Dynamic Covalent and Noncovalent Bonds Based Self-assembled Biomaterials: From Construction to Biomedical Applications

IF 5.5 1区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chinese Journal of Chemistry Pub Date : 2025-05-20 DOI:10.1002/cjoc.70041

Chengfei Liu, Yifan Jin, Jiaqi Li, Zeyi Wang, Jingxia Wang, Wei Tian

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Abstract

Self-assembly processes are ubiquitous in biological systems, playing essential roles in sustaining life activities. The exploration of self-assembled biomaterials (SABMs) holds great potential for advancing various fields, particularly in biomedicine and materials science. Because of the unique reversibility and responsiveness to stimuli, dynamic covalent bonds (DCBs) and noncovalent bonds (NCBs) endow SABMs with self-healing properties, stimuli responsiveness and controllable degradation, making them highly versatile for a wide range of biomedical applications. In this article, recent advances and future trends for SABMs based on DCBs and NCBs are thoroughly reviewed. We begin by introducing the molecular principles and characteristics of DCBs and NCBs that govern the formation of SABMs. We also explore the responsive and functional features of these materials in detail. Finally, we summarize the perspectives and challenges associated with the development of SABMs in biomedical applications. We aim for this review to offer a comprehensive overview of SABMs, serving as a valuable resource for chemists and materials scientists striving to further advance the design of SABMs in biological applications.

Key Scientists

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基于自组装生物材料的动态共价键和非共价键：从构建到生物医学应用

自组装过程在生物系统中无处不在，在维持生命活动中发挥着重要作用。对自组装生物材料（SABMs）的探索在推进各个领域，特别是生物医学和材料科学方面具有巨大的潜力。由于其独特的可逆性和对刺激的反应性，动态共价键（DCBs）和非共价键（NCBs）赋予sabm自愈特性、刺激反应性和可控降解，使其具有广泛的生物医学应用。本文全面回顾了基于dcb和ncb的sabm的最新进展和未来趋势。我们首先介绍控制sabm形成的dcb和ncb的分子原理和特征。我们还详细探讨了这些材料的响应特性和功能特性。最后，我们总结了与SABMs在生物医学应用中的发展相关的前景和挑战。本文旨在对SABMs进行全面的综述，为化学家和材料科学家进一步推进SABMs在生物应用中的设计提供宝贵的资源。关键的科学家

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来源期刊

Chinese Journal of Chemistry 化学-化学综合

CiteScore

8.80

自引率

14.80%

发文量

422

审稿时长

1.7 months

期刊介绍： The Chinese Journal of Chemistry is an international forum for peer-reviewed original research results in all fields of chemistry. Founded in 1983 under the name Acta Chimica Sinica English Edition and renamed in 1990 as Chinese Journal of Chemistry, the journal publishes a stimulating mixture of Accounts, Full Papers, Notes and Communications in English.