Chinese Journal of Chemistry最新文献

{"title":"Dynamic Covalent and Noncovalent Bonds Based Self-assembled Biomaterials: From Construction to Biomedical Applications","authors":"Chengfei Liu,&nbsp;Yifan Jin,&nbsp;Jiaqi Li,&nbsp;Zeyi Wang,&nbsp;Jingxia Wang,&nbsp;Wei Tian","doi":"10.1002/cjoc.70041","DOIUrl":"https://doi.org/10.1002/cjoc.70041","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <p>Self-assembly processes are ubiquitous in biological systems, playing essential roles in sustaining life activities. The exploration of self-assembled biomaterials (SABMs) holds great potential for advancing various fields, particularly in biomedicine and materials science. Because of the unique reversibility and responsiveness to stimuli, dynamic covalent bonds (DCBs) and noncovalent bonds (NCBs) endow SABMs with self-healing properties, stimuli responsiveness and controllable degradation, making them highly versatile for a wide range of biomedical applications. In this article, recent advances and future trends for SABMs based on DCBs and NCBs are thoroughly reviewed. We begin by introducing the molecular principles and characteristics of DCBs and NCBs that govern the formation of SABMs. We also explore the responsive and functional features of these materials in detail. Finally, we summarize the perspectives and challenges associated with the development of SABMs in biomedical applications. We aim for this review to offer a comprehensive overview of SABMs, serving as a valuable resource for chemists and materials scientists striving to further advance the design of SABMs in biological applications.\u0000 </p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Key Scientists</h3>\u0000 \u0000 <p>\u0000 </p>\u0000 </section>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 16","pages":"2053-2068"},"PeriodicalIF":5.5,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144624783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visible-Light-Driven Multicomponent Reactions of Diazosulfonium Triflates with Amines and CS2 or CO2: Direct Synthesis of Bis-Dithiocarbamates/Carbamates","authors":"Xue-Cen Xu,&nbsp; Yue-Gong,&nbsp;Jie Wang,&nbsp;Yu-Xuan Meng,&nbsp;Yu-Long Zhao","doi":"10.1002/cjoc.70083","DOIUrl":"https://doi.org/10.1002/cjoc.70083","url":null,"abstract":"<div>\u0000 \u0000 <p>Visible light-induced transformation of CO₂ and CS₂ into value-added products has attracted worldwide attention because it mimics nature. In this context, although visible-light-induced direct synthesis of dithiocarbamates and carbamates employing SO₂ and CO₂ as a C1 source has been reported, all these reactions are limited to the preparation of <i>S</i>-alkyl mono-dithiocarbamates and <i>O</i>-alkyl mono-carbamates. Herein, we report a visible-light photoredox-catalyzed multicomponent reaction of diazosulfonium triflates with amines and CS₂ or CO₂. Mechanistic studies indicate that the diazomethyl radicals might be generated as the key intermediates, thus providing a direction for the application of diazomethyl radicals with other radical acceptors.</p>\u0000 <p></p>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 16","pages":"1997-2004"},"PeriodicalIF":5.5,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144624852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the Dynamic Landscape of RNA Modifications: Insights from MS, NMR, and Beyond","authors":"Jiang Zhou,&nbsp;Chun Tang","doi":"10.1002/cjoc.70017","DOIUrl":"https://doi.org/10.1002/cjoc.70017","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <p>RNA modifications greatly expand the functional diversity of RNA molecules, impacting RNA's stability, folding, and interactions with other biomolecules. These modifications play critical roles in cellular processes and are increasingly linked to disease states. Developments in mass spectrometry (MS), nuclear magnetic resonance (NMR), and chemical probing techniques have provided insights into the mechanisms and functions of RNA modifications. Combining these experimental approaches allows researchers to explore the complexities of RNA modifications and their effects on RNA structure and dynamics. This review highlights recent progresses in the field and examines how the integration of MS, NMR, and complementary techniques is advancing our understanding of RNA modifications and their biological significance.