Journal of Cardiovascular and Thoracic Research最新文献_第9页

Spontaneous pneumomediastinum; Time for a consensus. 自发的纵隔气肿;是时候达成共识了。

IF 1.1

Journal of Cardiovascular and Thoracic Research Pub Date : 2022-01-01 Epub Date: 2022-08-30 DOI: 10.34172/jcvtr.2022.26

Santiago Campbell-Silva

{"title":"Spontaneous pneumomediastinum; Time for a consensus.","authors":"Santiago Campbell-Silva","doi":"10.34172/jcvtr.2022.26","DOIUrl":"https://doi.org/10.34172/jcvtr.2022.26","url":null,"abstract":"Dear Editor, Considering the article published by Hülya Dirol and Hakan Keskin: Risk factors for mediastinitis and mortality in Pneumomediastinum,1 I would like to respectfully give my opinion on the so-called spontaneous pneumomediastinum. We agree in dividing pneumomediastinum into primary and secondary, but we consider that the primary is the truly spontaneous or idiopathic, terms that should be omitted and called primary. This pneumomediastinum cannot have any predisposing or precipitating factor. The secondary, can in turn be traumatic and non-traumatic, and the latter is where the predisposing and precipitating factors influence (Figure 1). According to current literature, any pneumomediastinum that is not traumatic is “spontaneous”, but it happens that the group called spontaneous is the one with the greatest triggering cause. This creates confusion and causes conceptual difficulty. We believe that the classification should evolve towards greater accuracy. For us, if a PM has a predisposing factor that compromises the pulmonary structure whether congenital, hereditary, or genetic (bronchiectasis, cystic fibrosis, surfactant alterations, etc.) or acquired (asthma, COPD, interstitial lung disease, COVID-19, etc.), it cannot be spontaneous because there is an underlying predisposing disease. Similarly, the pneumomediastinum that occurs due to a precipitating factor (coughing, labor, intense exercise, use of inhaled drugs, mechanical ventilation, etc.) in a healthy subject or with an underlying lung disease cannot be","PeriodicalId":15207,"journal":{"name":"Journal of Cardiovascular and Thoracic Research","volume":"14 3","pages":"212-213"},"PeriodicalIF":1.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9617058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40712302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 107

Predictive value of C-reactive protein/albumin ratio for no-reflow in patients with non-ST-elevation myocardial infarction. c反应蛋白/白蛋白比值对非st段抬高型心肌梗死患者无血流的预测价值。

IF 1.1

Journal of Cardiovascular and Thoracic Research Pub Date : 2022-01-01 DOI: 10.34172/jcvtr.2022.30549

Aydın Rodi Tosu, Tufan Çinar, Muhsin Kalyoncuoğlu, Halil İbrahim Biter, Sinem Çakal, Beytullah Çakal, Murat Selçuk, Erdal Belen, Mehmet Mustafa Can

{"title":"Predictive value of C-reactive protein/albumin ratio for no-reflow in patients with non-ST-elevation myocardial infarction.","authors":"Aydın Rodi Tosu, Tufan Çinar, Muhsin Kalyoncuoğlu, Halil İbrahim Biter, Sinem Çakal, Beytullah Çakal, Murat Selçuk, Erdal Belen, Mehmet Mustafa Can","doi":"10.34172/jcvtr.2022.30549","DOIUrl":"https://doi.org/10.34172/jcvtr.2022.30549","url":null,"abstract":"Introduction: The focus of this research was to explore the link between CRP (C-reactive protein) /albumin ratio (CAR), a novel inflammatory response marker, and no-reflow (NR) phenomena in non-ST elevation myocardial infarction (non-STEMI) patients during percutaneous coronary intervention (PCI). Methods: The current study recruited 209 non-STEMI participants who underwent PCI. The patients were divided into two groups based on their post-intervention Thrombolysis in Myocardial Infarction (TIMI) flow grade; those with and without NR. Results: In all, 30 non-STEMI patients (6.9%) had NR after PCI. CAR values were substantially greater in the NR group. The CAR was identified to be a determinant of the NR (OR: 1.250, 95% CI: 1.033-1.513, P=0.02), although CRP and albumin were not independently related with NR in the multivariate analysis. In our investigation, low density lipoprotein-cholesterol levels and high thrombus burden were also predictors of the occurrence of NR. According to receiver operating characteristic curve evaluation, the optimal value of CAR was>1.4 with 60% sensitivity and 47% specificity in detecting NR in non-STEMI patients following PCI. Conclusion: To the best of knowledge, this is the first investigation to demonstrate that the CAR, a new and useful inflammatory marker, can be utilized as a predictor of NR in patients with non-STEMI prior to PCI.","PeriodicalId":15207,"journal":{"name":"Journal of Cardiovascular and Thoracic Research","volume":"14 4","pages":"214-219"},"PeriodicalIF":1.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9871161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9178058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simultaneous beat-to-beat heart rate and systolic blood pressure variability in patients with and without neurally mediated syncope. 伴有和不伴有神经介导性晕厥的患者的同时搏动心率和收缩压变异性。

