Chinese Journal of Chemistry最新文献

{"title":"Recent Advances of Terpenoids with Intriguing Chemical Skeletons and Biological Activities","authors":"Yi Zang,&nbsp;Ruo-nan Sun,&nbsp;Ran-qi Feng,&nbsp;Hong-hui Zhu,&nbsp;Xu-wen Li","doi":"10.1002/cjoc.202400697","DOIUrl":"https://doi.org/10.1002/cjoc.202400697","url":null,"abstract":"<div>\u0000 \u0000 <p>Terpenoids are a large and diverse family of secondary metabolites that have gained more attention from chemists and pharmacologists for their intriguing skeletons and broad biological activities, including anti-inflammatory, antitumoral, antimicrobial, and anti-viral effects. Based on the previous reviews, this review comprehensively summarized recent advances on bioactive terpenoids, focusing on their intriguing structural features and promising biological activities, covering literature from 2020 to 2023. In this review, 532 terpenoids with remarkable chemical architectures and biological properties are classified into sesquiterpenoids (142), diterpenoids (129), sesterterpenoids (24), triterpenoids (52), and meroterpenoids (185), that were isolated from terrestrial and marine resources. This review would provide a reference for researchers to rapidly discover the interesting terpenoids for further study as promising drug leads.</p>\u0000 <p>\u0000 </p>\u0000 <p>\u0000 \u0000 </p>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 4","pages":"443-469"},"PeriodicalIF":5.5,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143117588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radical Functionalization of 1,6-Diene via Transannular Cyano Migration: Synthesis of Polysubstituted Cyclopentanes†","authors":"Ziqiang Wang,&nbsp;Yasu Chen,&nbsp;Chen Zhu","doi":"10.1002/cjoc.202401072","DOIUrl":"https://doi.org/10.1002/cjoc.202401072","url":null,"abstract":"<div>\u0000 \u0000 <p>An efficient transannular cyano migration is reported for <i>gem</i>-dicyano-1,6-diene, which is triggered by the addition of external arylsulfonyl radicals. The overall transformation proceeds through a sequence of intramolecular 5-exo-trig cyclization, suprafacial 1,4-cyano migration, and the capture by H or D atom, leading to the production of valuable polysubstituted cyclopentanes under mild photoredox catalytic conditions. The reaction is adapted to a wide range of sodium (hetero)arylsulfinates, demonstrating good functional group compatibility. This method provides a new protocol for radical-mediated functional group migration.</p>\u0000 <p>\u0000 </p>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 4","pages":"437-442"},"PeriodicalIF":5.5,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143117586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering the Biosynthetic Logic for C14 Oxidative Modifications of Polycyclic Tetramate Macrolactams","authors":"Peng Jiang,&nbsp;Hongbo Jin,&nbsp;Wenjun Zhang,&nbsp;Wei Tang,&nbsp;Xiaodong Jiang,&nbsp;Yiguang Zhu,&nbsp;Ying Wang,&nbsp;Liping Zhang,&nbsp;Changsheng Zhang","doi":"10.1002/cjoc.202400982","DOIUrl":"https://doi.org/10.1002/cjoc.202400982","url":null,"abstract":"<div>\u0000 \u0000 <p>Polycyclic Tetramate Macrolactams (PoTeMs) are a family of structurally complex natural products with significant bioactivities. Most of the widespread biosynthetic gene clusters (BGCs) of PoTeMs in bacteria remain silent under normal fermentation conditions. Herein, we report the construction of an efficient chassis (306A) to facilitate the heterologous studies of PoTeM BGCs, which reveals a biosynthetic logic for sequential C14 modifications of PoTeMs through characterizing a PoTeM gene cluster (<i>fla</i>) from marine-derived <i>Streptomyces falvogriseus</i> SCSIO 40032. The C14 hydroxylation was mediated by flavin-dependent oxidoreductase FlaB1 when catalyzing the crucial C6—C13 cyclization, which was supported by feeding and ¹⁸O₂ labeling studies; the C14-OH groups in 5/5/6-type PoTeMs are subsequently converted to ketones by the cytochrome P450 enzyme FlaD. The FlaD homologs FtdF and SSHG_05717 were assayed to show similar functions as FlaD. Besides, the crystal structure of pactamide N (<b>5</b>) provides a critical reference for determining the absolute configuration of 5/5/6-type PoTeMs lacking C14 modifications. This study not only affords an efficient chassis for studying silent PoTeM BGCs, but also provides insights into the biosynthetic logic for C14 oxidative modifications of predominant 5/5- and 5/5/6-type PoTeMs.