</p>\u0000 \u0000 <p></p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Key Scientists</h3>\u0000 \u0000 <p>The landscape of RNA biology has undergone a dramatic transformation due to the development of powerful methodologies that specifically target the identification, characterization, and functional analysis of RNA modifications. Scientists have pioneered advancements in mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy, enabling the detailed study of these modifications and their impact on RNA structure, dynamics, and function. These techniques have been instrumental in revealing the vast complexity of RNA modifications, demonstrating how chemical alterations to RNA molecules can profoundly influence cellular processes. This timeline highlights the contributions of key figures who have specifically developed and applied these techniques to investigate RNA modifications, advancing our understanding of their biological significance and potential roles in disease.</p>\u0000 \u0000 <p></p>\u0000 </section>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 15","pages":"1885-1893"},"PeriodicalIF":5.5,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144520145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficient Allylation of Dihalides: A Versatile Approach to C/N/O-Functionalized Derivatives","authors":"Mengdi Pang,&nbsp;Wentao Hao,&nbsp;Xiulin Li,&nbsp;Chunyan Zhang,&nbsp;Ali Morsali,&nbsp;Ali Ramazani,&nbsp;Guoying Zhang","doi":"10.1002/cjoc.70084","DOIUrl":"https://doi.org/10.1002/cjoc.70084","url":null,"abstract":"<div>\u0000 \u0000 <p>This study presents an efficient and innovative allylation strategy utilizing C/N/O nucleophilic reagents with attenuated reactivity, enabling the construction of versatile allyl compounds. The approach focuses on the sequential allylation of dihalides in large-scale chemical manufacturing, effectively addressing the challenge of achieving selectivity in cascade reactions. The methodology is centered on the Cu-catalyzed <i>C</i>-olefination of alkynes with dihalides, significantly expediting the synthesis of a diverse array of finely conjugated enyne derivatives. Furthermore, a base-facilitated sequential condensation process has been developed to achieve the <i>N</i>-allylation of hydrazines, yielding a wide range of trisubstituted alkenyl hydrazones. Additionally, the protocol enables the synthesis of high-value ester compounds through <i>O</i>-allylation or esterification with dihalides. This transformation also facilitates the one-step synthesis of a variety of essential pharmaceuticals, demonstrating its broad synthetic utility and potential.</p>\u0000 <p>\u0000 </p>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 16","pages":"2005-2014"},"PeriodicalIF":5.5,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144624853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expedient Cyano-hydroxylation of Alkenes Enabled by Halogen Atom Transfer Induced Radical Ring-Opening Elaboration of 3-Bromo-isoxazoline Cycloadducts","authors":"Hui Wang,&nbsp;Qing Chen,&nbsp;Shuhui Wang,&nbsp;Cheng-Qiang Wang,&nbsp;Chao Feng","doi":"10.1002/cjoc.70070","DOIUrl":"https://doi.org/10.1002/cjoc.70070","url":null,"abstract":"<div>\u0000 \u0000 <p>Herein, we present a highly efficient one-pot, two-step synthesis of <i>β</i>-hydroxy nitrile scaffolds, which possess both significant synthetic value and notable biological activity, starting from readily accessible alkenes. This methodology relies crucially on the seamless integration of a highly regioselective (3+2) cycloaddition reaction, employing the commercially available 1,1-dibromoformaldoxime as the 1,3-dipole precursor, with a subsequent halogen atom transfer-induced radical ring-opening elaboration of the resulting 3-bromo-2-isoxazoline cycloadducts. This protocol is featured by mild reaction conditions, broad alkene scope and various derivatizations of the obtained cyano-hydroxylation products, offering a versatile and practical pathway to accessing multi-functionalized molecules.