IF 1.1

Journal of Cardiovascular and Thoracic Research Pub Date : 2022-01-01 Epub Date: 2022-06-21 DOI: 10.34172/jcvtr.2022.18

Amirhossein Akbarzadeh, Fariborz Akbarzadeh, Babak Kazemi

{"title":"Simultaneous beat-to-beat heart rate and systolic blood pressure variability in patients with and without neurally mediated syncope.","authors":"Amirhossein Akbarzadeh, Fariborz Akbarzadeh, Babak Kazemi","doi":"10.34172/jcvtr.2022.18","DOIUrl":"https://doi.org/10.34172/jcvtr.2022.18","url":null,"abstract":"Introduction: Autonomic changes play an essential role in the genesis of neurally mediated syncope (NMS). The aim of this study was to compare the changes of the autonomic nervous system (ANS) by measuring spectral indices of beat-to-beat systolic blood pressure and heart rate variability (SBPV and HRV) in ranges of low frequency (LF), high frequency (HF), and the LF/HF ratio during head-up tilt test (HUTT) in patients with and without a syncope response. Methods: In this case-control study of 46 patients with a suspected history of unexplained syncope, data were recorded separately during the typical three phases of HUTT. Patients who developed syncope were designated as the case group and the rest as the control group. Results: Thirty one patients experienced syncope during HUTT. Resting HRV and SBPV indices were significantly lower in cases than controls. After tilting in the syncope group, both HF and LF powers of SBPV showed a significant and gradual decrease. LF/HF in HRV increased in both groups similarly during the test but in SBPV, mainly driven by oscilations in its LF power, it increased significantly more during the first two phases of the test in syncope patients only to paradoxically decrease during active tilt (P< 0.001). Conclusion: Our findings show an abnormal autonomic function in patients with syncope, both at rest and tilting. Fluctuations of spectral indices of beat-to-beat SBPV, a potential noval index of pure sympathetic activity, show an exaggerated response during tilt and its withdrawal before syncope.","PeriodicalId":15207,"journal":{"name":"Journal of Cardiovascular and Thoracic Research","volume":"14 2","pages":"108-115"},"PeriodicalIF":1.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40676128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive role of novel echocardiographic parameter aortic velocity propagation, QRISK3 and Framingham risk score for presence and severity of CAD in Asian patients. 新型超声心动图参数主动脉速度传播、QRISK3和Framingham风险评分对亚洲患者冠心病存在和严重程度的预测作用

IF 1.1

Journal of Cardiovascular and Thoracic Research Pub Date : 2022-01-01 Epub Date: 2022-07-26 DOI: 10.34172/jcvtr.2022.25

Pooja Vyas, Jaykumar Vadodariya, Vijay Kalsariya, Iva Patel, Radhakisan Dake, Kunal Parwani

