Chinese Journal of Chemistry最新文献

{"title":"Inside Cover Picture","authors":"","doi":"10.1002/cjoc.70207","DOIUrl":"https://doi.org/10.1002/cjoc.70207","url":null,"abstract":"<p>An innovative base-promoted efficient coupling strategy has been developed: leveraging weak C/N/O nucleophiles in synergy with the Cu-catalyst. This one-pot approach enables the highly selective synthesis of significant unsaturated chemicals via vinylation, allylation, and propargylation reactions of commodity dihalides with high efficiency. More details are discussed in the article by Zhang <i>et al</i>. on pages 2005—2014.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 16","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cjoc.70207","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144624262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inside Cover Picture","authors":"","doi":"10.1002/cjoc.70182","DOIUrl":"https://doi.org/10.1002/cjoc.70182","url":null,"abstract":"<p>A new palladium-catalyzed aminocarbonylative [3+2+1]/[4+2] heteroannulation of allylamines with CO and 4-en-1-yn-3-yl acetates for the synthesis of 1,7,8,8a-tetrahydroisoquinolin-3(2<i>H</i>)-ones has been developed. The method enables the construction of two new six-membered rings in a single reaction step leading to the formation of the isoquino-linone scaffolds. More details are discussed in the article by Li <i>et al</i>. on pages 1819—1823.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 15","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cjoc.70182","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144519706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inside Cover Picture","authors":"","doi":"10.1002/cjoc.70162","DOIUrl":"https://doi.org/10.1002/cjoc.70162","url":null,"abstract":"<p>With the idea of simple units integration to introduce new reactivities, a novel reaction between γ-hydroxyl enals and 1,3-dicarbonyl compounds has been discovered and developed, yielding polyfunctionalized 5-alkenyl-3-carbonylfurans. In this process, the γ-hydroxyl group is demonstrated to exert a critical neighboring group effect, facilitating the ring-opening isomerization of the initially generated 2<i>H</i>-pyran intermediate to the target furanones. More details are discussed in the article by Ma <i>et al</i>. on pages 1643—1650.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 14","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cjoc.70162","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144292261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meet Our New Associate Editor","authors":"","doi":"10.1002/cjoc.70147","DOIUrl":"https://doi.org/10.1002/cjoc.70147","url":null,"abstract":"<p></p><p><b>Associate Editor</b></p><p><b>Wei Liu</b></p><p><b>Associate Professor</b></p><p><b>Department of Chemistry</b></p><p><b>University of Cincinnati, Cincinnati, Ohio, United States</b></p><p><b>(+1)513-556-5865</b></p><p><b>[email protected]</b></p><p><b>http://weiliulab.org</b></p><p>2004−2008 B. S. College of Chemistry and Molecular Engineering, Peking University (Supervisor: Prof. Gu Yuan)</p><p>2008−2014 Ph.D., Department of Chemistry, Princeton University (Supervisor: Prof. John T. Groves)</p><p>2017−2020 Assistant Professor, Department of Chemistry and Biochemistry, Miami University, Oxford, OH, USA</p><p>2020−2024 Assistant Professor, Department of Chemistry, University of Cincinnati, Cincinnati, OH, USA</p><p>2024−present Associate Professor, Department of Chemistry, University of Cincinnati, Cincinnati, OH, USA</p><p>2023 National Science Foundation CAREER award</p><p>2022 National Institute of Health Maximizing Investigators' Research Award</p><p>2022 American Chemical Society Herman Frasch Foundation Award</p><p>2022 Thieme Chemistry Journals Award</p><p><b>High-Valent Metal Catalysis</b></p><p>The ability of transition metals to reach high oxidation states, particularly among second- and third-row transition metals, has enabled the development of various catalytic transformations. However, the reactivity and catalytic potential of high-valent intermediates in earth abundant metals, especially first-row late transition metals, remain poorly understood. The research in the Liu group focuses on understanding of high-valent metal complexes to unlock new reactivity and address long-standing challenges in synthetic chemistry and biomedical research. To achieve these goals, we aim to <b>1)</b> understand the organometallics of elusive intermediates, <b>2)</b> develop new catalytic reactions and activation modes, and <b>3)</b> translate our chemistry to address unmet challenges in biomedical research.