</p>\u0000 <p>\u0000 </p>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 5","pages":"483-490"},"PeriodicalIF":5.5,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143117589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polymer Degradation via a Mechanochemical Gating Strategy","authors":"Xiaojing Liang,&nbsp;Hai Qian","doi":"10.1002/cjoc.202400952","DOIUrl":"https://doi.org/10.1002/cjoc.202400952","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <p>The extensive use of plastics, valued for their lightweight, durability, and cost-effectiveness, has led to severe environmental pollution, with 72% of plastic waste ending up in landfills or natural habitats. Traditional methods for plastic decomposition, including both mechanical and chemical approaches, often face challenges such as incomplete degradation and stability concerns. The innovative concept of mechanical gating presents a promising solution by incorporating mechanophores into polymer structures, enabling controlled degradation. Recent advancements have focused on utilizing mechanophores, such as cyclobutane, as \"door locks\" to regulate the degradation process. This perspective highlights recent progress in this field, demonstrating the potential of mechanophore-based strategies for achieving on-demand polymer degradation. It addresses the limitations of conventional recycling methods and explores how this approach can balance polymer stability with environmental degradability, paving the way for more sustainable plastic management solutions.</p>\u0000 \u0000 <p></p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Early Day Record</h3>\u0000 \u0000 <p></p>\u0000 </section>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 3","pages":"349-354"},"PeriodicalIF":5.5,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143117510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two-Dimensional Janus p-n Heterojunction of Co3O4 and CoMoO4 for Boosting Photocatalytic Oxidative Desulfurization","authors":"Dongxiao Wang,&nbsp;Zheng Lan,&nbsp;Yue Li,&nbsp;Ying Huang,&nbsp;Kun Yin,&nbsp;Lixia Yang,&nbsp;Liangjiu Bai,&nbsp;Donglei Wei,&nbsp;Huawei Yang,&nbsp;Hou Chen,&nbsp;Mingchuan Luo","doi":"10.1002/cjoc.202400848","DOIUrl":"https://doi.org/10.1002/cjoc.202400848","url":null,"abstract":"<div>\u0000 \u0000 <p>Photocatalytic aerobic oxidative desulfurization (PAODS) is a sustainable alternative technology to traditional, energy-intensive fuel desulfurization methods. Nonetheless, its advancement is hindered by the notable challenge of inadequate electron-hole separation efficiency within the existing catalytic systems. Herein, a Janus 2D/2D heterostructure composed of Co₃O₄ and CoMoO₄ is reported for the PAODS of thiophenic sulfides. Through a combination of detailed experimental characterizations and density functional theory (DFT) calculations, we elucidate the formation of a type II p-n heterojunction in the catalyst, significantly enhancing electron-hole separation through electric field force and reducing the possibility of electron-hole recombination due to the spatial separation of redox centres. The photocatalyst exhibits exceptional activity and demonstrates an impressive performance of 10.4 mmol·g^–1·h^–1 in the oxidation of dibenzothiophene (DBT). Moreover, the photocatalyst demonstrates profound desulfurization capabilities in real diesel, reinforcing its promising prospects for industrial application. These discoveries provide invaluable insights, both scientifically and practically, towards the development of advanced photocatalysts for PAODS processes.</p>\u0000 <p>\u0000 </p>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 3","pages":"308-314"},"PeriodicalIF":5.5,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143117508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Advances in the Development of Indolizine Scaffolds: Synthetic Methodology and Mechanistic Insights","authors":"Jiuzhong Huang,&nbsp;Chunsheng Li,&nbsp;Xiaoning Li,&nbsp;Guangyu Li,&nbsp;Ziyi Yang,&nbsp;Yinke Yu,&nbsp;Yanping Xie,&nbsp;Hao Huang,&nbsp;Fuchao Yu,&nbsp;Zhihua He","doi":"10.1002/cjoc.202400798","DOIUrl":"https://doi.org/10.1002/cjoc.202400798","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Comprehensive Summary</h3>\u0000 \u0000 <p>Indolizine is a nitrogen-containing heterocycle with strong aromaticity, possessing a delocalized 10π-electron system. Based on the indolizine scaffolds, numerous molecules with biological activity and organic functional materials have been synthesized. Since 2016, over 110 papers have been published on the synthesis of indolizine scaffolds, but the reviews on synthesizing indolizine scaffolds have been incomplete and not up-to-date. Herein, from the perspective of the structure of indolizine with the combination of pyrrole and pyridine ring, we focus on the construction of indolizine scaffolds through the diversity of starting substrates, including pyridine derivatives (N1-substituted pyridinium salt derivatives, C2-substituted pyridine derivatives, N1- and C2-free substituted pyridine derivatives), pyrrole derivatives and unoriginal ring substrates. Furthermore, the corresponding reaction mechanisms of synthetic methodologies are also elaborated. Therefore, this review not only paves the way for indolizine synthesis but also provides insight into exploring new reaction modes for constructing nitrogen-containing heterocycles.