{"title":"Predictive role of novel echocardiographic parameter aortic velocity propagation, QRISK3 and Framingham risk score for presence and severity of CAD in Asian patients.","authors":"Pooja Vyas, Jaykumar Vadodariya, Vijay Kalsariya, Iva Patel, Radhakisan Dake, Kunal Parwani","doi":"10.34172/jcvtr.2022.25","DOIUrl":"https://doi.org/10.34172/jcvtr.2022.25","url":null,"abstract":"Introduction: Despite having clinical relevance, arterial stiffness is neglected and not routinely used parameter for evaluation of atherosclerosis. This study aimed to investigate the predictive role of simple non-invasive echocardiographic index of aortic stiffness aortic velocity propagation (AVP), Framingham risk score (FHS) and QRISK3 score for presence and severity of CAD. Methods: This cross-sectional comparative study included 250 patients who required conventional coronary angiogram for stable CAD. The relationship of AVP, FHS and QRISK3 score with CAD were evaluated using spearman’s correlation, logistic regression analysis and ROC curve. Results: On logistic regression analysis, AVP, FHS and QRISK3 were found significant predictors for the presence and severity of CAD. Inverse correlation between AVP and presence of CAD, number of coronary vessels involved and severity of CAD was observed with P=0.001. AVP value≤78 cm/s predicted presence of CAD with 86.4% sensitivity and 84.6% specificity (P≤0.0001, AUC=0.948) and≤39 cm/s predicted severe CAD (Syntax score>22) with 66.7% sensitivity and 97.9% specificity (P≤0.0001, AUC=0.868). FHS value>10 predicted the presence of CAD with a sensitivity of 33.9% and specificity of 91 % (P=0.01, AUC=0.644). QRISK3value>13.4 predicted presence of CAD with 57.1% sensitivity and 87% specificity (P≤0.0001, AUC=0.788). Conclusion: Arterial stiffness parameter AVP is inversely associated with the presence and severity of CAD. AVP and QRISK3 score may be used as a simple bedside tool for risk stratification of patients suspected of having atherosclerotic CAD.","PeriodicalId":15207,"journal":{"name":"Journal of Cardiovascular and Thoracic Research","volume":"14 3","pages":"153-158"},"PeriodicalIF":1.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9617064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40712299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The incidence and mortality rates due to stroke and myocardial infarction following implementing the package of essential non-communicable diseases; A historical cohort study. 在实施一揽子基本非传染性疾病后，中风和心肌梗死的发病率和死亡率;一项历史队列研究。

IF 1.1

Journal of Cardiovascular and Thoracic Research Pub Date : 2022-01-01 Epub Date: 2022-09-07 DOI: 10.34172/jcvtr.2022.32

Sayed Ali Ayat, Shayeste Rostami, Reza Khadivi

{"title":"The incidence and mortality rates due to stroke and myocardial infarction following implementing the package of essential non-communicable diseases; A historical cohort study.","authors":"Sayed Ali Ayat, Shayeste Rostami, Reza Khadivi","doi":"10.34172/jcvtr.2022.32","DOIUrl":"https://doi.org/10.34172/jcvtr.2022.32","url":null,"abstract":"Introduction: The package of essential non-communicable diseases (PEN) has been implemented in 2016 in Iran. The present study aimed to evaluate the incidence rate of myocardial infarction (MI) and stroke, and the mortality rate due to these diseases, following the lunch of the PEN project. Methods: This is a historical cohort study that was performed in 2020. Data were gathered through the hospital information system in the exposed and the control counties hospitals in the Isfahan province. The data about over 30-year-old patients who were hospitalized as definite cases of MI and/or stroke were collected via census sampling. The incidence rates of MI, stroke, and mortality due to those diseases were compared in 2015 (one year before the launch of the PEN project) and 2019 (4 years after the project initiation). Results: Following the implementation of the PEN project, the incidence and mortality rates due to MI among the over 30-year-old population in the exposed county, were reduced by 0.31 per 1000 and 9 per 100 000 respectively. Furthermore, the incidence rate due to stroke in the exposed county further slowed down, and the mortality rate due to stroke was reduced by 33 per 100,000 more than 30 years old population significantly. Conclusion: Following the implementation of the PEN project, the incidence rate due to MI and mortality rates due to MI and stroke decreased significantly. In addition, the incidence rate due to stroke further slowed down in the exposed county in comparison with the control county.","PeriodicalId":15207,"journal":{"name":"Journal of Cardiovascular and Thoracic Research","volume":"14 3","pages":"191-196"},"PeriodicalIF":1.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9617061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40712303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of off-label compounded oral sildenafil in the management of persistent pulmonary hypertension of the newborn: A case report. 非说明书复合口服西地那非治疗新生儿持续性肺动脉高压1例

IF 1.1

Journal of Cardiovascular and Thoracic Research Pub Date : 2022-01-01 Epub Date: 2022-03-07 DOI: 10.34172/jcvtr.2022.03

Olapeju Daniyan, Obumneme Ezeanosike, Dorathy Obu, Fortune Ujunwa

引用次数: 1

Effects of curcumin and metformin on oxidative stress and apoptosis in heart tissue of type 1 diabetic rats. 姜黄素和二甲双胍对1型糖尿病大鼠心脏组织氧化应激和细胞凋亡的影响。

