Journal of cataract and refractive surgery最新文献

{"title":"One-Year Outcomes after implantation of an Extended Depth of Focus Intraocular Lens in Cataract patients.","authors":"Joaquín Fernández, Noemí Burguera, Marina Rodríguez-Calvo-de-Mora, Carlos Rocha-de-Lossada, Manuel Rodríguez-Vallejo","doi":"10.1097/j.jcrs.0000000000001737","DOIUrl":"https://doi.org/10.1097/j.jcrs.0000000000001737","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the clinical outcomes of a new extended depth of focus (EDF) intraocular lens (IOL) in patients with cataracts.</p><p><strong>Setting: </strong>(\"Masked by journal requirement\").</p><p><strong>Design: </strong>Retrospective observational.</p><p><strong>Methods: </strong>Data was retrospectively reviewed for a cohort of 51 consecutively operated cataract patients implanted with the ELON (Medicontur) IOL and followed over a 12-month period. The variables collected for analysis included visual acuities (VAs) at various distances (far, intermediate, and near), light distortion index (LDI), defocus curves (DC), and prediction error. Additionally, patient-reported outcomes were gathered to assess spectacle dependence, satisfaction with vision, positive dysphotopsia, difficulties in daily activities, and patients' willingness to undergo the same IOL procedure again.</p><p><strong>Results: </strong>Monocular data for efficacy was available for 36 patients at the 3-month follow-up and 23 patients at the 12-month follow-up. Median monocular distance-corrected VAs were 0, 0.1, and 0.3 logMAR at 4 m, 66 cm, and 40 cm, respectively, at 3 and 12 months. Correlations between VAs and pupil diameter were found but only at near for binocular uncorrected (rho=0.38, p=0.02) and monocular distance corrected (rho=0.31, p=0.07). The median LDI reduced up to 9% at 12-month. No significant differences were found between follow-up visits for VAs and LDI (p>0.05); however, satisfaction, positive dysphotopsia, and willingness to undergo the same IOL procedure significantly improved from 3 to 12 months (p<0.05).</p><p><strong>Conclusions: </strong>The ELON IOL extended the depth of field from far to intermediate distances, with some patients with smaller pupil diameters also achieving near vision restoration.</p>","PeriodicalId":15214,"journal":{"name":"Journal of cataract and refractive surgery","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144608494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Demand for Cataract Surgery in the United States: A Google Trends Analysis.","authors":"Justin H Cheong, Zacharia H Nayer, Danielle F Trief","doi":"10.1097/j.jcrs.0000000000001736","DOIUrl":"https://doi.org/10.1097/j.jcrs.0000000000001736","url":null,"abstract":"<p><strong>Descriptive abstract: </strong>This study estimates public demand for cataract surgery across the United States and identifies potential areas of unmet need. Google Trends search data for \"cataract surgery\" were used to determine the relative search volume (RSV) by state. The American Society of Cataract and Refractive Surgery (ASCRS) member directory was used to estimate the state-by-state concentrations of cataract and refractive surgeons. The demand index (DI) was computed as RSV divided by surgeon concentration. From 2004-2023, the RSV for \"cataract surgery\" increased by 277%. In 2023, RSVs were highest in Maine and West Virginia (100) and lowest in Utah (56). Surgeon density was highest in Massachusetts (1.93) and lowest in Alaska (0.41). The DI was highest in Alaska (180.9) and lowest in Utah (38.3). This study reveals significant geographic variability in the RSV, availability of surgeons, and demand index for cataract surgery across the United States.</p>","PeriodicalId":15214,"journal":{"name":"Journal of cataract and refractive surgery","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144608491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INTRAOCULAR LENS POWER CALCULATION ADAPTED TO SUTURELESS SCLERAL FIXATION WITH YAMANE TECHNIQUE.","authors":"Antonia Maria Luce De Vitto, Fiammetta Pasculli, Ferdinando Cione, Paolo Santorum, Nicola Rosa, Maddalena De Bernardo, Martin Emesz, Enrico Bertelli","doi":"10.1097/j.jcrs.0000000000001739","DOIUrl":"10.1097/j.jcrs.0000000000001739","url":null,"abstract":"<p><strong>Purpose: </strong>To assess reliability of different IOL power calculation formulas in secondary IOL implantation with sutureless scleral fixation (Yamane technique).