Chinese Journal of Chemistry最新文献

{"title":"Inside Cover Picture","authors":"","doi":"10.1002/cjoc.70033","DOIUrl":"https://doi.org/10.1002/cjoc.70033","url":null,"abstract":"<p>Dimeric cyclotryptamine alkaloids are a large class of structurally intricate and biologically active natural products that have attracted significant attention from synthetic community. Herein, we developed a phosphine-catalyzed divergent <i>γ</i>,<i>γ</i>- and <i>ε</i>,<i>γ</i>-umpolung domino addition of bisoxindoles with allenoates and applied it to the syntheses of calycanthine, chimonanthine and folicanthine. More details are discussed in the article by Wang <i>et al</i>. on pages 995—1000.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 9","pages":"974"},"PeriodicalIF":5.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cjoc.70033","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inside Cover Picture","authors":"","doi":"10.1002/cjoc.70022","DOIUrl":"https://doi.org/10.1002/cjoc.70022","url":null,"abstract":"<p>The rapid and efficient construction of C—C, C—N, and C—O bonds is a prominent research area in organic synthesis. A biomass derived Cu/Chitosan-800 catalyst is prepared for carbenoid insertion reactions to form C—X (X = C, N, O) bond. The substrate scope is well-demonstrated by C—H bond insertion of arenes, heteroarenes, and 1,3-diketones; N—H bond insertion of alkylamines and aromatic amines; and O—H bond insertion of carboxylic acids and diphenylphosphinic acids. Notably, the late-stage functionalization of drug molecules using this approach is also feasible. More details are discussed in the article by Tang <i>et al</i>. on pages 916—924.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 8","pages":"862"},"PeriodicalIF":5.5,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cjoc.70022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143629763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inside Cover Picture","authors":"","doi":"10.1002/cjoc.202590072","DOIUrl":"https://doi.org/10.1002/cjoc.202590072","url":null,"abstract":"<p>Enhanced H₂ dissociation and H spillover facilitates the <i>in situ</i> generation of Fe⁰ at the Cu/Fe₃O₄ catalyst interfaces, which promotes C₂–C₃ production through a photothermal CO hydrogenation pathway powered by solar energy. More details are discussed in the article by Zhong <i>et al</i>. on pages 791—797.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 7","pages":"734"},"PeriodicalIF":5.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cjoc.202590072","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143521942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chiral Porous Frameworks for Enantioselective Separation and Asymmetric Catalysis","authors":"Bing Yan,&nbsp;Jin-Hui Song,&nbsp;Da-Long Zhang,&nbsp;Zong-Jie Guan,&nbsp;Yu Fang","doi":"10.1002/cjoc.202401094","DOIUrl":"https://doi.org/10.1002/cjoc.202401094","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <p>The preparation and resolution of chiral molecules hold significant importance in scientific and industrial domains, such as drug development and manufacturing. In recent years, chiral porous frameworks have attracted increasing attention in asymmetric catalysis and enantiomer resolution due to their excellent performance. The metal-organic frameworks (MOFs), covalent organic frameworks (COFs), porous organic cages (POCs), and porous coordination cages (PCCs) are important representative of the porous framework family. Significantly, chirality can be easily introduced into these framework materials through simple bottom-up or post-modification methods, thereby promoting their applications related to chirality. In this review, we systematically summarize the synthesis strategies of four classes of chiral framework materials and their applications in asymmetric catalysis and enantiomeric resolution. Finally, we present some perspectives on the future development in chiral porous frameworks.</p>\u0000 \u0000 <p>\u0000 </p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Key Scientists</h3>\u0000 \u0000 <p>Significant progress has been made in the development of chiral porous frameworks, primarily driven by the application of chiral molecules. This area of research has seen contributions from many distinguished scientists. A particularly important milestone was reached in 2000, when Kimoon Kim reported the first catalytic Chiral Metal-Organic Framework (CMOF). In 2001, Lin <i>et al</i>. reported a new generation of recyclable CMOF capable of chiral separation and heterogeneous catalysis. Simultaneously, researchers such as Cui and Duan have made substantial contributions, advancing the field considerably. Furthermore, notable developments have been made in the area of Chiral Covalent Organic Frameworks (CCOFs), with pioneering work by researchers like Jiang, Wang, and Cui. Meanwhile, some groups such as Su and Li have made significant strides in the chiral cages. These remarkable accomplishments have drawn considerable interest.