</p>\u0000 <p></p>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 16","pages":"2015-2020"},"PeriodicalIF":5.5,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144624854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simple Units Integration Brings New Reactivity: Neighboring Group Effect in the Synthesis of Polyfunctionalized 5-Alkenyl-3-furanones from γ-Hydroxyl Enal","authors":"Jun Tan,&nbsp;Chengyan Xie,&nbsp;Youai Qiu,&nbsp;Dengke Ma","doi":"10.1002/cjoc.70032","DOIUrl":"https://doi.org/10.1002/cjoc.70032","url":null,"abstract":"<div>\u0000 \u0000 <p>With the hypothesis of simple units integration to create new reactivities, a strategy for the synthesis of polyfunctionalized 5-alkenyl-3-carbonylfurans from γ-hydroxyl enal and 1,3-dicarbonyl compounds is established, featuring readily available starting materials, high efficiency, good functional groups compatibility, green chemistry with high atom economy and only water release, <i>etc</i>., to provide a series of polyfunctionalized 5-alkenyl-3-carbonylfurans, which could be applied to the late-stage functionalization of naturally occurring compounds and bioactive molecules, as well as the transformation to pyrroles and polycyclic aromatic hydrocarbon via electrocyclic reaction. The γ-hydroxyl has played an important role in the unexpected process of ring opening isomerization of 2<i>H</i>-pyran to furanones, as confirmed by detailed mechanistic studies.</p>\u0000 <p>\u0000 </p>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 14","pages":"1643-1650"},"PeriodicalIF":5.5,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144292852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inside Cover Picture","authors":"","doi":"10.1002/cjoc.70102","DOIUrl":"https://doi.org/10.1002/cjoc.70102","url":null,"abstract":"<p>Zeng <i>et al</i>. demonstrate various synthetic pathways for DNA coacervates based on liquid-liquid phase separation, exploring their biological and biomimetic applications. Benefiting from the programmability of DNA and the fluidity of coacervate structures, DNA coacervates can not only act as artificial cells with cell-like behaviors but also achieve intelligent sensing and precise therapy through specific signal transduction with natural cells. More details are discussed in the article on pages 1442—1462.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 12","pages":"1330"},"PeriodicalIF":5.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cjoc.70102","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual Photoredox/Copper-Catalyzed 1,2-Diphosphorothiolation of Alkenes with P(O)SH Compounds to Access Vicinal Bisphosphorothioates","authors":"Pengbo Zhang,&nbsp;Longyu Wang,&nbsp;Xinyi Guo,&nbsp;Yaxin Liu,&nbsp;Qihang Yang,&nbsp;Xia Gao","doi":"10.1002/cjoc.70089","DOIUrl":"https://doi.org/10.1002/cjoc.70089","url":null,"abstract":"<div>\u0000 \u0000 <p>An efficient photoredox/copper dual-catalyzed 1,2-diphosphorothiolation of alkenes with P(O)SH compounds was realized under oxidative conditions. In this transformation, P(O)SH acted as both the phosphorothioate radical source and the coupling partner. A wide range of valuable vicinal bisphosphorothioates can be easily constructed starting from simple raw materials in a step- and atom-economical manner. Notably, this reaction system has been successfully used to incorporate two phosphorothioate groups into many drug molecules, highlighting the substantial synthetic potential of this protocol.