</p><p><strong>Setting: </strong>\"San Maurizio\" Hospital, Bolzano, Italy; University of Salerno, Italy.</p><p><strong>Design: </strong>Retrospective cohort study.</p><p><strong>Methods: </strong>Fifty eyes of 50 patients who underwent secondary IOL implantation with Yamane technique were analyzed. Surgery was performed with a standardized technique using the needle stabilizer. Barrett Universal-II, EVO-2.0, Hoffer-Q, Holladay-1, SRKT, T2 and T2.2 formulas were analyzed in terms of mean error (ME), median absolute error (MedAE) and percentages of eyes with refractive prediction error (PE) less than ±0.50/±1.00D. Both IOLCon and optimized constants through zeroing-out the MEs were analyzed. Additionally, formulas were also tested with decreased optimized-IOLCon constants (DOC) by a fixed value of -0.5.</p><p><strong>Results: </strong>All formulas reported a myopic shift of MEs with IOLCon constants (ranging from -0.43D to -0.31D, all p<0.050). No statistically significant differences among methods in terms of MedAE were reported both with IOLCon and optimized constants (all p>0.050). By using DOC-0.5, all formulas reported MEs not different from zero (all p≥0.491) and all MEs were lower than IOLCon MEs (all p<0.001), with comparable MedAE and percentages of eyes with PE less than ±0.50/±1.00D (all p>0.050).</p><p><strong>Conclusion: </strong>In case of \"out-of-the-bag\" IOL implantation, a systematic error independent from the applied formula but linked to surgery technique was found. Using DOC-0.5 can eliminate such a bias. The study highlights the importance of refining lens constants in case of scleral fixation, to eliminate any systematic error in IOL power calculation.</p>","PeriodicalId":15214,"journal":{"name":"Journal of cataract and refractive surgery","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144608492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nationwide study of the association between keratoconus and autism spectrum disorder.","authors":"Hilde Bjerkreim, Bjarne Løberg Thorbjørnsen, Terje Nærland, Liv Drolsum, Olav Kristianslund","doi":"10.1097/j.jcrs.0000000000001740","DOIUrl":"https://doi.org/10.1097/j.jcrs.0000000000001740","url":null,"abstract":"<p><strong>Purpose: </strong>To examine whether there was an association between keratoconus and autism spectrum disorder (ASD) in Norway and compare to the general population.</p><p><strong>Setting: </strong>The total population of Norway, including all individuals with ASD and keratoconus.</p><p><strong>Design: </strong>Cross-sectional epidemiological study.</p><p><strong>Methods: </strong>Data was obtained from the Norwegian Patient Registry, which provides information from all publicly-funded specialist care. The keratoconus prevalence among persons with ASD, was estimated from the total number of individuals with keratoconus in the period 2010-2019, and compared to the prevalence in the general population of Norway during the same time period.</p><p><strong>Results: </strong>A population-based sample in Norway identified 23 763 persons with ASD, equivalent to 0.5% of the population, and of these 115 (0.5%) had a diagnosis of keratoconus. The average age at keratoconus diagnosis among individuals with ASD was 27.3 years, and 83.5% of those diagnosed with both ASD and keratoconus were men. During the same time period, the prevalence of keratoconus in the general population of Norway was 0.2%, resulting in an odds ratio of 2.5 (95% CI: 2.0-3.0).</p><p><strong>Conclusion: </strong>Based on our findings, people with ASD have significantly higher prevalence of keratoconus compared to the general population of Norway. This implicates that one should have increased awareness for keratoconus and low threshold for corneal tomography in patients with ASD.</p>","PeriodicalId":15214,"journal":{"name":"Journal of cataract and refractive surgery","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144608493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variations in morphology and patency of disposable hydrodissection cannulas used in cataract surgery.","authors":"Shwetha Mudalegundi, Melissa Yao, Jesse Chew, Neil Kelkar, Kevin Eid, Jesus Paulo Perez, Ethan Driffill, Nick Mamalis, Liliana Werner","doi":"10.1097/j.jcrs.0000000000001735","DOIUrl":"https://doi.org/10.1097/j.jcrs.0000000000001735","url":null,"abstract":"<p><strong>Purpose: </strong>To perform a detailed laboratory assessment of the variability in morphology (shape of opening port and surface finishing), as well as patency of Chang-style hydrodissection cannulas used in cataract surgery.