</p>\u0000 \u0000 <p></p>\u0000 </section>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 9","pages":"1078-1089"},"PeriodicalIF":5.5,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inside Cover Picture","authors":"","doi":"10.1002/cjoc.202590062","DOIUrl":"https://doi.org/10.1002/cjoc.202590062","url":null,"abstract":"<p>Cooperativity, fluxionality, biocompatibility and self-adaption are four essential criteria in designing new generation artificial cell walls. The cover story adopted the image of Feitian in armor who was playing pipa and Chinese landscape to interpret these four characteristics of the artificial cell wall. General methods of fabricating artificial cell walls were introduced in this review and interpreted in the cover story. The artificial cell walls are able to play significant roles in the fields of cytoprotection, cellular metabolic regulation, <i>etc</i>., and are potential in the field of cell therapy and tissue engineering. More details are discussed in the article by Huang <i>et al</i>. on pages 715—728.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 6","pages":"590"},"PeriodicalIF":5.5,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cjoc.202590062","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143423819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unlocking the Potential of Rare Earth-Enriched Aluminum Oxo Clusters for Enhanced Dielectric Properties","authors":"Ruiduan Ji,&nbsp;Xiaoyu Liu,&nbsp;Haizhou Pei,&nbsp;Wei-Hui Fang,&nbsp;Weiguo Huang,&nbsp;Jian Zhang","doi":"10.1002/cjoc.202401181","DOIUrl":"https://doi.org/10.1002/cjoc.202401181","url":null,"abstract":"<div>\u0000 \u0000 <p>This study highlights the innovative use of increased rare earth elements to enhance the dielectric properties of materials and devices. The AlOC-129Ln series, features the highest number of rare earth dopants in aluminum oxo clusters to date. The trivalent ions in AlOC-129Ln impart a high dipole moment, significantly elevating the dielectric constant (<i>k</i>) of the doped polymer films. AlOC-129Ce, in particular, exhibits the largest molecular size, which enhances interfacial effects and achieves a relative dielectric constant four times greater than that of undoped polymers and 1.5 times higher than those with single rare earth dopants. The substantial molecular size (~2.5 nm) and robust charge scattering and trapping capabilities of AlOC-129Ln reduce dielectric loss by up to 50% at high frequencies. Additionally, its excellent solution processability enhances breakdown strength by 147%, ensuring superior electrical stability. This research demonstrates the versatility of the cluster doping strategy in effectively balancing dielectric constant and loss, unveiling the promising potential of solution-processable cluster materials in electronic devices.</p>\u0000 <p>\u0000 </p>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 9","pages":"1042-1050"},"PeriodicalIF":5.5,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Homochiral Dy2 Schiff Base Complexes Based on (R)/(S)-Chlocyphos: Single-Molecule Magnet Behaviours, Proton Conductivities and MCD Effects","authors":"Cai-Ming Liu,&nbsp;Hua-Hong Zou,&nbsp;Yi-Quan Zhang,&nbsp;Xiang Hao,&nbsp;Xiao-Ming Ren","doi":"10.1002/cjoc.202401318","DOIUrl":"https://doi.org/10.1002/cjoc.202401318","url":null,"abstract":"<div>\u0000 \u0000 <p>Chiral proton conductive single-molecule magnets (SMMs) are multifunctional molecular materials that can combine conductor, magnet, and chirality at the nanoscale, but there are still significant challenges to their synthesis. Herein, the hydrazone Schiff base ligand (<i>E</i>)-<i>N</i>′-(2-hydroxybenzylidene)-3-aminopyrazine-2-carbohydrazide (H₂L_Schiff) and the homochiral ligands (<i>R</i>)-(+)-chlocyphos/ (<i>S</i>)-(−)-chlocyphos (<i>R</i>-HL)/(<i>S</i>-HL) were chosen to assemble a pair of Dy₂ enantiomers [Dy₂(<i>R</i>-L)₂(L_Schiff)₂(DMA)₂]·2.5H₂O (<i>R</i>-<b>1</b>) (DMA = <i>N</i>,<i>N</i>-dimethylacetamide) and [Dy₂(<i>S</i>-L)₂(L_Schiff)₂(DMA)₂]·2.5H₂O (<i>S</i>-<b>1</b>) at room temperature. Magnetic investigation indicated that they are field-induced SMMs, with a <i>U</i>_eff/<i>k</i> value of 42.2 K at 1000 Oe, and there is ferromagnetic coupling within the molecule; these magnetic properties may be explained by the <i>ab initio</i> calculations. The presence of a hydrogen bonding network confers the enantiomers proton conductivities. Moreover, <i>R</i>-<b>1</b> and <i>S</i>-<b>1</b> show prominent magnetic circular dichroism (MCD) effects at room temperature.