Chinese Journal of Chemistry最新文献

{"title":"Nonchemically-Amplified Molecular Resists Based on Calixarene Derivatives Enabling 14 nm Half-Pitch Nanolithography","authors":"Rongrong Peng,&nbsp;Jinping Chen,&nbsp;Tianjun Yu,&nbsp;Yi Zeng,&nbsp;Shuangqing Wang,&nbsp;Xudong Guo,&nbsp;Rui Hu,&nbsp;Peng Tian,&nbsp;Michaela Vockenhuber,&nbsp;Dimitrios Kazazis,&nbsp;Jun Zhao,&nbsp;Yanqin Wu,&nbsp;Yasin Ekinci,&nbsp;Guoqiang Yang,&nbsp;Yi Li","doi":"10.1002/cjoc.202500041","DOIUrl":"https://doi.org/10.1002/cjoc.202500041","url":null,"abstract":"<div>\u0000 \u0000 <p>We developed single-component nonchemically-amplified resists (n-CARs) based on calixarene derivatives for high-resolution nanopatterning with electron beam lithography (EBL) and extreme ultraviolet lithography (EUVL). The calixarene derivatives decorated with 2 and 4 photosensitive sulfonium groups (C2S and C4S, respectively) were synthesized and characterized. Both derivatives exhibit excellent thermal stability and film-forming properties, making them suitable as resist materials. A comparative EBL study reveals that C2S resist exhibits superior lithographic performance. The presence of hydrogen bonds between C2S molecules enhances the mechanical strength and the Young's modulus of the resist film, effectively mitigating pattern collapse. The C2S resist achieved an 18 nm line/space (L/S) pattern and a 14 nm L/2S semi-dense pattern with EBL. Performance studies with EUVL yielded an impressive 14 nm half-pitch (HP) pattern with a remarkably low line-edge roughness (LER) of 1.7 nm. Extensive studies of the EUV exposure mechanism, conducted using <i>in-situ</i> quadrupole mass spectrometry (QMS) and X-ray photoelectron spectroscopy (XPS), demonstrated that the solubility switch of the resist material depends on the decomposition of the sulfonium groups and triflate anions.</p>\u0000 <p>\u0000 </p>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 13","pages":"1513-1522"},"PeriodicalIF":5.5,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144190735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic trans-Activity Comparison of Several Reported Cas12f Nucleases†","authors":"Yannan Wang,&nbsp;Na Tang,&nbsp;Quanjiang Ji","doi":"10.1002/cjoc.202401325","DOIUrl":"https://doi.org/10.1002/cjoc.202401325","url":null,"abstract":"<div>\u0000 \u0000 <p>Cas12f possesses both <i>cis</i>- and <i>trans</i>-cleavage activities, with the former being extensively studied for its application in genome editing, while the latter remains less explored, particularly for diagnostic purposes, and is mostly focused on Un1Cas12f1. In this study, we conducted a comprehensive comparison of the <i>trans</i>-cleavage activities of four characterized Cas12f proteins, demonstrating that all four exhibit <i>trans</i>-DNase activity triggered by double-stranded DNA (dsDNA), single-stranded DNA (ssDNA), and single-stranded RNA (ssRNA). Additionally, we identified distinct base preferences for <i>trans</i>-cleavage substrates among these proteins. Our further investigation into the activities of Cas12f revealed the intricate relationship between <i>cis</i>- and <i>trans</i>-cleavage activities under various conditions. Our study provides a multifaceted characterization of the <i>trans</i>-cleavage features of Cas12f nucleases, offering new avenues for a deeper comprehension of the mechanisms underlying Cas12f's functionality.</p>\u0000 <p>\u0000 </p>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 12","pages":"1339-1347"},"PeriodicalIF":5.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving Pure Organic Room-Temperature Phosphorescence by Substituent Effect of Thianthrene","authors":"Zhe Feng,&nbsp;Zhiqiang Yang,&nbsp;Shuaiqiang Zhao,&nbsp;Junjie Qian,&nbsp;Shi-Tong Zhang,&nbsp;Haichao Liu,&nbsp;Bing Yang","doi":"10.1002/cjoc.202500024","DOIUrl":"https://doi.org/10.1002/cjoc.202500024","url":null,"abstract":"<div>\u0000 \u0000 <p>To gain insights into the potential of thianthrene (TA), its substituent effects were systematically studied on the room-temperature phosphorescence (RTP) properties, including the electron-donating and electron-withdrawing substituents at 1- and 2-positions of TA, respectively. Both theoretical and experimental investigations show that the 2-position electron-withdrawing substituents greatly enhance RTP performance than the 1-position substituents, while the