</p>\u0000 \u0000 <p>\u0000 </p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Key Scientists</h3>\u0000 \u0000 <p>Indolizine was discovered by Angeli in 1890 and first prepared by Scholtz in 1912 from α-picoline and acetic anhydride. A general approach was developed by Chichibabin in 1927, that is of practical value for the preparation of 2-alkyl- or 2-arylindolizines. The Chichibabin reaction was the ring closure of quaternary pyridinium halides. At the begining of the 21st century, Basavaiah introduced a new dimension in the Baylis-Hillman chemistry leading to a novel facile convenient methodology for synthesis of indolizine scaffolds in one-pot operation. In 2010, Barluenga reported Cu(I)-catalyzed regioselective [3+2] cyclization of unsubstituted pyridines toward alkenyldiazoacetates leading to functionalized indolizine derivatives, that was the first successful example of metal-catalyzed cyclization of a π-deficient heterocyclic system with alkenyldiazo compounds. In 2019 and 2022, Xi and Liu exploited the methods of non-pyridine derivatives as starting materials to synthesize indolizines, respectively. In 2022, Guo developed an environmentally benign electrooxidative approach for constructing formyl- and acyl-substituted indolizines.</p>\u0000 \u0000 <p>\u0000 </p>\u0000 </section>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 3","pages":"315-348"},"PeriodicalIF":5.5,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143117509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tailoring Na+ Diffusion Kinetics and Structural Stability of P2-Layered Material by W-Lattice Doping†","authors":"Hang Fan,&nbsp;Lei Xu,&nbsp;Ying Lei,&nbsp;Jianying Li,&nbsp;Tinghong Huang,&nbsp;Weifeng Fan,&nbsp;Yun Zhang","doi":"10.1002/cjoc.202400861","DOIUrl":"https://doi.org/10.1002/cjoc.202400861","url":null,"abstract":"<div>\u0000 \u0000 <p>The pursuit of advanced sodium-ion batteries (SIBs) has been intensified due to the escalating demand for sustainable energy storage solutions. A W-doped P2-type layered cathode material, Na_0.67Ni_0.246W_0.004Mn_0.75O₂ (NNWMO), has been developed to address the limitations of traditional cathode materials. Compared to the pristine Na_0.67Ni_0.25Mn_0.75O₂ (NNMO), NNWMO exhibits improved reversible capacity, excellent cycle performance, and remarkable rate performance. It can deliver an increased discharge capacity of 142.20 mAh/g at 0.1 C, with an admirable capacity retention of 80.5% after 100 cycles at high voltage. <i>In situ</i> XRD results demonstrate that the rivet effect related to the strong W—O bonds inhibits irreversible phase transition and enhances structural reversibility during charge/discharge processes. High-resolution scanning transmission electron microscopy and X-ray diffraction results confirm successful lattice doping of W⁶⁺ and increased layer spacing, contributing to favorable sodium ion diffusion kinetics. Density-functional theory (DFT) calculation results further reveal that the smoother Na⁺ ion diffusion dynamics is attributed to the reduced migration energy barrier of Na⁺ with the insertion of W⁶⁺. This study provides valuable insights into the design of high-performance cathode materials for next-generation SIBs, showcasing the potential for more efficient, stable, and enduring energy storage solutions.</p>\u0000 <p>\u0000 </p>\u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 4","pages":"399-407"},"PeriodicalIF":5.5,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143116658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meet Our New Associate Editor","authors":"","doi":"10.1002/cjoc.202490244","DOIUrl":"https://doi.org/10.1002/cjoc.202490244","url":null,"abstract":"","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"42 24","pages":"3623"},"PeriodicalIF":5.5,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142642039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meet Our New Editorial Board Members of Spotlights","authors":"","doi":"10.1002/cjoc.202490245","DOIUrl":"https://doi.org/10.1002/cjoc.202490245","url":null,"abstract":"","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"42 24","pages":"3624-3626"},"PeriodicalIF":5.5,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142642040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inside Cover Picture","authors":"","doi":"10.1002/cjoc.202490242","DOIUrl":"https://doi.org/10.1002/cjoc.202490242","url":null,"abstract":"<p>A chemical investigation of the deep-sea-derived fungus <i>Penicillium allii-sativi</i> resulted in the discovery of four new (<b>1</b>—<b>4</b>) and one known (<b>5</b>) meroterpenoids. Compound <b>3</b> significantly blocked the mTOR signaling pathway, resulting in the arrest of cell cycle at G0-G1 phase and triggering mitochondrial apoptosis in Hela cells. While macrophorin A effectively triggered cell death in MDA-MB-231 cancer cells by activating apoptosis pathways involving death receptors, mitochondria, mTOR, and TNF. More details are discussed in the article by Yang <i>et al</i>. on pages 3283—3292.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"42 24","pages":"3174"},"PeriodicalIF":5.5,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cjoc.202490242","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142642141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}