</p>\u0000 <p>\u0000 </p>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 9","pages":"1051-1058"},"PeriodicalIF":5.5,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fast DNA-Based Molecular Classifier for Cancer Diagnosis Using Freeze-Thaw Cycling†","authors":"Mengyao Cao,&nbsp;Xiewei Xiong,&nbsp;Li Li,&nbsp;Hao Pei","doi":"10.1002/cjoc.202401212","DOIUrl":"https://doi.org/10.1002/cjoc.202401212","url":null,"abstract":"<div>\u0000 \u0000 <p>Monitoring and analyzing expression levels of multiple biomarkers in biological samples can improve disease risk prediction and guide precision medicine but suffers from high cost and being time-consuming. Here, we construct a fast molecular classifier based on freeze-thaw cycling that implements an <i>in silico</i> support vector machine (SVM) classifier model at the molecular level with a panel of disease-related biomarkers expression patterns for rapid disease diagnosis. The molecular classifier employs DNA reaction networks as the computing module and repeated dehydration and concentration process as the driving force to implement a set of simplified mathematical operations (such as multiplication, summation and subtraction) for efficient classification of complex input patterns. We demonstrate that the fast DNA-based molecular classifier enables precise cancer diagnosis within a short turnaround time in synthetic samples compared to those of free diffusion classifiers. We envision that this all-in-one molecular classifier will create more opportunities for inexpensive, accurate, and rapid disease diagnosis, prognosis and therapy, particularly in emergency departments or the point of care.</p>\u0000 <p>\u0000 </p>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 9","pages":"1035-1041"},"PeriodicalIF":5.5,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Natural Product Total Syntheses Involving Cycloadditions of Allenes","authors":"Chen-Chen Gu,&nbsp;Xiong-En Long,&nbsp;Xiuping Chen,&nbsp;Junyang Liu,&nbsp;Chuang-Chuang Li","doi":"10.1002/cjoc.202401143","DOIUrl":"https://doi.org/10.1002/cjoc.202401143","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Comprehensive Summary</h3>\u0000 \u0000 <p>Allenes, characterized by their cumulated carbon–carbon double bonds, have emerged as indispensable synthons in the construction of complex natural products. Their unique reactivity and stereochemical properties render allenes a powerful tool for the efficient and streamlined total synthesis of structurally intricate natural products. This review comprehensively summarizes the total syntheses of complex natural products involving allene cycloaddition reactions reported over the past decade (2014—2024). Among the nearly 20 total syntheses reviewed, the [2+1], [2+2], [3+2], [4+2], [4+3], [5+1] and [2+2+1] cycloaddition reactions of allenes are the most important transformations to construct the key skeleton. This is because of their ability to form multiple bonds in a single step with high atom economy, stereoselectivity, and regioselectivity, often under mild conditions. The strategic application of these reactions in forming key carbon–carbon bonds and controlling stereochemistry makes them practical for the efficient assembly of complex molecular frameworks. With the ongoing exploration of methods for allene generation, particularly the enantioselective approaches, and the continued discovery of novel cyclization reactions of allenes, allene chemistry will maintain its crucial and indispensable role in the total synthesis of natural products.</p>\u0000 \u0000 <p>\u0000 </p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Key Scientists</h3>\u0000 \u0000 <p></p>\u0000 </section>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 9","pages":"1059-1077"},"PeriodicalIF":5.5,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Halogen Modulation and Physical Property Variation in Two Novel Mixed-Cation Organic-Inorganic Hybrid Perovskites†","authors":"Xiaomei Fu,&nbsp;Zining Zhou,&nbsp;Yawen Yang,&nbsp;Lei He,&nbsp;Jie Mu,&nbsp;Qiong Ye","doi":"10.1002/cjoc.202401102","DOIUrl":"https://doi.org/10.1002/cjoc.202401102","url":null,"abstract":"<div>\u0000 \u0000 <p>Organic-inorganic hybrid perovskites (OIHPs) offer precise control over material properties through the substitution of organic cations and halogens. In this study, two OIHPs, [(C₆H₁₀P)(<i>n</i>-BA)]Sb₂X₉ ([C₆H₁₀P]⁺ = [Me₃PCH₂CH₂CH₃]⁺, [<i>n</i>-BA]⁺ = <i>n</i>-butylamine cation, X = I (<b>1</b>), Br (<b>2</b>)), were synthesized by varying halogens within a mixed-cation system. The halogen substitution induced a shift from compound <b>1</b>, which remains stable without phase transitions, to compound <b>2</b>, which undergoes a ferroelastic phase transition (<i>mmmF</i>2/<i>m</i>). Compound <b>1</b> crystallizes in the non-centrosymmetric <i>Pca</i>2₁ space group and demonstrates a second harmonic generation (SHG) response, while compound <b>2</b> displays elasticity in nanoindentation tests. Halogen substitution alters Sb—X bond lengths, inducing structural distortions in the inorganic framework and influencing the spatial configuration of organic cations and inorganic anions. These changes lead to distinct crystallization behaviors, resulting in different physical properties for compounds <b>1</b> and <b>2</b>. This work contributes to the development of multifunctional materials based on halogen regulation in mixed-cation OIHPs.</p>\u0000 <p></p>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 9","pages":"1029-1034"},"PeriodicalIF":5.5,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}