IF 1.1

Journal of Cardiovascular and Thoracic Research Pub Date : 2022-01-01 Epub Date: 2022-06-28 DOI: 10.34172/jcvtr.2022.23

Atefeh Naghdi, Mohammad Taghi Goodarzi, Jamshid Karimi, Mohammad Hashemnia, Iraj Khodadadi

{"title":"Effects of curcumin and metformin on oxidative stress and apoptosis in heart tissue of type 1 diabetic rats.","authors":"Atefeh Naghdi, Mohammad Taghi Goodarzi, Jamshid Karimi, Mohammad Hashemnia, Iraj Khodadadi","doi":"10.34172/jcvtr.2022.23","DOIUrl":"https://doi.org/10.34172/jcvtr.2022.23","url":null,"abstract":"Introduction: Hyperglycemia enhances oxidative stress and apoptosis and induces damages in heart tissue. Based on antioxidant properties of curcumin and metformin, we hypothesized that these agents may exhibit cardioprotective effects by attenuating oxidative stress and modulating expression of the genes involved in apoptosis in type-1 diabetes. Methods: Thirty-six male rats were randomly divided into six groups; (N): control; (D): streptozotocin-induced diabetic rats; (D+Cur50) and (D+Cur150): diabetic rats treated with 50 and 150 milligram of curcumin per kilogram of body weight (mg/kg.bw), respectively; (D+Met300) and (D+Met500): diabetic rats received 300 and 500 mg/kg.bw of metformin, respectively. Heart tissues were dissected and gene expression levels of Bax, Bcl-2, and caspase-3 were analyzed. Total anti-oxidant capacity (TAC), total oxidant status (TOS), and malondialdehyde (MDA) level, and activities of catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) were measured. Results: Enhancement in TOS, OSI, and MDA levels as well as increased in the activity of CAT and reduction in SOD and GPx activities were observed in diabetic group (D) compared with control rats. Treatment of diabetic animals with either curcumin or metformin normalized TOS, OSI, and MDA levels and restored CAT, SOD, and GPx activities. Diabetes caused extensive damages in heart tissue of rats (group D) and increased expression of caspase-3 and Bax genes and enhanced ratio of Bax/Bcl-2 expression compared with controls. Treatment with curcumin or metformin mitigated histopathological changes and dampened apoptosis by normalizing Bax and caspase-3 expression. Conclusion: Curcumin and metformin modulated diabetes-induced cardiac damage probably by reducing oxidative stress.","PeriodicalId":15207,"journal":{"name":"Journal of Cardiovascular and Thoracic Research","volume":"14 2","pages":"128-137"},"PeriodicalIF":1.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40676130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

IGF-I combined with exercise improve diabetes-induced vascular dysfunction in heart of male Wistar rats igf - 1联合运动可改善雄性Wistar大鼠糖尿病诱导的心脏血管功能障碍

IF 1.1

Journal of Cardiovascular and Thoracic Research Pub Date : 2021-12-16 DOI: 10.34172/jcvtr.2021.54

Z. Niknam, Mahrokh Samadi, Ataollah Ghalibafsabbaghi, L. Chodari

{"title":"IGF-I combined with exercise improve diabetes-induced vascular dysfunction in heart of male Wistar rats","authors":"Z. Niknam, Mahrokh Samadi, Ataollah Ghalibafsabbaghi, L. Chodari","doi":"10.34172/jcvtr.2021.54","DOIUrl":"https://doi.org/10.34172/jcvtr.2021.54","url":null,"abstract":"Introduction: This research investigates the impact of insulin-like growth factor-I (IGF -I)and exercise on mediators associated with angiogenesis (VEGF-A, TSP-1, and NF-кβ) and capillarization status of the diabetic rats’ hearts. Methods: Splitting of forty Wistar male rats into five groups occurred as following: control,diabetes, diabetes+IGF-I, diabetes+exercise, and diabetes+exercise+IGF-I.Through intraperitoneal administration of 60 mg/kg streptozotocin, the condition of Type 1diabetes was escalated. After four weeks of treatment with IGF-I (2 mg/kg/day) or treadmill exercise (17 m/min, zero degrees slope, 30 min/day), in the heart, microvascular density and protein levels of VEGF-A, TSP-1, and NF-кβ were determined by H&E staining and ELISA,respectively. Results: Within the diabetic group, observations present a significant decrease in VEGF-A and MVD levels, whereas an increase in the TSP-1 and NF-Κb levels. While these impacts were reversed by either IGF-I or exercise treatments, simultaneous treatment had synergistic effects. Moreover, among diabetic rats, undesirable histologic alterations of the heart were demonstrated, including myonecrosis, interstitial edema, hemorrhage, and mononuclear immune cell infiltration, whereas treatments improved these changes. Conclusion: These data manifest that IGF-I and exercise can increase the cardiac angiogenesis of diabetic rats through increasing expression of VEGF-A, and decreasing TSP-1 and NF-кβproteins level, also can improve myocardial tissue damages.","PeriodicalId":15207,"journal":{"name":"Journal of Cardiovascular and Thoracic Research","volume":"14 1","pages":"34 - 41"},"PeriodicalIF":1.1,"publicationDate":"2021-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47169089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pancreaticopleural fistula: An insidious cause of pleural effusion –case report 胰胸膜瘘：胸腔积液的一个潜在原因——病例报告