</p><p></p><p>1. <i>J. Am. Chem. Soc</i>. <b>2024</b>, <i>146</i>, 46, 31982–31991.</p><p>2. <i>J. Am. Chem. Soc</i>. <b>2024</b>, <i>146</i>, 43, 29297–29304.</p><p>3. <i>J. Am. Chem. Soc</i>. <b>2024</b>, <i>146</i>, 22, 15176–15185.</p><p>4. <i>Nature Catalysis</i> <b>2024</b>, <i>7</i>, 1372–1381.</p><p>5. <i>J. Am. Chem. Soc</i>. <b>2023</b>, <i>145</i>, 48, 26152–26159.</p>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 13","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cjoc.70147","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144190814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inside Cover Picture","authors":"","doi":"10.1002/cjoc.70139","DOIUrl":"https://doi.org/10.1002/cjoc.70139","url":null,"abstract":"<p>A series of regioselective [3+2] cycloaddition reactions between a potassium diazaphospholidinyl diazomethylide and unsaturated substrates are reported, enabling access to structurally diverse nitrogen-containing heterocycles. Depicted are robotic hands guiding the assembly of diazo anions and dipolarophiles to construct pyrazolide, triazolide, diazaphospholide, and pyrazolinide frameworks. This work, illustrated through an interplay of digital precision and molecular design, underscores the potential of electron-rich diazomethyl anions in click chemistry and heterocycle construction. More details can be found in the article by Liu <i>et al</i>. on pages 1547—1552.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 13","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cjoc.70139","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144190812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polydimethylsiloxane-Driven Microdroplet Systems: Propelling Forces in Advancing Chemical and Materials Innovation","authors":"Chao Liu,&nbsp;Xin Chen,&nbsp;Shuangyi Li,&nbsp;Haodi Zhu,&nbsp;Ying Wei,&nbsp;Shasha Wang,&nbsp;Linghai Xie","doi":"10.1002/cjoc.70045","DOIUrl":"https://doi.org/10.1002/cjoc.70045","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <p>Microfluidic technology is an emerging arena that manipulates tiny fluids through the use of microchannels, which typically range in dimensions from tens to hundreds of micrometers. This technology has been widely applied in chemical analysis, biological detection, and materials synthesis due to its precise processing and manipulation of tiny fluids. Moreover, droplet microfluidics with polydimethylsiloxane (PDMS) devices is one of the most famous ways to carry out some applications or investigations that were not previously possible using conventional techniques. This review covers the mechanisms of droplet formation, innovative applications in synthesis, and potential integration with advanced techniques. Precise control over microfluidic channels, excellent efficiency, product consistency, and high-throughput screening capabilities are highlighted. In this respect, employing this technology in the synthesis of nanomaterials, small molecules, and polymers is discussed, as well as facilitating the development of novel materials. Additionally, we discuss future prospects, including optimizing device design, integrating with cutting-edge technologies, and advancing precision medicine. Despite challenges related to device complexity and fabrication costs, the potential for resolution through new materials and methods underscores the critical role of droplet microfluidics in scientific innovation.