双光氧化还原/铜催化烯烃与P(O)SH化合物的1,2-二磷硫基化制备邻双磷硫酸盐

IF 5.5 1区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chinese Journal of Chemistry Pub Date : 2025-05-12 DOI:10.1002/cjoc.70089

Pengbo Zhang, Longyu Wang, Xinyi Guo, Yaxin Liu, Qihang Yang, Xia Gao

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引用次数: 0

摘要

在氧化条件下，实现了光氧化还原/铜双催化烯烃与P(O)SH化合物的1,2-二磷硫代化反应。在此转化过程中，P(O)SH既是硫代磷酸酯自由基源，也是偶联伙伴。从简单的原料开始，以步进和原子经济的方式，可以很容易地构建各种有价值的邻域双硫代酸盐。值得注意的是，该反应体系已成功地将两个硫代磷酸酯基团结合到许多药物分子中，突出了该方案的巨大合成潜力。

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Dual Photoredox/Copper-Catalyzed 1,2-Diphosphorothiolation of Alkenes with P(O)SH Compounds to Access Vicinal Bisphosphorothioates

An efficient photoredox/copper dual-catalyzed 1,2-diphosphorothiolation of alkenes with P(O)SH compounds was realized under oxidative conditions. In this transformation, P(O)SH acted as both the phosphorothioate radical source and the coupling partner. A wide range of valuable vicinal bisphosphorothioates can be easily constructed starting from simple raw materials in a step- and atom-economical manner. Notably, this reaction system has been successfully used to incorporate two phosphorothioate groups into many drug molecules, highlighting the substantial synthetic potential of this protocol.

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来源期刊

Chinese Journal of Chemistry 化学-化学综合

CiteScore

8.80

自引率

14.80%

发文量

422

审稿时长

1.7 months

期刊介绍： The Chinese Journal of Chemistry is an international forum for peer-reviewed original research results in all fields of chemistry. Founded in 1983 under the name Acta Chimica Sinica English Edition and renamed in 1990 as Chinese Journal of Chemistry, the journal publishes a stimulating mixture of Accounts, Full Papers, Notes and Communications in English.