</p><p><strong>Setting: </strong>John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.</p><p><strong>Design: </strong>Experimental Study.</p><p><strong>Methods: </strong>A total of 44 disposable cannulas from 3 different manufacturers were evaluated in this study. Seventeen cannulas were primed with solution, and then underwent analyses under gross and light microscopy. Twenty-seven other cannulas were directly removed from the package, and underwent the same above-mentioned analyses, before priming. Selected cannulas from the 3 manufacturers were also evaluated under scanning electron microscopy and surface analyses for elemental composition.</p><p><strong>Results: </strong>There was variability in all parameters evaluated in this study, including opening ports that were irregular in shape, partially or totally blocked, as well as a cannula with a second, lateral opening port. The surface finishing of the tips of the cannulas was also variable, with cannulas exhibiting irregular and/or sharp edges, as well as what appeared to be debris/residues. Fluid streams obtained with the cannulas also varied, and while some cannulas produced a normal stream, others produced a weak stream, no stream, or double stream. All cannulas were composed of stainless steel, and debris/residues appeared to correspond to organic residues.</p><p><strong>Conclusion: </strong>The findings in this study raise concerns about potential damage to the capsule, as well as toxic anterior segment syndrome. Priming before use in surgery is advisable to confirm appropriate fluid flow.</p>","PeriodicalId":15214,"journal":{"name":"Journal of cataract and refractive surgery","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of visual performance among three higher-order aspheric enhanced monofocal intraocular lenses and a standard aspheric monofocal lens.","authors":"Shunsuke Hayashi, Motoaki Yoshida, Ken Hayashi, Kazuno Negishi","doi":"10.1097/j.jcrs.0000000000001734","DOIUrl":"https://doi.org/10.1097/j.jcrs.0000000000001734","url":null,"abstract":"<p><strong>Purpose: </strong>To compare visual performance among three types of higher-order aspheric enhanced monofocal intraocular lenses (IOL) and a standard aspheric monofocal IOL.</p><p><strong>Setting: </strong>Hayashi Eye Hospital, Fukuoka, Japan.</p><p><strong>Design: </strong>Randomized comparative study.</p><p><strong>Methods: </strong>Three hundred forty-four eyes of 172 patients scheduled for phacoemulsification were randomly assigned to one of four groups according to the IOL type: three types of enhanced monofocal IOL, 1) Eyhance, 2) Impress, and 3) NSP-3, and a standard monofocal IOL, 4) Tecnis monofocal. At 2 months postoperatively, monocular and binocular distance-corrected visual acuity (VA) from far to near simulated distances, photopic and mesopic contrast VA, and degree of halo and glare symptoms were measured and compared among groups.</p><p><strong>Results: </strong>Mean monocular and binocular distance-corrected intermediate VA at 0.5, 0.7, and 1.0 m was essentially better in the three enhanced monofocal IOL groups than in the standard monofocal IOL group (P ≤ .04), whereas mean far and near distance-corrected VAs at 0.3, 2.0, 3.0, 5.0, and ∞ m did not differ significantly among the four groups. Mean photopic and mesopic contrast VA and the size and intensity of halo and glare symptoms did not differ significantly among groups.</p><p><strong>Conclusions: </strong>The three enhanced monofocal IOL types evaluated provided significantly better intermediate VA than a standard monofocal IOL with no significant deterioration in contrast sensitivity or photic symptoms. All visual performance test results examined were comparable among the three enhanced monofocal IOL types, suggesting that enhanced monofocal IOLs can serve as a replacement for standard monofocal IOLs.</p>","PeriodicalId":15214,"journal":{"name":"Journal of cataract and refractive surgery","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishing the ground truth for keratoconus progression: combining repeated measures and adapting precision limits to disease severity in tomography.","authors":"Dr Shafi Balal, Dr Yijun Cai, Ms Lynn Kandakji, Dr Siyin Liu, Dr Pádraig J Mullholand, Mr Marcello Leucci, Dr Nikolas Pontikos, Dr Daniel Gore, Bruce Allan","doi":"10.1097/j.jcrs.0000000000001692","DOIUrl":"10.1097/j.jcrs.0000000000001692","url":null,"abstract":"<p><strong>Purpose: </strong>Keratoconus progression is defined with reference to precision limits in corneal tomography. We set out to analyse measurement precision using a contemporary tomography device (MS-39, CSO Italia, Florence, Italy) in a large sample of keratoconus patients.