situation is exactly the opposite for electron-donating substituents. Compared with the 1-position substitution, the 2-position electron-withdrawing substituents induce the higher RTP radiation rate and lower non-radiation rate, in favor of the enhancement of RTP efficiency. Furthermore, the introduction of phenylene into the 2-position substitution greatly suppresses the non-radiation, resulting in the simultaneously improved RTP efficiency and elongated lifetime. Finally, using these RTP materials, the dynamically reversible operations of information (write-read-erase) are realized, as well as the encryption and time-dependent decryption demonstration. This work not only provides a better understanding of structure–property relationship on TA-based RTP materials, but also suggests an intramolecular structural modification strategy to improve the performance of pure organic RTP materials.</p>\u0000 <p>\u0000 </p>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 11","pages":"1306-1314"},"PeriodicalIF":5.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143896921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polarity Sensitive and H2O2/Lipid Droplets Sequence-Activated Asymmetric Cyanine Probe Achieves Multi-marker Imaging of Atherosclerosis","authors":"Weihua Wang,&nbsp;Han Zhu,&nbsp;Bo Gu,&nbsp;Yongze Xie,&nbsp;Xinlei Xu,&nbsp;Shu-Lin Liu,&nbsp;Heng Song","doi":"10.1002/cjoc.202401274","DOIUrl":"https://doi.org/10.1002/cjoc.202401274","url":null,"abstract":"<div>\u0000 \u0000 <p>Atherosclerosis is a lipoprotein-driven disease. In-depth understanding of pathology and accurate identification are particularly important in clinical assessment and treatment due to the irreversibility of atherosclerotic plaque formation. Atherosclerosis is not only accompanied by lipid droplets accumulation but also closely related to inflammation, which is accompanied by excessive reactive oxygen species (ROS) and changes in microenvironment. However, there is still a lack of a simple and rapid detection platform to simultaneously evaluate multiple indicators of atherosclerosis in multiple channels. In this study, we propose a multicolor imaging probe <b>Cy7P-B</b> for polarity, H₂O₂ and lipid droplets to evaluate atherosclerotic plaques <i>in vivo</i>. <b>Cy7P-B</b> is sensitive to environmental polarity and can monitor polarity changes by near-infrared ratio. Moreover, <b>Cy7P-B</b> has H₂O₂/lipid droplets dual-analyte sequential activation characteristics. Based on the multifunctional properties of <b>Cy7P-B</b>, the classical biomarkers of atherosclerotic plaque, lipid accumulation and up-regulation of oxidative stress are effectively detected in atherosclerotic plaques, and more importantly, the change of aortic polarity in atherosclerosis was detected for the first time. This work provides a general molecular design approach for multi-species imaging of AS, which is helpful for effective cardiovascular disease stewardship.</p>\u0000 <p>\u0000 </p>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 11","pages":"1246-1254"},"PeriodicalIF":5.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143896920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-assembled Metal−Organic Framework Microspheres for Thermodynamic−Kinetic Synergistic Separation of Propylene and Propane†","authors":"Tianhao Lan,&nbsp;Bin Yu,&nbsp;Yutao Liu,&nbsp;Dandong Ning,&nbsp;Chao Zhi,&nbsp;Yang Chen,&nbsp;Lin-Bing Sun,&nbsp;Xili Cui,&nbsp;Jinping Li,&nbsp;Libo Li","doi":"10.1002/cjoc.202500122","DOIUrl":"https://doi.org/10.1002/cjoc.202500122","url":null,"abstract":"<div>\u0000 \u0000 <p>Separating propylene (C₃H₆) from propane (C₃H₈) is a complex procedure in the petrochemical sector due to the comparable characteristics of the two gases. Herein, we reported the self-assembly phenomenon of NbOFFIVE-1-Ni (KAUST-7) crystals under different synthetic routes. The material features a decreased framework strain energy compared to original KAUST-7 and exhibits completely different adsorption performance, achieving the efficient separation of C₃H₆/C₃H₈ by synergetic effect of equilibrium and kinetics. The C₃H₆ adsorption capacity was as high as 46.2 cm³·g⁻¹ (298 K, 1 bar), increasing by 53% compared to the original material. The diffusion rates of C₃H₆ were faster than C₃H₈ as confirmed by time dependent kinetic adsorption profiles. It concurrently combines an excellent C₃H₆/C₃H₈ uptake ratio of 3.1 and kinetic selectivity (96.5) for C₃H₆/C₃H₈ separation with an equilibrium-kinetic combined selectivity of 42.5. Meanwhile, it can be regenerated easily due to moderate isosteric heat of adsorption (28.7 kJ·mol⁻¹). Breakthrough experiment for C₃H₆/C₃H₈ gas mixture was conducted and confirmed the high-purity recovery of C₃H₆ over C₃H₈. Moreover, it exhibited excellent water and moisture stability and can be easily synthesized through stirring at room temperature, which confers them with great potential for industrial application.