{"title":"Inside Cover Picture","authors":"","doi":"10.1002/cjoc.70102","DOIUrl":"https://doi.org/10.1002/cjoc.70102","url":null,"abstract":"<p>Zeng <i>et al</i>. demonstrate various synthetic pathways for DNA coacervates based on liquid-liquid phase separation, exploring their biological and biomimetic applications. Benefiting from the programmability of DNA and the fluidity of coacervate structures, DNA coacervates can not only act as artificial cells with cell-like behaviors but also achieve intelligent sensing and precise therapy through specific signal transduction with natural cells. More details are discussed in the article on pages 1442—1462.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 12","pages":"1330"},"PeriodicalIF":5.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cjoc.70102","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Inside Cover Picture","authors":"","doi":"10.1002/cjoc.70077","DOIUrl":"https://doi.org/10.1002/cjoc.70077","url":null,"abstract":"<p>Accurate prediction of chemical reaction performance is crucial for automated chemical synthesis. In this study, a novel multi-modal chemical reaction prediction model is proposed, using graph and textual information, eliminating the need for computationally intensive DFT parameters with capability to handling reactions involving a fluctuating number of molecules. This model outperforms at least 7 generalized methods on 4 datasets, while maintaining chemical interpretability towards atomic and feature importance. Further details are comprehensively discussed in the article by Li <i>et al</i>. on pages 1230—1238.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 11","pages":"1214"},"PeriodicalIF":5.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cjoc.70077","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuqi Zeng, Long Zhao, Yihao Liu, Tianhuan Peng, Yifan Lyu, Quan Yuan
{"title":"Biomimetic and Biological Applications of DNA Coacervates","authors":"Yuqi Zeng, Long Zhao, Yihao Liu, Tianhuan Peng, Yifan Lyu, Quan Yuan","doi":"10.1002/cjoc.202401276","DOIUrl":"https://doi.org/10.1002/cjoc.202401276","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Comprehensive Summary</h3>\u0000 \u0000 <p>Recent progress in nanotechnology and synthetic biology has demonstrated the potential of DNA coacervates for biomimetic and biological applications. DNA coacervates are micron-scale, membrane-free, spherical structures formed by liquid-liquid phase separation of DNA materials. They uniquely combine the programmability of DNA with the fluidic properties of coacervates, allowing for controlled modulation of their structures, biomimetic and biological functions, and dynamic behaviors through rational sequence design. This review summarizes methods for the formation of different DNA coacervates and explores their extensive applications in biomimicry, biosensing and therapeutics. Limitations and prospects of DNA coacervates are also discussed.</p>\u0000 \u0000 <p>\u0000 </p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Key Scientists</h3>\u0000 \u0000 <p></p>\u0000 </section>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 12","pages":"1442-1462"},"PeriodicalIF":5.5,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Inside Cover Picture","authors":"","doi":"10.1002/cjoc.70062","DOIUrl":"https://doi.org/10.1002/cjoc.70062","url":null,"abstract":"<p>An electrochemical method is developed for the direct decarboxylative phosphorylation of α-amino acids to α-amino phosphonates using continuous-flow electrochemistry. The method eliminates the need for strong oxidants and multi-step processes, offering a straightforward and scalable approach. Key to its success is the establishment of a microenvironment on the anode surface in acidic conditions, facilitating selective decarboxylation and C—P bond formation. More details are discussed in the article by Xu <i>et al</i>. on pages 1167—1172.