</p><p><strong>Setting: </strong>Moorfields Eye Hospital, London, UK.</p><p><strong>Design: </strong>Prospective and retrospective analysis of clinical data.</p><p><strong>Methods: </strong>For a range of key corneal tomographic indices, repeatability and reproducibility were compared in a prospective series of 1,248 scans (n= 208 eyes) with 2 observers each acquiring 3 scans per eye. Measurement repeatability for single measures versus the mean of 3 consecutive measures was then compared using the same dataset. 95% repeatability coefficients (RC) were mapped at each unit interval through the measurement range in a retrospective analysis of 13,734 scans (n=4,578 eyes) to adapt progression thresholds to disease severity. Finally, keratoconus classification using alternate progression definitions was compared at 1 and 2 year time points.</p><p><strong>Results: </strong>For all corneal tomographic indices examined, no significant differences were found between MS-39 measurement repeatability and reproducibility (p>0.05), repeatability was (average) 44% improved using the mean of 3 consecutive measures, and measurement repeatability deteriorated as keratoconus advanced. Progression was classified incorrectly in over 50% of cases at both time points where adaptive thresholds and repeated measures were not used.</p><p><strong>Conclusions: </strong>MS-39 measurement precision is not significantly influenced by the operator. Consecutive repeated measures and adaptive thresholds for observed change in key tomographic parameters based on device specific precision limits tailored to disease severity are necessary for accurate classification of progression.</p>","PeriodicalId":15214,"journal":{"name":"Journal of cataract and refractive surgery","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calorimetric Method for Measuring Phacoemulsification Energy Delivered During Cataract Surgery.","authors":"Dr Rosa Braga-Mele, Satish Yalamanchili, Sarah Makari, Guangyao Jia","doi":"10.1097/j.jcrs.0000000000001730","DOIUrl":"https://doi.org/10.1097/j.jcrs.0000000000001730","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to determine the ultrasound (US) energy delivered to the eye during cataract surgery in Joules, a universal System Internacional (SI) unit of energy. This SI energy unit of measurement allows for comparison among various US modalities, phacoemulsification systems and other applications.</p><p><strong>Setting: </strong>Laboratory.</p><p><strong>Design: </strong>Experimental laboratory phacoemulsification energy dissipation model.</p><p><strong>Methods: </strong>A calorimetric method of energy measurement was used, with a US handpiece, tip, and sleeve were held in place by an adaptor into a test chamber holding 0.5 g of water. Thermocouples measured the water temperature rise. The ultrasound power was tested in 10% increments from 10% to 100% with each ultrasound modality.</p><p><strong>Results: </strong>High repeatability was observed in both the torsional and longitudinal modality, as indicated by a coefficient of variation less than 0.5 for each power level and the low standard deviation magnitude across the tests (0.020 J/s to 0.149 J/s in the torsional modality and 0.036 J/s to 0.150 J/s in the longitudinal modality, depending on ultrasound power levels). Third order polynomials demonstrated strong and non-linear correlations between ultrasound energy and power levels as indicated by high R2 values (>0.99).</p><p><strong>Conclusion: </strong>A calorimetric ultrasound energy measurement method provides greater insight into the total energy in the eye. Measuring total phacoemulsification energy in Joules allows for a standardized way to compare total energy across variable platforms and to be used as a potentially more clinically relevant proxy for assessing and improving clinical outcomes.