117/290, 40%) and the inferolateral wall was the rarest (50/290, 17%). In patients with MVP, the prevalence of MAD was higher (21/24, 88%), mainly driven by a higher prevalence of pseudo-MAD, as the prevalence of true-MAD did not vary significantly in patients with vs without MVP (p = 0.22), except for the inferolateral wall (9/24, 38% vs 20/266, 8%; p < 0.001). The extent of pseudo-MAD was greater in patients with MVP (4.0 [3.0-5.6] mm) than in those without MVP (2.0 [1.5-3.0]; p < 0.001), whereas the extent of true-MAD did not differ significantly (2.5 [2.0-3.2] mm and 1.9 [1.5-2.9] mm; p = 0.06). At the inferolateral wall, the prevalence of pseudo-MAD was 7/24, 29% vs 14/266, 5% (p < 0.001) in patients with vs without MVP.</p><p><strong>Conclusion: </strong>True-MAD was a common imaging finding in patients undergoing CMR, irrespective of MVP. Patients with MVP showed higher prevalence and extent of pseudo-MAD in all locations and true-MAD in the inferolateral wall.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101413"},"PeriodicalIF":4.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786680/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiparametric cardiovascular magnetic resonance is associated with outcomes in pediatric heart transplant recipients.","authors":"Andrew A Lawson, Kae Watanabe, Lindsay Griffin, Christina Laternser, Michael Markl, Cynthia K Rigsby, Joshua D Robinson, Nazia Husain","doi":"10.1016/j.jocmr.2024.101138","DOIUrl":"10.1016/j.jocmr.2024.101138","url":null,"abstract":"<p><strong>Background: </strong>Multiparametric cardiovascular magnetic resonance (CMR) has an emerging role in non-invasive surveillance of pediatric heart transplant recipients (PHTR). Higher myocardial T2, higher extracellular volume fraction (ECV), and late gadolinium enhancement (LGE) have been associated with adverse clinical outcomes in adult heart transplant recipients. The purpose of this study was to investigate the prognostic value of CMR-derived T1 and T2 mapping, ECV, and LGE for clinical outcomes in PHTR.</p><p><strong>Methods: </strong>We performed a single-center, retrospective chart review of consecutive, gadolinium-enhanced CMR studies in PHTR over a 7.5-year period, excluding follow-up studies. Standard CMR ventricular volume and function analysis, T1 mapping with ECV, T2 mapping, and LGE assessment were performed. The composite outcome included cardiac death, non-cardiac death, re-transplantation, and cardiac hospitalization.</p><p><strong>Results: </strong>Among 113 PHTR, mean age was 13.0 ± 5.1 years, with 6.0 ± 4.0 years since transplant. The indication for CMR was surveillance in 79%. Mean native T1 was 1050 ± 48 ms, T2 49.2 ± 3.9 ms, and ECV 29.7 ± 4.5%. Left ventricular LGE was present in 37% (42/113) and right ventricular LGE in 3.5% (4/113). The mean follow-up time was 2.3 years and median was 1.4 years. Cardiac death occurred in 2% (2/113), re-transplantation in 4% (4/113), and cardiac hospitalization in 22% (25/113). Non-cardiac death did not occur. Using Kaplan-Meier analysis, high T1 (≥1061 ms), T2 (≥50.0 ms), and ECV (≥31.4%) were each associated with decreased freedom from the composite outcome in follow-up. In univariable Cox regression analyses, high T1 was associated with increased risk of the composite outcome (hazard ratios [HR] 4.0, 95% confidence interval [CI] 1.7-9.2, p = 0.001), as were high T2 (HR 2.8, 95% CI 1.1-7.1, p = 0.026), and high ECV (HR 3.5, 95% CI 1.5-8.1, p = 0.004).</p><p><strong>Conclusion: </strong>T1 and T2 mapping are associated with early differences in adverse cardiac events in PHTR. These data suggest a role for a multicenter study with a longer follow-up duration.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101138"},"PeriodicalIF":4.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular magnetic resonance worldwide: A global commitment to cardiovascular care.","authors":"Carlos E Rochitte","doi":"10.1016/j.jocmr.2025.101842","DOIUrl":"10.1016/j.jocmr.2025.101842","url":null,"abstract":"","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101842"},"PeriodicalIF":4.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12182810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing extravascular lung water-A dual-contrast agent extracellular volume approach by cardiovascular magnetic resonance.","authors":"Felicia Seemann, Rim N Halaby, Andrea Jaimes, Kendall O'Brien, Peter Kellman, Daniel A Herzka, Robert J Lederman, Adrienne E Campbell-Washburn","doi":"10.1016/j.jocmr.2025.101883","DOIUrl":"10.1016/j.jocmr.2025.101883","url":null,"abstract":"<p><strong>Background: </strong>Pathological extravascular lung water is a facet of decompensated congestive heart failure that current cardiovascular magnetic resonance (CMR) methods fail to quantify. CMR can measure total lung water density, but cannot distinguish between intravascular and extravascular fluid, and thus is not diagnostic. Therefore, we develop and evaluate a novel method to measure extravascular lung water by distinguishing intravascular from extracellular fluid compartments using two different contrast agents, extracellular gadolinium chelates and iron-based intravascular ferumoxytol.