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 10","pages":"1098"},"PeriodicalIF":5.5,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cjoc.70062","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143836139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Inside Cover Picture","authors":"","doi":"10.1002/cjoc.70033","DOIUrl":"https://doi.org/10.1002/cjoc.70033","url":null,"abstract":"<p>Dimeric cyclotryptamine alkaloids are a large class of structurally intricate and biologically active natural products that have attracted significant attention from synthetic community. Herein, we developed a phosphine-catalyzed divergent <i>γ</i>,<i>γ</i>- and <i>ε</i>,<i>γ</i>-umpolung domino addition of bisoxindoles with allenoates and applied it to the syntheses of calycanthine, chimonanthine and folicanthine. More details are discussed in the article by Wang <i>et al</i>. on pages 995—1000.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 9","pages":"974"},"PeriodicalIF":5.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cjoc.70033","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Condition-Controlled Selective Synthesis of CF3-Chromene and CF3-Benzofuran from N-Phenoxyacetamide and CF3-Ynone","authors":"Huihang Hou, Shengnan Yan, Yuanshuang Xu, Chunhua Ma, Xinying Zhang, Xuesen Fan","doi":"10.1002/cjoc.70008","DOIUrl":"https://doi.org/10.1002/cjoc.70008","url":null,"abstract":"<div>\u0000 \u0000 <p>Presented herein is a condition-controlled selective synthesis of CF<sub>3</sub>-chromene and CF<sub>3</sub>-benzofuran based on the reaction of <i>N</i>-phenoxyacetamide and CF<sub>3</sub>-ynone. When the reaction is carried out in MeOH under the catalysis of Rh(III), CF<sub>3</sub>-chromene is formed <i>via</i> C—H metalation-initiated alkenylation, acetamide group migration and intramolecular <i>oxo</i>-nucleophilic addition. On the other hand, when the reaction is run in DMSO under the promotion of CsOAc, CF<sub>3</sub>-benzofuran is generated <i>via aza</i>-Michael addition-initiated [3,3]-σ rearrangement, intramolecular <i>oxo</i>-nucleophilic addition and water elimination. To our knowledge, this is the first report on the selective construction of chromene or benzofuran scaffold along with introduction of a CF<sub>3</sub> unit from the same starting materials. The methodology was scalable and the products could be readily transformed into other valuable products. Moreover, the products thus obtained possess decent anticancer activity.</p>\u0000 <p>\u0000 </p>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 12","pages":"1392-1398"},"PeriodicalIF":5.5,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Houqiang Ji, Tianyu Huang, Guangxun Zhang, Shuai Cao, Yangyang Sun, Huan Pang
{"title":"Modified UiO-66 and Its Applications in Environmental and Energy Fields","authors":"Houqiang Ji, Tianyu Huang, Guangxun Zhang, Shuai Cao, Yangyang Sun, Huan Pang","doi":"10.1002/cjoc.202401244","DOIUrl":"https://doi.org/10.1002/cjoc.202401244","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <p>UiO-66, a prototypical and stable zirconium-based metal-organic framework (MOF), consists of zirconium-oxide clusters (Zr<sub>6</sub>O<sub>4</sub>(OH)<sub>4</sub>) and benzene-1,4-dicarboxylate (BDC) organic linkers. It exhibits abundant active sites, a high specific surface area, a tunable pore structure, and exceptional chemical and thermal stability, making it highly advantageous for various practical applications. The integration of functional components within UiO-66 has been shown to optimize its electronic properties and coordination environment, thereby enhancing its multifunctionality and catalytic performance. This review highlights the analysis of structural characteristics of UiO-66, explores various modification strategies such as the introduction of functional organic linkers, selection of metal nodes, defect engineering, and doping with external functional components, and discusses its applications in environmental remediation and energy-related fields.</p>\u0000 \u0000 <p></p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Key Scientists</h3>\u0000 \u0000 <p></p>\u0000 </section>\u0000 \u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 12","pages":"1417-1441"},"PeriodicalIF":5.