</p>\u0000 <p>\u0000 </p>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 10","pages":"1141-1147"},"PeriodicalIF":5.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143836437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inside Cover Picture","authors":"","doi":"10.1002/cjoc.70022","DOIUrl":"https://doi.org/10.1002/cjoc.70022","url":null,"abstract":"<p>The rapid and efficient construction of C—C, C—N, and C—O bonds is a prominent research area in organic synthesis. A biomass derived Cu/Chitosan-800 catalyst is prepared for carbenoid insertion reactions to form C—X (X = C, N, O) bond. The substrate scope is well-demonstrated by C—H bond insertion of arenes, heteroarenes, and 1,3-diketones; N—H bond insertion of alkylamines and aromatic amines; and O—H bond insertion of carboxylic acids and diphenylphosphinic acids. Notably, the late-stage functionalization of drug molecules using this approach is also feasible. More details are discussed in the article by Tang <i>et al</i>. on pages 916—924.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 8","pages":"862"},"PeriodicalIF":5.5,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cjoc.70022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143629763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tuning Spin Crossover Properties in Hofmann-Type Framework by Guest-Adaptive Deformation","authors":"Kai-Ping Xie,&nbsp;Hai-Ling Wang,&nbsp;Ze-Yu Ruan,&nbsp;Pei-Yu Liao,&nbsp;Guang Yang,&nbsp;Zi-Cheng Xiao,&nbsp;Yi-Fei Deng,&nbsp;Si-Guo Wu,&nbsp;Yan Shi,&nbsp;Ming-Liang Tong","doi":"10.1002/cjoc.202500033","DOIUrl":"https://doi.org/10.1002/cjoc.202500033","url":null,"abstract":"<div>\u0000 \u0000 <p>Three three-dimensional Hofmann-type metal-organic frameworks (MOFs) [Fe(bpn){Ag(CN)₂}₂]·Ph₂S (<b>1·Ph</b>_<b>2</b><b>S</b>, bpn = 1,4-di(pyridin-4-yl)naphthalene, Ph₂S = diphenylsulfide), [Fe(bpn){Ag(CN)₂}₂]·Ph₂SO (<b>1·Ph</b>_<b>2</b><b>SO</b>, Ph₂SO = diphenylsulfoxide) and [Fe(bpn){Ag(CN)₂}₂]·Ph₂SO₂ (<b>1·Ph</b>_<b>2</b><b>SO</b>_<b>2</b>, Ph₂SO₂ = diphenylsulfone) were synthesized by employing sulfur-containing aromatic guests varying in oxidation states. <b>1·Ph</b>_<b>2</b><b>S</b> performed a complete four-step spin crossover (SCO) behavior with the sequence of HS↔~LS_1/3HS_2/3↔~LS_1/2HS_1/2↔ ~LS_2/3HS_1/3↔LS, while an incomplete two-step SCO profile with the sequence of HS↔~LS_1/3HS_2/3↔~LS_2/3HS_1/3 and a faint SCO behavior at low temperature for <b>1·Ph</b>_<b>2</b><b>SO</b> and <b>1·Ph</b>_<b>2</b><b>SO₂</b>. Photomagnetic experiments indicate the light-induced excited spin-state trapping (LIESST) effect in <b>1·Ph</b>_<b>2</b><b>S</b> and the bi-directional LIESST effect for <b>1·Ph</b>_<b>2</b><b>SO</b> and <b>1·Ph</b>_<b>2</b><b>SO₂</b>. Variable-temperature structural analyses reveal the evolution of host-guest synergy and highlight the mechanism of adaptive deformation of guests mediated by phenyl rotation amid spin transition. As the oxidation state of sulfur-containing guests increases, the host-guest cooperation within the lattice is limited by the steric effect, which stabilizes the high-spin state and consequently diminishes the SCO capability in this system. These results demonstrated herein open a new perspective on host-guest chemistry within SCO frameworks.