</p>\u0000 \u0000 <p>\u0000 </p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Key Scientists</h3>\u0000 \u0000 <p>\u0000 </p>\u0000 </section>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 16","pages":"2036-2052"},"PeriodicalIF":5.5,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144624806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Achieving Efficient TTA-UC Both in Organogels and Solvent-Free Dry Gels by Co-assembling Annihilator with Gelators","authors":"Jiao Chen,&nbsp;Pinyou Wang,&nbsp;Jinbo Liu,&nbsp;Cheng Yang,&nbsp;Wanhua Wu","doi":"10.1002/cjoc.70073","DOIUrl":"https://doi.org/10.1002/cjoc.70073","url":null,"abstract":"<div>\u0000 \u0000 <p>Supramolecular organogels were highly promising matrices for triplet–triplet annihilation-based upconversion (TTA-UC), but the dispersion and diffusion of the UC components were greatly relied on the microscopically interconnected solution phase in gels. Herein, 12-hydroxystearic acid (<b>CA</b>) and its derivatives with different alkyl chain (<b>CA3</b>, <b>CA4</b>, <b>CA6</b> and <b>CA8</b>) were synthesized as low-molecular-weight gelators (LMMGs), and <b>D-1</b> with <b>CA</b> attached on DPA unit was synthesized as annihilator. It was found that by co-assembling <b>D-1</b> with the LMMGs, the DPA units were uniformly dispersed in the gel network regardless of whether there was a solvent or not. By chemically tuning LMMGs to optimize the morphologies of organogels, the DPA units were orderly arranged in the gel network, and showing efficient UC emission in <b>CA</b>, <b>CA3</b>, and <b>CA8</b> which showed more regular morphologies. UC quantum yield of up to 13.4% (out of 50% maximum) was achieved in <b>CA3</b> organogel. Moreover, when all solvents were removed from the organogels, <b>D-1</b> also showed significant UC emissions, which was more than 6-fold higher than that of DPA, indicating that co-assembling the annihilator with the matrix to achieve an order arrangement presented an efficient strategy towards efficient TTA-UC in solid state.\u0000 </p>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 16","pages":"2021-2028"},"PeriodicalIF":5.5,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144624781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural Coumarin-Hybridized Thiazolylbenzonitriles as New Structural Scaffolds to Exert Potentially Multitargeting Supramolecular Antibacterial Behavior","authors":"Qian-Yue Li,&nbsp;Chun-Mei Zeng,&nbsp;Yao Chen,&nbsp;Nisar Ahmad,&nbsp;Shao-Lin Zhang,&nbsp;Cheng-He Zhou","doi":"10.1002/cjoc.70072","DOIUrl":"https://doi.org/10.1002/cjoc.70072","url":null,"abstract":"<div>\u0000 \u0000 <p>A unique type of natural coumarin skeleton-based thiazolylbenzonitriles as novel structural scaffolds to exert potential multitargeting supramolecular antibacterial behavior was developed for the first time from resorcinol through multi-step reactions. All the new compounds were characterized by NMR and HRMS spectra. Structure-activity relationships revealed that the ethoxycarbonyl group was the optimal substituent to exert the effective supramolecular antibacterial action of benzopyronyl thiazolylbenzonitriles (BTBs), and BTB <b>13a</b> gave an extremely low MIC value of 0.002 mM against <i>Staphylococcus aureus</i> 29213, being 3-fold more active than norfloxacin. Compound <b>13a</b> exerting the most effective supramolecular antibacterial behaviour possessed favourable druggability with no obvious haemolysis, acceptable cytotoxicity and low propensity to induce bacterial resistance. A series of medicinal chemobiological evaluations disclosed that BTB <b>13a</b> could not only intercalate into DNA to produce stable biosupramolecular complexes to block DNA replication, and form biosupermolecules with DNA gyrase, but also disturb cell membrane to tempt leakage of intracellular contents, fluctuate the metabolism and induce oxidative stress, finally resulting in bacterial cell death. Moreover, the promising BTB <b>13a</b> exhibited good <i>in vivo</i> antibacterial efficacy against <i>Staphylococcus aureus</i> 29213. These results implied that benzopyronyl thiazolylbenzonitriles possessed large promise as novel structural antibacterial members to combat <i>Staphylococcus aureus</i> 29213.