Chinese Journal of Chemistry最新文献_第3页

Enantioselective Construction of Spirooxindole-γ-butyrolactones via NHC-Bound Isobenzofulvene [10π+2π] Cycloaddition nhc键合异苯并呋喃[10π+2π]环加成对映选择性构建螺虫吲哚-γ-丁内酯

IF 5.5 1区化学

Chinese Journal of Chemistry Pub Date : 2025-05-12 DOI: 10.1002/cjoc.70071

Shuixiu Su, Ying Chen, Qiyu Wang, Jian Zhang, Yang-Zi Liu, Wei-Ping Deng

引用次数: 0

Photoinduced Ring-Opening Functionalization of α-Imino-Oxy Acids and Alkanols Enabled by Phthalate-Derived Proton-Coupled Electron Transfer Mediator 邻苯二甲酸盐衍生质子耦合电子转移介质使α-亚胺氧酸和烷醇的光诱导开环功能化

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Chinese Journal of Chemistry Pub Date : 2025-05-12 DOI: 10.1002/cjoc.70074

Chao Tian, Lei Shi

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Interfacial Microenvironment Engineering Based on Ordered TiO2 Porous Films for Enhanced Visible Light Driven Photocatalysis 基于有序TiO2多孔膜的界面微环境工程用于增强可见光驱动光催化

IF 5.5 1区化学

Chinese Journal of Chemistry Pub Date : 2025-05-09 DOI: 10.1002/cjoc.70069

ZhaoYue Tan, Xi Chen, Zhiping Liu, JingYu Lu, Xia Sheng, Xinjian Feng

{"title":"Interfacial Microenvironment Engineering Based on Ordered TiO2 Porous Films for Enhanced Visible Light Driven Photocatalysis","authors":"ZhaoYue Tan, Xi Chen, Zhiping Liu, JingYu Lu, Xia Sheng, Xinjian Feng","doi":"10.1002/cjoc.70069","DOIUrl":"https://doi.org/10.1002/cjoc.70069","url":null,"abstract":"<div>\u0000 \u0000 Visible-light-driven photocatalysis has great potential in environmental remediation and organic synthesis. Rational design and regulation of the reaction interfacial microenvironment is critical for photocatalytic performance, yet challenging. We report here a highly efficient photocatalytic system based on hydrophobic TiO2 porous (H-OTP) film for visible-light-driven dye-sensitized photo-oxidation. Such interface architecture design enhances the adsorption capability of organic dyes and enables the formation of air trapped triphase reaction interface microenvironment as confirmed via three-dimensional (3D) laser scanning confocal microscopy. Based on this interface architecture, the concentrations of O2 and organic molecule at the local reaction zone are both significantly increased, which promotes the generation of reactive oxygen species (•O2− and •OH), and enhances the photocatalytic performance in terms of both kinetics and organic mineralization efficiency. This study highlights the importance of interface microenvironment design and reveals an effective way to develop highly efficient photocatalytic systems.\u0000 \u0000 \u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 16","pages":"1961-1967"},"PeriodicalIF":5.5,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144624273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural Factors Tuning Peptide Proton Transport via Self-Assembly Monolayers 通过自组装单层调节肽质子运输的结构因素

IF 5.5 1区化学

Chinese Journal of Chemistry Pub Date : 2025-05-09 DOI: 10.1002/cjoc.70067

Pan Qi, Xiaobing Li, Houguo Fei, Zijie Wang, Cunlan Guo

{"title":"Structural Factors Tuning Peptide Proton Transport via Self-Assembly Monolayers","authors":"Pan Qi, Xiaobing Li, Houguo Fei, Zijie Wang, Cunlan Guo","doi":"10.1002/cjoc.70067","DOIUrl":"https://doi.org/10.1002/cjoc.70067","url":null,"abstract":"<div>\u0000 \u0000 Proton transport (PT) in solid-state materials is crucial for applications in energy conversion and protonic devices. Nevertheless, the highly complex and disordered structures of conventional proton-conducting materials, such as polymers and proteins, hinder a clear understanding of the mechanisms underlying PT, particularly the formation of hydrogen bond (H-bond) networks and their role in mediating PT. Here, we show that self-assembling monolayers (SAMs) of oligopeptides provide a promising platform for elucidating the key factors that modulate PT related H-bonds, including amide bond interactions, peptide sequence, and chain length. Combined with structural characterizations of SAMs, the electrical measurements under both direct and alternating current modes demonstrate that longer and more extended oligopeptide chains in SAMs result in an ordered molecular arrangement, leading to a more pronounced response of current density (J) to increasing relative humidity (RH). Moreover, this increase in molecular order also shifts the transition from electron-dominated to proton-dominated charge transport to a higher RH. The synergy between carrier concentration and mobility is a key factor contributing to the increase in J. This study not only elucidates the critical role of ordered H-bonds in PT but also expands the application of SAM technology in controlling molecular conformation and enhancing proton conduction.\u0000 \u0000 \u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 16","pages":"1924-1930"},"PeriodicalIF":5.5,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144624716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heterogeneous Organic Polymers Embedded with Chiral Bisoxazoline Ligands for Photoinduced Cu-Catalyzed Asymmetric Cyanation 手性双恶唑啉配体包埋的非均相有机聚合物用于光诱导cu催化不对称氰化