IF 1.1

Journal of Cardiovascular and Thoracic Research Pub Date : 2021-09-06 DOI: 10.34172/jcvtr.2021.37

Fábio Murteira, T. Costa, S. Pinto, E. Francisco, A. C. Gomes

引用次数: 0

Effects of sodium selenite and selenium-enriched yeast on cardiometabolic indices of patients with atherosclerosis: A double-blind randomized clinical trial study. 亚硒酸钠和富硒酵母对动脉粥样硬化患者心脏代谢指标的影响:一项双盲随机临床试验研究

IF 1.1

Journal of Cardiovascular and Thoracic Research Pub Date : 2021-01-01 Epub Date: 2021-12-05 DOI: 10.34172/jcvtr.2021.51

Mahdiyeh Khabbaz Koche Ghazi, Samad Ghaffari, Mohammad Naemi, Rezvaniyeh Salehi, Mohammadreza Taban Sadeghi, Meisam Barati, Alireza Namazi Shabestari, Behnam Kafil, Naimeh Mesri Alamdari, Hamid Soleimanzadeh, Ali Tarighat-Esfanjani, Neda Roshanravan

{"title":"Effects of sodium selenite and selenium-enriched yeast on cardiometabolic indices of patients with atherosclerosis: A double-blind randomized clinical trial study.","authors":"Mahdiyeh Khabbaz Koche Ghazi, Samad Ghaffari, Mohammad Naemi, Rezvaniyeh Salehi, Mohammadreza Taban Sadeghi, Meisam Barati, Alireza Namazi Shabestari, Behnam Kafil, Naimeh Mesri Alamdari, Hamid Soleimanzadeh, Ali Tarighat-Esfanjani, Neda Roshanravan","doi":"10.34172/jcvtr.2021.51","DOIUrl":"https://doi.org/10.34172/jcvtr.2021.51","url":null,"abstract":"Introduction: Atherosclerosis and related cardiovascular diseases (CVDs) are the major causes of mortality worldwide. The available reports regarding the effects of selenium (Se) supplementation in the realm of atherosclerosis have been equivocal. The present investigation is aimed to assess the effects of sodium selenite and Se-enriched yeast supplementation on metabolic parameters among atherosclerotic patients. Methods: In this double-blind placebo-controlled randomized clinical trial, 60 patients diagnosed with atherosclerosis were randomly allocated into either 200 μg/day selenite, yeast, or placebo groups for eight consecutive weeks. Serum levels of lipid profile and glycemic indices were measured at the baseline and end of the intervention. Results: There were no significant within-or between-group changes in levels of total cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-c), fasting blood sugar, insulin, and homeostatic model assessment for IR throughout the study (P ≥0.05). Only the low density lipoprotein cholesterol (LDL-c) levels were significantly lower in the yeast group in comparison with the placebo group (P = 0.015). Conclusion: The administration of Se-enriched yeast is significantly effective in decreasing LDL-c levels in patients with atherosclerosis. Additional clinical trial studies investigating the effect of Se administration on glucose homeostasis parameters and lipid profiles in atherosclerotic patients are suggested for a more definitive conclusion.","PeriodicalId":15207,"journal":{"name":"Journal of Cardiovascular and Thoracic Research","volume":"13 4","pages":"314-319"},"PeriodicalIF":1.1,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8749358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39695752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5