\u0000 </p>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 16","pages":"1909-1923"},"PeriodicalIF":5.5,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144624780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DNA Synthesis and Assembly Technologies: From Oligonucleotides to Complete Genomes","authors":"Wei Tan,&nbsp;Xuemei Jia,&nbsp;Ying Liu,&nbsp;Chi Yao,&nbsp;Dayong Yang","doi":"10.1002/cjoc.202401134","DOIUrl":"https://doi.org/10.1002/cjoc.202401134","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Comprehensive Summary</h3>\u0000 \u0000 <p>DNA synthesis and assembly technology is the fundamental enabling technology of synthetic biology, providing methods for humans to understand and modify organisms. Oligonucleotide chains and long DNA fragments synthesized through DNA synthesis and assembly technology are becoming increasingly widely used in fields such as biomedicine, energy, new materials, and information storage, with strong application prospects. This review provides a comprehensive and systematic introduction and exposition of current DNA synthesis and assembly technologies, discussing current challenges and future research prospects.</p>\u0000 \u0000 <p>\u0000 </p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Key Scientists</h3>\u0000 \u0000 <p>DNA synthesis and assembly technology is a cutting-edge technology for human understanding and modification of living organisms, with wide applications in the fields of biomedicine, energy, new materials, and information storage. In 1962, the Bollum group first proposed that TDT enzyme could be used for the synthesis of DNA oligonucleotide chains. In 1987, the Carruthers group established column-based oligo synthesis. In 1992, the Fodor group established microarray-based oligo synthesis. In 1995, the Stemmer and Crameri groups established PCR based DNA assembly. In 2003, the Knight group proposed BioBricks^TM. In 2007, the Elledge group was the first to report sequence and ligation-independent cloning assembly. In 2008, three scientists Hamilton O. Smith, Clyde A. Hutchison III, and J Craig Venter co-established transformation associated recombination technology. In the same year, the Marillonnet group established Gloden Gate technology. In 2009, the Gibson group established Gibson assembly technology. In 2012, the Zhang group established Red/Rec technology. In 2016, the Qin group established Cas9-facilitated homologous recombination assembly. In the same year, the Dai group established Meiotic recombination-mediated assembly. In 2017, the Bader group established switching auxotrophies progressively for integration. The Yuan group established yeast life cycle assembly in 2023 and established haploidization-based DNA assembly and delivery in yeast in 2024. This review systematically introduces the latest research progress in DNA synthesis and assembly technology, providing a reference for subsequent research.</p>\u0000 \u0000 <p>\u0000 </p>\u0000 </section>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 16","pages":"2069-2081"},"PeriodicalIF":5.5,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144624784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chiral Ag-Complex Catalyzed Enantioselective α-Functionalization of Cyclic Azomethine Ylides with Concomitant Remote-Controlled Asymmetric Desymmetrization of N-Arylmaleimides and Cyclopentene-1,3-diones","authors":"Ji-Hong Liu,&nbsp;Jian-Mei Wang,&nbsp;Yan-Ping Zhang,&nbsp;Zhen-Hua Wang,&nbsp;Lei Yang,&nbsp;Jian-Qiang Zhao,&nbsp;Ming-Qiang Zhou,&nbsp;Yong You,&nbsp;Wei-Cheng Yuan","doi":"10.1002/cjoc.70076","DOIUrl":"https://doi.org/10.1002/cjoc.70076","url":null,"abstract":"<div>\u0000 \u0000 <p>The asymmetric cycloaddition reactions of 1,3-fused cyclic azomethine ylides have been extensively studied, but the non-cyclic <i>α</i>-functionalization of these compounds remains unexplored. Herein, an efficient combination of the catalytic enantioselective non-cyclic <i>α</i>-functionalization of 1,3-fused cyclic azomethine ylides and the remote-controlled asymmetric desymmetrization of <i>N</i>-arylmaleimides and cyclopentene-1,3-diones has been achieved with a catalyst system consisting of a chiral <i>P,N</i>-ferrocene ligand and AgNO₂. This reaction allowed for the synthesis of a series of enantioenriched 3,4-dihydroisoquinoline derivatives bearing multiple stereogenic elements/centers with good yields and stereoselectivities. The practicality of this method was demonstrated by gram-scale synthesis and derivatizations of the products.</p>\u0000 <p></p>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 16","pages":"2029-2035"},"PeriodicalIF":5.5,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144624782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}