</p>","PeriodicalId":15214,"journal":{"name":"Journal of cataract and refractive surgery","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barrett RX tool for intraocular lens power calculation in pseudophakic eyes undergoing intraocular lens exchange.","authors":"Klemens Paul Kaiser, Tyll Jandewerth, Joukje C Wanten, Christoph Lwowski, Mariam Sobhi, Rudy M M A Nuijts, Thomas Kohnen","doi":"10.1097/j.jcrs.0000000000001732","DOIUrl":"https://doi.org/10.1097/j.jcrs.0000000000001732","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the accuracy of refraction prediction after intraocular lens (IOL) exchange using a software integrated in a Scheimpflug-based biometer.</p><p><strong>Setting: </strong>Two tertiary referral hospitals.</p><p><strong>Design: </strong>A first case series.</p><p><strong>Methods: </strong>Eyes that underwent uneventful bag-to-bag IOL exchange between 2017 and 2024 and complete pre- and postoperative measurements were included. IOL exchange was performed by two experienced surgeons. IOL power was calculated using the Barrett RX formula integrated in Pentacam software (Oculus Optikgeräte GmbH, Wetzlar, Germany), incorporating both phakic and pseudophakic biometric data and subjective refraction. Prediction errors were computed by comparing actual postoperative and predicted refractions. Moreover, a unpublished estimation formula was applied.</p><p><strong>Results: </strong>Twenty-five eyes of 25 patients (mean age 60.2±11.4 years) were included. Mean interval between primary IOL implantation and exchange was 25.3±31.5 weeks. In 11/25 eyes, a different IOL model was implanted during the exchange. Using the Barrett RX formula, the mean prediction error (MPE) was 0.02±0.32D, mean absolute error (MAE) 0.27±0.17D, and median absolute error (MedAE) 0.22D. A total of 56% and 92% of eyes were within ±0.25D and ±0.50D of target refraction, respectively. The conventional formula yielded a comparable MPE of -0.12±0.68D (p=0.479), but higher MAE and MedAE (0.53±0.42D and 0.40D, p<0.001), with 32% and 56% of eyes within ±0.25D and ±0.50D, respectively.</p><p><strong>Conclusion: </strong>The Barrett RX formula has been demonstrated to be an efficacious method for calculating IOL power in eyes undergoing IOL exchange, with more than half of cases within ±0.25D of the predicted post-exchange refraction.</p>","PeriodicalId":15214,"journal":{"name":"Journal of cataract and refractive surgery","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Variants in Genes Regulating Lens Capsule Structure and Stability in Dead Bag Syndrome - Part 1.","authors":"Abhay R Vasavada, Sankaranarayanan Rajkumar, Shail A Vasavada, Vaishali Vasavada, Suchi Dholu, Vijaylaxmi Meena","doi":"10.1097/j.jcrs.0000000000001733","DOIUrl":"https://doi.org/10.1097/j.jcrs.0000000000001733","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate potential genetic variants associated with spontaneous Posterior Capsule Rupture (sPCR) in patients diagnosed with Dead Bag Syndrome (DBS).</p><p><strong>Setting: </strong>Iladevi Cataract and Intraocular Lens (IOL) Research Centre and Raghudeep Eye Hospital, Ahmedabad, Gujarat, India.</p><p><strong>Design: </strong>Laboratory Study.</p><p><strong>Methods: </strong>We collected blood samples from 30 DBS patients and 37 controls. Whole-exome sequencing (WES) was performed. Genetic variants in genes encoding extracellular matrix (ECM) components of the lens capsule were screened. The association of selected variants with DBS was analysed using the Optimal Unified Sequence Kernel Association Test (SKAT-O) in R and Logistic Regression. Genes showing significant associations were further analysed using in silico predictions via the Ensembl Variant Effect Predictor (eVEP) to assess their potential impact on protein function.</p><p><strong>Results: </strong>Three genes-FBN2 (P=.027, OR=4.9, 95% CI=0.56-42.72), LAMB1 (P=.005, OR=11.0, 95% CI=1.56-77.31), and LAMB2 (P=.091, OR=8.2, 95% CI=1.03-65.57)-were found to be positively associated with DBS. A total of 15 distinct, functionally deleterious genetic variants, including 6 in FBN2, 3 in LAMB1, and 6 in LAMB2 genes were identified across 17 (56.7%) patients with DBS. Of the 17 patients, 5 (29.4%) carried a common genetic variant (p.Ile1547Thr; rs35915664, MAF=0.016) in the LAMB1 gene, which was absent in controls.</p><p><strong>Conclusions: </strong>The genetic variants found in FBN2, LAMB1, and LAMB2 genes may compromise the strength and stability of the lens capsule over time, predisposing individuals to DBS and sPCR later in life. The study shows for the first time that the DBS has a genetic predisposition.</p>","PeriodicalId":15214,"journal":{"name":"Journal of cataract and refractive surgery","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}