</p>\u0000 <p>\u0000 </p>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 11","pages":"1279-1286"},"PeriodicalIF":5.5,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143896827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nickel-Catalyzed Asymmetric Reductive 1,4- and 1,5-Dicarbofunctionalization†","authors":"Yutong Xiang,&nbsp;Chang Zhang,&nbsp;Chuan Wang","doi":"10.1002/cjoc.202500074","DOIUrl":"https://doi.org/10.1002/cjoc.202500074","url":null,"abstract":"<div>\u0000 \u0000 <p>Herein, we present the first examples of asymmetric reductive 1,4-dicarbofunctionalization of 1,3-dienes and 1,5-dicarbofunctionalization of vinylcyclopropanes, which proceed under the catalysis of a chiral nickel/bis-imidazoline complex using alkyl halides and aryl iodides or alkenyl bromides as the electrophilic coupling partners. In these highly enantioselective transformations operating in a radical relay mechanism, the C(sp³)- and C(sp²)-type carbo-moieties are respectively installed on the terminal and internal position with a newly formed olefinic unit in high <i>E</i>-selectivity.</p>\u0000 <p></p>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 11","pages":"1271-1278"},"PeriodicalIF":5.5,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143896826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probing the Structure and Dynamics of the [NH4]M(HCO2)3 Ferroelectric Phases: Dielectric Relaxation through Orientational Disorder†","authors":"Thomas J. Hitchings,&nbsp;Helen M. Wickins,&nbsp;Lydia G. Burley,&nbsp;Silvia C. Capelli,&nbsp;Franz Demmel,&nbsp;Anthony E. Phillips,&nbsp;Paul Hodgkinson,&nbsp;Paul J. Saines","doi":"10.1002/cjoc.202401192","DOIUrl":"https://doi.org/10.1002/cjoc.202401192","url":null,"abstract":"<p>Neutron diffraction studies of the low-temperature relaxor ferroelectric phases of [NH₄]M(HCO₂)₃, where M = Mn²⁺ and Zn²⁺, show that a third of the NH₄⁺ cations remain subtly structurally disordered to low temperature. All NH₄⁺ cations within the channels are well separated from each other, with significant hydrogen bonds only with the anionic M(HCO₂)₃ framework. Complementary studies of the dynamics using ²H solid state NMR and quasielastic neutron scattering indicate significant rotational motion in both paraelectric and ferroelectric phases, which evolves gradually with increasing temperature with no abrupt change at the phase transition. Nudged elastic band calculations suggest that the activation barrier for flipping between “up” and “down” orientations of the NH₄⁺ cations is low in the ferroelectric phase, with the NH₄⁺ cations primarily interacting with the framework rather than neighbouring NH₄⁺ cations. It is likely this motion that is responsible for scrambling the NH₄⁺ cation orientation locally in the ferroelectric phase. We propose that this disorder, with the same basic motion active above and below the phase transition, induces the significant dielectric relaxation in these materials. This suggests that <i>orientational</i> disorder may be an effective substitution for <i>compositional</i> disorder commonly associated with relaxor ferroelectrics in molecular materials.</p><p>\u0000 </p>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 10","pages":"1190-1198"},"PeriodicalIF":5.5,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cjoc.202401192","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143835841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of Silyl-Protected Phosphoramidite Building Blocks for Short ssDNA Synthesis†","authors":"Jia-Yi Liu,&nbsp;Yu-Ting He,&nbsp;Xue-Qiang Wang,&nbsp;Yuntian Zhu","doi":"10.1002/cjoc.202500078","DOIUrl":"https://doi.org/10.1002/cjoc.202500078","url":null,"abstract":"<div>\u0000 \u0000 <p>To overcome the depurination challenges associated with classical DNA synthesis methods, this study introduces a novel approach using fluoride-sensitive, triisopropylsilyl (TIPS)-protected phosphoramidite monomers for the efficient synthesis of short single-stranded DNA. The bulky TIPS group selectively protects the 5'-hydroxyl group of nucleosides and can be rapidly removed under mild, non-acidic conditions using fluoride ions, minimizing side reactions. Four novel TIPS-protected phosphoramidite monomers were synthesized and characterized, achieving &gt;99% deprotection efficiency. These monomers were applied to the solid-phase synthesis of a 5-mer ssDNA sequence, yielding an overall efficiency of 99% for each cycle. The strategy demonstrates significant potential for improving the reliability and scalability of oligonucleotide synthesis, offering a promising alternative for applications in synthetic biology and nucleic acid research.</p>\u0000 <p>\u0000 </p>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 11","pages":"1293-1298"},"PeriodicalIF":5.5,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143896873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}