</p><p><strong>Methods: </strong>We created two porcine models of pulmonary edema: reversible catheter-induced mitral regurgitation to induce extravascular lung water (n = 5); intravascular volume overload using rapid colloid infusion (n = 5); and compared to normal controls (n = 8). We sequentially acquired lung T1 maps and lung water density maps at 0.55T with native, gadolinium-based, and ferumoxytol contrast, from which we calculated the extracellular volume fraction (ECV) and blood plasma volume fraction in the pulmonary tissue, respectively. We computed extravascular ECV as the difference in ECV and plasma volume fractions. Extravascular lung water volumes were estimated.</p><p><strong>Results: </strong>In the mitral regurgitation model, baseline vs mitral regurgitation ECV_{extravascular} increased from 27 ± 4.1% to 32 ± 1.9% (p = 0.006), and extravascular lung water volume increased from 105 ± 19 mL to 143 ± 15 mL (p = 0.048). Plasma volume fraction was similar at baseline vs mitral regurgitation (43 ± 4.2% vs 46 ± 5.4%, p = 0.26). Compared to naïve pigs, we measured higher plasma volume fractions in the intravascular volume-loaded model (42 ± 4.7% vs 51 ± 2.7%, p = 0.0054), but no differences in ECV_{extravascular} (21 ± 4.6% vs 21 ± 3.6%, p = 0.99) or extravascular lung water volume (67 ± 13 mL vs 89 ± 24 mL, p = 0.11). Assessing the regional distribution, the plasma volume was higher posteriorly, indicating gravitational dependency, whereas, the extravascular lung water was higher anteriorly.</p><p><strong>Conclusion: </strong>Extravascular lung ECV measurements and derived lung water volumes corresponded well with predicted increases in extravascular and intravascular pulmonary fluid in animal models. This method may enable mechanistic studies of lung water in patients with dyspnea.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101883"},"PeriodicalIF":4.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12182819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myocardial native T1 and extracellular volume measurements at 5T: Feasibility study and initial experience.","authors":"Yubo Guo, Lu Lin, Keting Xu, Shihai Zhao, Gan Sun, Yuyan Chen, Ke Xue, Yuxin Yang, Shuo Chen, Yan Zhang, Yanjie Zhu, Yining Wang","doi":"10.1016/j.jocmr.2025.101896","DOIUrl":"10.1016/j.jocmr.2025.101896","url":null,"abstract":"<p><strong>Background: </strong>T1 mapping is a robust and highly reproducible technique for quantitative assessment of cardiomyopathy. The aim of this study is to investigate the feasibility of 5T myocardial T1 mapping and to establish preliminary reference values for myocardial T1 at 5T.</p><p><strong>Methods: </strong>Twenty-eight healthy volunteers (median age, 42 [interquartile range (IQR): 29-54] years; 14 male) and 11 patients (median age, 44 [IQR: 34-51] years; 7 male) underwent cardiovascular magnetic resonance at 5T. T1 mapping was acquired using a motion-corrected modified Look-Locker inversion recovery sequence [5(3)3 scheme for pre-contrast, (4(1)3(1)2) scheme for post-contrast] in three short-axis planes (base, middle, and apex). T1 values were quantified per segment, per slice, and globally.</p><p><strong>Results: </strong>Healthy volunteers had a mean global native T1 value of 1506.2 ± 41.7 ms, with T1 values decreasing progressively from the base to the apex slice (P = 0.08). Significantly higher T1 values were revealed in the septum compared to the non-septal myocardium (1540.1 ± 69.3 vs 1477.6 ± 93.7, P < 0.001). No statistically significant gender- and age-related differences were observed in native T1 values (both, P > 0.05). Within the spectrum of cardiac pathologies analyzed in this study, patients exhibited higher native T1 values (1638.7 ± 108.6 ms vs 1506.2 ± 41.7 ms, P < 0.001) and higher extracellular volume fraction (37.5% ± 5.5% vs 29.5% ± 2.1%, P = 0.074) compared to healthy volunteers, late gadolinium enhancement (LGE)-positive segments exhibited significantly higher T1 values than LGE-negative segments (1685.2 ± 144.1 vs 1582.6 ± 88.7, P < 0.001). There was excellent intra-scanner test-retest, intra-observer, and inter-observer reproducibility for measurement of native T1.</p><p><strong>Conclusion: </strong>The present study demonstrated the feasibility of T1 mapping quantification at 5T and presented mean native T1 values in healthy human myocardium at this field strength, which can be used as reference values specific for this magnetic resonance setting.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":"27 1","pages":"101896"},"PeriodicalIF":4.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12182820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}