IF 5.5 1区化学

Chinese Journal of Chemistry Pub Date : 2025-05-09 DOI: 10.1002/cjoc.70052

Ren-Jie Yu, Rui-Rui Zhao, Fang Hu, Zhen Su, Ke Gao, Liang-Qiu Lu, Wen-Jing Xiao

引用次数: 0

A Self-immobilizing PET Tracer for Imaging of H2O2 Level in the Brain 一种用于脑内H2O2水平成像的自固定PET示踪剂

IF 5.5 1区化学

Chinese Journal of Chemistry Pub Date : 2025-05-02 DOI: 10.1002/cjoc.70059

Ke Li, Shiliang Zhu, Ying Peng, Ling Qiu, Jianguo Lin

{"title":"A Self-immobilizing PET Tracer for Imaging of H2O2 Level \u0000in the Brain","authors":"Ke Li, Shiliang Zhu, Ying Peng, Ling Qiu, Jianguo Lin","doi":"10.1002/cjoc.70059","DOIUrl":"https://doi.org/10.1002/cjoc.70059","url":null,"abstract":"<div>\u0000 \u0000 Reactive oxygen species (ROS) are involved in the onset and development of neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD). Hydrogen peroxide (H2O2), a key type of ROS, is overexpressed in the early stages of AD and PD and is involved in the disease progression. Assessing H2O2 levels in the brain is considered to be a valuable tool for detecting neurodegenerative diseases and exploring their pathogenesis. In this study, we developed two self-immobilizing PET tracers ([18F]HYAS and [18F]HYAT) based on a quinone methide (QM) scaffold for non-invasive imaging of H2O2 in the brain. Both tracers can respond to H2O2 by forming a QM intermediate, which rapidly reacts with nucleophiles. [18F]HYAT, with proper physicochemical properties, is able of crossing the blood-brain barrier. Increased uptake of [18F]HYAT was observed in the brains of mice treated with 1-methyl-4-phenyl- l,2,3,6-tetrahydropyridine (MPTP), indicating that [18F]HYAT is a useful tracer for PET imaging of H2O2 in the brain.\u0000 \u0000 \u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 16","pages":"1938-1944"},"PeriodicalIF":5.5,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144624198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Chemo-Enzymatic Approach for the Synthesis of C7-Substituted (p)ppGpp Derivatives† 化学-酶法合成c7 -取代(p)ppGpp衍生物

IF 5.5 1区化学

Chinese Journal of Chemistry Pub Date : 2025-05-02 DOI: 10.1002/cjoc.70049

Bianbian Huo, Xiong Zhao, Tingting Li, Xiguang Zhang, Anlain Zhu, Patrick Moser, Jessen J Henning, Lingjun Li

{"title":"A Chemo-Enzymatic Approach for the Synthesis of C7-Substituted (p)ppGpp Derivatives†","authors":"Bianbian Huo, Xiong Zhao, Tingting Li, Xiguang Zhang, Anlain Zhu, Patrick Moser, Jessen J Henning, Lingjun Li","doi":"10.1002/cjoc.70049","DOIUrl":"https://doi.org/10.1002/cjoc.70049","url":null,"abstract":"<div>\u0000 \u0000 More modifiable sites on the nucleoside motif may need to be explored for developing novel (p)ppGpp molecular tools. Herein, we report for the first time that the C7-substituted deazapurine nucleoside triphosphates bearing small modifications as substrates could be effectively accepted by RelSeqNTD protein to react with ATP to give pppGpp derivatives with 65%—89% yields. Further structural derivatization via metal-coupling reaction was performed to produce C7-substituted GTP derivatives with larger bulkiness, and those GTP derivatives were also proven to be good substrates of RelSeqNTD protein. Alkynyl modified pppGpp could be coupled with probes by click reactions as the potential molecular tools for fishing proteins in biological research. We further explored whether the C7-alkynyl-pppGpp (pppGEpp) could be recognized by pppGpp interaction proteins. A micromolar level binding affinity (with a KD value of less than 10 μM) between pppGpp(pppGEpp) and its binding proteins was obtained from the Isothermal Titration Curve (ITC). All those illustrate that these easily accessible functionalized C7-substituted pppGpp derivatives were suitable tools for further exploring the molecular interaction between pppGpp and its binding proteins.\u0000 \u0000 \u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 15","pages":"1841-1846"},"PeriodicalIF":5.5,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144519879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of Allylic Phosphate Linked Dinucleotide Phosphoramidite: For the Application of Oligonucleotide Synthesis, Gene Assembly and Protein Expression† 烯丙基磷酸键合二核苷酸磷酸酰胺的合成：在寡核苷酸合成、基因组装和蛋白表达中的应用

