Human cardiac organoids: A recent revolution in disease modeling and regenerative medicine.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-01-01 DOI:10.34172/jcvtr.2023.31830

Neda Roshanravan, Samad Ghaffari, Sepideh Bastani, Sara Pahlavan, Samira Asghari, Mohammad Amin Doustvandi, Sepideh Jalilzadeh-Razin, Mohammadreza Dastouri

引用次数: 0

Abstract

Three-dimensional (3D) myocardial tissues for studying human heart biology, physiology and pharmacology have recently received lots of attention. Organoids as 3D mini-organs are created from multiple cell types (i.e. induced pluripotent stem cells (iPSCs) or embryonic stem cells (ESCs)) with other supporting co-cultured cells such as endothelial cells or fibroblasts. Cardiac organoid culture technologies are bringing about significant advances in organ research and allows for the establishment of tissue regeneration and disease modeling. The present review provides an overview of the recent advances in human cardiac organoid platforms in disease biology and for cardiovascular regenerative medicine.

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人类心脏类器官:疾病建模和再生医学的最新革命。

用于心脏生物学、生理学和药理学研究的三维心肌组织近年来受到广泛关注。作为3D微型器官的类器官是由多种细胞类型(即诱导多能干细胞(iPSCs)或胚胎干细胞(ESCs))与其他支持性共培养细胞(如内皮细胞或成纤维细胞)形成的。心脏类器官培养技术在器官研究方面取得了重大进展，并允许建立组织再生和疾病模型。本文综述了人类心脏类器官平台在疾病生物学和心血管再生医学方面的最新进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.