</p>\u0000 <p>\u0000 </p>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 16","pages":"1977-1982"},"PeriodicalIF":5.5,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144624287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Three-Phase Indirect Electrolysis System for Kilo-scale Generation of C–S Bond Products","authors":"Gang Liu,&nbsp;Xianqiang Huang,&nbsp;Yingjie Li,&nbsp;Shiqi Fu,&nbsp;Guodong Shen,&nbsp;Zhen Li,&nbsp;Yalin Zhang,&nbsp;Qingde Zhang,&nbsp;Fei Yu,&nbsp;Yifa Chen","doi":"10.1002/cjoc.70068","DOIUrl":"https://doi.org/10.1002/cjoc.70068","url":null,"abstract":"<div>\u0000 \u0000 <p>The development of new strategy for environmentally friendly, cost-effective and large-scale electro-synthesis of anticancer drugs is highly desirable to replace high-cost traditional methods and realize high atomic economy. GW 610, an antitumor agent with potent and selective anticancer activity against lung, colon, and breast cancer cell lines in real medical treatment processes, has a market price of ~10⁷ USD/kg and calls for novel methods like electro-synthesis to reduce the cost. Here, for the first time, we design a solid-liquid-gas three-phase indirect electrolysis system based on a kind of microwave-synthesized polyoxometalate-based metal-organic framework (MW-POMOF) that can converse S–S bond substrates into valuable C–S bond products like anticancer drug molecules (<i>e.g</i>., GW 610). Specifically, the solid-phase MW-POMOF as heterogeneous redox mediator exhibits the excellent electrocatalytic efficiency for the formation of liquid-phase C–S bond products (yields up to 95%) coupling with the generation of gas-phase H₂ product (~402 μmol·g^–1·h^–1), resulting in an interesting three-phase indirect electrolysis system. Remarkably, it enables the kilo-scale production (~1 kg in a batch experiment) of GW 610 at one thousandth of the market price (from ~10⁷ to ~3200 USD/kg). This work may inaugurate a new electrocatalytic avenue to explore porous crystalline materials in electrocatalysis field.</p>\u0000 <p>\u0000 </p>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 16","pages":"1968-1976"},"PeriodicalIF":5.5,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144624644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chiral Hydrogen-Bonded Organic Frameworks: Design, Synthesis, and Applications†","authors":"Jialin Cui,&nbsp;Qingyan Pan,&nbsp;Xiaotao Wang,&nbsp;Hongbo Ma,&nbsp;Hailong Yu,&nbsp;Shiwei Liu,&nbsp;Yingjie Zhao","doi":"10.1002/cjoc.70042","DOIUrl":"https://doi.org/10.1002/cjoc.70042","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <p>Chiral framework materials, such as chiral metal-organic frameworks (MOFs) and chiral covalent organic frameworks (COFs), have been extensively reported and studied. However, research on chiral hydrogen-bonded organic frameworks (HOFs) is far behind. HOFs present a novel approach for creating chiral materials, thanks to their mild synthesis conditions, solution processability, and ease of repair and regeneration. This review provides a comprehensive overview of the design and synthesis strategies for chiral HOFs, highlighting recent advancements and exploring the applications of emerging chiral HOFs materials.</p>\u0000 \u0000 <p>\u0000 </p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Key Scientists</h3>\u0000 \u0000 <p>In the 1990s, Wuest and his collaborators advanced the development of the HOF field through the design and synthesis of porous hydrogen-bonded networks. In 2011, Chen and co-workers reported one of the first examples of microporous HOFs achieved through permanent porosity. In 2014, Ward and co-workers developed a series of two-dimensional guanidine-sulfonate hydrogen-bonded frameworks with tunable crystal structures, whose flexibility allowed them to be used for structural detection. Further, in 2015, Chen, Li and co-workers constructed the first example of chiral HOF derived from the chiral building block. In 2017, Yuan, Wu, and co-workers synthesized an ultrastable, easily regenerated hydrogen-bonded organic molecular framework with permanent porosity. In 2018, Cao, Liu and co-workers synthesized an ultrastable, crystalline, and recyclable HOF for synergistic chemo photodynamic therapy. In 2021, Zhang and co-workers achieved ethylene/ethane separation in a stable HOF through a gating mechanism. In 2022, Cao, Liu, and co-workers developed an innovative mechanochemical strategy for HOF synthesis. The story of HOFs is still unfolding.</p>\u0000 \u0000 <p>\u0000 </p>\u0000 </section>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 14","pages":"1756-1769"},"PeriodicalIF":5.5,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144292198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}