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Polar [NH(CH2SO3)2]2− Dimers Enable the First Promising Iminodimethanesulfonate with Nonlinear Optical Properties and Wide UV Transparency","authors":"Yipeng Song, Yuexin Zhang, Yanqiang Li, Zhiyong Bai, Weiqi Huang, Kunpeng Wang, Sangen Zhao, Junhua Luo","doi":"10.1002/cjoc.70006","DOIUrl":"https://doi.org/10.1002/cjoc.70006","url":null,"abstract":"<div>\u0000 \u0000 <p>Non-π-conjugated groups have recently emerged as excellent fundamental building blocks (FBUs) for UV nonlinear optical (NLO) crystals, due to their ability to achieve wide transparency. However, their generally high crystallographic symmetry often results in limited optical anisotropy, making few resultant crystals phase-matchable in the UV wavelength range. In this work, we introduce the polar [NH(CH<sub>2</sub>SO<sub>3</sub>)<sub>2</sub>]<sup>2−</sup> dimer as a novel non-π-conjugated FBU, and synthesize the first NLO iminodimethanesulfonate crystal, namely Cs<sub>2</sub>NH(CH<sub>2</sub>SO<sub>3</sub>)<sub>2</sub>·H<sub>2</sub>O. Experimental results demonstrate that this crystal exhibits second-harmonic generation (SHG) responses with 0.8 times of KDP, moderate birefringence of 0.044@550 nm, and broad UV transparency (< 200 nm), enabling phase-matchable SHG at the key UV wavelength of 266 nm. First-principles calculations confirm that polar [NH(CH<sub>2</sub>SO<sub>3</sub>)<sub>2</sub>]<sup>2−</sup> dimers contribute to the optical properties of Cs<sub>2</sub>NH(CH<sub>2</sub>SO<sub>3</sub>)<sub>2</sub>·H<sub>2</sub>O. This work highlights an excellent UV NLO-active FBU for exploring high-performance UV NLO crystals.</p>\u0000 <p>\u0000 </p>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 12","pages":"1399-1404"},"PeriodicalIF":5.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Machine Learning-Based Prediction of Bond Dissociation Energies for Metal-Trifluoromethyl Compounds†","authors":"Yingbo Shao, Haisong Xu, Feiying You, Yao Li, Qi Yang, Xiao-Song Xue","doi":"10.1002/cjoc.202500083","DOIUrl":"https://doi.org/10.1002/cjoc.202500083","url":null,"abstract":"<div>\u0000 \u0000 <p>This study explores the application of machine learning to predict the bond dissociation energies (BDEs) of metal-trifluoromethyl compounds. We constructed a dataset comprising 2219 metal-trifluoromethyl BDEs using density functional theory (DFT). Through a comparative analysis of various machine learning algorithms and molecular fingerprints, we determined that the XGBoost algorithm, when combined with MACCS and Morgan fingerprints, exhibited superior performance. To further enhance predictive accuracy, we integrated chemical descriptors alongside multiple fingerprints, achieving an <i>R</i><sup>2</sup> value of 0.951 on the test set. The model demonstrated excellent generalization capabilities when applied to synthesized metal-trifluoromethyl compounds, highlighting the critical role of chemical descriptors in improving predictive performance. This research not only establishes a robust predictive model for metal-trifluoromethyl BDEs but also underscores the value of incorporating chemical insights into machine learning workflows to enhance the prediction of chemical properties.</p>\u0000 <p>\u0000 </p>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 12","pages":"1363-1372"},"PeriodicalIF":5.5,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synthesis of 1,7-Annulated Indazole Derivatives via Bifunctional Brønsted Base Catalyzed Cascade Reaction","authors":"Pengcheng Shao, Weiwu Ren","doi":"10.1002/cjoc.70010","DOIUrl":"https://doi.org/10.1002/cjoc.70010","url":null,"abstract":"<div>\u0000 \u0000 <p>A novel method for the asymmetric synthesis of 1,7-annulated indazoles has been developed via bifunctional Brønsted base catalyzed cascade reaction. This process enabled the formation of multiple chiral centers including a quaternary carbon center in high yields with excellent diastereoselectivities and enantioselectivities. The reaction exhibited broad functional group tolerance and mild reaction conditions.</p>\u0000 <p>\u0000 </p>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 12","pages":"1373-1378"},"PeriodicalIF":5.5,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}