IF 5.5 1区化学

Chinese Journal of Chemistry Pub Date : 2025-05-02 DOI: 10.1002/cjoc.70066

Anzhe Shi, Yi Xu, Xiang Song, Xinxiu Deng, Fei Sun, Xiaoyang He, Shengqi Wang

{"title":"Synthesis of Allylic Phosphate Linked Dinucleotide Phosphoramidite: For the Application of Oligonucleotide Synthesis, Gene Assembly and Protein Expression†","authors":"Anzhe Shi, Yi Xu, Xiang Song, Xinxiu Deng, Fei Sun, Xiaoyang He, Shengqi Wang","doi":"10.1002/cjoc.70066","DOIUrl":"https://doi.org/10.1002/cjoc.70066","url":null,"abstract":"<div>\u0000 \u0000 Chain elongation via dinucleotide (dimer) block coupling was considered as an improved chemical technique capable of synthesizing high-quality longer oligonucleotide for de novo DNA synthesis in synthetic biology. However, this dimer block-wise approach was constrained by readily available dimer phosphoramidite with sufficient quality. Herein, through the usage of a one-pot coupling-oxidation-deprotection cascade process for preparing the key precursors 3'-hydroxyl dimers, then condensation with phosphorodiamidite, purification by flash column chromatography and precipation in methyl tert-butyl ether, a rationally designed dimer phosphoramidite bearing an internucleotide allyl phosphate and a β-cyanoethyl phosphoramidite at the 3’-hydroxyl was synthesized. All sixteen allylic dimer phosphoramidites 2a–p were smoothly prepared with overall yields exceeding 50% and HPLC purities ranging from 97.40% to 99.69%. With these allylic reagents, oligonucleotides were successfully synthesized using a modified solid-phase phosphoramidite method and were completely deprotected under normal ammonialysis condition. Our results indicated that these dimer block-wise synthesized oligonucleotides were of sufficient quality for gene assembly and protein expression, thus, the allylic phosphate linked dimer phosphoramidite can serve as a promising dimer reagent that will enable the applications of long oligonucleotides.\u0000 \u0000 \u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 16","pages":"1945-1952"},"PeriodicalIF":5.5,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144624220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A 3D Heterostructural Composite Comprising MOF-Derived Ni(OH)2 and NiAl LDH on rGO for Supercapacitors 由mof衍生的Ni(OH)2和NiAl LDH组成的三维异质结构复合材料在rGO上的超级电容器

IF 5.5 1区化学

Chinese Journal of Chemistry Pub Date : 2025-05-02 DOI: 10.1002/cjoc.70056

Zheng Liu, Huifang Lv, Yanli Gong, Yang Zhao, Hualiang Wei, Guanhua Ding, Xiao Zhang, Yu-Lun Chueh, Chunming Gao, Yan Wang

{"title":"A 3D Heterostructural Composite Comprising MOF-Derived Ni(OH)2 and NiAl LDH on rGO for Supercapacitors","authors":"Zheng Liu, Huifang Lv, Yanli Gong, Yang Zhao, Hualiang Wei, Guanhua Ding, Xiao Zhang, Yu-Lun Chueh, Chunming Gao, Yan Wang","doi":"10.1002/cjoc.70056","DOIUrl":"https://doi.org/10.1002/cjoc.70056","url":null,"abstract":"<div>\u0000 \u0000 The development of high-performance cathode materials through rational heterointerface engineering remains pivotal for advancing hybrid supercapacitors (HSCs) technologies. Here, we construct a three-dimensional ternary heterostructure composite Ni(OH)2/NiAl LDH/rGO (N-OH/NA/rG) by sequential integration of metal-organic frameworks (MOF)-derived Ni(OH)2, NiAl LDH and reduced graphene oxide (rGO). The covalent anchoring of NiAl LDH nanosheets on oxygen-functionalized rGO substrates mitigates restacking issues, establishing a conductive network with enhanced charge transfer kinetics. The alkaline etching of Ni-MOF precursors preserves their hierarchical porosity while converting to pseudocapacitive Ni(OH)₂. Synergistic effects among components yield increased active site density, dual charge storage mechanisms, and optimized ion diffusion pathways. The optimized composite achieves a high specific capacitance of 1481.7 F/g at 1A/g, along with excellent rate capability and cycle performance, establishing a new paradigm for designing multi-component heterostructure electrodes through MOF-derived interface engineering. Furthermore, the N-OH/NA/rG//AC HSC device demonstrates a high power density and energy density, coupled with long-term cycle stability, underscoring the substantial potential of N-OH/NA/rG as a cathode material for HSCs.\u0000 \u0000 \u0000 </div>","PeriodicalId":151,"journal":{"name":"Chinese Journal of Chemistry","volume":"43 15","pages":"1869-1884"},"PeriodicalIF":5.5,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144519878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Enantioselective Synthesis of Chiral γ-Amino Acid Esters via Photoredox/Nickel-Catalyzed Aryl-Aminoalkylation of Alkenes 烯光氧化还原/镍催化芳基氨基烷基化对映选择性合成手性γ-氨基酸酯

IF 5.5 1区化学

Chinese Journal of Chemistry Pub Date : 2025-05-02 DOI: 10.1002/cjoc.70060

Fu Ye, Youzhi Xu, Songlin Zheng, Genping Huang, Weiming Yuan

引用次数: 0